DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and arr

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster


Alignment Length:1698 Identity:464/1698 - (27%)
Similarity:728/1698 - (42%) Gaps:317/1698 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1251 FSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGY---------ICSCPD 1306
            ::|......|||...::.||.|.:...|...             |:..|:         ||.   
  Fly     6 YTKSAEIEPQLCQVIDNNEDVTTKATKCTKS-------------NSGVGWRQMLIGFLLICF--- 54

  Fly  1307 HLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYV---- 1367
                   |...|.|:...|..:.|.:..|                         .|...:|    
  Fly    55 -------GISNSWQYKNVHMPSSSSLIAS-------------------------PPASAFVNTPA 87

  Fly  1368 --IFTNRQDIKGINLKTLNVGN-----FYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHL 1425
              :||.|.||:..|: |...|.     ....|...:|:||.|  ..|: :.|||...:.|.....
  Fly    88 TLLFTTRHDIQVANI-TRPTGGPQIDVIVRDLAEAMAIDFYY--AKNL-VCWTDSGREIIECAQT 148

  Fly  1426 VGESLRNV-----EAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNME 1485
            ...:|:.:     :.||.:||...||||:||....:||.|...::||||.|:|.:::.|...:::
  Fly   149 NSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLD 213

  Fly  1486 SPRAIALDPREGLLFWTDWDDNSPRIERASMSGDG-RRMISTSWQLSAGWPNGLTLDYTQKRVYW 1549
            .|||:|:.|...||.||||.: .|:||||||.||. .||  |..:....|||||.:|...:.:||
  Fly   214 QPRAVAVVPARKLLIWTDWGE-YPKIERASMDGDPLSRM--TLVKEHVFWPNGLAVDLKNELIYW 275

  Fly  1550 VDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQV- 1613
            .|.|...|.....|||....::.|   |.:||:::.:::.:|||||:..|:      |..|:|. 
  Fly   276 TDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSL------NALDLQTR 331

  Fly  1614 ----LQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGT-FKCECPHVMRLDPANE 1673
                |..|...|..::....|.||::.|||..|||.|||||||:.... |.|.||..::|..|| 
  Fly   332 ELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISAN- 395

  Fly  1674 RNCVPNEQVLLFVMV-DEIRGIDLHQPNHHTIP-TIRQSPRLVAPQRIDFLVDESRIFWSDIQQN 1736
             .|....|.::|::. .:|..|.|..|::...| .:.:....:|   ||:...|..|:|||::..
  Fly   396 -TCANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIA---IDYDPVEEHIYWSDVETY 456

  Fly  1737 EISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASI-IHEDLN 1800
            .|..|......:...:.:.:..|.|.|:||:|||:|::. .:...|....|.|....: |:|.|.
  Fly   457 TIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTD-TVTDRIEVCRLDGTARKVLIYEHLE 520

  Fly  1801 MVDSIVLDPANGKMYWIHSASDGS--MSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRL 1860
            ...:|.:.|:.|.|:|    ||.:  ..::|:::||||.|.::.  ..||   ..:.:|.:::.:
  Fly   521 EPRAIAVAPSLGWMFW----SDWNERKPKVERASLDGSERVVLV--SENLGWPNGIALDIEAKAI 579

  Fly  1861 YYA---YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNM 1922
            |:.   .|...:|..|   ...|:|:::..:..:..|::.:..||:.:..:..|.:..|...:|.
  Fly   580 YWCDGKTDKIEVANMD---GSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNR 641

  Fly  1923 SYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTG 1987
            ..:......:..:|:.......|.|.||  ...|||..||| ....|:|||||:.|:: .|:...
  Fly   642 IVVVDQYPDLMGLKVTRLREVRGQNACA--VRNGGCSHLCL-NRPRDYVCRCAIDYEL-ANDKRT 702

  Fly  1988 CVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSI 2052
            ||..|.|:.:|.....|...|:.:|  ...:...:|...|..|..:|.......:||.|.:...|
  Fly   703 CVVPAAFLLFSRQEHIGRISIEYNE--GNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCI 765

  Fly  2053 SRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVV- 2116
            .|...:|:..:.|::: .|:|      ..|||:||:|.||||||.:...|||||||||.|.|:: 
  Fly   766 FRAFLNGSYVQRIVDS-GLIG------PDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLW 823

  Fly  2117 SNLEKPTALAVDPLQGLLFYVTQ--QHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYW 2179
            ..:|:|.:|.::|.:|.:::...  ..|.|..:|||....:|  ..||.|.| |..|.|..::||
  Fly   824 KGVEEPRSLVLEPRRGYMYWTESPTDSIRRAAMDGSDLQTIV--AGANHAAG-LTFDQETRRLYW 885

  Fly  2180 C-ERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEG-IIRVAPLANLSQSK 2242
            . :..|..:...|:||..|:.|:...::.|.|::...||:||::  :|.| |.||.  ....|::
  Fly   886 ATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSD--WNTGDIERVH--KTTGQNR 946

  Fly  2243 VVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLF--NGTSAVCAC-AHSRLASDGYSCE 2304
            .::.:....|..|.:::...|.|.|||..:||.|..|||.  ......||| .|.:||.||.||.
  Fly   947 SLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCI 1011

  Fly  2305 PYENFLLFSYRSNIESI--HMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTI 2367
            |..|:::||.|:....:  :.||..:...||.       .:|:.|:.|:.....:|:.:.:..:|
  Fly  1012 PPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVS-------GKNIRAVDYDPITHHIYWIEGRSHSI 1069

