DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and LRP2

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_004516.2 Gene:LRP2 / 4036 HGNCID:6694 Length:4655 Species:Homo sapiens


Alignment Length:4689 Identity:1510/4689 - (32%)
Similarity:2209/4689 - (47%) Gaps:715/4689 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 CSSNSSGRINSRSSSSGYRKVQWQEQQEA--------PTLRPLP-DKGNAHKSRNRIKPTVFIRP 76
            |||:.....|.:...|.||....::..:.        ||...|. |.|..:.:..:....|..|.
Human   108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRD 172

  Fly    77 NAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKADCPDMSDEGSECAPKCNEGQFRCGVSRHCIP 141
            ::........|..:.|:|.:|.|||..:.||...||.|.|||.:...|.|...||.|...| ||.
Human   173 SSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGR-CIY 236

  Fly   142 NNWLCDGEFDCGKGDISDELNCPNG--DTPKCRAFEGQC-RNGDCLELSRFCDGRWDCDNDELQC 203
            .||:||||.||  .|..||..|.:|  |..||...|..| .:|.|:.:.:.|||..||...|   
Human   237 QNWVCDGEDDC--KDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRE--- 296

  Fly   204 DKQNAA---------CAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQV 259
            |:.|.:         |:||||.:.|..||.|..|:||...:...::|..||::|:|...|.|||.
Human   297 DENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQK 361

  Fly   260 CRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVGTNGTE-VIGPPGAKDN 323
            |.:.||.:.|.|..||...:|..|:|.:  .....::||          :||.: :||       
Human   362 CESRPGRHLCHCEEGYILERGQYCKAND--SFGEASIIF----------SNGRDLLIG------- 407

  Fly   324 DKVTDKDGVGSEEELLLSQPLRFVH---AFEVWHRNR-----TLCSLLFSWPELQMRCQRVDDAR 380
                  |..|....:|:....|.|.   ||. :|..|     |:.:.:||.....:..|.|.:..
Human   408 ------DIHGRSFRILVESQNRGVAVGVAFH-YHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVS 465

  Fly   381 VNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTY-CRVILQQVDPLSSLDL 444
            |.         :|:    .|.:||::...|||......:.:.....:| ..:|.:.:.....:.:
Human   466 VE---------TPE----NLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAV 517

  Fly   445 DPTKGFMFYTDW-----TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVN 504
            |||.|::|::||     .|.|.|:.:|||||..||..::..|:.||||:.::.|||:|...|.:.
Human   518 DPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIE 582

  Fly   505 RVDYEGRNRWTLKRPLDSPVPLKTIH--AVEVFENSIYLAAWMDTAIVALDKFSLKTHILQSN-- 565
            .|.|:|..|.|:... .|.:|    |  .|.:||..::...|...|::..:||:      ::|  
Human   583 TVTYDGIQRKTVVHG-GSLIP----HPFGVSLFEGQVFFTDWTKMAVLKANKFT------ETNPQ 636

  Fly   566 VSRGANLR-----IFHRQKQPEVAHPCRDNNAGCNQICVPQWTK-----GFASAKCMCTAGYKLH 620
            |...|:||     ::|..:||...:||:|||.||.|:||.....     ||   :|.||.|::|.
Human   637 VYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGF---RCKCTFGFQLD 698

  Fly   621 -NQTTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVY-NVSKTLAIDVNV 683
             ::..|:  |:..||::|.:  ..|.|||.         .:..|.||||||. |.|..:.||.:.
Human   699 TDERHCI--AVQNFLIFSSQ--VAIRGIPF---------TLSTQEDVMVPVSGNPSFFVGIDFDA 750

  Fly   684 RGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSVSRLLAQG-LKRVHAVAFDWINDHLYWT-SH 746
            :...:|:    |..|..       .|..|.::|:...:||.. ::.|.::|||||:.:|||| ||
Human   751 QDSTIFF----SDMSKH-------MIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSH 804

