DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and LRP1

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	XP_016874792.1	Gene:	LRP1 / 4035	HGNCID:	6692	Length:	4561	Species:	Homo sapiens

Alignment Length:	4926	Identity:	1762/4926 - (35%)
Similarity:	2513/4926 - (51%)	Gaps:	677/4926 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CPASYFTCNDGF-CIPMRWKCDSKADCPDMSDEGSECAP-----KCNEGQFRCGVSRHCIPNNWL 145
            |....|.|.|.. ||...|:||.:.||||.|||..|..|     :|...:..|..:..|:|.:.|
Human    27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRL 91

  Fly   146 CDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAAC 210
            |:|..||..|  |||       .|.||..:|.                                |
Human    92 CNGVQDCMDG--SDE-------GPHCRELQGN--------------------------------C 115

  Fly   211 AALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGY 275
            :.|.|..:|..|..|..|||......::...| |.|:||||..|||.|:|.||.||:.|.||.||
Human   116 SRLGCQHHCVPTLDGPTCYCNSSFQLQADGKT-CKDFDECSVYGTCSQLCTNTDGSFICGCVEGY 179

  Fly   276 AKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGTNGTEV--IGPPGAKDNDKVTDKDGVGSEEE 337
            .....|| |:|.|.|...|..|:..:...:.:...:|.:|  |.|...:...
Human   180 LLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTT------------- 231

  Fly   338 LLLSQPLRFVHAFEVWHRNRTLCSLLFSW-------PELQMRCQR-------VDDARVNWTLPFS 388
                       |.:..:.|.|:|     |       .:.|::|.|       ||:..:|.:|..
Human   232 -----------AMDFSYANETVC-----WVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSL- 279

  Fly   389 SFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVI--LQQVDPLSSLDLDPTKGFM 451
                  ....::.:|||:||:|.|.:.|..:::|......|..:  |:..:| ..:.|||..|.:
Human   280 ------HHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNP-KGIALDPAMGKV 337

  Fly   452 FYTDW--TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRW 514
            |:||:  .|.:.|..:||.|||.||..::..|..:||||.:.||||.|.|.|.:..|||||:.|.
Human   338 FFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQ 402

  Fly   515 TLKRPLDSPVPLKTIHAVEVFENSIYLA------AWMDTAIVALDKFSLKTHILQSNVSRGANLR 573
            |:.:    .:.::.::.:.||||.:|..      |...|:::.:::|:...:.:.:.|.:|..|.
Human   403 TIIQ----GILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALH 463

  Fly   574 IFHRQKQPEV-AHPCRDNN----AGCNQICVPQWTKGFASAKCMCTAGYKLHNQ-TTCLLSALDK 632
            |:|:::||.| :|.|.::.    .||:.||:  ......:..|.|.:|:.|.:. .:|.....:.
Human   464 IYHQRRQPRVRSHACENDQYGKPGGCSDICL--LANSHKARTCRCRSGFSLGSDGKSCKKPEHEL 526

  Fly   633 FLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDV-MVPVYNVSKTLAIDVNVRGKAVFYVVADSG 696
            ||||.......|.|:.:.          .:.||. |:|:.|:....|:|.:.....:::  ||:
Human   527 FLVYGKGRPGIIRGMDMG----------AKVPDEHMIPIENLMNPRALDFHAETGFIYF--ADT- 578

  Fly   697 ASPFGNGEPSCSIRSQSLNGSV-SRLLAQGLKRVHAVAFDWINDHLYWTS---HKKMQVAPLRNL 757
                    .|..|..|.::|:. ..:|..|:..|..||.||:.|:||||.   .|.:.||.|...
Human   579 --------TSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKA 635

  Fly   758 S---KVLTFNTDCDAMSLELDPTTGLLYWSQWE---SQSCEAGIYSSWMDGTHKELLAKGTSSMP 816
            :   |.|.........::.:||..|.:||:.||   ..|....:..:||||:|:::.   .:|..
Human   636 AQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIF---VTSKT 697

  Fly   817 MQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNGLIYWADNKN 880
            :.||..|.:|.....|||.|.....||.:.|:||.|:::::..:. |.:.:..:...::|.:.::
Human   698 VLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRS 762

