DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and LRP1B

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_061027.2 Gene:LRP1B / 53353 HGNCID:6693 Length:4599 Species:Homo sapiens


Alignment Length:526 Identity:97/526 - (18%)
Similarity:166/526 - (31%) Gaps:203/526 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   498 GNEGLAFKIDNNTGRISINNRLDYETVREYTLIVQVDDGIFQDNATVSIKVKNVNDNPPRFTGLR 562
            ||.|:|    |:....::|                 :.|:...|..|:  ::|:||....:  |.
Human    52 GNTGVA----NSCAGFTVN-----------------EGGLLSGNEKVT--MQNLNDRLASY--LD 91

  Fly   563 NVTIPEETIPSGCIMTVQAYDPDIENRSDPQHIRFFYVDEYDDAIEIDDSGCLRLKRALDRD--- 624
            ||            ..:|..:.|:|     |.|:.:|.       :.....|    |.||.|   
Human    92 NV------------QALQEANADLE-----QKIKGWYE-------KFGPGSC----RGLDHDYSR 128

  Fly   625 --PPLGSKRWQFIITATDEDGAGKKTPATVIISLEDINDNAPRLSNTMPVVWVENRPPGLIVKLR 687
              |.:...:.|.|.:.|                           ||...|:.::|      .:|.
Human   129 YFPIIDDLKNQIITSTT---------------------------SNANAVLQIDN------ARLT 160

  Fly   688 ADDVD-EPQNGPPFHFSIDPN-------------ARYEIKKRFKVQGEELHALVEFDREEQKEYQ 738
            |||.. :.:|....|.|::.:             .|.:::.:::...|||..|.:..:||.:..|
Human   161 ADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHKEEMQALQ 225

  Fly   739 IPILIRDSG---EEPMSAVSMLHLVIGDDNDNKMRPGKSRIFVYNYKGESPNTEIGRVYVDDPDD 800
            ..     :|   ...|:|...:.|.:   ..|.||.....:...|.:              |.:.
Human   226 CA-----AGGNVNVEMNAAPGVDLTV---LLNNMRAEYEALAEQNRR--------------DAEA 268

  Fly   801 WDLPDKTFIWDDATRHQSVAFFDLNRDTGMITMLQGTRRGDYELNFHVIEHSRHFPRHNVT-AKV 864
            |      |....|:..|.:     ..|.|..|.                      .|:.:| .|.
Human   269 W------FQEKSASLQQQI-----TEDVGATTS----------------------ARNELTEMKR 300

  Fly   865 TVTVKEIPEEAVDKSGSIRFHNVTAEEFVSRTPGQLTTPKDRLQASIANTLNVSRENVDVFTVLK 929
            |:...||..:      |:.....:.|..::.|.|...|...::||.|    :...|.:.      
Human   301 TLQTLEIELQ------SLLATKHSLECSLTETEGNYCTQLAQIQAQI----SALEEQLH------ 349

  Fly   930 RDNDNGTFLDVRFSAHGSPYYAPERLNGMMGYQLHQLEEDVGLSVLMVGIDECIEEGRNCELSCK 994
                     .||....|......:.||    .:.| ||:::....|::|.||.         :||
Human   350 ---------QVRTETEGQKLEYEQLLN----VKAH-LEKEIETYCLLIGGDEG---------ACK 391

