DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp8

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_006238632.1 Gene:Lrp8 / 362558 RGDID:1305729 Length:1013 Species:Rattus norvegicus


Alignment Length:776 Identity:285/776 - (36%)
Similarity:407/776 - (52%) Gaps:87/776 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly  2728 DMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPD 2792
            |.|||.:..|||..:.||...||.|.|||..|....|..:|.|   |.|.. ||..||:|||:.:
  Rat    47 DQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFT---CDNGH-CIPERWKCDGEEE 107

  Fly  2793 CPDGTDE--LDCANH----TSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHN 2851
            ||||:||  ..|::.    ..|||.|     .|..|:..||.|||||||..|:||..|.|.|..:
  Rat   108 CPDGSDESKATCSSEECPAEKLSCGP-----TSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPH 167

  Fly  2852 QFAC-DKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPS 2915
            :|.| :::|:.:.:.|||..||.||||| ..|.:..|.|..|:|...|.|||::|||||:.||  
  Rat   168 EFQCSNRSCLASVFVCDGDDDCGDGSDE-RGCSDPACPPREFRCGGGGTCIPERWVCDGQFDC-- 229

  Fly  2916 GLGDEGSEDEGPQCG----GVAHIP-DCPPPAHL-CTSGLCIDSHYVCDGDEDCPGGDDEYEGCV 2974
               ::.|::....||    |....| .|.|.... |.||.||...:.||||.||....||.: | 
  Rat   230 ---EDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDGDRDCKDKSDEAD-C- 289

  Fly  2975 PAFQPHSCPGGSLMH--QCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNG 3037
                  |.||....:  ||.||.||...:.|:.:.||.|||||..  |.....|.|...|:||:|
  Rat   290 ------SAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAG--CLQESTCEGPRRFQCKSG 346

  Fly  3038 ACIHADLLCDRRNDCADFSDE--ELC-------------NVNECLIPD-ICEHECEDKVVGYQCH 3086
            .|:....:||.:.||.|:|||  ::|             .:||||..: .|.|.|.|..:|::|.
  Rat   347 ECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNECLHNNGGCSHICTDLKIGFECT 411

  Fly  3087 CRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHT--CKATSNVSME 3149
            |..|:::|.:.  .|.|||||.:...|||.|:|..|.:||.|..||.: |..|  |||.:..|..
  Rat   412 CPAGFQLLDQK--TCGDIDECQDPDACSQICVNYKGYFKCECHPGYEM-DTLTKNCKAVAGRSPS 473

  Fly  3150 LIFSNRYYIRQVDMTGNG-SILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQ- 3212
            |||:||:.:|::|:.... |.||..|.|.||||.:.|:..:||.|::..    |.|....:|.. 
  Rat   474 LIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYR----KIYSAHMDKASI 534

  Fly  3213 -----TLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHP 3272
                 .|....|.:|:|||||||.|::||.|.|..|:.|:..||:.|..|.|..|.|||.||:.|
  Rat   535 PDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDP 599

  Fly  3273 YQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLD 3337
            .:..::|||||....|.|||::|::.:.::.|.:.|||.:|:...:|:|:|.|::...:|..|.:
  Rat   600 LRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFN 664

  Fly  3338 GNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDL 3402
            |.:.::|:..:.    .|.|.|.:||:|..::|:|.|.::|...:..||...:.|...::.|.|:
  Rat   665 GGNRKMLIFSTD----FLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 725

  Fly  3403 RVFHPYRQQQPMSGNPC-LAA----NCSTLCVLSPE----EPYYKCMCPTNFILADDGRTC 3454
            .:||..:  ||.:.:.| |:|    .|..||:.:|:    .|.|.|.||....|..|.:.|
  Rat   726 VIFHELK--QPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:464251
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060 15/30 (50%)
LDLa 2773..2802 CDD:238060 15/30 (50%)
LDLa 2810..2844 CDD:238060 16/33 (48%)
LDLa 2848..2878 CDD:238060 12/30 (40%)
LDLa 2887..2916 CDD:197566 15/28 (54%)
LDLa 2938..2969 CDD:197566 13/31 (42%)
LDLa 2989..3015 CDD:197566 12/27 (44%)
LDLa 3030..3061 CDD:238060 13/32 (41%)
EGF_CA 3062..>3091 CDD:214542 11/29 (38%)
EGF_CA 3103..3141 CDD:214542 18/39 (46%)
LY 3212..3254 CDD:214531 19/47 (40%)
Ldl_recept_b 3275..3314 CDD:459654 14/38 (37%)
LY 3299..3340 CDD:214531 12/40 (30%)
LY 3354..3389 CDD:214531 12/34 (35%)
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp8XP_006238632.1 LDLa 44..78 CDD:238060 15/30 (50%)
LDLa 82..114 CDD:197566 16/35 (46%)
LDLa 124..160 CDD:238060 18/40 (45%)
LDLa 203..235 CDD:197566 16/36 (44%)
LDLa 256..289 CDD:238060 14/33 (42%)
LDLa 295..329 CDD:238060 14/35 (40%)
Ldl_recept_a 333..369 CDD:395011 15/35 (43%)
FXa_inhibition 390..424 CDD:464251 11/35 (31%)
EGF_CA 426..456 CDD:214542 15/29 (52%)
YncE <477..610 CDD:442618 52/136 (38%)
LY 540..581 CDD:214531 19/40 (48%)
Ldl_recept_b 602..642 CDD:459654 15/39 (38%)
LY 626..668 CDD:214531 12/41 (29%)
Ldl_recept_b 689..729 CDD:459654 9/39 (23%)
FXa_inhibition 747..784 CDD:464251 11/36 (31%)
Blue background indicates that the domain is not in the aligned region.

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