DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and LRP6

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_002327.2 Gene:LRP6 / 4040 HGNCID:6698 Length:1613 Species:Homo sapiens


Alignment Length:1755 Identity:516/1755 - (29%)
Similarity:783/1755 - (44%) Gaps:328/1755 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1365 PYVIFTNRQDIK------GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRG 1423
            |.:::.||:|::      |....|:.||    .|.:..|:||::   |:..|||:||.::.|.|.
Human    21 PLLLYANRRDLRLVDATNGKENATIVVG----GLEDAAAVDFVF---SHGLIYWSDVSEEAIKRT 78

  Fly  1424 HLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPR 1488
            ..  ....:|:.|:.|||.:.:|||.||:|:.|||.||..::|||:.|:||.|:.|....::.||
Human    79 EF--NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPR 141

  Fly  1489 AIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAK 1553
            ||||||..|.::||||.: .|:||||.|.|..|.:|..|   ...|||||||||.::::||.|||
Human   142 AIALDPSSGFMYWTDWGE-VPKIERAGMDGSSRFIIINS---EIYWPNGLTLDYEEQKLYWADAK 202

  Fly  1554 SDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQ 1618
            .:.|..:..||:....|::..  |.||||:::||:.:|||||.|.|::..||:.|..::.:....
Human   203 LNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDI 265

  Fly  1619 SQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSG-RGTFKCECPHVMRLDPANERNCVPN-EQ 1681
            ..|..|......|||...||||.:|||||||||:|. :..::|.||..::| ..|.:.|... .:
Human   266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKL-LENGKTCKDGATE 329

  Fly  1682 VLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNG 1746
            :||.....::|.|.|..|:...|  :.|...:.....||:...|..|:|:|.:...|..:.|...
Human   330 LLLLARRTDLRRISLDTPDFTDI--VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS 392

  Fly  1747 LIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDP 1809
            ..:.::...|..|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|||....:|||||
Human   393 GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRKILISEDLEEPRAIVLDP 455

  Fly  1810 ANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA------- 1863
            ..|.|||    :| |.:.::|::.||||.|.::.  ..:|   ..|.:|:|..::|:.       
Human   456 MVGYMYW----TDWGEIPKIERAALDGSDRVVLV--NTSLGWPNGLALDYDEGKIYWGDAKTDKI 514

  Fly  1864 ----YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSY 1924
                .|.:|           |:|||...|..|...|:....:|:.:..:..|.:..|.: :....
Human   515 EVMNTDGTG-----------RRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREV 567

  Fly  1925 LRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCV 1989
            :......:..:|........|||.|||  ..|||..|||.... ...|.|.:|:::..:..|..|
Human   568 IIDQLPDLMGLKATNVHRVIGSNPCAE--ENGGCSHLCLYRPQ-GLRCACPIGFELISDMKTCIV 629

  Fly  1990 PRAEFIFYSIDVLQGVEMIDPSEQFDTPSPAL--------VPISRVSSASFIDYLANTDTLYWGD 2046
            |.|..:|              |.:.|....:|        :|::.|..||.:|:....:.:||.|
Human   630 PEAFLLF--------------SRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTD 680

  Fly  2047 NELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSH 2111
            ..|.:|||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.|||::|||.|
Human   681 ISLKTISRAFMNGSALEHVVE----FGL---DYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738

  Fly  2112 RYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLV-NQTRANWAVGSLVLD 2171
            |.|:| .:|:.|.|||:||.:|.:::..   :..|.|..:|||:...|| |..|||    .|.:|
Human   739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRAN----GLTID 799

  Fly  2172 IEATKVYWCERYPDALMKVDYDGNLRE---------QLLNESLNNPVALAKMGDYLYWAENKYNE 2227
            ....::||          .|.|.||.|         :::.:.|.:|..|.:..||:||.:  ::.
Human   800 YAKRRLYW----------TDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTD--WSR 852

  Fly  2228 GIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSA-VCAC 2291
            ..|..|...: .|::.::|...|.:.|:.::....|.|.|.||.|||.|..|||...... ||.|
Human   853 RSIERANKTS-GQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGC 916

  Fly  2292 -AHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQ 2355
             ||..|.:|..:|.....|||||.:|.|..:.:    |:.....:|.....:|||.||.|:..::
Human   917 PAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI----DEQQSPDIILPIHSLRNVRAIDYDPLDK 977

  Fly  2356 LVYYSDVQLSTINQVHFNGT-GHRVLLEQ--QQRVE----GLAYDIVNEQLFWTSNNNATIRSVE 2413
            .:|:.|.:.:.|.:...:|: |..|::..  .|.:|    .|:.||.:..::||......|....
Human   978 QLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTR 1042

  Fly  2414 LRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVII 2478
            |       |...|.|  ||. .|.|:||.:.|.|..|.:|:||..|.||.|:|:.|.|...||:.
Human  1043 L-------DGRSVGV--VLK-GEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLF 1097

  Fly  2479 KTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDW 2543
            .:.:..|.||.||....||:|||:.|.:||.::..|:||:||..|.......:.|:.:.|:|.|.
Human  1098 FSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDK 1162

  Fly  2544 VLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINC---------DANQCKILNGQCEDVCI 2599
            ....:.:.: .||      ||..|:....:| |.:.|:.         ..:.|...||.|..:|:
Human  1163 QQQMIEKID-MTG------REGRTKVQARIA-QLSDIHAVKELNLQEYRQHPCAQDNGGCSHICL 1219

