DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and lrp13

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_021327248.1 Gene:lrp13 / 562438 ZFINID:ZDB-GENE-130729-1 Length:1354 Species:Danio rerio


Alignment Length:1462 Identity:394/1462 - (26%)
Similarity:561/1462 - (38%) Gaps:381/1462 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  2630 CGLSQYNC--HSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPET----HFMCQNHR-CIPKE 2687
            |.|....|  .|| |:.....||....|.|||||       ..||..    ||.|.:.: ||...
Zfish    36 CRLGFQLCEDRSG-CVLNTHLCDGENDCDDGSDE-------DNCPTVCSVGHFQCAHGKMCIWLR 92

  Fly  2688 HKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRD 2752
            ..|||..||.|.|||  |.| .:.:|...|..:.||:            |:|..|:||...||.|
Zfish    93 QVCDGVPQCQDRSDE--LNC-FKPDDGCAHRCDGNTR------------CVPESFVCDGDVDCVD 142

  Fly  2753 FSDEKMC----------APIPCEKNDMTFVH---------------------CGNSTICIMPRWR 2786
            .|||..|          ..:..||.:||..|                     |.:.|.|:|....
Zfish   143 GSDEANCENPDDDDDDDEDLLDEKEEMTGEHEVSQNVPATKGPLRCSIASKLCRDGTDCVMLNHV 207

  Fly  2787 CDGDPDCPDGTDELDCANHTSLSCDPGQFRCASG-NCIAGSWHCDGEKDCPDGSDEINC---RTE 2847
            |||:.||.||:||.||    .:.|:.|||:||.| .||.....|||...|.|.|||:||   ..:
Zfish   208 CDGELDCKDGSDEEDC----PVQCESGQFQCAHGKKCIDRRQLCDGVPQCQDRSDELNCFKPDDD 268

  Fly  2848 CRHNQFACDKT--CIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGE 2910
            |.|.   ||:.  |:|.|:.|||..||.|||||. .|....|....:|| |||:|:.....|||.
Zfish   269 CAHR---CDENTRCVPESFVCDGDPDCVDGSDEA-NCGEESCSSAEWQC-SSGQCVSLSMRCDGH 328

  Fly  2911 KDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSH------YVCDGDEDCPGGDDE 2969
            .||     .:.|::|           ||..|....|:..|..||      ::|||:.||..|.||
Zfish   329 SDC-----RDHSDEE-----------DCAEPPPCSTNRRCPKSHECLLDEWMCDGETDCKDGTDE 377

  Fly  2970 YEGCVPAFQPHSCPGGSLMHQCQDGL-CIFKNQTCDGKPDCGDGSDETSSLCA------HTRGCN 3027
             :.|..:  |..|  |.....|.... ||.::..|||..||.|||||  |.||      |.    
Zfish   378 -KNCKES--PVQC--GEYQFSCSSKTQCIPQSWRCDGSEDCRDGSDE--SACASVSCPPHL---- 431

  Fly  3028 GTDDFRCKNGACIHADLLCDRRNDCADFSDE-ELCNVNECLIPDICEHECEDKVVGYQCHCRPGY 3091
                |:|.:..|:....||:...:|.|.||| ..|...:|.....|..:|.....|.:|.||.||
Zfish   432 ----FQCGSSECVEFSQLCNGVTNCLDGSDEGGSCQTEKCSEQLKCAQDCHSTPAGARCGCRMGY 492

  Fly  3092 KVLPKSPHL-CTDIDECDEQ-QPCSQTCINTYGSYKCLCAKGYAL-VDHHTCKATSNVSMELIFS 3153
            |  |....| |.|:|||.|: ..||..|.||.||::|.|:.||.| .|.|:||.|....:.....
Zfish   493 K--PVDDGLRCADVDECVERPNICSHRCNNTLGSFQCSCSHGYVLEPDGHSCKITGEPYLLASVQ 555

  Fly  3154 NRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAM 3218
            :..::..:..:....:|..|....::|||||..|.:||  :.....|||.....:....|..:.:
Zfish   556 SEVFLLGLRSSSLDILLSAEKRFVLSLDYDWQKQRVYW--INLNTDTIKWLSLDQKNKGTFLKGI 618

  Fly  3219 LKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKY-----RKVLINEYLREPRGIALHPYQQHIF 3278
              :.|.|||||||:||||.|.....|...:||.:.     |.:::.|.|.:.|.|||.|.:..:|
Zfish   619 --SADSLAVDWVARNLYWTDSENSQINAVRLDSEIGRSTDRVMILGEDLGQLRSIALMPQKGIMF 681

  Fly  3279 WSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRL 3343
            ||:.||...|.:||||||:.::::...|.||.:||:....|:::|.|.:...|..:::||...:|
Zfish   682 WSETGDEAQIERAGMDGSDRRVLVSKSLRWPVSLTVDSLHQRIYWTDEKLKCIGSANIDGGDVKL 746

  Fly  3344 L-LARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHP 3407
            | |..:.:|       |:::|:...:||||.:..:|:......|:....|:....:|..|:|.|.
Zfish   747 LQLMETPSP-------FSVSVFNDQVYWSDTKRGTIQRAHKTTGKQRQVLLKRPGQPFGLKVIHG 804

  Fly  3408 YRQQQPMSGNPCLAANCSTLCVLSPEEPYYKCMCPTNFILADDGRTCR-------------ANCT 3459
            ..|:.  ..|||.:..||.||||:|..... |.|.|.|:|.:||.||.             |..|
Zfish   805 LLQED--VSNPCESQGCSHLCVLAPGLKAV-CKCSTQFLLDEDGLTCSKPKDSSFLLFLSPAAVT 866

  Fly  3460 AAHFECVNTYKCI-PFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCD---- 3519
            ..:.:  |.:..: |..|                        |...:....|..|| |:.|    
Zfish   867 QVYLQ--NRHSDVTPQKW------------------------PEHRRFDLPKMNHP-NMLDLVLR 904

  Fly  3520 --------------GINQCGDGS--------------------DELNCDKFTCFDNHMKCGATAN 3550
                          |:.:..|.:                    |.:..:.:...:.......|:.
Zfish   905 DLTLYVSDTDQPLVGLFKMKDAALVPRGKLFQLHKDSVRVFSVDWITLNVYWSSEKLPGIQVTSP 969

  Fly  3551 SSAFCVDNVKRCDGVKDCPGGEDESACTPLVC--------KKDQFQC----GNNRCMPFVWVCDG 3603
            ...|....::...|:.:..|.|..|.   .:|        |....:|    |.||.:  ||....
Zfish   970 DGRFTSVLIREGVGIIESIGLEPPSG---RLCFSNRIQEGKMSMVECVFMNGLNRTV--VWRNSV 1029

  Fly  3604 DIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYF 3668
            .......:||.|        ..:..|:|..:..:...|.........:|....|:..........
Zfish  1030 RPTSLILTDEGN--------RVYWADTGLAVIASVGTDGSGYKEIKTEEGLMAFTLVNKVLVWIT 1086

  Fly  3669 KCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDE 3733
            |.:::||    |                     .||.|.|.|     |..:..|.||        
Zfish  1087 KKDSTKC----W---------------------FSEDEQRSG-----KLWFEVDTEI-------- 1113

  Fly  3734 INCNITCKENQFKCAAFNTCINKQYKCDGDDDC-------PDGSDEVNCTCHSDHFSCGNGKCIM 3791
            :|.....|..|   ...|.|.|      |:..|       |.|.   .|.|..||....:|.|.:
Zfish  1114 VNLKAFTKSRQ---KGTNLCSN------GNGGCNQLCLAFPGGK---TCRCAHDHRLLDDGDCRL 1166

