DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Ndg

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster


Alignment Length:1613 Identity:349/1613 - (21%)
Similarity:564/1613 - (34%) Gaps:520/1613 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2012 EQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILE-ALNLVGY- 2074
            |..:.|.|       :..||...:.:|.||.:  .:|..|||..:   ::.::||: |.:||.| 
  Fly    92 EYLNQPFP-------LEYASIAAFYSNVDTSF--SDEGTSISLFE---SKEQSILDRASSLVRYA 144

  Fly  2075 --KQQDWLGGIAIDWVAGNIYWSDTKR---NIIEVARLDGSHRYVVVSNLEKPTALAVDPLQGLL 2134
              .|.::.....|.....|:.:.|:|.   |..:||         :::|.:......:.|..|| 
  Fly   145 FSSQSEFEARQVIVATWRNVGYFDSKTDRLNTFQVA---------LIANEQSTFVQFIYPDGGL- 199

  Fly  2135 FYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSL----VLDIEATKVYWCERYPDALMKVDYDGN 2195
                                       ||..|..    :.||.|...:..|  ......::..|:
  Fly   200 ---------------------------NWLQGETAGLGLPDIRAQAGFVAE--DGRFYTLNGSGS 235

  Fly  2196 LREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSK 2260
            ...:.|:||.|    |...|.:|:           .|||:.|  :..|......:::.:....:.
  Fly   236 ENARFLSESTN----LGVPGVWLF-----------EVAPIEN--EQNVRSPDNAESLTESPALAL 283

  Fly  2261 HLQRGSNPCAHSNGAC----EQLCLFNGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESI 2321
            ..|..::.| |....|    |..|        |.|. |....:|.||           .:|.:.|
  Fly   284 SCQAHAHQC-HEKAECHDKAEGYC--------CVCG-SGFYGNGKSC-----------LANDQPI 327

  Fly  2322 HMTDHADKNWPVQMISNTSLMRNVIAI----TYNYEEQLVYYSDVQL------------------ 2364
            .:|.........|.:|..:.:::.:..    ||.....|......||                  
  Fly   328 RVTGTLTGELNKQPVSEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSV 392

  Fly  2365 --------------STINQVHFNGTGHRVLLEQQQRVEGLAY----------------------- 2392
                          :.::::.|: :|..  |...|..|||.|                       
  Fly   393 GGVANGYQLTGGVYTHVSRLQFD-SGEN--LHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVL 454

  Fly  2393 ---DIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYW 2454
               |.|.|   :|......::||::.::      |....::||.|:.:.:   |....||     
  Fly   455 ILPDYVEE---YTFERPGELKSVQVLNI------NITEEQRVLGLQVEQR---ILYRSCL----- 502

  Fly  2455 TNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVV 2519
             ..:|..|.         .|:|:                 ||:  :...||.:||   |.:.|: 
  Fly   503 -RDDEADPS---------ATKVL-----------------QKI--SKVALDYVER---DQALRI- 534

  Fly  2520 LAHSTPKHAFAMAVYG---------DLLFWTDWVLHAV-------VRANKYTGTDVLFLREHVTR 2568
                     .||:..|         |  ...|.|.::|       .|.:.|.|    |..:    
  Fly   535 ---------GAMSKVGVTPESNACND--GTADCVENSVCVPYEDTYRCDCYHG----FAAQ---- 580

  Fly  2569 PMGIVAVQNTSINCDANQCKILNGQCED--VCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCG 2631
                :..:...:..|.::|...:..|::  ||. |..|...|:||:| ...:|.||::  |::..
  Fly   581 ----LDERGVEVCLDIDECATGSHVCDENAVCD-NTEGGFNCYCTEG-FEGNGYRCLS--NSTAD 637

  Fly  2632 LSQY-NCHSGECIPLELTCDNVTHCAD-GSDEFRSYCIFR---QCPETHFMCQNHRCIPKE---- 2687
            ..:| ....|:..|......|.:...| |.|:.|.    |   |.|:.:........||:.    
  Fly   638 NIEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQERE----REDDQYPQPNPYPYPEEQIPQHPDEC 698

  Fly  2688 HKCDGEQQCGDGSDETPLLCKC-QSEDIDMHPSNNNTKEMPDMFRCGSGE------CIPRKF--- 2742
            ::|..:..|..|.      |.| :..|.|.:...|         .||.||      |.|...   
  Fly   699 YRCSKDADCYQGR------CTCHEGFDGDGYTCTN---------ICGHGEVWENGRCEPLLLERH 748

  Fly  2743 ----LCDSLKDCR-----DFS-DEKMCAPIPCEKNDMTFVH--CGNSTICIMPRWRCDGDPDCPD 2795
                |||:|.:||     :.| |.:.|          |:|.  .|.....::|   ||.|.:|  
  Fly   749 DVDPLCDALGECRCPYGYELSEDSQRC----------TYVQEFDGERNADLIP---CDVDENC-- 798