  Fly   881 STILRFHAHQANLSSTFSSTVHLQRTGRAA--DLRIFDIASQPLPQTPSACAQSKCPGMCLNTPK 943
            .::.|........    ..||.|.|:.|..  ::|::|...|.:...........|..:||.||.
Human   763 GSVYRLERGVGGA----PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPG 823

  Fly   944 GAICRCPDGFTLNGTGSHCI--PQLAPSPIRPNCTSG-YMCRSTRQCLDTKDMCDGFEDCEDGID 1005
            ...|.|.:...|:..|..|:  |...|.   |.|..| :.|.::| |:..:..|||..||   :|
Human   824 SRQCACAEDQVLDADGVTCLANPSYVPP---PQCQPGEFACANSR-CIQERWKCDGDNDC---LD 881

  Fly  1006 ESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQAN--CHQNTCNSNEFTCHK 1067
            .|.:....|:.:|| .:..|.| |.||.....||.....|.:..|::|  |...||..|:|:| .
Human   882 NSDEAPALCHQHTC-PSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC-A 944

  Fly  1068 SGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCP--EFDCNNGRCRQF-------ADVCDGID 1123
            |||||.::|..|...|||  |.|||::...:.:..|  :|.||||||...       .|..||.|
Human   945 SGRCIPISWTCDLDDDCG--DRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNEKDCGDGSD 1007

  Fly  1124 ----------NCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSD 1178
                      :||:|:||..|...|...:..|....|..|...|||.:||.|:|||.:.|.|...
Human  1008 EQTCPEPADNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQA 1072

  Fly  1179 NHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNC---THI--NTTRFDMN- 1237
            ..|.      |.|...||.|.....|||...||||.:.|.|.:||.:|   ||:  .:.:|...
Human  1073 TRPP------GGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKD 1131

  Fly  1238 --------------------------ETVICEHPDRLCGFSKQ-CVTVDQLCDGKNDCEDTTDEG 1275
                                      |::.|..|...|..:.. |:..|:||||.:||.|.:|||
Human  1132 SARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG 1196

  Fly  1276 FLCADKLCDRGHECSHRCHNTP-EGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKG 1339
            .|| |:.......|||.|...| ||.:||||..:.|.|:...|.:|..|.....|||.|:.:...
Human  1197 ELC-DQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1260

  Fly  1340 YDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNN 1404
            ..|.|.:|:.|..|..:|:|..|.:|::||:||.:|:.|:|...:.......|||.|||||   :
Human  1261 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDF---H 1322

  Fly  1405 ESNVEIYWTDVIDDKIYRGHLVGE-SLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEV 1468
            .|...:|||||::||||||.|:.. :|.:.|.||..||:|.|||||||:..|:||::||||||||
Human  1323 LSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1387

  Fly  1469 AKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAG 1533
            |||:|:.|.||:||::|.|||||||||:|:|||||||.:.||||.|||||.|||.:..... |.|
Human  1388 AKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETG-SGG 1451

  Fly  1534 WPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTT 1598
            ||||||:||.:||:.|:||:||:|.|..||||.|..|||..|.||||||::::...||||||||.
Human  1452 WPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTN 1516

  Fly  1599 SVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGG---CSHLCLLSGRGTFKC 1660
            ::.:||||.|.:|.|:|||.:|||.:||.|.||||...||| |.|||   ||||||::...|..|
Human  1517 TLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPC-EANGGQGPCSHLCLINYNRTVSC 1580

  Fly  1661 ECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHH-----TIPTIRQSPRLVAPQRID 1720
            .|||:|:|...| ..|...::.||:....||||:||..|.::     |:|.|.....|      |
Human  1581 ACPHLMKLHKDN-TTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL------D 1638

  Fly  1721 FLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQI-KCNILA 1784
            :...|.|::|||::...|..|.|:...:|.:::.::...:|.||||::||::::|... |..|..
Human  1639 YDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINV 1703

  Fly  1785 SNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQ 1849
            :.|.|.|.:.:.:.|.....:|:.|..||:||    :||  ..:..:|:|||:|:|::..:....
Human  1704 ARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYW----TDG--DNISMANMDGSNRTLLFSGQKGPV 1762

