DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and LRP1B

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_061027.2 Gene:LRP1B / 53353 HGNCID:6693 Length:4599 Species:Homo sapiens


Alignment Length:4924 Identity:1687/4924 - (34%)
Similarity:2476/4924 - (50%) Gaps:679/4924 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 CNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDEL--NCPNGDTPKCRAFEGQC-RNGDCLELS 187
            |:.|:|.|.....|:..:|||||:.||  .|.|||.  .||.....||......| ....|:.||
Human    32 CDPGEFLCHDHVTCVSQSWLCDGDPDC--PDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLS 94

  Fly   188 RFCDGRWDCDN--DE-LQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDE 249
            :.|:|..||.:  || :.|.:..:.|..|||.:.|.:.....|||| :|....:.:...|.|.||
Human    95 QLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYC-EDGFEITEDGRSCKDQDE 158

  Fly   250 CSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGTNGTE 313
            |:..|||.|.||||.|||.||||.||.....|| |:|...|...|..|:..:.:.::....||: 
Human   159 CAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS- 222

  Fly   314 VIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPEL-----QMRC 373
                       |:.....|...|          :|..:..:....:|     |.|.     |::|
Human   223 -----------KMATLSSVNGNE----------IHTLDFIYNEDMIC-----WIESRESSNQLKC 261

  Fly   374 QRVDDA---RVNWTLP-FSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQ 434
            .::..|   ...||:. ..||.:.||    :.:|||:.|.|.|......:::|.:..:.|..::.
Human   262 IQITKAGGLTDEWTINILQSFHNVQQ----MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLID 322

  Fly   435 -QVDPLSSLDLDPTKGFMFYTDW--TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWI 496
             ::....::.:||..|.:|:||:  ...:.|..:||.|||.::..:...|:::.|||.|:||||:
Human   323 LELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWV 387

  Fly   497 DIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALDKFS-LKTH 560
            |:|.|.|..|||:|:||.|:.:...    ::.::.:.|||:.:|.....:..||.:::|: ...|
Human   388 DLYLDYVGVVDYQGKNRHTVIQGRQ----VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIH 448

  Fly   561 ILQSNVSRGANLRIFHRQKQPEV-AHPCRDN----NAGCNQICVPQWTKGFASAKCMCTAGYKLH 620
            .| ..:.....:||:.::.||.| :|.|..:    ..||:.||:  .:..:.:..|.|..|:.|.
Human   449 SL-IKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL--LSSSYKTRTCRCRTGFNLG 510

  Fly   621 NQ-TTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVR 684
            :. .:|.....:.||.|.......:.|:.|:|:...         :.|:|:.|:....|:|.:..
Human   511 SDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIAD---------EYMIPIENLVNPRALDFHAE 566

  Fly   685 GKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSV-SRLLAQGLKRVHAVAFDWINDHLYWTS--H 746
            ...:::  ||:         .|..|..|.::|:. ..:|...|..|..:|.|||.::||||:  |
Human   567 TNYIYF--ADT---------TSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620

  Fly   747 KK-MQVAPLRNLS---KVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCE---AGIYSSWMDGTH 804
            :| :.||.|...|   |.|..........:.:||..|.:||:.||....:   ..|..:||||.:
Human   621 RKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFN 685

  Fly   805 KELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQ 868
            :::..  ||.  |.||..|.:|..|..|||||.....||.:.|:||.|::::...:. ||:.:..
Human   686 RQIFV--TSK--MLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSH 746

  Fly   869 NNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAA--DLRIFDIASQPLPQTPSACAQ 931
            :...::|.|..|.:|.:.        ...:|.|.|.|..|..  .|:|:|...|   |..:.|..
Human   747 HGNYVFWTDYMNGSIFQL--------DLITSEVTLLRHERPPLFGLQIYDPRKQ---QGDNMCRV 800

