DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and LRP4

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_002325.2 Gene:LRP4 / 4038 HGNCID:6696 Length:1905 Species:Homo sapiens


Alignment Length:1789 Identity:569/1789 - (31%)
Similarity:862/1789 - (48%) Gaps:253/1789 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   962 CIPQLAPSPIRPNCTSG---YMCRSTR----QCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTC 1019
            |...||.|   |.|..|   :.|..:.    .|:..:..|||..||.|..||..     |.:.||
Human    15 CAHGLASS---PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG-----CILPTC 71

  Fly  1020 DKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVD 1083
            ... :|.| ||:|.:||.:|.....|.|.:|:.:|....|..:||.| ::|.||:..|..||..|
Human    72 SPL-DFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QNGYCIRSLWHCDGDND 134

  Fly  1084 CGPDDDSDETSETIFASKC--PEFDCNNGRCRQFADVCDGIDNCGNNADEMEC------------ 1134
            ||  |:|||..:   ..||  .||.|::|.|......|||..:|.:.:||..|            
Human   135 CG--DNSDEQCD---MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLE 194

  Fly  1135 EQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACM 1199
            |.:|.:|.       |..:::.|||..||.|:|||::|    |.:.|         |...||.|.
Human   195 EFQCAYGR-------CILDIYHCDGDDDCGDWSDESDC----SSHQP---------CRSGEFMCD 239

  Fly  1200 FPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDG 1264
            ... ||....||||.:.|.|::||.|||           |.:|......| .|.:||.:...|||
Human   240 SGL-CINAGWRCDGDADCDDQSDERNCT-----------TSMCTAEQFRC-HSGRCVRLSWRCDG 291

  Fly  1265 KNDCEDTTDE--------------GFLCAD-------KLCD--------------------RGHE 1288
            ::||.|.:||              .|||.:       |||:                    .|.|
Human   292 EDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEE 356

  Fly  1289 --------CSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCL 1345
                    |:.:|........|:|.....|..:|..|...:.|.....|||.|.:|...:.|.|.
Human   357 NCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCE 421

  Fly  1346 DGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGI----NLKTLNVGNFYSSLRNIIALDFLYNNES 1406
            .|::|..||.:||:..| ||.::|.||.||:.:    :..||.:.|    |.|.|||||.:..|.
Human   422 TGYELRPDRRSCKALGP-EPVLLFANRIDIRQVLPHRSEYTLLLNN----LENAIALDFHHRREL 481

  Fly  1407 NVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKL 1471
               ::|:||..|:|.|.:|.|.   |||.|:.:||.:..|||||||...|||.||...:||||.|
Human   482 ---VFWSDVTLDRILRANLNGS---NVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL 540

  Fly  1472 NGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPN 1536
            :|:.|:.|:..|:|.||||||.|.||.::|||| .|:||||.:||.|.|||:|:.:...   |||
Human   541 DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW-GNTPRIEASSMDGSGRRIIADTHLF---WPN 601

  Fly  1537 GLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVI 1601
            |||:||..:|:||||||...|.....|||....|:  .:.|.|||||:|||:.:|||||.|.|:.
Human   602 GLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFEDSLYWTDWHTKSIN 664

  Fly  1602 RANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECPHVM 1666
            .|||:.|.:.::::.....|..|..||..|||..:|.||:|||||:||||.||: .:.|.||...
Human   665 SANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQ-NYTCACPTGF 728

  Fly  1667 RLDPANERNCVPN-EQVLLFVMVDEIRGI--DLHQPNHHTIP--TIRQSPRLVAPQRIDFLVDES 1726
            |  ..:...|..: ::.|||....:||.|  |....:...||  .:|.:..|      |:...:.
Human   729 R--KISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVAL------DWDSRDD 785

  Fly  1727 RIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEF 1791
            .::|:|:..:.||.|.......|.:::|::|.|.|.|:||:...:|::..... .|..:|..|..
Human   786 HVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTD-RIEVANTDGSM 849

  Fly  1792 ASI-IHEDLNMVDSIVLDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSL 1851
            .:: |.|:|:....||::|..|.|||    :| |:..::|::.:|.|.|.:|.  .:||   ..|
Human   850 RTVLIWENLDRPRDIVVEPMGGYMYW----TDWGASPKIERAGMDASGRQVII--SSNLTWPNGL 908