  Fly  1850 SLTMDFDSQRLYYA-----------YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYF 1903
            .|.:||...:||:.           .|.||:...|..|::..|.         ::|.:....|::
Human  1763 GLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKA---------TALAIMGDKLWW 1818

  Fly  1904 PENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQ---TGSNTCAEWAYRGGCQQLCLAT 1965
            .:.:...:..|.|...|....||.:|..:..||::....|   .|:|.|:  ...|.|.||||.|
Human  1819 ADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCS--VNNGDCSQLCLPT 1881

  Fly  1966 SSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSI-DVLQGVEMIDPSEQFDTPSPALVPISRVSS 2029
            |.....|.|..||.:. :....|.....|:.||: :.::|:. :||:::.|    ||||:|..|.
Human  1882 SETTRSCMCTAGYSLR-SGQQACEGVGSFLLYSVHEGIRGIP-LDPNDKSD----ALVPVSGTSL 1940

  Fly  2030 ASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYW 2094
            |..||:.|..||:||.|..|.:|||.|||.|.||.::  .|.:|..:     |||:||:||||||
Human  1941 AVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVV--TNGIGRVE-----GIAVDWIAGNIYW 1998

  Fly  2095 SDTKRNIIEVARLDGSHRYVVVS-NLEKPTALAVDPLQGLLFYV---TQQHIGRVGLDGSQPFVL 2155
            :|...::||||||:||.||||:| .|:||.|:.|.|.:|.||:.   ....|.|..|||::..||
Human  1999 TDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVL 2063

  Fly  2156 VNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYD-GNLREQLLNESLNNPVALAKMGDYLY 2219
            || ...:|..| :.:|.:..|:|||:...|.:.::|.: |..||.:|:.:..:..:::...|::|
Human  2064 VN-VSISWPNG-ISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIY 2126

  Fly  2220 WAENKYNEGIIRVAPLANLSQSKVVLQTEQDA-IRDLKIYSKHLQRGSNPCAHSNGACEQLCLFN 2283
            |::..:..|.|:.....|.:.| |.|:|.... ::|:|::::..|:|:|.||.:||.|:||||:.
Human  2127 WSDRTHANGSIKRGSKDNATDS-VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYR 2190

  Fly  2284 GT-SAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIA 2347
            |. ...|||||..||.||.||..|..:||:|.|:.::|||::|..:.|.|||...:...|:||||
Human  2191 GRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIA 2255

  Fly  2348 ITYNYE-------EQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNN 2405
            :.::|.       ...:::||:....|.|::.:|:....::|....||||||....:.|:|||..
Human  2256 LAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYT 2320

  Fly  2406 NATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLT 2470
            .:||    .||..:.........:.|:::..||.||...::.|..:::||||||..|.|.|:.|:
Human  2321 TSTI----TRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS 2381

  Fly  2471 GYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYG 2535
            |.....:|:.||:.||.|.:|...:|||::||.||||||..||||:|.|:..|.|.|.|.:||||
Human  2382 GANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYG 2446

  Fly  2536 DLLFWTDWVLHAVVRANKYTGTDVLFLREHV-TRPMGIVAVQNTSINCDANQCKILNGQCEDVCI 2599
            :.:||||||..||.||||:.|:::..||..: .:||||:||.|.:.:|:.:.|:|.||.|:|:|:
Human  2447 EHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCL 2511

  Fly  2600 LNKSGQATCHCTQGVLAPDGRRCIAPVNTSC-GLSQYNCHSGECIPLELTCDNVTHCADGSDEFR 2663
            |...|...|.|..|.:..|...|.| ||:|| ...::.|.:||||...||||.|.||.|.|||..
Human  2512 LTHQGHVNCSCRGGRILQDDLTCRA-VNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKP 2575

  Fly  2664 SYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPD 2728
            |||..|:|.:|...|.|.||:.....|:|...|||||||.|    |           |.|.....
Human  2576 SYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIP----C-----------NKTACGVG 2625

  Fly  2729 MFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEK------NDMTFVHCGNSTICIMPRWRC 2787
            .|||..|.||.....|:...||.|.|||..|:...|..      ..:.|..|..:::|..|.|.|
Human  2626 EFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVC 2690