  Fly   932 SK--CPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSPIRPN-CTSG-YMCRSTRQCLDTKD 992
            :.  |..:||..|.|.:|.|.|...|:..|:.|  ...|....|: |.:| :.|:: |.|:..:.
Human   801 NNGGCSTLCLAIPGGRVCACADNQLLDENGTTC--TFNPGEALPHICKAGEFRCKN-RHCIQARW 862

  Fly   993 MCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQAN--CH 1054
            .|||.:||.||.||.|   ..|..::| ....|.| |.||..:..||.....|....|::|  |.
Human   863 KCDGDDDCLDGSDEDS---VNCFNHSC-PDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCT 923

  Fly  1055 QNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCP--EFDCNNGRCRQFAD 1117
            ..||..::|:| .:||||...|:.|...|||  |.:||.:...|.:..|  :|.|.:|||.....
Human   924 ARTCQVDQFSC-GNGRCIPRAWLCDREDDCG--DQTDEMASCEFPTCEPLTQFVCKSGRCISSKW 985

  Fly  1118 VCDGIDNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPV 1182
            .||..|:||:.:||:.|...|...:..|....|......|||.:||.||||||..|.||.:.|  
Human   986 HCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIH-- 1048

  Fly  1183 TEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHI-----NTTRFD------- 1235
                ....|...||.|.....|:||..||||...|.|.:||..|...     :.|:|.       
Human  1049 ----SPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRC 1109

  Fly  1236 MNETVIC-------EHPDR------LCGFSKQ--------CVTVDQLCDGKNDCEDTTDEGFLCA 1279
            :|:..:|       :..|.      |||..|.        |:..::||:||.||.|.:|||:||.
Human  1110 INKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCD 1174

  Fly  1280 DKLCDRGHECSHRCHNTP-EGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCR 1343
            :...:.| .||:.|...| .|.:||||:.|.|..:.|.|.:...|.:...||||||.......|.
Human  1175 ECSLNNG-GCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCS 1238

  Fly  1344 CLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNV 1408
            |.:|:.|..|..:|.|..|.|.::||:.|.:|:.|:|...:.......|||.|||||.:|...  
Human  1239 CYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSL-- 1301

  Fly  1409 EIYWTDVIDDKIYRGHLVGES--LRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKL 1471
             :|||||::|:||||.| .||  :..:|.|:..||:|.|||.|||:..|:|||||||||||||||
Human  1302 -LYWTDVVEDRIYRGKL-SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKL 1364

  Fly  1472 NGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPN 1536
            :||.|.|||||.||.|||||||||.|:|||||||.|.||||.|||||.||:.|....:..| |||
Human  1365 DGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGA-WPN 1428

  Fly  1537 GLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVI 1601
            |||:|:.:||:.|.||:||:|.|.:|||:....::|..|.||||||:|::.:.||||||||.::.
Human  1429 GLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLS 1493

  Fly  1602 RANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENN--GGCSHLCLLSGRGTFKCECPH 1664
            :||||.|.:|.|:|:|.:|||.:|:.|.||||...|||..|:  |.|||:||::...:..|.|||
Human  1494 KANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPH 1558

  Fly  1665 VMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQP--NHHTIPTIRQSPRLVAPQRIDFLVDESR 1727
            :|:|. ::::.|...::.||:....||||:|:..|  |..|..|:   |.:.....|||...|.|
Human  1559 LMKLS-SDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTV---PDIDDVTVIDFDASEER 1619

  Fly  1728 IFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQI-KCNILASNLKGEF 1791
            ::|:||:...|..|.|:...:|.:|:.:|:...|.||||::||:|:.|.:. :..|..:.|.|..
Human  1620 LYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSL 1684

  Fly  1792 -ASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDF 1855
             .|||| .::....:...|..||:||    :||  :.:..:|:|||:..:::|::.....|::|:
Human  1685 KTSIIH-GIDKPQCLAAHPVRGKLYW----TDG--NTINMANMDGSNSKILFQNQKEPVGLSIDY 1742

  Fly  1856 DSQRLYYAYDNSG-IAYYDIPRNETRKV-LVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEA 1918
            ...:||:....:| |...::.......: .:...:|..::||:.:..|::.:...:.:..|.|..
Human  1743 VENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRD 1807

  Fly  1919 CSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPN 1983
            ..|.:.||..|..:..||::..:||.|||:|.  ...|||.||||.||.....|.|.:||.::.|
Human  1808 GRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQ--LNNGGCSQLCLPTSETTRTCMCTVGYYLQKN 1870

  Fly  1984 NPTGCVPRAEFIFYSI-DVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDN 2047
            . ..|.....|:.||: :.::|:. ::||::.|    ||:|||..|.|..||:.|..||:||.|.
Human  1871 R-MSCQGIESFLMYSVHEGIRGIP-LEPSDKMD----ALMPISGTSFAVGIDFHAENDTIYWTDM 1929

  Fly  2048 ELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHR 2112
            ....|||.|||.|.:|.|:  .|.:|..:     |||:||:||||||:|...|:||||||:||.|
Human  1930 GFNKISRAKRDQTWKEDII--TNGLGRVE-----GIAVDWIAGNIYWTDHGFNLIEVARLNGSFR 1987

  Fly  2113 YVVVS-NLEKPTALAVDPLQGLLFYV---TQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIE 2173
            ||::| .|::|.::||.|.:||||:.   ....||:..||||:..|||:...| |..| :.:|.|
Human  1988 YVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA-WPNG-ISIDYE 2050

  Fly  2174 ATKVYWCERYPDALMKVDYD-GNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLAN 2237
            ..|:|||:...|.:.::|.: |..||.:|:.|..:..::|..|.|:||::..:..|.:|... .|
Human  2051 ENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGH-KN 2114

  Fly  2238 LSQSKVVLQTEQDA-IRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTS-AVCACAHSRLASDG 2300
            .:...:.::|.... ::::||:::..::|:|.||..||.|:||||:.|.| ..|||||..||.||
Human  2115 DATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDG 2179

  Fly  2301 YSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQ-----LVYYS 2360
            .:|..:|.:||:|.|:.::|||::|..:.|.|::...|....:||||:.::|.::     .::||
Human  2180 VTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYS 2244

  Fly  2361 DVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQ 2425
            |.....|..:..|....:|::|....||||||....:.|:|||:..::|    .||..:......
Human  2245 DAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSI----TRHTVDQTRPGA 2305

  Fly  2426 VHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTL 2490
            ...:.|:::.|||.|..:|::.|..:::||||||..|.|.||.|||...:|::.|||..||.||:
Human  2306 FDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTI 2370

  Fly  2491 DLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYT 2555
            |...:|||::|..|.||||..||||.|.|:..|.|....::|||.:.:||:||...|::|:||||
Human  2371 DYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYT 2435

  Fly  2556 GTDVLFLREHVT-RPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDG 2619
            |.|...||..:. :||||:||.|.:.:|:.:.|.:|||.|.|:|:|..:|:..|.|....:..:.
Human  2436 GGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLED 2500

  Fly  2620 RRCIAPVNTSC-GLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRC 2683
            .||:.. |:|| ..|::.|.:||||..:||||.:.||.|.|||...||..|.|......|.|.||
Human  2501 NRCVTK-NSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRC 2564

  Fly  2684 IPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLK 2748
            ||....||||..|||.|||           :|...|...|.|    |||..|.||||...|:...
Human  2565 IPHGKLCDGENDCGDNSDE-----------LDCKVSTCATVE----FRCADGTCIPRSARCNQNI 2614

  Fly  2749 DCRDFSDEKMCAPIPCEK------NDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTS 2807
            ||.|.||||.|....|..      ....|:.|.::::|::|.|.|||..||.|.:|||.|.....
Human  2615 DCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNK 2679

  Fly  2808 LSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACD-KTCIPASWQCDGKSD 2871
            ..|:...|.|.||.||..:|.|||:|||.||.||.:|.:.|..|||||. :.||...|.|||:.|
Human  2680 HKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDD 2744