  Fly  2368 NQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVL 2432
            .:...|||...:|....|..: ||.||:...||||.:.:.:|.....  |.|...        |:
  Fly  1070 KRSLANGTKVSLLANSGQPFD-LAIDIIGRLLFWTCSQSNSINVTSF--LGESVG--------VI 1123

  Fly  2433 SLREDDKPRGIAVEPCLGMIYWTNWNEGS-PCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQK 2496
            ...:.:|||.|||.....:::||  :.|| ..|.|:.:.| ...|.:...::...||.||.:...
  Fly  1124 DTGDSEKPRNIAVHAMKRLLFWT--DVGSHQAIIRARVDG-NERVELAYKLEGVTALALDQQSDM 1185

  Fly  2497 LYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLF 2561
            :|:|..:  :|:..:.:|.|:..|..........:|..|..::|.|          ..||     
  Fly  1186 IYYAHGK--RIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD----------DKTG----- 1233

  Fly  2562 LREHVTRPMGIVAVQNTSINCDANQCKILN-GQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAP 2625
                         |:..::|.:....::.. .|..|:              :.|..||.:   ..
  Fly  1234 -------------VERITVNGERRSAELQRLPQITDI--------------RAVWTPDPK---VL 1268

  Fly  2626 VNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKC 2690
            .|.:|..|:..| |..||.          ..:|....|..|   .||: |.|     .:..:..|
  Fly  1269 RNHTCMHSRTKC-SHICIA----------SGEGIARTRDVC---SCPK-HLM-----LLEDKENC 1313

  Fly  2691 DGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSD 2755
            .....||                             ||.|.|.:    |...:.|..|||     
  Fly  1314 GAFPACG-----------------------------PDHFTCAA----PVSGISDVNKDC----- 1340

  Fly  2756 EKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASG 2820
                  ||..                   |||||..||||.:||:.|.     :|...||.|.||
  Fly  1341 ------IPAS-------------------WRCDGQKDCPDKSDEVGCP-----TCRADQFSCQSG 1375

  Fly  2821 NCIAGSWHCDGEKDCPDGSDEINCRTEC-RHNQFAC--DKTCIPASWQCDGKSDCEDGSDEGPQ- 2881
            .||..|..|||..:|.:|.||.:|   | |..:|.|  :|.||.|:..|||..:|.||:||... 
  Fly  1376 ECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDI 1437

  Fly  2882 CPNRPCRP 2889
            |..|...|
  Fly  1438 CLQRRMAP 1445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251 5/36 (14%)
LY 1434..1476 CDD:214531 19/41 (46%)
LY 1477..1521 CDD:214531 21/44 (48%)
LY 1533..1567 CDD:214531 14/33 (42%)
LY 1568..1611 CDD:214531 11/42 (26%)
FXa_inhibition 1639..1676 CDD:464251 18/37 (49%)
LY 1751..1789 CDD:214531 11/37 (30%)
LY 1794..1838 CDD:214531 15/46 (33%)
LY 2078..2112 CDD:214531 21/33 (64%)
NHL <2082..>2152 CDD:302697 33/72 (46%)
NHL repeat 2082..2120 CDD:271320 23/38 (61%)
FXa_inhibition 2269..2303 CDD:464251 15/36 (42%)
LY 2430..2471 CDD:214531 13/41 (32%)
LY 2475..2517 CDD:214531 9/41 (22%)
LDLa 2630..2661 CDD:238060 7/30 (23%)
LDLa 2671..2702 CDD:238060 7/30 (23%)
LDLa 2727..2759 CDD:238060 9/31 (29%)
LDLa 2773..2802 CDD:238060 11/28 (39%)
LDLa 2810..2844 CDD:238060 16/33 (48%)
LDLa 2848..2878 CDD:238060 14/32 (44%)
LDLa 2887..2916 CDD:197566 1/3 (33%)
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
arrNP_524737.2 LY 162..201 CDD:214531 18/38 (47%)
NHL 168..503 CDD:302697 122/352 (35%)
NHL repeat 172..237 CDD:271320 27/65 (42%)
LY 252..293 CDD:214531 15/40 (38%)
NHL repeat 261..298 CDD:271320 13/36 (36%)
NHL repeat 303..339 CDD:271320 12/41 (29%)
NHL repeat 341..419 CDD:271320 29/79 (37%)
NHL repeat 428..476 CDD:271320 10/50 (20%)
LY 472..511 CDD:214531 12/39 (31%)
NHL repeat 477..503 CDD:271320 10/26 (38%)
Ldl_recept_b 534..574 CDD:459654 12/45 (27%)
LY 558..599 CDD:214531 7/45 (16%)
LY 600..641 CDD:214531 6/40 (15%)
FXa_inhibition 668..703 CDD:464251 16/38 (42%)
YncE <736..886 CDD:442618 55/159 (35%)
LY 776..818 CDD:214531 24/48 (50%)
LY 905..946 CDD:214531 13/44 (30%)
FXa_inhibition 973..1010 CDD:464251 15/36 (42%)
YncE <1047..1191 CDD:442618 41/157 (26%)
LDLa 1319..1362 CDD:238060 24/105 (23%)
LDLa 1365..1399 CDD:238060 16/33 (48%)
LDLa 1399..1433 CDD:197566 15/36 (42%)
Blue background indicates that the domain is not in the aligned region.

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