  Fly   747 KK----MQVAPLRNLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKEL 807
            .|    |::|.....:.|...|   :..|:.:.|..|.|:::.|..   .|.|..:|.||:|...
Human   805 YKSISVMRLADKTRRTVVQYLN---NPRSVVVHPFAGYLFFTDWFR---PAKIMRAWSDGSHLLP 863

  Fly   808 LAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNG 871
            :...|    :.||..|.:|.....|||.|.....||....||..|..|...:|. ||:.:.....
Human   864 VINTT----LGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGE 924

  Fly   872 LIYWADNKNSTILRFH----AHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPS-ACAQ 931
            .:::.|.:...|:|..    .....:.|..:..:||    ::.|:.|         ||.| ||.|
Human   925 HLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL----KSYDVNI---------QTGSNACNQ 976

  Fly   932 -----SKCPGMCLNTPK-GAICRCPDGFTLNGTGSHCIPQLAPSPIRPNC-TSGYMCRSTRQCLD 989
                 ..|...|...|. ..:|.||.|..|......|.......|....| ...:.|::.| |:.
Human   977 PTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGR-CVP 1040

  Fly   990 TKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQANC 1053
            ...:|||.:||.|..||..  .|..| |||..: .|.| :|.|......|.....|.||:|:.||
Human  1041 NYYLCDGVDDCHDNSDEQL--CGTLN-NTCSSS-AFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101

  Fly  1054 HQN---TCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDE----TSETIFASKCPEFDCNNGR 1111
            ..:   :|...::|| .:.:||...||.|...|||  |.|||    ::||...|   :|:|.|.|
Human  1102 PTHAPASCLDTQYTC-DNHQCISKNWVCDTDNDCG--DGSDEKNCNSTETCQPS---QFNCPNHR 1160

  Fly  1112 CRQFADVCDGIDNCGNNADEMEC-------EQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDE 1169
            |...:.||||..:|.:.:||:.|       :.:|..|:|      |.|..:.|||:.||.|.|||
Human  1161 CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDK------CIGVTNRCDGVFDCSDNSDE 1219

  Fly  1170 ANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDE----------- 1223
            |.|        |.   :..|.|...||.|.....|||:|..|||...|...:||           
Human  1220 AGC--------PT---RPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPS 1273

  Fly  1224 --FNCTHINTTR-----------FDMNETVIC-EHPDRLCGFSKQ------CVTVDQLCDGKNDC 1268
              |:|.:.|...           .||::...| ..|.|...:..|      ||.:..:|||..||
Human  1274 SYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDC 1338

  Fly  1269 EDTTDEGFLCADKLC-DRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQV 1332
            .:.|||..||....| |....|:|.|...|.|..|.||....|..:.|.|.....||...:|||.
Human  1339 PNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQH 1403

  Fly  1333 CESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRN--- 1394
            |.:....:.|.|..|:.|..|..|||.||.:...::..::..|...:: |..|.|.||.:.|   
Human  1404 CYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSV-TSQVHNIYSLVENGSY 1467

  Fly  1395 IIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWI 1459
            |:|:||   :..:..|:|:|....|.:.....|...|   .|..|.:..||.:|:||||:||||.
Human  1468 IVAVDF---DSISGRIFWSDATQGKTWSAFQNGTDRR---VVFDSSIILTETIAIDWVGRNLYWT 1526

  Fly  1460 DSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPR--EGLLFWTDWDDNSPRIERASMSGDGRR 1522
            |..|:.|||:|::||.|..||:.|:.:||.:|||||  |.||||:|| .:.||||||||.|..|.
Human  1527 DYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDW-GHHPRIERASMDGSMRT 1590

  Fly  1523 MISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFE 1587
            :|.   |....||.|||:||..:.:|::|:..|.:....|:|.....|:.:..|:.||:|:::||
Human  1591 VIV---QDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFE 1652

  Fly  1588 NYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLL 1652
            :.|||||..|..|:|||||:|.:..|:......|.||..:|.|:||...|||..:.  |||||||
Human  1653 DSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLL 1715