  Fly  1852 TMDFDSQRLYYAYDNSGIAYYDIP--RNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQC 1914
            .:|:.|||||:|  ::|:...:..  ....||||:.|.:.....||:|...:|:.:.....|...
Human   909 AIDYGSQRLYWA--DAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSA 971

  Fly  1915 EKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCL-ATSSIDHVCRCALGY 1978
            ::....:...|:.|.:::..:.:|:......|..||  ...|||..||| :.:.....|.|..|.
Human   972 DRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCA--MENGGCSHLCLRSPNPSGFSCTCPTGI 1034

  Fly  1979 DVEPNNPTGCVP-RAEFIFYS--IDVLQGVEMIDPSEQFDTP--SPALVPIS-RVSSASFIDYLA 2037
            ::..:..| |.| ...|:.::  ||    :.|:    ..|.|  :..:|||: .:.:...|....
Human  1035 NLLSDGKT-CSPGMNSFLIFARRID----IRMV----SLDIPYFADVVVPINITMKNTIAIGVDP 1090

  Fly  2038 NTDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNII 2102
            ....:||.|:.|..|||...||:|.|.|:    ..|.:..|   |:|:|.:...:||:||..|.|
Human  1091 QEGKVYWSDSTLHRISRANLDGSQHEDII----TTGLQTTD---GLAVDAIGRKVYWTDTGTNRI 1148

  Fly  2103 EVARLDGSHRYVVV-SNLEKPTALAVDPLQGLLFYV---TQQHIGRVGLDGSQPFVLVNQTRANW 2163
            ||..||||.|.|:| .||:.|.|:.:....|.:::.   ....:.|.|:|||...||:| ....|
Human  1149 EVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLIN-NNLGW 1212

  Fly  2164 AVGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAE------ 2222
            ..| |.:|..::::.|.:.:.:.:...|.:|..|..|:: .:.:|..|..:..|:||.:      
Human  1213 PNG-LTVDKASSQLLWADAHTERIEAADLNGANRHTLVS-PVQHPYGLTLLDSYIYWTDWQTRSI 1275

  Fly  2223 NKYNEGIIRVAPLANLSQSKVVL-QTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTS 2286
            ::.::|          :.|.|:| ::....:.|::...:....|.|.|...||.|..|||...:.
Human  1276 HRADKG----------TGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG 1330

  Fly  2287 AVCACAHS-RLASDGYSCEPY-ENFLLFSYRSNIE--SIHMTDHADKNWPVQMISNTSLMRNVIA 2347
            ..|||... :|..||.:|:|. |.:||||.|.:|.  |:..:||.|.:.||..::      |||:
Human  1331 FSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELN------NVIS 1389

  Fly  2348 ITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQ-QQRVEGLAYDIVNEQLFWTSNNNATIRS 2411
            :.|:..:..|||:||.|..|.:...||:....::.: .:..:|||.|.|...|:||.....||.:
Human  1390 LDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1454

  Fly  2412 VELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEV 2476
            ..|          ....:|||.....|:||.|||.|..|.::||:|...:. |:|:.|.|...:|
Human  1455 SRL----------DGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAK-IERANLDGSERKV 1508

  Fly  2477 IIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWT 2541
            :|.||:..||.||||.:.:::||.||.||:||..:.:|..|.||. |...|.||:......::||
Human  1509 LINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIYWT 1572

  Fly  2542 DWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQA 2606
            ||...::.|.:||:|.:...:..:|...|.|:.| :.......|.|.:.||.|..:|.. ::...
Human  1573 DWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVV-SPQRQTGTNACGVNNGGCTHLCFA-RASDF 1635