  Fly   995 NTLYKS 1000
            ::.|||
Human   392 SSSYKS 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531 5/14 (36%)
LY 817..852 CDD:214531 4/34 (12%)
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:464251
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
LRP1BNP_061027.2 LDLa 76..109 CDD:197566 12/53 (23%)
FXa_inhibition 163..193 CDD:464251 4/29 (14%)
NHL 282..459 CDD:302697 35/177 (20%)
NHL repeat 285..321 CDD:271320 9/63 (14%)
LDL-receptor class B 1 295..337 10/47 (21%)
LY 319..361 CDD:214531 11/60 (18%)
NHL repeat 328..367 CDD:271320 9/57 (16%)
LDL-receptor class B 2 338..381 12/66 (18%)
NHL repeat 371..406 CDD:271320 12/37 (32%)
LDL-receptor class B 3 382..425 8/25 (32%)
NHL repeat 415..445 CDD:271320
FXa_inhibition 475..516 CDD:464251
LY 548..590 CDD:214531
LDL-receptor class B 4 568..610
LY 591..630 CDD:214531
LDL-receptor class B 5 611..656
LY 637..686 CDD:214531
LDL-receptor class B 6 657..706
LY 687..729 CDD:214531
LDL-receptor class B 7 707..750
FXa_inhibition 798..833 CDD:464251
LDLa 886..919 CDD:238060
LDLa 926..958 CDD:197566
LDLa 1006..1038 CDD:238060
LDLa 1053..1088 CDD:238060
LDLa 1097..1131 CDD:238060
LDLa 1136..1169 CDD:197566
FXa_inhibition 1176..1212 CDD:464251
YncE 1282..1506 CDD:442618
LDL-receptor class B 8 1300..1346
LY 1327..1367 CDD:214531
LDL-receptor class B 9 1347..1389
LY 1371..1414 CDD:214531
LDL-receptor class B 10 1390..1436
LDL-receptor class B 11 1437..1480
LDL-receptor class B 12 1481..1522
LDL-receptor class B 13 1618..1660
Ldl_recept_b 1618..1658 CDD:459654
LY 1641..1683 CDD:214531
LDL-receptor class B 14 1661..1704
LDL-receptor class B 15 1705..1744
Ldl_recept_b 1705..1742 CDD:459654
LY <1735..1766 CDD:214531
LDL-receptor class B 16 1745..1787
FXa_inhibition 1838..1874 CDD:464251
Vgb 1921..>2110 CDD:443399
LDL-receptor class B 17 1922..1964
LY 1947..1987 CDD:214531
LDL-receptor class B 28 1965..2007
LDL-receptor class B 19 2008..2051
LY 2033..2075 CDD:214531
LDL-receptor class B 20 2052..2095
FXa_inhibition 2147..2182 CDD:464251
LDL-receptor class B 21 2239..2280
LDL-receptor class B 22 2281..2329
LDL-receptor class B 23 2330..2374
Ldl_recept_b 2330..2372 CDD:459654
LY 2355..2397 CDD:214531
LDL-receptor class B 24 2375..2416
LDL-receptor class B 25 2417..2459
FXa_inhibition 2468..2502 CDD:464251
LDLa 2514..2543 CDD:238060
LDLa 2552..2586 CDD:238060
LDLa 2591..2625 CDD:238060
LDLa 2645..2674 CDD:238060
LDLa 2682..2716 CDD:238060
LDLa 2720..2753 CDD:238060
LDLa 2760..2793 CDD:197566
LDLa 2844..2877 CDD:197566
LDLa 2891..2925 CDD:238060
FXa_inhibition 2937..2966 CDD:464251
EGF_CA 2968..2998 CDD:214542
LY 3035..3079 CDD:214531
LDL-receptor class B 26 3055..3098
LY 3080..3118 CDD:214531
LDL-receptor class B 27 3099..3141
LY 3123..3164 CDD:214531
LDL-receptor class B 28 3142..3185
LY 3167..3206 CDD:214531
LDL-receptor class B 29 3186..3224
LDL-receptor class B 30 3225..3268
FXa_inhibition 3277..3313 CDD:464251
LDLa 3317..3348 CDD:197566
LDLa 3357..3391 CDD:238060
LDLa 3396..3431 CDD:238060
LDLa 3436..3471 CDD:238060
LDLa 3476..3510 CDD:238060
LDLa 3515..3549 CDD:238060
LDLa 3553..3587 CDD:238060
LDLa 3594..3628 CDD:238060
LDLa 3632..3667 CDD:238060
LDLa 3674..3706 CDD:238060
LDLa 3721..3751 CDD:238060
LDLa 3762..3796 CDD:238060
EGF_CA 3844..3878 CDD:214542
LDL-receptor class B 31 3933..3980
LY <3971..>3990 CDD:214531
LDL-receptor class B 32 3981..4038
LDL-receptor class B 33 4039..4082
Ldl_recept_b 4039..4080 CDD:459654
LY 4063..4102 CDD:214531
LDL-receptor class B 34 4083..4127
EGF_CA 4250..4284 CDD:238011
Endocytosis signal. /evidence=ECO:0000255 4492..4495
Endocytosis signal. /evidence=ECO:0000255 4559..4562
Blue background indicates that the domain is not in the aligned region.

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