  Fly  2788 DGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQ 2852
            ||..||.|.:||.||.......|....|.|.||.||..||.||.|.||..|.||.:|...|...|
Human  2691 DGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQ 2755

  Fly  2853 FAC-DKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSG 2916
            |.| :..||...|.|||..||.|||||...|..:.|.|..|.|..:..|:|::|:|||:|||..|
Human  2756 FECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADG 2820

  Fly  2917 LGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHS 2981
             .||..      ..|..:...|.....:|.:..||..|:|||.|.||..|.||...|    :..:
Human  2821 -ADESI------AAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPEC----EYPT 2874

  Fly  2982 CPGGSLMHQCQDGLCIFKNQ-TCDGKPDCGDGSDETSS---LCAHTRGCNGTDDFRCKNGACIHA 3042
            |  |....:|.:|.|:...| .|||:.||.|.|||...   ..:....||.:..|.|.:|.|:..
Human  2875 C--GPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAE 2937

  Fly  3043 DLLCDRRNDCADFSDEELCNVNECLIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDID 3105
            .|||:.::||.|.|||..|::||||...:  |..:|||..:|::|.||||:: |......|.|:|
Human  2938 ALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFR-LKDDGRTCADVD 3001

  Fly  3106 ECDEQQPCSQTCINTYGSYKCLCAKGYAL--VDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGS 3168
            ||....||||.||||:|||||||.:|||.  .|.|:|||.::....|||:||||:|::::.|:..
Human  3002 ECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNY 3066

  Fly  3169 ILINE-LSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAK 3232
            .|:.: |:||||||:|:..|.:||:|||:....|:|.....:..|.||:..|.||||||||||..
Human  3067 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGG 3131

  Fly  3233 NLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSN 3297
            ||||||||.||||||:|:|.||.||::..|||||.:.:.....:::|:||||...||:.|||||:
Human  3132 NLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSS 3196

  Fly  3298 PKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIA 3362
            ..:|:...:.|||.||:.:.|::::|.|||||.|..:.|||::..::|::.|      .||||:.
Human  3197 RSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI------PHIFALT 3255

  Fly  3363 VWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CS 3425
            ::|.::||:|||||||.......|.|.|.||:|:||||||.|||..||.. :..:||...|  ||
Human  3256 LFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD-VPNHPCKVNNGGCS 3319

  Fly  3426 TLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDE 3490
            .||:|||... :||.|||||.|..|||||.:||||:.|.|.|. |||||:|:|||:|||||.|||
Human  3320 NLCLLSPGGG-HKCACPTNFYLGSDGRTCVSNCTASQFVCKND-KCIPFWWKCDTEDDCGDHSDE 3382

  Fly  3491 PETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFC 3555
            |..||.|.|.|||:||:...||:|:.:|||.|.|.|.|||.|||...|..:..||..|..    |
Human  3383 PPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNR----C 3443

  Fly  3556 VDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCG-NNRCMPFVWVCDGDIDCPDKSDE-ANCDN 3618
            :..:.||:|..:|..||||..|..:.|..:||||. ..||:|.|||||.|.||.|.||| |||..
Human  3444 IPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 3508

  Fly  3619 VSCGPNDFQC-DSGRCIPLAWRCDDDHDCPNGEDEP-ASCFSSKATCDPTYFKCNNSKCIPGRWR 3681
            ::||.::|:| |||||||..|:||.:.||.:|.||| ..|  .:.||:|..|:|.|::|:||||:
Human  3509 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQ 3571

  Fly  3682 CDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFK 3746
            |||:|||||.|||.:|..|.||||||.|..|:||...::|||:..|.|.|||.:|...|..:||:
Human  3572 CDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQ 3636

  Fly  3747 CAAFNTCINKQYKCDGDDDCPDGSDEVNC-----TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGS 3806
            |.: ..||..:::||.|.||.|||||..|     ||..|.|.|.|..|....|||||.|||.|.|
Human  3637 CKS-GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNS 3700