  Fly  1653 SGRGT--FKCECPHVMRLDPANERNCVPNEQ-VLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLV 1714
            |.:|.  :.|.||....|.| :..||:.::| .|:.|....|.||.|:       |.::.:..:|
Human  1716 SSQGPHFYSCVCPSGWSLSP-DLLNCLRDDQPFLITVRQHIIFGISLN-------PEVKSNDAMV 1772

  Fly  1715 APQRIDFLVD------ESRIFW----SDIQQ------NEISSAGISNGLIEPIINTNIEKPYGFA 1763
            ....|...:|      |..|:|    .:|.:      |....|.||  ::.|.:|        .|
Human  1773 PIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFASIS--MVGPSMN--------LA 1827

  Fly  1764 VDWIARNMYFSSGQIKCNILASNLKGEF---ASIIHED-----LNMVDSIVLDPANGKMYWIHSA 1820
            :|||:||:|.::.:.: :|....|.|:.   .::|..|     :.....|.:|||.||:||....
Human  1828 LDWISRNLYSTNPRTQ-SIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQG 1891

  Fly  1821 SD-GSMSQLEQSNLDGSS-RSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNE---TR 1880
            :| |..:::..:|:||:| ::|...:..:|:.:|:|.:.|:||:|....|:    |.|..   |.
Human  1892 TDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGV----IERGNVDGTD 1952

  Fly  1881 KVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFY-ADAQT 1944
            ::::...::....:.|::..||:.:....||.:.:|...:|...||.|..:::.::::: .:|..
Human  1953 RMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAE 2017

  Fly  1945 GSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYS-IDVLQG--VE 2006
            .||.|:.  ....|||:||........|.||.|:.:.|:| ..|.|...||..| :..::|  :|
Human  2018 SSNGCSN--NMNACQQICLPVPGGLFSCACATGFKLNPDN-RSCSPYNSFIVVSMLSAIRGFSLE 2079

  Fly  2007 MIDPSEQFDTPSPALVPIS-RVSSASFIDYLANTDTLYW--------GDNELGSISRVKRDGTQR 2062
            :.|.||       .:||:: :..:|..:|...::..:||        .||   :|.|:|.||:  
Human  2080 LSDHSE-------TMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDN---AIRRIKPDGS-- 2132

  Fly  2063 ETILEALNLVGYK-QQDWLGGIAIDWVAGNIYWSD--TKRNIIEVARLDGSHRYVVVS-NLEKPT 2123
                ..:|:|.:. .::.:.|||:||||||:|:::  ....:|||.|::.::|.|::. .::.|.
Human  2133 ----SLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPR 2193

  Fly  2124 ALAVDPLQGLLF---YVTQQHIGRVGLDGSQPFVLVNQTRANWAVG-----SLVLDIEATKVYWC 2180
            .:.|||....||   |..:..|.|..||.:...|||::       |     .|.:|.....|||.
Human  2194 HIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSE-------GIVTPRGLAVDRSDGYVYWV 2251

  Fly  2181 ERYPDALMKVDYDGNLREQL-LNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVV 2244
            :...|.:.::..:|...|.: .......|..:....:.:.|.:....: |.:.:.....::...|
Human  2252 DDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK-IFQASKEPENTEPPTV 2315

  Fly  2245 LQTEQDAIRDLKIYSKHLQRGS------NPCAHSNGACEQLC--LFNGTSAVCACAHSRLASDGY 2301
            ::...:.:||:.|:.|.:|..|      |||..:||.|..||  |....:..|.||...|.|||.
Human  2316 IRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGK 2380

  Fly  2302 SCE-PYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLS 2365
            :|. ..||||:|:..:::.|:|: |..:.:.|.|.|   ::.|.|:::.|:.....:|::....|
Human  2381 NCAISTENFLIFALSNSLRSLHL-DPENHSPPFQTI---NVERTVMSLDYDSVSDRIYFTQNLAS 2441