  Fly  2607 TCHCTQGVLAPDGRRC------IAPVNTSCGLSQ 2634
            .|.|..   .||.|.|      :.|...:.|:|:
Human  1636 VCACPD---EPDSRPCSLVPGLVPPAPRATGMSE 1666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566 15/34 (44%)
LDLa 1104..1134 CDD:238060 11/29 (38%)
FXa_inhibition 1289..1317 CDD:291342 6/27 (22%)
LY 1434..1476 CDD:214531 22/41 (54%)
LY 1477..1521 CDD:214531 24/43 (56%)
LY 1533..1567 CDD:214531 19/33 (58%)
LY 1568..1611 CDD:214531 21/42 (50%)
FXa_inhibition 1639..1676 CDD:291342 17/36 (47%)
LY 1794..1838 CDD:214531 15/45 (33%)
LY 2078..2112 CDD:214531 16/33 (48%)
NHL <2082..>2152 CDD:302697 28/73 (38%)
NHL repeat 2082..2120 CDD:271320 19/38 (50%)
FXa_inhibition 2269..2303 CDD:291342 13/34 (38%)
LY 2430..2471 CDD:214531 17/40 (43%)
LY 2475..2517 CDD:214531 19/41 (46%)
LDLa 2630..2661 CDD:238060 2/5 (40%)
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
LRP4NP_002325.2 LDLa 27..66 CDD:238060 11/43 (26%)
Ldl_recept_a 70..105 CDD:278486 13/35 (37%)
LDLa 110..142 CDD:238060 16/34 (47%)
LDLa 148..182 CDD:238060 12/33 (36%)
LDLa 231..265 CDD:238060 14/34 (41%)
LDLa 270..304 CDD:238060 13/34 (38%)
LDLa 311..343 CDD:197566 6/31 (19%)
FXa_inhibition 358..393 CDD:291342 6/34 (18%)
EGF_CA 395..434 CDD:214542 12/38 (32%)
NHL <471..622 CDD:302697 82/160 (51%)
NHL repeat 471..507 CDD:271320 18/41 (44%)
LDL-receptor class B 1 480..522 21/47 (45%)
LY 505..545 CDD:214531 21/39 (54%)
NHL repeat 510..550 CDD:271320 21/39 (54%)
LDL-receptor class B 2 523..565 22/41 (54%)
NHL repeat 555..589 CDD:271320 21/34 (62%)
LDL-receptor class B 3 566..609 25/46 (54%)
LY 590..632 CDD:214531 21/44 (48%)
NHL repeat 598..622 CDD:271320 15/26 (58%)
LDL-receptor class B 4 610..652 21/43 (49%)
LY 633..673 CDD:214531 21/41 (51%)
LDL-receptor class B 5 653..693 15/39 (38%)
FXa_inhibition 702..>729 CDD:291342 16/27 (59%)
LY 766..806 CDD:214531 10/45 (22%)
LDL-receptor class B 6 785..827 13/41 (32%)
LY 808..850 CDD:214531 12/42 (29%)
LDL-receptor class B 7 828..870 10/42 (24%)
LDL-receptor class B 8 871..914 15/48 (31%)
Ldl_recept_b 871..911 CDD:278487 14/45 (31%)
LY 895..937 CDD:214531 12/45 (27%)
LDL-receptor class B 9 915..956 14/42 (33%)
LY 938..979 CDD:214531 9/40 (23%)
LDL-receptor class B 10 957..998 5/40 (13%)
FXa_inhibition 1006..1043 CDD:291342 12/39 (31%)
NHL <1085..1277 CDD:302697 60/201 (30%)
NHL repeat 1085..1123 CDD:271320 13/41 (32%)
LDL-receptor class B 11 1093..1135 17/48 (35%)
NHL repeat 1128..1161 CDD:271320 16/32 (50%)
LDL-receptor class B 12 1136..1178 19/41 (46%)
NHL repeat 1166..1203 CDD:271320 9/36 (25%)
LDL-receptor class B 13 1179..1222 13/44 (30%)
Ldl_recept_b 1179..1219 CDD:278487 12/41 (29%)
NHL repeat 1212..1244 CDD:271320 7/32 (22%)
LDL-receptor class B 14 1223..1263 7/40 (18%)
NHL repeat 1253..1277 CDD:271320 5/23 (22%)
LDL-receptor class B 15 1264..1306 8/51 (16%)
FXa_inhibition 1313..1348 CDD:291342 13/34 (38%)
LY 1379..1418 CDD:214531 15/44 (34%)
LDL-receptor class B 16 1397..1439 13/41 (32%)
LY 1420..1460 CDD:214531 11/49 (22%)
LDL-receptor class B 17 1440..1482 16/51 (31%)
LDL-receptor class B 18 1483..1526 18/43 (42%)
Ldl_recept_b 1483..1523 CDD:278487 16/40 (40%)
LY 1507..1547 CDD:214531 18/39 (46%)
LDL-receptor class B 19 1527..1568 16/41 (39%)
LY 1549..1589 CDD:214531 15/40 (38%)
LDL-receptor class B 20 1569..1610 12/41 (29%)
FXa_inhibition 1617..>1641 CDD:291342 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1686 2/8 (25%)
Endocytosis signal. /evidence=ECO:0000255 1766..1769
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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