  Fly  3807 DESLETCAKTHCHAN-AFKCRN-QLCVRNSALCDGINDCGENEDESDAVC----AALPKCR-HDQ 3864
            ||:.|.||:..|..| .|:|:| ::|:.....|||.::||:..||.|  |    |....|: ..:
Human  3701 DENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEED--CEPPTAHTTHCKDKKE 3763

  Fly  3865 FQCENDDCISKAFRCDGQYNCVDGSDEMNC-----------QPPVCG------------------ 3900
            |.|.|..|:|.:.||:...:|.|||||.:|           ...:||
Human  3764 FLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRS 3828

  Fly  3901 -------------------FGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPD-QILLL 3945
                               ||:|||:|...|.||. |.||..:.|   .:.||.|.|.: |:|.:
Human  3829 GFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHL-CSCARNFMK---THNTCKAEGSEYQVLYI 3889

  Fly  3946 ASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVE 4010
            |.:.|.|.:.|..........|...:|::||..|:.:  |...::|.:.|.|.:....:......
Human  3890 ADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHV--KAGRVYWTNWHTGTISYRSLPPAAPP 3952

  Fly  4011 GTGVRVRRDL-KELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGM 4074
            .|..|.||.: :.:|..||..|..|:.:|:||::..||..||..:.|....::|:...:|:| ||
Human  3953 TTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLIS-GM 4016

  Fly  4075 --NPTDIVLEPESRIMIWSTLEN--GILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADY 4135
              .|..||::|....|.||...|  .|..|::||:.:::||:.::.||..|::||...||||||.
Human  4017 IDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADA 4081

  Fly  4136 RKGTIETCRLNGKDRNVVRRFGNR--EKPQKIDVFEDYLY-IKLYDQSIIKMNKFGNDNGTYLLK 4197
            :...|.:.||||.| .:|.....|  ..|..|||||||:| :...:..:.|::|||:.....|..
Human  4082 KLSVIGSIRLNGTD-PIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 4145

  Fly  4198 GY-RSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAH 4261
            |. .:||:.:.|..|| ..::|||.:..|:   .||:||....|   |.|..|..: |:|.|
Human  4146 GLSHASDVVLYHQHKQ-PEVTNPCDRKKCE---WLCLLSPSGPV---CTCPNGKRL-DNGTC--- 4199

  Fly  4262 ADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPP 4326
              :|                 ||                                    |..|||
Human  4200 --VP-----------------VP------------------------------------SPTPPP 4209

  Fly  4327 LKCTCTAGWSGARCETSMP-ACQSRCHNGGSCLISETEGMKCSCPKMFTGEQC------EHCRNL 4384
                          :...| .|..:|.|||||.::.....||.|...:||::|      ||||
Human  4210 --------------DAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCR-- 4258

  Fly  4385 TCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHC 4449
               |||.|..:.:|.|.|.||.||||.:|....||.:|.|..:|.::...|.||:|..|:.|:.|
Human  4259 ---NGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRC 4320

  Fly  4450 ESNSCRDFCRNGGTCS-ERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMI 4513
            :...|..:|.|.|||. ...|...|.|...:.|..||.:.|..                 |.
Human  4321 QYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSR-----------------CL--- 4365

  Fly  4514 CQNAGTCHIIK--GVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEW 4576
               .|.|.:.|  |...|||||......|.       .|..:|:|||.|.::...:|.|.|
Human  4366 ---EGACVVNKQSGDVTCNCTDGRVAPSCL-------TCVGHCSNGGSCTMNSKMMPECQC---- 4416

  Fly  4577 QGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLV 4641
                   |||..|..|.                          :.:..:|:|   |.:.|:::.:
Human  4417 -------PPHMTGPRCE--------------------------EHVFSQQQP---GHIASILIPL 4445

  Fly  4642 LAVILLVFALFAGAVYFLKKHRI--AQPFSHARLTD---NVEI-MLTNAMYRG----------DA 4690
            |.::|||  |.||.|::.|: |:  |:.|.|.|:|:   |||| ..|..||.|          ||
Human  4446 LLLLLLV--LVAGVVFWYKR-RVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDA 4507