  Fly  2872 CEDGSDEGPQ-CPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHI 2935
            |.||.||... |....|...:|.|:.|..|:|:.|:||||:|||.| .||.|      ..|.|..
Human  2745 CGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDG-SDELS------TAGCAPN 2802

  Fly  2936 PDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE-----YEGCVPAFQPHSCPGGSLMHQCQDGL 2995
            ..|...|.:|.:.:||...:|||.|:||..|.||     |..|           |:....|.||.
Human  2803 NTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQC-----------GTEEFSCADGR 2856

  Fly  2996 CIFKNQ-TCDGKPDCGDGSDET--SSLC-AHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFS 3056
            |:...| .|||..||.|.|||.  :..| :..:.|| :..|.||||.||.:..|||.::||.|.|
Human  2857 CLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCN-SSFFMCKNGRCIPSGGLCDNKDDCGDGS 2920

  Fly  3057 DEELCNVNECLIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCIN 3119
            ||..|::||||...:  |..:|:|..|.|:|.|.||:: |......|.|||||....||||.|||
Human  2921 DERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQ-LKDDGKTCVDIDECSSGFPCSQQCIN 2984

  Fly  3120 TYGSYKCLCAKGYALV--DHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINE-LSNAVALD 3181
            |||:|||||..||.:.  :.:.||:.|:....||.::.:.||::...|:...|:.: |:|.:|:|
Human  2985 TYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAID 3049

  Fly  3182 YDWDSQCLYWSDVTSTVGT-IKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIE 3245
            :|:..:.:||.|.:...|: |.|.|...:..:.:|...:  |:.|||||:.|||||.|.....||
Human  3050 FDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRIIE 3112

  Fly  3246 VSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPN 3310
            ||:|:|.|..:|:::.|:.||.::|.|...:::|.|..:.||||:.||||:|..::|...:..|.
Human  3113 VSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPM 3177

  Fly  3311 ALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWET 3375
            ||||.:..::|:|.|  |:.|..|::||:|      |...|..::..:.|:.::|.:|||:|.:|
Human  3178 ALTIDYVNRRLYWAD--ENHIEFSNMDGSH------RHKVPNQDIPGVIALTLFEDYIYWTDGKT 3234

  Fly  3376 KSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYK 3438
            ||:......:|.:..:||.:.|...|::|:|.|||.. :|.:.|:..|  ||.||:|:|.:. :.
Human  3235 KSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPD-VSKHLCMINNGGCSHLCLLAPGKT-HT 3297

  Fly  3439 CMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQ 3503
            |.|||||.||.|.|||.:||||:.|.| .|.|||||:|:|||.||||||||||:.||.|.|:||:
Human  3298 CACPTNFYLAADNRTCLSNCTASQFRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGR 3361

  Fly  3504 YQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDC 3568
            :||....|..|:.:|||.|.|||.|||||||...|.....||  |.|..  |:....||:|..||
Human  3362 FQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKC--TKNQK--CIPVNLRCNGQDDC 3422

  Fly  3569 PGGEDESACTPLVCKKDQFQCGNNR-CMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGR 3632
            ...|||..|....|..|.|||...: |:..:||||.|.||.|.|||||||..:|||::|||.:..
Human  3423 GDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN 3487

  Fly  3633 CIPLAWRCDDDHDCPNGEDEP----------------ASCFSSKATCDPTY-------------- 3667
            |||..||||..:||.:..||.                ..|.||:..||..:              
Human  3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETS 3552

  Fly  3668 -----FKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRN--CSESEFRCGTGKCIKHNYRCDGEI 3725
                 |:|:|.:|||.:|:||...||..|.||.:|:..:  ||..|:.|.:..||..:.:|:||.
Human  3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEY 3617

  Fly  3726 HCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC-----TCHSDHFSCG 3785
            .|.|.|||::|...|||:||:|.....||..::.|||..||.|||||.||     .|.:|.|.|.
Human  3618 DCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCN 3682

  Fly  3786 NGKCIMSRWKCDGWDDCLDGSDESLETCAKTHC-HANAFKCR-NQLCVRNSALCDGINDCGENED 3848
            |..|.:..|.|||.|||.|.|||:.:.|.|..| .....:|| |::|:::..:|:||::||:|.|
Human  3683 NSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSD 3747

  Fly  3849 ESDAVCA------ALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQ-PPV-------- 3898
            |..  |.      |.| |:.|:|.|.|..||....:||...:|.|||||..|: .|.        
Human  3748 EDH--CGGKLTYKARP-CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNV 3809

  Fly  3899 --CG-------------------------------------FGSCSQICIEKKAGHYNCKCADGY 3924
              ||                                     ||:||..||..: |.|.|.|...:
Human  3810 NPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVE-GSYKCVCDQNF 3873

  Fly  3925 HKGPEKNATCLASG-PDQILLLASEQE-FRFILPAKQEGT-TVVGFFQTDSLKIDVFDILIRPKD 3986
            .   |:|.||:|.| .||:|.:|::.: ..||.|....|. ..:...:.:| :|...|:..: :|
Human  3874 Q---ERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNS-RITGMDVYYQ-RD 3933

  Fly  3987 TLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIID- 4050
            .:::....:.|.:...:|          ..|...:..:....||...|:.:||||::..:|..| 
Human  3934 MIIWSTQFNPGGIFYKRI----------HGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDH 3988

  Fly  4051 --------------SRHNQILATDIEGKKYISLVSTGM--NPTDIVLEPESRIMIWSTL--ENGI 4097
                          |....|....:.|.....|: |.|  .|..|.:.|:..:|.|:.:  .:.|
Human  3989 SRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL-TNMAGEPYAIAVNPKRGMMYWTVVGDHSHI 4052

  Fly  4098 LVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNRE-- 4160
            ..|::||:.::.||::::..|..|::||.:.|:||||:....|.:...:|.  |.|....:::  
Human  4053 EEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGS--NSVVSVSSKQGL 4115

  Fly  4161 -KPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYL-LKGYRSSDIGILHPMKQNRNISNPCAKD 4223
             .|.:||:||||:|.......:.::.|||:.:..|| |...::..:.|.|..|| .::.|||...
Human  4116 LHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQ-LDLPNPCLDL 4179

  Fly  4224 PCKSSRALCILSSESSVGYSCKCAEG-YVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCI 4287
            .|:   .||:|:..   |.:|.|.|| |::  :|.|...:.:.|.|.|                 
Human  4180 ACE---FLCLLNPS---GATCVCPEGKYLI--NGTCNDDSLLDDSCKL----------------- 4219

  Fly  4288 CQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCH 4352
                                                                          .|.
Human  4220 --------------------------------------------------------------TCE 4222

  Fly  4353 NGGSCLISETEGMKCSCPKMFTGEQCE--HCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEI 4415
            |||.|:::|...::|.|...::||:||  ||.|. |:|||.|..::.|.|.|.|..||||..|..
Human  4223 NGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNY-CQNGGTCVPSVLGRPTCSCALGFTGPNCGK 4286

  Fly  4416 DECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCS-ERGGRLSCTCPPRY 4479
            ..|.|||:|||:|:::...|..|.|...|.|:.|:...|..:|.|..:|: ...|.:.|.||.||
Human  4287 TVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRY 4351

  Fly  4480 IGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGV--ALCNCTDQWNGDLCTL 4542
            .|..||.|.|                      :.| :.|.|.|.|..  ..||||:......|.|
Human  4352 EGPKCEVDKC----------------------VRC-HGGHCIINKDSEDIFCNCTNGKIASSCQL 4393

  Fly  4543 PVTDDNPCARYCANGGVCHLD-EYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLC 4606
                   |..||.|||.|.|| |..:|.|.|...|.|..||.|           .|.||      
Human  4394 -------CDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERP-----------APKSS------ 4434

