DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and LRP5

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_011543331.1 Gene:LRP5 / 4041 HGNCID:6697 Length:1662 Species:Homo sapiens


Alignment Length:1582 Identity:486/1582 - (30%)
Similarity:720/1582 - (45%) Gaps:271/1582 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1325 HWD---TCSQVCESSGKGYDCRCL---DGFDLGFDRFTCKSTAPDEPYVIFTNRQDIK-----GI 1378
            |||   :|.:....:|     :||   :|.:.....|      |..|.::|.||:|::     |:
Human     7 HWDGAVSCRKGGVRAG-----QCLSSRNGKEEAAQYF------PASPLLLFANRRDVRLVDAGGV 60

  Fly  1379 NLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHL--VGESLRNVEAVIHSGL 1441
            .|::..|   .|.|.:..|:||.:   |...:|||||.::.|.:.:|  .|.:::|   |:.|||
Human    61 KLESTIV---VSGLEDAAAVDFQF---SKGAVYWTDVSEEAIKQTYLNQTGAAVQN---VVISGL 116

  Fly  1442 STTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDD 1506
            .:.:|||.|||||.|||.||..::||||.|||:.|:.|...:::.||||||||..|.::||||.:
Human   117 VSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGE 181

  Fly  1507 NSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVL 1571
             :||||||.|.|..|::|..|   ...||||||:|..::::||.|||...|.....|||....|:
Human   182 -TPRIERAGMDGSTRKIIVDS---DIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVV 242

  Fly  1572 RNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDR 1636
            ...  |:||||:::..:.:|||||:|.|:...||..|...:.:......|..||||...|||:..
Human   243 EGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFH 305

  Fly  1637 NPCGENNGGCSHLCLLSGRGTF-KCECPHVMRLDPANERNCVPN-EQVLLFVMVDEIRGIDLHQP 1699
            ..|.|:|||||||||||....| .|.||..::|.. |.|.|... |:|||.....::|.|.|..|
Human   306 TRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQD-NGRTCKAGAEEVLLLARRTDLRRISLDTP 369

  Fly  1700 NHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAV 1764
            :...|  :.|...:.....||:...|..::|:|.:...|..|.:.....:.::||.|..|.|.||
Human   370 DFTDI--VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAV 432

  Fly  1765 DWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDPANGKMYWIHSASD-GSMS 1826
            ||:|||:|:: :|..:..:  :.|.|....| :.|||:...:|.|.|..|.|||    :| |...
Human   433 DWVARNLYWTDTGTDRIEV--TRLNGTSRKILVSEDLDEPRAIALHPVMGLMYW----TDWGENP 491

  Fly  1827 QLEQSNLDGSSRSLIYQHENNL-QSLTMDFDSQRLYYA---YDNSGIAYYDIPRNETRKVLVASP 1887
            ::|.:||||..|.::....... ..|.:|....:||:.   .|...:...|   ...|:.|:...
Human   492 KIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD---GTKRRTLLEDK 553

  Fly  1888 ITSISSLTVYNGTLYFPENIQSVIMQCEKEACSN----------MSYLRVNTKSIQSMKMFYADA 1942
            :..|...|:....:|:.:..:..|.:..|...|.          |....||...:          
Human   554 LPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKV---------- 608

  Fly  1943 QTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEM 2007
             .|:|.||:  ..|||..||..|..... |.|.:|.::..:..|..||.|..:|.|...:..:.:
Human   609 -VGTNPCAD--RNGGCSHLCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 669

  Fly  2008 IDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNLV 2072
            ...:      :...:|::.|..||.:|:..:.:.:||.|..|.:|||...:|:..|.::|    .
Human   670 ETNN------NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVE----F 724

  Fly  2073 GYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVV-SNLEKPTALAVDPLQGLLFY 2136
            |.   |:..|:|:||:..|:||:||..|.||||||||..|.|:| .:|:.|.:||:||.:|.:::
Human   725 GL---DYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYW 786

  Fly  2137 VT---QQHIGRVGLDGSQPFVLVNQT-RANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLR 2197
            ..   :..|.|..:||:....||::. |||    .|.:|....::||          .|.|.|:.
Human   787 TEWGGKPRIVRAFMDGTNCMTLVDKVGRAN----DLTIDYADQRLYW----------TDLDTNMI 837

  Fly  2198 EQ---------LLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIR 2253
            |.         ::.:.|.:|..|.:..||:||.:  :|...|..|...: .:::.::|...|.:.
Human   838 ESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTD--WNLHSIERADKTS-GRNRTLIQGHLDFVM 899

  Fly  2254 DLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACA-HSRLASDGYSCEPYENFLLFSYRSN 2317
            |:.::....|.|.|.|.|:||.|.||||.......|.|| |..|.....:|.|...|||||.:|.
Human   900 DILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSA 964