  Fly  2600 LNKSGQATCHCTQG-VLAPDGRRCIAPVNTSCGLSQYNCHSGE--CIPLELTCDNVTHCADGSDE 2661
            :...|...|.|... ||..|...|..|  .:|...|:.|.:||  |||:...||..|.|.|.|||
Human  1220 VKGDGTTRCSCPMHLVLLQDELSCGEP--PTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282

  Fly  2662 FRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE--TPLLCKCQSEDIDMHPSNNNTK 2724
            ..  |  ..|.|:.|.|.:.:||....:|:|:..|.|.|||  ..:||                 
Human  1283 LN--C--PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLC----------------- 1326

  Fly  2725 EMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC----APIPCEKNDM---------TFVHCGN 2776
             :.|.|||.:|:||.:...||...||.|.|||..|    .|.|...|.:         .||....
Human  1327 -LIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTV 1390

  Fly  2777 STIC---IMPRWRCDGDPDCPD------GTDELDCANH-TSLSCD-PGQFRCASGNCIAGSWHCD 2830
            ..||   :.||.:.||:....|      .:..|....| :|||.. ||..|   |..:..|....
Human  1391 YFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSR---GKSMISSLSIM 1452

  Fly  2831 GEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCP------------ 2883
            |....|                 ..|:..:      .|.|.....|.:|...|            
Human  1453 GGSSGP-----------------PYDRAHV------TGASSSSSSSTKGTYFPAILNPPPSPATE 1494

  Fly  2884 ------------NRPC-------RPHLFQ--------CKSSGRCIPQKWVCDGEKDCPS------ 2915
                        |.|.       ||:.::        |.:.        |||.:. .||      
Human  1495 RSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTD--------VCDSDY-APSRRMTSV 1550

  Fly  2916 ----GLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPA 2976
                |...:.:.|..|       :|..|.|.          |.|:        ..::.||.|.|:
Human  1551 ATAKGYTSDLNYDSEP-------VPPPPTPR----------SQYL--------SAEENYESCPPS 1590

  Fly  2977  2976
            Human  1591  1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 21/43 (49%)
LY 1533..1567 CDD:214531 17/33 (52%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:291342 17/37 (46%)
LY 1794..1838 CDD:214531 21/45 (47%)
LY 2078..2112 CDD:214531 17/33 (52%)
NHL <2082..>2152 CDD:302697 33/73 (45%)
NHL repeat 2082..2120 CDD:271320 20/38 (53%)
FXa_inhibition 2269..2303 CDD:291342 16/35 (46%)
LY 2430..2471 CDD:214531 18/40 (45%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 14/32 (44%)
LDLa 2671..2702 CDD:238060 11/30 (37%)
LDLa 2727..2759 CDD:238060 15/31 (48%)
LDLa 2773..2802 CDD:238060 8/37 (22%)
LDLa 2810..2844 CDD:238060 7/34 (21%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 8/53 (15%)
LDLa 2938..2969 CDD:197566 4/30 (13%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
LRP6NP_002327.2 Beta-propeller 1 20..275 104/268 (39%)
NHL 55..272 CDD:302697 94/227 (41%)
NHL repeat 55..93 CDD:271320 13/42 (31%)
LY 89..127 CDD:214531 19/37 (51%)
NHL repeat 97..132 CDD:271320 18/34 (53%)
NHL repeat 140..176 CDD:271320 21/36 (58%)
Ldl_recept_b 150..190 CDD:278487 21/43 (49%)
LY 175..216 CDD:214531 19/43 (44%)
NHL repeat 181..217 CDD:271320 17/35 (49%)
NHL repeat 226..253 CDD:271320 14/26 (54%)
LDL-receptor class B 5 237..276 12/38 (32%)
FXa_inhibition 286..323 CDD:291342 17/37 (46%)
Beta-propeller 2 328..589 70/282 (25%)
LY 353..393 CDD:214531 9/39 (23%)
LY 397..437 CDD:214531 14/41 (34%)
LY 438..481 CDD:214531 21/46 (46%)
LY 483..524 CDD:214531 7/53 (13%)
LY 525..558 CDD:214531 8/32 (25%)
FXa_inhibition 592..627 CDD:291342 12/37 (32%)
Beta-propeller 3 631..890 84/296 (28%)
LY 656..694 CDD:214531 12/37 (32%)
LY 697..739 CDD:214531 20/48 (42%)
LY 740..783 CDD:214531 15/42 (36%)
LY 783..825 CDD:214531 15/55 (27%)
LY 827..866 CDD:214531 10/41 (24%)
FXa_inhibition 893..929 CDD:291342 16/35 (46%)
Beta-propeller 4 933..1202 85/290 (29%)
LY 958..998 CDD:214531 11/39 (28%)
Ldl_recept_b 1069..1110 CDD:278487 16/40 (40%)
LY 1094..1136 CDD:214531 16/41 (39%)
FXa_inhibition 1207..1243 CDD:291342 11/35 (31%)
LDLa 1249..1285 CDD:238060 16/37 (43%)
LDLa 1288..1322 CDD:238060 13/33 (39%)
LDLa 1326..1360 CDD:238060 16/51 (31%)
PPPSP motif A 1487..1493 0/5 (0%)
PPPSP motif B 1527..1534 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613 11/60 (18%)
PPPSP motif C 1568..1575 3/16 (19%)
PPPSP motif D 1588..1593 1/3 (33%)
PPPSP motif E 1603..1610
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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