  Fly  4607 ENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRI----AQP 4667
                            |.:...|.|   .:::|.::.::.|:..|..|.|...:|.|.    .||
Human  4435 ----------------KSDHISTRS---IAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQP 4480

  Fly  4668 FSHARLTDNVEI------------------------ML--TNAMYRGDADEA--------PTFAS 4698
            ..:..:  ||||                        |:  |.|.|.|....|        |.:.:
Human  4481 IINGGI--NVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLN 4543

  Fly  4699 EDDKG-------NFANPVYESMYADAIPEPVSTEITHST-APDERKGLL 4739
            .|.||       |::||||..:|.|      .....:|. :.||||.||
Human  4544 SDLKGPLTAGPTNYSNPVYAKLYMD------GQNCRNSLGSVDERKELL 4586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060 16/38 (42%)
EGF_CA 246..283 CDD:214542 23/37 (62%)
Ldl_recept_b 449..487 CDD:278487 11/39 (28%)
LY 472..513 CDD:214531 17/40 (43%)
LY 817..852 CDD:214531 16/34 (47%)
LDLa 1057..1092 CDD:197566 14/34 (41%)
LDLa 1104..1134 CDD:238060 12/29 (41%)
FXa_inhibition 1289..1317 CDD:291342 12/28 (43%)
LY 1434..1476 CDD:214531 29/41 (71%)
LY 1477..1521 CDD:214531 34/43 (79%)
LY 1533..1567 CDD:214531 19/33 (58%)
LY 1568..1611 CDD:214531 22/42 (52%)
FXa_inhibition 1639..1676 CDD:291342 14/38 (37%)
LY 1794..1838 CDD:214531 14/43 (33%)
LY 2078..2112 CDD:214531 21/33 (64%)
NHL <2082..>2152 CDD:302697 40/73 (55%)
NHL repeat 2082..2120 CDD:271320 25/38 (66%)
FXa_inhibition 2269..2303 CDD:291342 20/34 (59%)
LY 2430..2471 CDD:214531 18/40 (45%)
LY 2475..2517 CDD:214531 22/41 (54%)
LDLa 2630..2661 CDD:238060 15/31 (48%)
LDLa 2671..2702 CDD:238060 15/30 (50%)
LDLa 2727..2759 CDD:238060 16/31 (52%)
LDLa 2773..2802 CDD:238060 13/28 (46%)
LDLa 2810..2844 CDD:238060 18/33 (55%)
LDLa 2848..2878 CDD:238060 16/30 (53%)
LDLa 2887..2916 CDD:197566 14/28 (50%)
LDLa 2938..2969 CDD:197566 12/30 (40%)
LDLa 2989..3015 CDD:197566 12/26 (46%)
LDLa 3030..3061 CDD:238060 16/30 (53%)
EGF_CA 3062..>3091 CDD:214542 12/30 (40%)
EGF_CA 3103..3141 CDD:214542 22/39 (56%)
LY 3212..3254 CDD:214531 19/41 (46%)
LY 3255..3297 CDD:214531 16/41 (39%)
LY 3299..3340 CDD:214531 14/40 (35%)
LY 3354..3389 CDD:214531 10/34 (29%)
LDLa 3458..3490 CDD:238060 22/31 (71%)
LDLa 3499..3533 CDD:238060 18/33 (55%)
LDLa 3582..3616 CDD:238060 18/34 (53%)
LDLa 3621..3652 CDD:197566 15/30 (50%)
LDLa 3663..3697 CDD:238060 16/52 (31%)
LDLa 3702..3736 CDD:238060 14/33 (42%)
LDLa 3776..3808 CDD:197566 15/31 (48%)
LDLa 3818..3849 CDD:197566 11/32 (34%)
LDLa 3860..3894 CDD:238060 15/33 (45%)
NHL 4029..>4158 CDD:302697 39/147 (27%)
NHL repeat 4034..4074 CDD:271320 12/54 (22%)
NHL repeat 4076..4115 CDD:271320 11/40 (28%)
