Sequence 1: | NP_001260800.2 | Gene: | LRP1 / 35799 | FlyBaseID: | FBgn0053087 | Length: | 4752 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
Alignment Length: | 1755 | Identity: | 516/1755 - (29%) |
---|---|---|---|
Similarity: | 783/1755 - (44%) | Gaps: | 328/1755 - (18%) |
- Green bases have known domain annotations that are detailed below.
Fly 1365 PYVIFTNRQDIK------GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRG 1423
Fly 1424 HLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPR 1488
Fly 1489 AIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAK 1553
Fly 1554 SDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQ 1618
Fly 1619 SQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSG-RGTFKCECPHVMRLDPANERNCVPN-EQ 1681
Fly 1682 VLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNG 1746
Fly 1747 LIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDP 1809
Fly 1810 ANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA------- 1863
Fly 1864 ----YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSY 1924
Fly 1925 LRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCV 1989
Fly 1990 PRAEFIFYSIDVLQGVEMIDPSEQFDTPSPAL--------VPISRVSSASFIDYLANTDTLYWGD 2046
Fly 2047 NELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSH 2111
Fly 2112 RYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLV-NQTRANWAVGSLVLD 2171
Fly 2172 IEATKVYWCERYPDALMKVDYDGNLRE---------QLLNESLNNPVALAKMGDYLYWAENKYNE 2227
Fly 2228 GIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSA-VCAC 2291
Fly 2292 -AHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQ 2355
Fly 2356 LVYYSDVQLSTINQVHFNGT-GHRVLLEQ--QQRVE----GLAYDIVNEQLFWTSNNNATIRSVE 2413
Fly 2414 LRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVII 2478
Fly 2479 KTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDW 2543
Fly 2544 VLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINC---------DANQCKILNGQCEDVCI 2599
Fly 2600 LNKSGQATCHCTQG-VLAPDGRRCIAPVNTSCGLSQYNCHSGE--CIPLELTCDNVTHCADGSDE 2661
Fly 2662 FRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE--TPLLCKCQSEDIDMHPSNNNTK 2724
Fly 2725 EMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC----APIPCEKNDM---------TFVHCGN 2776
Fly 2777 STIC---IMPRWRCDGDPDCPD------GTDELDCANH-TSLSCD-PGQFRCASGNCIAGSWHCD 2830
Fly 2831 GEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCP------------ 2883
Fly 2884 ------------NRPC-------RPHLFQ--------CKSSGRCIPQKWVCDGEKDCPS------ 2915
Fly 2916 ----GLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPA 2976
Fly 2977 2976 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRP1 | NP_001260800.2 | LDLa | 87..118 | CDD:197566 | |
LDLa | 126..163 | CDD:238060 | |||
EGF_CA | 246..283 | CDD:214542 | |||
Ldl_recept_b | 449..487 | CDD:278487 | |||
LY | 472..513 | CDD:214531 | |||
LY | 817..852 | CDD:214531 | |||
LDLa | 1057..1092 | CDD:197566 | |||
LDLa | 1104..1134 | CDD:238060 | |||
FXa_inhibition | 1289..1317 | CDD:291342 | |||
LY | 1434..1476 | CDD:214531 | 21/41 (51%) | ||
LY | 1477..1521 | CDD:214531 | 21/43 (49%) | ||
LY | 1533..1567 | CDD:214531 | 17/33 (52%) | ||
LY | 1568..1611 | CDD:214531 | 18/42 (43%) | ||
FXa_inhibition | 1639..1676 | CDD:291342 | 17/37 (46%) | ||
LY | 1794..1838 | CDD:214531 | 21/45 (47%) | ||
LY | 2078..2112 | CDD:214531 | 17/33 (52%) | ||
NHL | <2082..>2152 | CDD:302697 | 33/73 (45%) | ||
NHL repeat | 2082..2120 | CDD:271320 | 20/38 (53%) | ||
FXa_inhibition | 2269..2303 | CDD:291342 | 16/35 (46%) | ||
LY | 2430..2471 | CDD:214531 | 18/40 (45%) | ||
