DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LRP1 and CG6024

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	NP_001368949.1	Gene:	CG6024 / 39325	FlyBaseID:	FBgn0036202	Length:	427	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	81/376 - (21%)
Similarity:	108/376 - (28%)	Gaps:	140/376 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2870 SDCEDG--SDEG--------PQCPNR---PCRP-----------HLFQCKSSGRCIPQKWVCDGE 2910
            :.|..|  :|.|        |.|..|   |.|.           .|.|.:|||..||| |:.
  Fly     6 TSCGPGPPNDHGPMSLPTSSPSCSKRARIPTRAADDDEPLRRSGTLTQRQSSGSGIPQ-WLL--- 66

  Fly  2911 KDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGG-----DDEY 2970
              ...||....::..|.|..       .....|.....|| .:|::........|.     ::..
  Fly    67 --ILIGLLAILAQTPGSQVA-------AEKSKHYYMQSLC-KNHFLQQLYRKIDGAVLWSQNERN 121

  Fly  2971 EGCVPAFQPHSCPGGSLMH------QCQDGLCIFKNQTCDGKP----DCGDGSDETSSLCAHTRG 3025
            ..|:..||.||.....::.      .|.|.|.::........|    .|.:..:..::|...|..
  Fly   122 LDCIITFQTHSVLQRFMLRFDMLQLDCNDHLLVYDGAHAVATPKIDISCRNTKNTVNALLTRTNF 186

  Fly  3026 CN--------GTD-------------------DFRCKNGA-CIHADLLCDRRNDCADFSDEELCN 3062
            ..        |||                   ||.|.... |||.|||||..|.|.|.|||.:.|
  Fly   187 VTLKYVTDGWGTDANGFKLVITSVKDPKHTCKDFTCATREFCIHPDLLCDGINHCGDNSDESVQN 251

  Fly  3063 VNECLIPDICEHECEDKVVGYQ------------------------CHCRPGYKVLPKSPHLCTD 3103
                    :|::|....|.|..                        |.||
  Fly   252 --------LCQNETSSTVFGLDMTWFVLIVVGVLLVLSALIVAVAICVCR--------------- 293

  Fly  3104 IDECDEQQPCSQTCI------NTYGSYKCL----CAKGYALVDHHTCKATS 3144
              ..||......|.:      :|.||.|.|    .:.|..|...||...||
  Fly   294 --RQDENAANQNTALQVHHTADTNGSSKHLHYHGISVGGTLTREHTQLPTS 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:278487
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		FXa_inhibition	1289..1317	CDD:291342
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:291342
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:291342
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060	2/9 (22%)
		LDLa	2887..2916	CDD:197566	10/39 (26%)
		LDLa	2938..2969	CDD:197566	5/35 (14%)
		LDLa	2989..3015	CDD:197566	5/35 (14%)
		LDLa	3030..3061	CDD:238060	18/50 (36%)
		EGF_CA	3062..>3091	CDD:214542	8/52 (15%)
		EGF_CA	3103..3141	CDD:214542	12/47 (26%)
		LY	3212..3254	CDD:214531
		LY	3255..3297	CDD:214531
		LY	3299..3340	CDD:214531
		LY	3354..3389	CDD:214531
		LDLa	3458..3490	CDD:238060
		LDLa	3499..3533	CDD:238060
		LDLa	3582..3616	CDD:238060
		LDLa	3621..3652	CDD:197566
		LDLa	3663..3697	CDD:238060
		LDLa	3702..3736	CDD:238060
		LDLa	3776..3808	CDD:197566
		LDLa	3818..3849	CDD:197566
		LDLa	3860..3894	CDD:238060
		NHL	4029..>4158	CDD:302697
		NHL repeat	4034..4074	CDD:271320
		NHL repeat	4076..4115	CDD:271320
		LY	4108..4150	CDD:214531
		NHL repeat	4121..4158	CDD:271320
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
CG6024	NP_001368949.1	LDLa	216..247	CDD:197566	15/30 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22722
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100