  Fly  4691 DEAPTFASEDDK-GNFANPVYESMYADAIPEPVSTEITHSTA-PDERKGLL 4739
            |    ||.:.|| .||.||||.::|......      .||.| .||::.||
Human  4508 D----FALDPDKPTNFTNPVYATLYMGGHGS------RHSLASTDEKRELL 4548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566	14/31 (45%)
		LDLa	126..163	CDD:238060	13/36 (36%)
		EGF_CA	246..283	CDD:214542	21/37 (57%)
		Ldl_recept_b	449..487	CDD:278487	15/39 (38%)
		LY	472..513	CDD:214531	19/40 (48%)
		LY	817..852	CDD:214531	13/34 (38%)
		LDLa	1057..1092	CDD:197566	17/34 (50%)
		LDLa	1104..1134	CDD:238060	16/46 (35%)
		FXa_inhibition	1289..1317	CDD:291342	13/28 (46%)
		LY	1434..1476	CDD:214531	28/41 (68%)
		LY	1477..1521	CDD:214531	31/43 (72%)
		LY	1533..1567	CDD:214531	22/33 (67%)
		LY	1568..1611	CDD:214531	23/42 (55%)
		FXa_inhibition	1639..1676	CDD:291342	19/39 (49%)
		LY	1794..1838	CDD:214531	13/43 (30%)
		LY	2078..2112	CDD:214531	20/33 (61%)
		NHL	<2082..>2152	CDD:302697	39/73 (53%)
		NHL repeat	2082..2120	CDD:271320	25/38 (66%)
		FXa_inhibition	2269..2303	CDD:291342	19/34 (56%)
		LY	2430..2471	CDD:214531	16/40 (40%)
		LY	2475..2517	CDD:214531	22/41 (54%)
		LDLa	2630..2661	CDD:238060	15/31 (48%)
		LDLa	2671..2702	CDD:238060	13/30 (43%)
		LDLa	2727..2759	CDD:238060	13/31 (42%)
		LDLa	2773..2802	CDD:238060	12/28 (43%)
		LDLa	2810..2844	CDD:238060	17/33 (52%)
		LDLa	2848..2878	CDD:238060	15/30 (50%)
		LDLa	2887..2916	CDD:197566	13/28 (46%)
		LDLa	2938..2969	CDD:197566	12/30 (40%)
		LDLa	2989..3015	CDD:197566	11/26 (42%)
		LDLa	3030..3061	CDD:238060	13/30 (43%)
		EGF_CA	3062..>3091	CDD:214542	13/30 (43%)
		EGF_CA	3103..3141	CDD:214542	24/39 (62%)
		LY	3212..3254	CDD:214531	30/41 (73%)
		LY	3255..3297	CDD:214531	18/41 (44%)
		LY	3299..3340	CDD:214531	17/40 (43%)
		LY	3354..3389	CDD:214531	15/34 (44%)
		LDLa	3458..3490	CDD:238060	21/31 (68%)
		LDLa	3499..3533	CDD:238060	18/33 (55%)
		LDLa	3582..3616	CDD:238060	21/35 (60%)
		LDLa	3621..3652	CDD:197566	17/31 (55%)
		LDLa	3663..3697	CDD:238060	21/33 (64%)
		LDLa	3702..3736	CDD:238060	18/33 (55%)
		LDLa	3776..3808	CDD:197566	17/31 (55%)
		LDLa	3818..3849	CDD:197566	11/32 (34%)
		LDLa	3860..3894	CDD:238060	14/34 (41%)
		NHL	4029..>4158	CDD:302697	47/132 (36%)
		NHL repeat	4034..4074	CDD:271320	12/39 (31%)
		NHL repeat	4076..4115	CDD:271320	14/40 (35%)
		LY	4108..4150	CDD:214531	18/41 (44%)
		NHL repeat	4121..4158	CDD:271320	16/36 (44%)
		EGF_CA	<4386..4414	CDD:238011	13/27 (48%)
		EGF_CA	4415..4450	CDD:238011	11/34 (32%)
LRP1	XP_016874792.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I3746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1744
Inparanoid	1	1.050	2931	1.000	Inparanoid score	I19
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46025
OrthoDB	1	1.010	-	-		D1326at33208
OrthoFinder	1	1.000	-	-		FOG0002316
OrthoInspector	1	1.000	-	-		otm41160
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4848
SonicParanoid	1	1.000	-	-		X1742
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910