  Fly  3792 SRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQ-LCVRNSALCDGINDCGENEDESDAVCA 3855
                                   ::||..|:..|.:: :|:.....|:|:.||.::.||:     
Zfish  1167 -----------------------ESHCPENSKPCLSEDMCLPLEQFCNGVADCPDHSDEN----- 1203

  Fly  3856 ALPKCRHD-QFQ---------------------CENDDCISKAFRCDGQYNCV--DGSDEMNCQP 3896
                |..| |::                     .|::.|..|.  |.|...||  :|....:|.|
Zfish  1204 ----CLDDKQYKTIGINPKSFAPGLSENIVPANVESEMCDIKL--CKGNGKCVSRNGKTVCDCHP 1262

  Fly  3897 PVCGFGSCSQICIEKKAGHYNCKCADGYHKGP 3928
            ...|               .||:...|..:||
Zfish  1263 EFSG---------------ENCENRSGLLQGP 1279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060 12/32 (38%)
LDLa 2671..2702 CDD:238060 14/35 (40%)
LDLa 2727..2759 CDD:238060 11/31 (35%)
LDLa 2773..2802 CDD:238060 14/49 (29%)
LDLa 2810..2844 CDD:238060 17/34 (50%)
LDLa 2848..2878 CDD:238060 15/31 (48%)
LDLa 2887..2916 CDD:197566 12/28 (43%)
LDLa 2938..2969 CDD:197566 12/36 (33%)
LDLa 2989..3015 CDD:197566 11/26 (42%)
LDLa 3030..3061 CDD:238060 10/31 (32%)
EGF_CA 3062..>3091 CDD:214542 7/28 (25%)
EGF_CA 3103..3141 CDD:214542 19/39 (49%)
LY 3212..3254 CDD:214531 17/46 (37%)
LY 3255..3297 CDD:214531 18/41 (44%)
LY 3299..3340 CDD:214531 11/40 (28%)
LY 3354..3389 CDD:214531 8/34 (24%)
LDLa 3458..3490 CDD:238060 4/32 (13%)
LDLa 3499..3533 CDD:238060 9/71 (13%)
LDLa 3582..3616 CDD:238060 10/45 (22%)
LDLa 3621..3652 CDD:197566 3/30 (10%)
LDLa 3663..3697 CDD:238060 4/33 (12%)
LDLa 3702..3736 CDD:238060 9/33 (27%)
LDLa 3776..3808 CDD:197566 5/31 (16%)
LDLa 3818..3849 CDD:197566 8/31 (26%)
LDLa 3860..3894 CDD:238060 11/57 (19%)
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
lrp13XP_021327248.1 LDLa 36..71 CDD:238060 14/42 (33%)
LDLa 75..110 CDD:238060 15/36 (42%)
LDLa 119..149 CDD:238060 14/41 (34%)
LDLa 195..223 CDD:238060 13/27 (48%)
LDLa 227..262 CDD:238060 17/34 (50%)
LDLa 271..301 CDD:238060 16/33 (48%)
LDLa 306..340 CDD:238060 14/50 (28%)
LDLa 351..380 CDD:238060 11/29 (38%)
LDLa 387..422 CDD:238060 16/38 (42%)
LDLa 427..458 CDD:197566 9/38 (24%)
EGF_CA 503..542 CDD:311536 19/38 (50%)
PHA02142 <569..>666 CDD:333147 32/100 (32%)
LY <622..648 CDD:214531 13/25 (52%)
Ldl_recept_b 680..718 CDD:278487 17/37 (46%)
LY 702..744 CDD:214531 11/41 (27%)
LY 744..786 CDD:214531 12/48 (25%)
FXa_inhibition 818..848 CDD:317114 14/30 (47%)
LY 976..1021 CDD:214531 8/47 (17%)
FXa_inhibition 1130..1162 CDD:317114 10/40 (25%)
LDLa 1170..1202 CDD:197566 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 161 1.000 Domainoid score I3979
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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