LY 4108..4150 CDD:214531 13/41 (32%)
NHL repeat 4121..4158 CDD:271320 12/36 (33%)
EGF_CA <4386..4414 CDD:238011 13/27 (48%)
EGF_CA 4415..4450 CDD:238011 13/34 (38%)
LRP1BNP_061027.2 FXa_inhibition 165..193 CDD:291342 17/27 (63%)
NHL 282..459 CDD:302697 52/185 (28%)
NHL repeat 285..321 CDD:271320 10/39 (26%)
LDL-receptor class B 1 295..337 7/41 (17%)
LY 319..361 CDD:214531 9/41 (22%)
NHL repeat 328..367 CDD:271320 12/38 (32%)
LDL-receptor class B 2 338..381 14/42 (33%)
NHL repeat 371..406 CDD:271320 19/34 (56%)
LDL-receptor class B 3 382..425 18/46 (39%)
NHL repeat 415..445 CDD:271320 7/29 (24%)
FXa_inhibition 483..516 CDD:291342 8/34 (24%)
LY 548..590 CDD:214531 11/52 (21%)
LDL-receptor class B 4 568..610 12/52 (23%)
LY 591..630 CDD:214531 15/38 (39%)
LDL-receptor class B 5 611..656 14/44 (32%)
LY 637..686 CDD:214531 14/48 (29%)
LDL-receptor class B 6 657..706 17/52 (33%)
LY 687..729 CDD:214531 18/45 (40%)
LDL-receptor class B 7 707..750 13/42 (31%)
FXa_inhibition 798..833 CDD:291342 11/34 (32%)
LDLa 886..919 CDD:238060 10/33 (30%)
LDLa 926..958 CDD:197566 14/34 (41%)
LDLa 1006..1038 CDD:238060 12/31 (39%)
LDLa 1053..1088 CDD:238060 15/34 (44%)
LDLa 1097..1131 CDD:238060 5/33 (15%)
LDLa 1136..1169 CDD:238060 11/32 (34%)
FXa_inhibition 1176..1212 CDD:291342 13/36 (36%)
LY 1280..1318 CDD:214531 20/41 (49%)
LDL-receptor class B 8 1300..1346 24/49 (49%)
LY 1327..1367 CDD:214531 27/39 (69%)
LDL-receptor class B 9 1347..1389 34/41 (83%)
LY 1371..1414 CDD:214531 34/42 (81%)
LDL-receptor class B 10 1390..1436 29/46 (63%)
LY <1426..1458 CDD:214531 19/31 (61%)
LDL-receptor class B 11 1437..1480 21/42 (50%)
LDL-receptor class B 12 1481..1522 22/40 (55%)
LDL-receptor class B 13 1618..1660 15/41 (37%)
Ldl_recept_b 1618..1657 CDD:278487 12/38 (32%)
LY 1641..1683 CDD:214531 14/41 (34%)
LDL-receptor class B 14 1661..1704 12/43 (28%)
LY 1685..1724 CDD:214531 14/45 (31%)
LDL-receptor class B 15 1705..1744 13/44 (30%)
LY <1735..1766 CDD:214531 6/30 (20%)
LDL-receptor class B 16 1745..1787 7/41 (17%)
FXa_inhibition 1838..1874 CDD:291342 15/38 (39%)
NHL 1913..2138 CDD:302697 89/234 (38%)
NHL repeat 1913..1952 CDD:271320 18/40 (45%)
LDL-receptor class B 17 1922..1964 21/48 (44%)
LY 1947..1987 CDD:214531 24/46 (52%)
NHL repeat 1957..1994 CDD:271320 25/36 (69%)
LDL-receptor class B 28 1965..2007 24/41 (59%)
NHL repeat 1998..2036 CDD:271320 16/37 (43%)
LDL-receptor class B 19 2008..2051 17/44 (39%)
Ldl_recept_b 2008..2048 CDD:278487 16/41 (39%)
LY 2033..2075 CDD:214531 15/43 (35%)
NHL repeat 2042..2080 CDD:271320 12/38 (32%)
LDL-receptor class B 20 2052..2095 13/42 (31%)
NHL repeat 2089..2128 CDD:271320 9/39 (23%)