LY | 2475..2517 | CDD:214531 | 16/41 (39%) | ||
LDLa | 2630..2661 | CDD:238060 | 14/32 (44%) | ||
LDLa | 2671..2702 | CDD:238060 | 11/30 (37%) | ||
LDLa | 2727..2759 | CDD:238060 | 15/31 (48%) | ||
LDLa | 2773..2802 | CDD:238060 | 8/37 (22%) | ||
LDLa | 2810..2844 | CDD:238060 | 7/34 (21%) | ||
LDLa | 2848..2878 | CDD:238060 | 4/29 (14%) | ||
LDLa | 2887..2916 | CDD:197566 | 8/53 (15%) | ||
LDLa | 2938..2969 | CDD:197566 | 4/30 (13%) | ||
LDLa | 2989..3015 | CDD:197566 | |||
LDLa | 3030..3061 | CDD:238060 | |||
EGF_CA | 3062..>3091 | CDD:214542 | |||
EGF_CA | 3103..3141 | CDD:214542 | |||
LY | 3212..3254 | CDD:214531 | |||
LY | 3255..3297 | CDD:214531 | |||
LY | 3299..3340 | CDD:214531 | |||
LY | 3354..3389 | CDD:214531 | |||
LDLa | 3458..3490 | CDD:238060 | |||
LDLa | 3499..3533 | CDD:238060 | |||
LDLa | 3582..3616 | CDD:238060 | |||
LDLa | 3621..3652 | CDD:197566 | |||
LDLa | 3663..3697 | CDD:238060 | |||
LDLa | 3702..3736 | CDD:238060 | |||
LDLa | 3776..3808 | CDD:197566 | |||
LDLa | 3818..3849 | CDD:197566 | |||
LDLa | 3860..3894 | CDD:238060 | |||
NHL | 4029..>4158 | CDD:302697 | |||
NHL repeat | 4034..4074 | CDD:271320 | |||
NHL repeat | 4076..4115 | CDD:271320 | |||
LY | 4108..4150 | CDD:214531 | |||
NHL repeat | 4121..4158 | CDD:271320 | |||
EGF_CA | <4386..4414 | CDD:238011 | |||
EGF_CA | 4415..4450 | CDD:238011 | |||
LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | 104/268 (39%) | |
NHL | 55..272 | CDD:302697 | 94/227 (41%) | ||
NHL repeat | 55..93 | CDD:271320 | 13/42 (31%) | ||
LY | 89..127 | CDD:214531 | 19/37 (51%) | ||
NHL repeat | 97..132 | CDD:271320 | 18/34 (53%) | ||
NHL repeat | 140..176 | CDD:271320 | 21/36 (58%) | ||
Ldl_recept_b | 150..190 | CDD:278487 | 21/43 (49%) | ||
LY | 175..216 | CDD:214531 | 19/43 (44%) | ||
NHL repeat | 181..217 | CDD:271320 | 17/35 (49%) | ||
NHL repeat | 226..253 | CDD:271320 | 14/26 (54%) | ||
LDL-receptor class B 5 | 237..276 | 12/38 (32%) | |||
FXa_inhibition | 286..323 | CDD:291342 | 17/37 (46%) | ||
Beta-propeller 2 | 328..589 | 70/282 (25%) | |||
LY | 353..393 | CDD:214531 | 9/39 (23%) | ||
LY | 397..437 | CDD:214531 | 14/41 (34%) | ||
LY | 438..481 | CDD:214531 | 21/46 (46%) | ||
LY | 483..524 | CDD:214531 | 7/53 (13%) | ||
LY | 525..558 | CDD:214531 | 8/32 (25%) | ||
FXa_inhibition | 592..627 | CDD:291342 | 12/37 (32%) | ||
Beta-propeller 3 | 631..890 | 84/296 (28%) | |||
LY | 656..694 | CDD:214531 | 12/37 (32%) | ||
LY | 697..739 | CDD:214531 | 20/48 (42%) | ||
LY | 740..783 | CDD:214531 | 15/42 (36%) | ||
LY | 783..825 | CDD:214531 | 15/55 (27%) | ||
LY | 827..866 | CDD:214531 | 10/41 (24%) | ||
FXa_inhibition | 893..929 | CDD:291342 | 16/35 (46%) | ||
Beta-propeller 4 | 933..1202 | 85/290 (29%) | |||
LY | 958..998 | CDD:214531 | 11/39 (28%) | ||
Ldl_recept_b | 1069..1110 | CDD:278487 | 16/40 (40%) | ||
LY | 1094..1136 | CDD:214531 | 16/41 (39%) | ||
FXa_inhibition | 1207..1243 | CDD:291342 | 11/35 (31%) | ||
LDLa | 1249..1285 | CDD:238060 | 16/37 (43%) | ||
LDLa | 1288..1322 | CDD:238060 | 13/33 (39%) | ||
LDLa | 1326..1360 | CDD:238060 | 16/51 (31%) | ||
PPPSP motif A | 1487..1493 | 0/5 (0%) | |||
PPPSP motif B | 1527..1534 | 1/6 (17%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | 11/60 (18%) | |||
PPPSP motif C | 1568..1575 | 3/16 (19%) | |||
PPPSP motif D | 1588..1593 | 1/3 (33%) | |||
PPPSP motif E | 1603..1610 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100345 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |