DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp8

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_006238632.1 Gene:Lrp8 / 362558 RGDID:1305729 Length:1013 Species:Rattus norvegicus


Alignment Length:776 Identity:285/776 - (36%)
Similarity:407/776 - (52%) Gaps:87/776 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly  2728 DMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPD 2792
            |.|||.:..|||..:.||...||.|.|||..|....|..:|.|   |.|.. ||..||:|||:.:
  Rat    47 DQFRCRNERCIPSVWRCDEDNDCSDNSDEDDC
PKRTCTDSDFT---CDNGH-CIPERWKCDGEEE 107

  Fly  2793 CPDGTDE--LDCANH----TSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHN 2851
            ||||:||  ..|::.    ..|||.|     .|..|:..||.|||||||..|:||..|.|.|..:
  Rat   108 CPDGSDE
SKATCSSEECPAEKLSCGP-----TSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPH 167

  Fly  2852 QFAC-DKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPS 2915
            :|.| :::|:.:.:.|||..||.||||| ..|.:..|.|..|:|...|.|||::|||||:.||  
  Rat   168 EFQCSNRSCLASVFVCDGDDDCGDGSDE-RGCSDPACPPREFRCGGGGTCIPERWVCDGQFDC-- 229

  Fly  2916 GLGDEGSEDEGPQCG----GVAHIP-DCPPPAHL-CTSGLCIDSHYVCDGDEDCPGGDDEYEGCV 2974
               ::.|::....||    |....| .|.|.... |.||.||...:.||||.||....||.: | 
  Rat   230 ---EDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDGDRDCKDKSDEAD-C- 289

  Fly  2975 PAFQPHSCPGGSLMH--QCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNG 3037
                  |.||....:  ||.||.||...:.|:.:.||.|||||..  |.....|.|...|:||:|
  Rat   290 ------SAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAG--CLQESTCEGPRRFQCKSG 346

  Fly  3038 ACIHADLLCDRRNDCADFSDE--ELC-------------NVNECLIPD-ICEHECEDKVVGYQCH 3086
            .|:....:||.:.||.|:|||  ::|             .:||||..: .|.|.|.|..:|::|.
  Rat   347 ECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNECLHNNGGCSHICTDLKIGFECT 411

  Fly  3087 CRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHT--CKATSNVSME 3149
            |..|:::|.:.  .|.|||||.:...|||.|:|..|.:||.|..||.: |..|  |||.:..|..
  Rat   412 CPAGFQLLDQK--TCGDIDECQDPDACSQICVNYKGYFKCECHPGYEM-DTLTKNCKAVAGRSPS 473

  Fly  3150 LIFSNRYYIRQVDMTGNG-SILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQ- 3212
            |||:||:.:|::|:.... |.||..|.|.||||.:.|:..:||.|::..    |.|....:|.. 
  Rat   474 LIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYR----KIYSAHMDKASI 534

  Fly  3213 -----TLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHP 3272
                 .|....|.:|:|||||||.|::||.|.|..|:.|:..||:.|..|.|..|.|||.||:.|
  Rat   535 PDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDP 599

  Fly  3273 YQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLD 3337
            .:..::|||||....|.|||::|::.:.::.|.:.|||.:|:...:|:|:|.|::...:|..|.:
  Rat   600 LRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFN 664

  Fly  3338 GNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDL 3402
            |.:.::|:..:.    .|.|.|.:||:|..::|:|.|.::|...:..||...:.|...::.|.|:
  Rat   665 GGNRKMLIFSTD----FLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 725

  Fly  3403 RVFHPYRQQQPMSGNPC-LAA----NCSTLCVLSPE----EPYYKCMCPTNFILADDGRTC 3454
            .:||..:  ||.:.:.| |:|    .|..||:.:|:    .|.|.|.||....|..|.:.|
  Rat   726 VIFHELK--QPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060 15/30 (50%)
LDLa 2773..2802 CDD:238060 15/30 (50%)
LDLa 2810..2844 CDD:238060 16/33 (48%)
LDLa 2848..2878 CDD:238060 12/30 (40%)
LDLa 2887..2916 CDD:197566 15/28 (54%)
LDLa 2938..2969 CDD:197566 13/31 (42%)
LDLa 2989..3015 CDD:197566 12/27 (44%)
LDLa 3030..3061 CDD:238060 13/32 (41%)
EGF_CA 3062..>3091 CDD:214542 11/29 (38%)
EGF_CA 3103..3141 CDD:214542 18/39 (46%)
LY 3212..3254 CDD:214531 19/47 (40%)
LY 3255..3297 CDD:214531 19/41 (46%)
LY 3299..3340 CDD:214531 12/40 (30%)
LY 3354..3389 CDD:214531 12/34 (35%)
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp8XP_006238632.1 LDLa 44..78 CDD:238060 15/30 (50%)
LDLa 82..114 CDD:197566 16/35 (46%)
LDLa 124..160 CDD:238060 18/40 (45%)
LDLa 203..235 CDD:197566 16/36 (44%)
LDLa 256..289 CDD:238060 14/33 (42%)
LDLa 295..329 CDD:238060 14/35 (40%)
LDLa 333..369 CDD:294076 15/35 (43%)
FXa_inhibition 390..424 CDD:291342 11/35 (31%)
EGF_CA 426..456 CDD:214542 15/29 (52%)
LY 495..530 CDD:214531 14/38 (37%)
LY 540..581 CDD:214531 19/40 (48%)
Ldl_recept_b 602..642 CDD:278487 15/39 (38%)
LY 626..668 CDD:214531 12/41 (29%)
Ldl_recept_b 689..728 CDD:278487 9/38 (24%)
FXa_inhibition 747..784 CDD:291342 11/36 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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