FXa_inhibition 2147..2182 CDD:291342 20/34 (59%)
LDL-receptor class B 21 2239..2280 13/40 (33%)
LDL-receptor class B 22 2281..2329 13/51 (25%)
LDL-receptor class B 23 2330..2374 22/43 (51%)
Ldl_recept_b 2330..2371 CDD:278487 21/40 (53%)
LY 2355..2397 CDD:214531 22/41 (54%)
LDL-receptor class B 24 2375..2416 20/40 (50%)
LDL-receptor class B 25 2417..2459 20/41 (49%)
LDLa 2514..2543 CDD:238060 15/28 (54%)
LDLa 2552..2586 CDD:238060 17/44 (39%)
LDLa 2591..2625 CDD:238060 18/37 (49%)
LDLa 2682..2716 CDD:238060 18/33 (55%)
LDLa 2720..2753 CDD:238060 18/32 (56%)
LDLa 2760..2793 CDD:197566 15/33 (45%)
LDLa 2844..2877 CDD:197566 14/43 (33%)
LDLa 2891..2925 CDD:238060 18/34 (53%)
cEGF 2948..2971 CDD:289433 9/23 (39%)
EGF_CA 2968..2998 CDD:214542 21/29 (72%)
LY 3035..3079 CDD:214531 13/43 (30%)
LDL-receptor class B 26 3055..3098 14/44 (32%)
LY 3080..3118 CDD:214531 18/39 (46%)
LDL-receptor class B 27 3099..3141 19/41 (46%)
LY 3123..3164 CDD:214531 16/40 (40%)
LDL-receptor class B 28 3142..3185 17/42 (40%)
LY 3167..3206 CDD:214531 15/46 (33%)
LDL-receptor class B 29 3186..3224 12/45 (27%)
LDL-receptor class B 30 3225..3268 14/42 (33%)
FXa_inhibition 3277..3313 CDD:291342 18/36 (50%)
LDLa 3317..3348 CDD:197566 22/31 (71%)
LDLa 3357..3391 CDD:238060 18/33 (55%)
LDLa 3396..3431 CDD:238060 14/38 (37%)
LDLa 3436..3471 CDD:238060 18/34 (53%)
LDLa 3476..3510 CDD:238060 17/33 (52%)
LDLa 3515..3549 CDD:238060 5/33 (15%)
LDLa 3553..3587 CDD:238060 14/33 (42%)
LDLa 3594..3628 CDD:238060 14/33 (42%)
LDLa 3632..3667 CDD:238060 18/34 (53%)
LDLa 3674..3706 CDD:238060 16/31 (52%)
LDLa 3721..3751 CDD:238060 12/31 (39%)
LDLa 3762..3796 CDD:238060 15/33 (45%)
EGF_CA 3844..3878 CDD:214542 11/37 (30%)
LDL-receptor class B 31 3933..3980 11/56 (20%)
LDL-receptor class B 32 3981..4038 11/57 (19%)
LDL-receptor class B 33 4039..4082 12/42 (29%)
Ldl_recept_b 4039..4079 CDD:278487 10/39 (26%)
LY 4063..4102 CDD:214531 12/38 (32%)
LDL-receptor class B 34 4083..4127 14/45 (31%)
Endocytosis signal. /evidence=ECO:0000255 4492..4495 0/2 (0%)
Endocytosis signal. /evidence=ECO:0000255 4559..4562 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 171 1.000 Domainoid score I3746
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2931 1.000 Inparanoid score I19
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46025
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 1 1.000 - - FOG0002316
OrthoInspector 1 1.000 - - otm41160
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR22722
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1742
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.980

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