  Fly  2366 TINQVHF--------------NGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRH 2416
            .:.|:.:              :|.|         ..:|:|:|.:..:::::...|..|.|     
Human  2442 GVGQISYATLSSGIHTPTVIASGIG---------TADGIAFDWITRRIYYSDYLNQMINS----- 2492

  Fly  2417 LSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTD 2481
            ::|.. .|:..:.:|      .|||.|.::||.|.:||.:|:..:. |:|:.|.|.....|:.:.
Human  2493 MAEDG-SNRTVIARV------PKPRAIVLDPCQGYLYWADWDTHAK-IERATLGGNFRVPIVNSS 2549

  Fly  2482 IKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLH 2546
            :.||:.||||.|:..|||.||.|.:|||:...|.:|.|:.::. .|||.:.:||..::|||....
Human  2550 LVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA-VHAFGLTLYGQYIYWTDLYTQ 2613

  Fly  2547 AVVRANKYTGTDVLFLREH-VTRPMGI-VAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCH 2609
            .:.|||||.|:..:.:..: :::|.|| ..|:|....|: |.|:..||.|..:|....:| |.|.
Human  2614 RIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCN-NPCEQFNGGCSHICAPGPNG-AECQ 2676

  Fly  2610 CT-QG--VLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQC 2671
            |. :|  .||.:.:.||......||.|.:.|.:|.||..|..|||...|.|||||..|.|....|
Human  2677 CPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTC 2741

  Fly  2672 PETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCK-CQSEDIDMHPSNNNTKEMPDMFRCGSG 2735
            ..|.|.|.|.||:...::||....|||||||...|.: |           |.|.|    |.|.:.
Human  2742 SPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDC-----------NATTE----FMCNNR 2791

  Fly  2736 ECIPRKFLCDSLKDCRD--FSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTD 2798
            .||||:|:|:.:.:|.|  .||||.|....|:..   :..|.||.|||...:.||||.||.|.:|
Human  2792 RCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSG---YTKCHNSNICIPRVYLCDGDNDCGDNSD 2853

  Fly  2799 E--LDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDE-INC----RTECRHNQFACD 2856
            |  ..|..||   |...:|:||||.||...|:||.|.||.|.||| .:|    || |..::|.||
Human  2854 ENPTYCTTHT---CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERT-CLADEFKCD 2914

  Fly  2857 -KTCIPASWQCDGKSDCEDGSDEGP--QCPNRPCRPHLFQCKS----SGRCIPQKWVCDGEKDCP 2914
             ..|||:.|.|||.:||.|.|||..  ||.|:.|....|.|.:    ..|||||.|||||:.||.
Human  2915 GGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCT 2979

  Fly  2915 SGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQP 2979
            .|.      ||...|..    ..|......|..||||...:.||...||....|| .||:  :| 
Human  2980 DGY------DENQNCTR----RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDE-RGCL--YQ- 3030

  Fly  2980 HSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADL 3044
             :|.....  .||:|.||.|...||...||||||||...||..........:|:|.||.||....
Human  3031 -TCQQNQF--TCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMK 3092

  Fly  3045 LCDRRNDCADFSDEELCNVNECLIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDEC 3107
            ||:..:||.|.|||:.|.:|||..|.|  |:|.|.|.:..:.|.||||||:: .....|.|||||
Human  3093 LCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLM-SDKRTCVDIDEC 3156

  Fly  3108 DEQQ-PCSQTCINTYGSYKCLCAKGYAL-VDHHTCKATSNVSMELIFSNRYYIRQVDMTGN-GSI 3169
            .|.. .|||.|.|..|||.|.||.||.. .|..||:..||:...||||||||:|.:.:.|. .|:
Human  3157 TEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSL 3221

  Fly  3170 LINELSNAVALDYDWDSQCLYWSDVTSTVGTIKR-YCPKENKTQTLHQAMLKNPDGLAVDWVAKN 3233
            ::..|.|.||||:|...:.|||.|....|  |:| :..|.|| :|:....|...:.||||||::.
Human  3222 ILEGLDNVVALDFDRVEKRLYWIDTQRQV--IERMFLNKTNK-ETIINHRLPAAESLAVDWVSRK 3283

