| Sequence 1: | NP_001260800.2 | Gene: | LRP1 / 35799 | FlyBaseID: | FBgn0053087 | Length: | 4752 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000518.1 | Gene: | LDLR / 3949 | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
| Alignment Length: | 768 | Identity: | 257/768 - (33%) |
|---|---|---|---|
| Similarity: | 372/768 - (48%) | Gaps: | 117/768 - (15%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 2730 FRCGSGECIPRKFLCDSLKDCRDFSDE--KMCAPIPCEKNDMTFVHCGNS-TICIMPRWRCDGDP 2791
Fly 2792 DCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRT-ECRHNQFAC 2855
Fly 2856 D-KTCIPASWQCDGKSDCEDGSDEGPQ-C--------PNRPCRPHLFQCKSSGRCIPQKWVCDGE 2910
Fly 2911 KDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVP 2975
Fly 2976 AFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACI 3040
Fly 3041 HADLLCDRRNDCADFSDEEL--CNVNECLIPD-ICEHECEDKVVGYQCHCRPGYKVLPKSPHLCT 3102
Fly 3103 DIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHT--CKATSNVSMELIFSNRYYIRQVDM-T 3164
Fly 3165 GNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKE-------NKTQTLHQAMLKNP 3222
Fly 3223 DGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPH 3287
Fly 3288 IGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPL 3352
Fly 3353 LNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGN 3417
Fly 3418 PC-----LAANCSTLCV----LSPEEPYYKCMCPTNFILADDGRTCRANCTAA 3461 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP1 | NP_001260800.2 | LDLa | 87..118 | CDD:197566 | |
| LDLa | 126..163 | CDD:238060 | |||
| EGF_CA | 246..283 | CDD:214542 | |||
| Ldl_recept_b | 449..487 | CDD:278487 | |||
| LY | 472..513 | CDD:214531 | |||
| LY | 817..852 | CDD:214531 | |||
| LDLa | 1057..1092 | CDD:197566 | |||
| LDLa | 1104..1134 | CDD:238060 | |||
| FXa_inhibition | 1289..1317 | CDD:291342 | |||
| LY | 1434..1476 | CDD:214531 | |||
| LY | 1477..1521 | CDD:214531 | |||
| LY | 1533..1567 | CDD:214531 | |||
| LY | 1568..1611 | CDD:214531 | |||
| FXa_inhibition | 1639..1676 | CDD:291342 | |||
| LY | 1794..1838 | CDD:214531 | |||
| LY | 2078..2112 | CDD:214531 | |||
| NHL | <2082..>2152 | CDD:302697 | |||
| NHL repeat | 2082..2120 | CDD:271320 | |||
| FXa_inhibition | 2269..2303 | CDD:291342 | |||
| LY | 2430..2471 | CDD:214531 | |||
| LY | 2475..2517 | CDD:214531 | |||
| LDLa | 2630..2661 | CDD:238060 | |||
| LDLa | 2671..2702 | CDD:238060 | |||
| LDLa | 2727..2759 | CDD:238060 | 13/30 (43%) | ||
| LDLa | 2773..2802 | CDD:238060 | 14/29 (48%) | ||
| LDLa | 2810..2844 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 2848..2878 | CDD:238060 | 16/30 (53%) | ||
| LDLa | 2887..2916 | CDD:197566 | 13/28 (46%) | ||
| LDLa | 2938..2969 | CDD:197566 | 2/30 (7%) | ||
| LDLa | 2989..3015 | CDD:197566 | 12/25 (48%) | ||
| LDLa | 3030..3061 | CDD:238060 | 13/32 (41%) | ||
| EGF_CA | 3062..>3091 | CDD:214542 | 12/29 (41%) | ||
| EGF_CA | 3103..3141 | CDD:214542 | 20/39 (51%) | ||
| LY | 3212..3254 | CDD:214531 | 17/41 (41%) | ||
| LY | 3255..3297 | CDD:214531 | 15/41 (37%) | ||
| LY | 3299..3340 | CDD:214531 | 11/40 (28%) | ||
| LY | 3354..3389 | CDD:214531 | 10/34 (29%) | ||
| LDLa | 3458..3490 | CDD:238060 | 2/4 (50%) | ||
| LDLa | 3499..3533 | CDD:238060 | |||
| LDLa | 3582..3616 | CDD:238060 | |||
| LDLa | 3621..3652 | CDD:197566 | |||
| LDLa | 3663..3697 | CDD:238060 | |||
| LDLa | 3702..3736 | CDD:238060 | |||
| LDLa | 3776..3808 | CDD:197566 | |||
| LDLa | 3818..3849 | CDD:197566 | |||
| LDLa | 3860..3894 | CDD:238060 | |||
| NHL | 4029..>4158 | CDD:302697 | |||
| NHL repeat | 4034..4074 | CDD:271320 | |||
| NHL repeat | 4076..4115 | CDD:271320 | |||
| LY | 4108..4150 | CDD:214531 | |||
| NHL repeat | 4121..4158 | CDD:271320 | |||
| EGF_CA | <4386..4414 | CDD:238011 | |||
| EGF_CA | 4415..4450 | CDD:238011 | |||
| LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 11/25 (44%) |
| Ldl_recept_a | 66..104 | CDD:278486 | 16/40 (40%) | ||
| Ldl_recept_a | 107..143 | CDD:278486 | 17/38 (45%) | ||
| Ldl_recept_a | 147..179 | CDD:278486 | 16/31 (52%) | ||
| Ldl_recept_a | 195..231 | CDD:278486 | 16/43 (37%) | ||
| Ldl_recept_a | 235..270 | CDD:278486 | 18/82 (22%) | ||
| LDLa | 278..308 | CDD:294076 | 12/29 (41%) | ||
| FXa_inhibition | 318..>346 | CDD:291342 | 11/27 (41%) | ||
| EGF_CA | 354..388 | CDD:214542 | 18/34 (53%) | ||
| LDL-receptor class B 1 | 397..438 | 13/41 (32%) | |||
| LY | 419..457 | CDD:214531 | 14/42 (33%) | ||
| LDL-receptor class B 2 | 439..485 | 14/50 (28%) | |||
| Ldl_recept_b | 439..482 | CDD:278487 | 11/47 (23%) | ||
| LDL-receptor class B 3 | 486..528 | 16/41 (39%) | |||
| Ldl_recept_b | 487..525 | CDD:278487 | 15/37 (41%) | ||
| LDL-receptor class B 4 | 529..572 | 12/42 (29%) | |||
| Ldl_recept_b | 529..569 | CDD:278487 | 12/39 (31%) | ||
| LY | 553..595 | CDD:214531 | 11/41 (27%) | ||
| LDL-receptor class B 5 | 573..615 | 13/45 (29%) | |||
| LDL-receptor class B 6 | 616..658 | 9/43 (21%) | |||
| Ldl_recept_b | 616..655 | CDD:278487 | 7/38 (18%) | ||
| FXa_inhibition | 671..711 | CDD:291342 | 12/39 (31%) | ||
| Clustered O-linked oligosaccharides | 721..768 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 734..755 | ||||
| Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 | 811..860 | ||||
| NPXY motif. /evidence=ECO:0000269|PubMed:22509010 | 823..828 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||