  Fly  2318 IESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVL-- 2380
            |..: :.|  |::.| .:|.....:|||.||.|:..::.:|:.|.: ..|.:...:||...||  
Human   965 ISRM-IPD--DQHSP-DLILPLHGLRNVKAIDYDPLDKFIYWVDGR-QNIKRAKDDGTQPFVLTS 1024

  Fly  2381 LEQQQRVE----GLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLRED-DKP 2440
            |.|.|..:    .|:.||.:..||||.....||   .:..||..|        ..:.||.| |||
Human  1025 LSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTI---NVHRLSGEA--------MGVVLRGDRDKP 1078

  Fly  2441 RGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLD 2505
            |.|.|....|.:|:||..:.:..|:|:.|.|...||:..|.:..|.||.:|....||:|.||.|.
Human  1079 RAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLK 1143

  Fly  2506 KIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPM 2570
            :||..:..|:||:.|..:.......:.:.|..|:|.|.....:.|..|.||.....::..|....
Human  1144 RIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLT 1208

  Fly  2571 GIVAVQNTSI-NCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQ 2634
            ||.||:..|: ...|:.|...||.|..:||....|...|.|                        
Human  1209 GIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSC------------------------ 1249

  Fly  2635 YNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDG 2699
                     |:.|.                            :.||            ...||: 
Human  1250 ---------PVHLV----------------------------LLQN------------LLTCGE- 1264

  Fly  2700 SDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGE--CIPRKFLCDSLKDCRDFSDEKMC--- 2759
                |..|.                  ||.|.|.:||  |||..:.||...:|.|.|||:.|   
Human  1265 ----PPTCS------------------PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVC 1307

  Fly  2760 --APIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNC 2822
              |..||.:..           |:..|.||||:.||.|.:||.||    ...|.|.|||||||.|
Human  1308 SAAQFPCARGQ-----------CVDLRLRCDGEADCQDRSDEADC----DAICLPNQFRCASGQC 1357

  Fly  2823 IAGSWHCDGEKDCPDGSDEINC 2844
            :.....||...||.|||||:.|
Human  1358 VLIKQQCDSFPDCIDGSDELMC 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 24/41 (59%)
LY 1477..1521 CDD:214531 22/43 (51%)
LY 1533..1567 CDD:214531 16/33 (48%)
LY 1568..1611 CDD:214531 16/42 (38%)
FXa_inhibition 1639..1676 CDD:291342 20/37 (54%)
LY 1794..1838 CDD:214531 18/45 (40%)
LY 2078..2112 CDD:214531 19/33 (58%)
NHL <2082..>2152 CDD:302697 32/73 (44%)
NHL repeat 2082..2120 CDD:271320 21/38 (55%)
FXa_inhibition 2269..2303 CDD:291342 14/34 (41%)
LY 2430..2471 CDD:214531 16/41 (39%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 2/30 (7%)
LDLa 2671..2702 CDD:238060 4/30 (13%)
LDLa 2727..2759 CDD:238060 16/33 (48%)
LDLa 2773..2802 CDD:238060 11/28 (39%)
LDLa 2810..2844 CDD:238060 19/33 (58%)
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
LRP5XP_011543331.1 NHL <46..>178 CDD:302697 58/140 (41%)
NHL repeat 74..113 CDD:271320 14/44 (32%)
LY 111..151 CDD:214531 24/39 (62%)
NHL repeat 116..157 CDD:271320 23/40 (58%)
Ldl_recept_b 172..212 CDD:278487 22/43 (51%)
LY 196..238 CDD:214531 18/44 (41%)
FXa_inhibition 308..345 CDD:291342 20/37 (54%)
LY 375..415 CDD:214531 8/39 (21%)
LY 417..459 CDD:214531 16/43 (37%)
LY 460..503 CDD:214531 18/46 (39%)
LY 504..546 CDD:214531 6/44 (14%)
LY 547..580 CDD:214531 5/32 (16%)
FXa_inhibition 614..649 CDD:291342 11/37 (30%)
NHL 694..887 CDD:302697 67/216 (31%)
LY 719..761 CDD:214531 22/48 (46%)
NHL repeat 729..765 CDD:271320 20/35 (57%)
NHL repeat 772..811 CDD:271320 12/38 (32%)
NHL repeat 856..880 CDD:271320 8/25 (32%)
FXa_inhibition 915..950 CDD:291342 14/34 (41%)
LY 979..1018 CDD:214531 11/39 (28%)
LY 1069..1112 CDD:214531 17/42 (40%)
LY 1113..1155 CDD:214531 16/41 (39%)
FXa_inhibition 1226..1262 CDD:291342 13/108 (12%)
Ldl_recept_a 1267..1304 CDD:278486 17/54 (31%)
LDLa 1307..1341 CDD:238060 14/44 (32%)
LDLa 1345..1379 CDD:238060 19/33 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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