  Fly  3234 LYWCDKGLDTIEVSQLDGKYRKVLINEYL--------REPRGIALHPYQQHIFWSDWGDSPHIGK 3290
            |||.|..||.:.||.|:|.:|::|....:        ..|||:||||...:::|:|||...:||:
Human  3284 LYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGR 3348

  Fly  3291 AGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNL 3355
            .||||:|..:||...|.|||.:||.:....|:|.||....|..|||:|:|...:...:      |
Human  3349 VGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA------L 3407

  Fly  3356 HHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCL 3420
            .|.|||.::|..|||:||.|:::|..:.::|.|..||:.|.|||.|:.|:||||  ||:..|||.
Human  3408 PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYR--QPIVSNPCG 3470

  Fly  3421 AAN--CSTLCVLSPEEPYYKCMCPTNF-ILADDGRT-CRANCTAAHFECVNTYKCIPFYWRCDTQ 3481
            ..|  ||.||::.|....:.|.||.:| .|...|.| |...|::..|.|.|..||||.:|:||.|
Human  3471 TNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQ 3535

  Fly  3482 DDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDE--LNCDKFTCFDNHMK 3544
            .||.|||||...||...|..||:||::..||.|..||:....|.|||||  |.|:...|..|..:
Human  3536 KDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ 3600

  Fly  3545 CGATANSSAFCVDNVKRCDGVKDCP--GGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDC 3607
            |   ||..  |:....:||...||.  ..||.|.|....|:..||:|.|.||:|..|.||.|.||
Human  3601 C---ANKR--CIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC 3660

  Fly  3608 PDKSDEA---------NCDNVSCGPNDFQCDSG-RCIPLAWRCDDDHDCPNGEDEPASCFSSKAT 3662
            .|.|||.         .|||.:    :|.|.:. ||||....|:...||.:..|| ..|  .:.|
Human  3661 GDHSDEPIEECMSSAHLCDNFT----EFSCKTNYRCIPKWAVCNGVDDCRDNSDE-QGC--EERT 3718

  Fly  3663 CDPT-YFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIH 3726
            |.|. .|:|.|..|||.||:||.:|||||.|||.||..|.|:||||||...:||...:.||....
Human  3719 CHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYND 3783

  Fly  3727 CDDNSDEINCNI-TCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCT--------CHSDHF 3782
            |.|||||.:|.: ||....|:|.: ..|::.:.||||..||.|.|||.:|.        |.:..|
Human  3784 CGDNSDERDCEMRTCHPEYFQCTS-GHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMF 3847

  Fly  3783 SCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHA-NAFKCRNQLCVRNSALCDGINDCGEN 3846
            .|.|..||...|||||.|||.|||||.|..|....|:: |.|:|.|..|:.:..:|:|::|||:.
Human  3848 ECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDG 3912

  Fly  3847 EDESDAVC-AALPK-CRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPP------------ 3897
            .||::..| ...|| |...:::|.|..||.....||...:|.|.|||:.|...            
Human  3913 TDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQ 3977

  Fly  3898 ----------VCG-----------------------FGSCSQICIEKKAGHYNCKCADGYHKGPE 3929
                      :|.                       ||:|.|.|...| |.|.|.||||:....:
Human  3978 NCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTK-GSYECVCADGFTSMSD 4041

  Fly  3930 K-NATCLASGPDQILLLASEQEFR-FILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKD----TL 3988
            : ...|.|.|...:|||......| :.|.:::     ...:..|...|...|....|||    .:
Human  4042 RPGKRCAAEGSSPLLLLPDNVRIRKYNLSSER-----FSEYLQDEEYIQAVDYDWDPKDIGLSVV 4101

  Fly  3989 LFWIDSHHGKVHTMKIA-TPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIIDSR 4052
            .:.:.....:...:|.| .|:.|..    |.:|.:.....:..:..|..:||||:.:.:|..|.:
Human  4102 YYTVRGEGSRFGAIKRAYIPNFESG----RNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVK 4162

