DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and sorl1

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_005157607.1 Gene:sorl1 / 497306 ZFINID:ZDB-GENE-050208-22 Length:2213 Species:Danio rerio


Alignment Length:1284 Identity:364/1284 - (28%)
Similarity:539/1284 - (41%) Gaps:298/1284 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  3005 GKPDCGDG-------SDETSSLC------------AHTRGCNGTDDFR---CKNGACIHADLLCD 3047
            |.| |.:|       |||..:.|            .|....||.|..|   ..|.:|...|..||
Zfish   623 GVP-CSEGDYKLWSPSDERGNGCLLGREMVYKRRSPHATCFNGEDFDRPISLSNCSCTRQDYECD 686

  Fly  3048 RRNDCADFSDEELCNVNECLIPDICEHECEDKV--------VGYQCHCRPGYKVLPKSPHLCT-- 3102
            .....::....|:|      :||   .|....:        ||...|...||:.:  |...||  
Zfish   687 YGFKLSEDLSLEVC------VPD---PEFSGNLYAPPVPCPVGTTYHRSKGYRKV--SGDSCTGG 740

  Fly  3103 DID-ECD-EQQPCSQTCINTYGSYKCLCAKGYALVDHHTCKATSNVSMELIFSNRYYIRQVDMTG 3165
            |:: ..| |..||.....|.:                            ::::.|..|.:.|:..
Zfish   741 DVEARLDGENLPCPVGESNEF----------------------------ILYAVRNSIHRYDLAS 777

  Fly  3166 --NGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQ-TLHQAMLKNPDGLAV 3227
              :..:.:..|..|||||:|::..||||:|:  ::.||:|.|...:..| .:.:..|:|.:.|:.
Zfish   778 GTDQQLPLTGLHEAVALDFDYEKNCLYWADI--SLDTIQRLCMNGSSGQEVIVKRDLQNVEALSF 840

  Fly  3228 DWVAKNLYWCDKGLDTIEVSQLDGKYRKVLIN-EYLREPRGIALHPYQQHIFWSDWGD-SPHIGK 3290
            |.:::.|||.|.|...||||..||..|:.|:| ..:.:||.:||.|.:..:||:|||| :..:.:
Zfish   841 DPISRLLYWVDAGAQKIEVSNSDGDLRRTLVNSSVVDQPRALALMPAESLMFWTDWGDRAAGVYR 905

  Fly  3291 AGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNL 3355
            :.|||||...|:.:|:.|||.:|.  :...|:|.:|..|.|..:|.:|....:::.       .|
Zfish   906 SWMDGSNISCIVSEGVRWPNGITA--DESWLYWTEAYGDRIERADFNGGSRTVIME-------GL 961

  Fly  3356 HHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCL 3420
            .|.:||||::..:||.||....|.........:...::..:...|||::|:..:.:   ..|.|.
Zfish   962 PHPYAIAVFKNDLYWDDWSRMGIFKAPKSGSPDSELIVGRLTGVMDLKIFYKGKNR---GQNACA 1023

  Fly  3421 AANCSTLCVLSPEEPYY-----------------KCMCPTNFILADDGRTC---RANCTAAHFEC 3465
            ...||.||:..|....:                 :|.||:.:.|.::  ||   ...|......|
Zfish  1024 DQPCSLLCLPQPGNQRHCVCPDGVPTSVLPSGERQCQCPSGYQLHNN--TCVKTEHTCLPNQHRC 1086

  Fly  3466 VNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPG-QYQC-ANKKCTHPSNLCDGINQCGDGS 3528
            .|. |||...|:||:.:||||.|||.| ||...|:|. |::| |:..|...:..||..:.|||.|
Zfish  1087 ANG-KCISSIWKCDSDNDCGDMSDEQE-CPTTSCDPSVQFRCVASGSCIPLAFKCDHEDDCGDNS 1149

  Fly  3529 DELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNNR 3593
            ||.:|      ::| |||                      ||               :|.|....
Zfish  1150 DEEHC------ESH-KCG----------------------PG---------------EFTCARGA 1170

  Fly  3594 CMPFVWVCDGDIDCPDKSDEANC--DNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE-PAS 3655
            |:...|.||||.||.|.||||||  .:.:|..:.|||.:|.|||..|.||.|.||.:|.|| |..
Zfish  1171 CIRDAWRCDGDNDCRDWSDEANCTVGHHTCESSSFQCHTGHCIPQRWVCDGDDDCQDGSDEDPTQ 1235

  Fly  3656 CFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRC-GTGKCIKHNY 3719
            |...|  |:.  |.|:|..|:|....|:...||..|:||.||........||.| ...:|:..:.
Zfish  1236 CGRQK--CNG--FLCSNGTCLPASAHCNGVEDCPGGADEQNCGPLCAHYMEFVCRNRAQCLFQSL 1296

  Fly  3720 RCDGEIHCDDNSDE----INCNI------TCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVN 3774
            .|||..||.|.|||    ..|:.      ||....|:|.. ..|:..::||||.|||.|.|||.|
Zfish  1297 VCDGTRHCADGSDEDPIYAGCSTSVEFEKTCDGYNFQCTN-GMCVTLEWKCDGMDDCGDYSDEAN 1360