  Fly  4053 HNQILATDIEGKKYISLVSTGMN-PTDIVLEPESRIMIWST--LENGILVASLDGSNKKSLVERD 4114
            :.:|....::|:....|:||.:: |..|.:.|:..:|.|:.  .|..|..|.::|.::..||..|
Human  4163 NKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFED 4227

  Fly  4115 VGWPISLSMDY-PTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLY-IKLY 4177
            :|||..||:|| ...|:||:|:::..|||.:.:|.||.|:.:  ....|..:|:|||.|| |...
Human  4228 LGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAK--EAMNPYSLDIFEDQLYWISKE 4290

  Fly  4178 DQSIIKMNKF--GNDNGTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSV 4240
            ...:.|.|||  |....|.::..: .:.:.|.|.::.|:::.|.| |..|..   ||:|...   
Human  4291 KGEVWKQNKFGQGKKEKTLVVNPW-LTQVRIFHQLRYNKSVPNLC-KQICSH---LCLLRPG--- 4347

  Fly  4241 GYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGY 4305
            ||||.|.:|                                       ....||...|       
Human  4348 GYSCACPQG---------------------------------------SSFIEGSTTE------- 4366

  Fly  4306 CQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCP 4370
                  |..|..||.:..||                     |  ||.:||:|...||:..||.||
Human  4367 ------CDAAIELPINLPPP---------------------C--RCMHGGNCYFDETDLPKCKCP 4402

  Fly  4371 KMFTGEQCE 4379
            ..:||:.||
Human  4403 SGYTGKYCE 4411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566 13/30 (43%)
LDLa 126..163 CDD:238060 18/36 (50%)
EGF_CA 246..283 CDD:214542 14/36 (39%)
Ldl_recept_b 449..487 CDD:278487 17/42 (40%)
LY 472..513 CDD:214531 15/40 (38%)
LY 817..852 CDD:214531 12/34 (35%)
LDLa 1057..1092 CDD:197566 13/34 (38%)
LDLa 1104..1134 CDD:238060 12/29 (41%)
FXa_inhibition 1289..1317 CDD:291342 10/27 (37%)
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 26/45 (58%)
LY 1533..1567 CDD:214531 12/33 (36%)
LY 1568..1611 CDD:214531 20/42 (48%)
FXa_inhibition 1639..1676 CDD:291342 15/38 (39%)
LY 1794..1838 CDD:214531 16/50 (32%)
LY 2078..2112 CDD:214531 14/35 (40%)
NHL <2082..>2152 CDD:302697 27/75 (36%)
NHL repeat 2082..2120 CDD:271320 16/40 (40%)
FXa_inhibition 2269..2303 CDD:291342 14/35 (40%)
LY 2430..2471 CDD:214531 14/40 (35%)
LY 2475..2517 CDD:214531 18/41 (44%)
LDLa 2630..2661 CDD:238060 15/30 (50%)
LDLa 2671..2702 CDD:238060 14/30 (47%)
LDLa 2727..2759 CDD:238060 14/33 (42%)
LDLa 2773..2802 CDD:238060 15/30 (50%)
LDLa 2810..2844 CDD:238060 18/34 (53%)
LDLa 2848..2878 CDD:238060 15/30 (50%)
LDLa 2887..2916 CDD:197566 15/32 (47%)
LDLa 2938..2969 CDD:197566 10/30 (33%)
LDLa 2989..3015 CDD:197566 14/25 (56%)
LDLa 3030..3061 CDD:238060 14/30 (47%)
EGF_CA 3062..>3091 CDD:214542 13/30 (43%)
EGF_CA 3103..3141 CDD:214542 21/39 (54%)
LY 3212..3254 CDD:214531 18/41 (44%)
LY 3255..3297 CDD:214531 18/49 (37%)
LY 3299..3340 CDD:214531 17/40 (43%)
LY 3354..3389 CDD:214531 14/34 (41%)
LDLa 3458..3490 CDD:238060 17/31 (55%)
LDLa 3499..3533 CDD:238060 17/35 (49%)
LDLa 3582..3616 CDD:238060 18/42 (43%)
LDLa 3621..3652 CDD:197566 9/31 (29%)
LDLa 3663..3697 CDD:238060 20/34 (59%)
LDLa 3702..3736 CDD:238060 17/33 (52%)
LDLa 3776..3808 CDD:197566 17/39 (44%)
LDLa 3818..3849 CDD:197566 11/31 (35%)
LDLa 3860..3894 CDD:238060 12/33 (36%)
NHL 4029..>4158 CDD:302697 42/132 (32%)
NHL repeat 4034..4074 CDD:271320 12/39 (31%)
NHL repeat 4076..4115 CDD:271320 11/40 (28%)
LY 4108..4150 CDD:214531 18/42 (43%)
NHL repeat 4121..4158 CDD:271320 15/37 (41%)
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
LRP2NP_004516.2 LDLa 28..62 CDD:238060
LDLa 108..142 CDD:238060 7/33 (21%)
LDLa 149..179 CDD:238060 5/29 (17%)
LDLa 183..217 CDD:238060 15/33 (45%)
LDLa 222..256 CDD:238060 18/36 (50%)
LDLa 266..300 CDD:238060 12/36 (33%)
LY 415..457 CDD:214531 10/42 (24%)
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 436..478 11/54 (20%)
LY 461..501 CDD:214531 9/52 (17%)
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 479..521 7/41 (17%)
LY 503..548 CDD:214531 14/44 (32%)
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 522..568 19/45 (42%)
LY 551..591 CDD:214531 15/39 (38%)
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 569..613 16/48 (33%)
FXa_inhibition 663..704 CDD:291342 16/43 (37%)
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 753..795 13/52 (25%)
LY 776..818 CDD:214531 17/41 (41%)
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 796..837 13/43 (30%)
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 838..881 14/49 (29%)
Ldl_recept_b 838..878 CDD:278487 13/46 (28%)
LY 864..904 CDD:214531 13/43 (30%)
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 882..925 13/42 (31%)
FXa_inhibition 981..1013 CDD:291342 8/31 (26%)
LDLa 1026..1060 CDD:238060 12/36 (33%)
LDLa 1067..1101 CDD:238060 10/34 (29%)
LDLa 1109..1143 CDD:238060 15/36 (42%)
LDLa 1149..1183 CDD:238060 13/36 (36%)
LDLa 1187..1222 CDD:238060 15/40 (38%)
LDLa 1230..1264 CDD:238060 14/33 (42%)
LDLa 1271..1305 CDD:238060 5/33 (15%)
LDLa 1311..1344 CDD:197566 10/32 (31%)
FXa_inhibition 1353..1388 CDD:291342 12/34 (35%)
EGF_CA 1390..1429 CDD:214542 12/38 (32%)
LY 1461..1500 CDD:214531 10/41 (24%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1478..1520 13/44 (30%)
LY 1501..1543 CDD:214531 22/44 (50%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1521..1563 22/41 (54%)
LY 1545..1589 CDD:214531 26/44 (59%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1566..1609 25/46 (54%)
LY 1591..1632 CDD:214531 14/43 (33%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1610..1654 12/43 (28%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1655..1695 18/39 (46%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1790..1832 12/51 (24%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1833..1882 11/49 (22%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1883..1930 14/46 (30%)