  Fly  3775 CTCHSD--------HFSCGNGKCIMSRWKCDGWDDCLDGSDES-------LETCA--KTHCHANA 3822
            |...::        .|.|.||:|:.:.|||||.:||.|.||||       |.|.|  ...|..|.
Zfish  1361 CASPTEEPGCTSYFRFECKNGRCVPAWWKCDGENDCGDWSDESQCSGGEALHTPAPGPATCAPNR 1425

  Fly  3823 FKCRNQLCVRNSALCDGINDCGENEDESDAVC----------AALP---KCRHDQFQC-ENDDCI 3873
            |:|.:..|:.::.:|||..||.::.||  |.|          ..||   :|..|||.| :...||
Zfish  1426 FRCGSGACIVDTWVCDGYADCPDSSDE--AGCPTVKGSVTSVTTLPPSGRCTKDQFLCVKPPACI 1488

  Fly  3874 SKAFRCDGQYNCVDGSDEMNCQ---PPVCGFGS-CS--QICI---EKKAGHYNC-------KCAD 3922
            |...||||..:|:|||||.||.   |.:|..|: |:  :.|:   |:..|..:|       .|.|
Zfish  1489 SDWKRCDGHSHCLDGSDEANCPTHGPLLCANGTRCADGEACLLNSERCDGFIDCSDRSDEHNCTD 1553

  Fly  3923 GYHKGPEKNATCLASGPDQILLLASE------QEFRFILPAKQEGTTVVGFFQTDSLKIDVFDIL 3981
            .......:|....|:....:.|..:.      ....|::..:..|........|:|.|......:
Zfish  1554 EQQVYKVQNLQWTANFSGAVKLTWTRPKNMPTSSCSFVIYFRPVGVQQWTSIDTNSNKGSAVLTV 1618

  Fly  3982 IRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAV------- 4039
            :.|..|       ::.||.|..::..|      |....|...|...:|  |.|:||.:       
Zfish  1619 LMPDTT-------YNVKVQTQCLSKQH------RTNEYLTLRTPEGLP--DPPQSLQLSCDKADD 1668

  Fly  4040 -----DWISQ-------RVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPES--RIMIW 4090
                 .|...       |.||::       .::.:..::.||.||..|.....|:|.|  |..:.
Zfish  1669 GTVLCSWSPPDKTHGHIREYIVE-------YSEKDSAEWFSLSSTSTNAEVKNLQPSSLYRFRVA 1726

  Fly  4091 STLENGILVASLDGSNKKSLVERDVGWP--------------ISLSMDY 4125
            :....|:    .:.:..||::.:....|              :|:|.||
Zfish  1727 AVTSRGV----GNWTEIKSIIPQKALSPPKVTITSITEDSMSLSISNDY 1771

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566 5/16 (31%)
LDLa 3030..3061 CDD:238060 8/33 (24%)
EGF_CA 3062..>3091 CDD:214542 6/36 (17%)
EGF_CA 3103..3141 CDD:214542 6/39 (15%)
LY 3212..3254 CDD:214531 16/42 (38%)
LY 3255..3297 CDD:214531 16/43 (37%)
LY 3299..3340 CDD:214531 13/40 (33%)
LY 3354..3389 CDD:214531 11/34 (32%)
LDLa 3458..3490 CDD:238060 14/31 (45%)
LDLa 3499..3533 CDD:238060 14/35 (40%)
LDLa 3582..3616 CDD:238060 15/33 (45%)
LDLa 3621..3652 CDD:197566 15/30 (50%)
LDLa 3663..3697 CDD:238060 12/33 (36%)
LDLa 3702..3736 CDD:238060 13/38 (34%)
LDLa 3776..3808 CDD:197566 14/39 (36%)
LDLa 3818..3849 CDD:197566 10/30 (33%)
LDLa 3860..3894 CDD:238060 18/34 (53%)
NHL 4029..>4158 CDD:302697 26/132 (20%)
NHL repeat 4034..4074 CDD:271320 11/58 (19%)
NHL repeat 4076..4115 CDD:271320 7/40 (18%)
LY 4108..4150 CDD:214531 7/32 (22%)
NHL repeat 4121..4158 CDD:271320 3/5 (60%)
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
sorl1XP_005157607.1 VPS10 130..754 CDD:214740 35/142 (25%)
Sortilin_C 589..754 CDD:292523 35/142 (25%)
LY 781..822 CDD:214531 16/42 (38%)
LY 825..864 CDD:214531 13/38 (34%)
LY 868..912 CDD:214531 16/43 (37%)
LY 916..954 CDD:214531 13/39 (33%)
LDLa 1079..1113 CDD:238060 17/35 (49%)
LDLa 1118..1154 CDD:238060 14/35 (40%)
LDLa 1159..1193 CDD:238060 19/70 (27%)
LDLa 1242..1273 CDD:238060 11/32 (34%)
LDLa 1282..1310 CDD:197566 11/27 (41%)
LDLa 1327..1361 CDD:238060 15/34 (44%)
LDLa 1376..1405 CDD:238060 17/28 (61%)
LDLa 1421..1455 CDD:238060 13/35 (37%)
LDLa 1474..1509 CDD:238060 18/34 (53%)
LDLa 1522..1551 CDD:238060 5/28 (18%)
FN3 1559..>1630 CDD:238020 11/77 (14%)
FN3 1653..1743 CDD:238020 21/102 (21%)
FN3 1750..1827 CDD:238020 5/22 (23%)
FN3 1931..2007 CDD:238020
FN3 2022..2097 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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