Ldl_recept_b 1883..1927 CDD:278487 13/43 (30%)
LY 1911..1953 CDD:214531 12/45 (27%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1931..1972 9/44 (20%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1973..2013 9/39 (23%)
FXa_inhibition 2022..2058 CDD:291342 12/38 (32%)
NHL 2091..2300 CDD:302697 54/225 (24%)
YncE 2092..>2285 CDD:225926 53/208 (25%)
NHL repeat 2097..2142 CDD:271320 13/53 (25%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2107..2156 16/57 (28%)
NHL repeat 2147..2186 CDD:271320 16/38 (42%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2157..2201 13/43 (30%)
NHL repeat 2192..2231 CDD:271320 14/38 (37%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2202..2245 13/49 (27%)
NHL repeat 2235..2275 CDD:271320 8/39 (21%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2246..2289 7/42 (17%)
FXa_inhibition 2346..2382 CDD:291342 14/35 (40%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2431..2477 8/54 (15%)
LY 2459..2500 CDD:214531 9/55 (16%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2478..2518 11/51 (22%)
LY 2500..2542 CDD:214531 15/48 (31%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2519..2562 15/43 (35%)
LY 2545..2585 CDD:214531 18/39 (46%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2563..2604 17/41 (41%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2605..2646 13/40 (33%)
FXa_inhibition 2655..2692 CDD:291342 12/37 (32%)
LDLa 2700..2732 CDD:238060 16/31 (52%)
LDLa 2741..2775 CDD:238060 16/33 (48%)
LDLa 2784..2817 CDD:238060 15/36 (42%)
LDLa 2821..2854 CDD:197566 14/35 (40%)
Ldl_recept_a 2863..2895 CDD:278486 17/34 (50%)
LDLa 2905..2937 CDD:197566 16/32 (50%)
LDLa 2948..2988 CDD:238060 18/45 (40%)
LDLa 2993..3027 CDD:238060 12/34 (35%)
LDLa 3031..3063 CDD:197566 15/33 (45%)
LDLa 3075..3109 CDD:238060 14/33 (42%)
cEGF 3132..3155 CDD:289433 10/23 (43%)
vWFA <3147..3190 CDD:294047 21/42 (50%)
LY 3219..3260 CDD:214531 16/42 (38%)
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3239..3281 17/44 (39%)
LY 3262..3304 CDD:214531 18/41 (44%)
Ldl_recept_b 3282..3329 CDD:278487 16/46 (35%)
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3282..3324 12/41 (29%)
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3333..3376 19/42 (45%)
Ldl_recept_b 3333..3373 CDD:278487 18/39 (46%)
LY 3358..3399 CDD:214531 17/40 (43%)
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3377..3419 16/47 (34%)
LY <3408..3441 CDD:214531 13/32 (41%)
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3420..3460 18/39 (46%)
FXa_inhibition 3469..>3498 CDD:291342 10/28 (36%)
LDLa 3512..3544 CDD:197566 17/31 (55%)
LDLa 3553..3584 CDD:197566 14/30 (47%)
LDLa 3594..3626 CDD:238060 10/36 (28%)
LDLa 3634..3666 CDD:197566 16/31 (52%)
LDLa 3682..3714 CDD:238060 11/36 (31%)
LDLa 3719..3754 CDD:238060 20/34 (59%)
LDLa 3759..3793 CDD:238060 17/33 (52%)
LDLa 3798..3832 CDD:238060 14/34 (41%)
LDLa 3885..3915 CDD:197566 10/29 (34%)
LDLa 3928..3962 CDD:238060 12/33 (36%)
EGF_CA 4007..4047 CDD:214542 13/40 (33%)
LY 4141..4176 CDD:214531 9/34 (26%)
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4154..4196 10/41 (24%)
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4197..4240 16/42 (38%)
Ldl_recept_b 4197..4237 CDD:278487 14/39 (36%)
LY 4222..4264 CDD:214531 18/41 (44%)
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4242..4283 15/42 (36%)
SH3-binding. /evidence=ECO:0000255 4453..4462
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4456..4461
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4459..4464
Endocytosis signal. /evidence=ECO:0000255 4521..4526
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4550..4574
Interaction with DAB2. /evidence=ECO:0000269|PubMed:10769163 4589..4602
NPXY motif 4595..4598
SH2-binding. /evidence=ECO:0000255 4598..4601
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4601..4655
SH3-binding. /evidence=ECO:0000255 4611..4622
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 84 1.000 Domainoid score I8272
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR22722
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.920

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