  Fly  2796 GTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCI 2860
                     |.:.:|               :|:  |:              |.||   .|  ||.
  Fly   799 ---------HINATC---------------NWY--GQ--------------ELRH---IC--TCQ 818

  Fly  2861 PASWQCDGKSDCEDGSDEGPQCPNRP--CRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSE 2923
            | .::.|| .:|:..||:  .|..||  |..|       ..|:.::.:  |:.:|....|..|: 
  Fly   819 P-GFRGDG-YNCDPISDD--SCAIRPDICDVH-------ADCVYEEHL--GKSECQCQAGYTGN- 869

  Fly  2924 DEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLM 2988
              |..|...|   :|....|...:..|.|....|..|.:    .|..:.||||            
  Fly   870 --GFNCQLAA---ECQSAEHCGENAFCDDGVCRCQADFE----RDVSDRCVPA------------ 913

  Fly  2989 HQCQDGLC--IFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRND 3051
                 |.|  :|    |.....|...|.|....|....|..|                  |....
  Fly   914 -----GRCGSVF----CGSNAICKWDSAEGVQYCDCLDGYQG------------------DALTG 951

  Fly  3052 CADFSDEELCNV-NECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPC-- 3113
            |.  |....|:| |.|.|...|| ..||. ..|:|.|..|:|         .|...|.|:|.|  
  Fly   952 CT--SKPLSCHVLNNCGIHATCE-PTEDP-ANYECQCIAGFK---------GDGYVCIEEQNCLN 1003

  Fly  3114 -------SQTCINTYGSYKCLCAKGYALVDHHTCKATSNVSME-LIFSNRYYIRQVDMTGNGSIL 3170
                   :..|.:|.....|:|.:|: ..:...|:...:...: ||.|....|.:|.:.|.....
  Fly  1004 NPTLCDMNAQCRSTNSGLVCVCNQGF-FGNGSLCQERQHQDSDFLIVSQGVMIARVPLNGRNVRP 1067

  Fly  3171 INELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKT--QTLHQAMLKNPDGLAVDWVAKN 3233
            |:....|:.||.|.....:||.|::    |.|....|.:.|  :......:::|:|:|:|.:::.
  Fly  1068 ISVAQMAIGLDKDCVEGRVYWGDIS----TKKIVSTKYDGTDLRPFITTDIESPEGIAIDVISRR 1128

  Fly  3234 LYWCDKGLDTIEVSQLDG-KYRKVLINEYLREPRGIALHPYQQHIFWSDWG-DSPHIGKAGMDGS 3296
            |||.|...|||||:.||. ..|.|:||:.|..|||||:.||::.:|||||. :||.|..:.:||:
  Fly  1129 LYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEMSNLDGT 1193

  Fly  3297 NPKMII-RDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLN-LHHIF 3359
            ..:::: :|.:..||:|.:...:.::.:.||  .|..|..::..:      |.|..:.| |.:.|
  Fly  1194 GRELLLGKDDVTLPNSLVVLENSGEVCYADA--GTKKVECIEPQN------RQIRTISNELSYPF 1250

  Fly  3360 AIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYR--------QQQPMSG 3416
            .|.......||:||.||.:|.......:.     |.|..|.    |..::        |..|...
  Fly  1251 GITFTHDQFYWTDWTTKKVEIVDSLGARQ-----TPIQPPF----FGSHKMYGMTVVEQHCPQYQ 1306

  Fly  3417 NPCLAAN--C--STLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFEC 3465
            :||..:|  |  |.||:::.:.|              .|::|:  ||:|...|
  Fly  1307 SPCQISNGGCTDSRLCLVNRQAP--------------SGKSCK--CTSASTGC 1343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531 7/36 (19%)
NHL <2082..>2152 CDD:302697 11/72 (15%)
NHL repeat 2082..2120 CDD:271320 8/40 (20%)
FXa_inhibition 2269..2303 CDD:291342 9/37 (24%)
LY 2430..2471 CDD:214531 8/40 (20%)
LY 2475..2517 CDD:214531 8/41 (20%)
LDLa 2630..2661 CDD:238060 6/32 (19%)
LDLa 2671..2702 CDD:238060 6/34 (18%)
LDLa 2727..2759 CDD:238060 14/50 (28%)
LDLa 2773..2802 CDD:238060 6/30 (20%)
LDLa 2810..2844 CDD:238060 3/33 (9%)
LDLa 2848..2878 CDD:238060 10/29 (34%)
LDLa 2887..2916 CDD:197566 5/28 (18%)
LDLa 2938..2969 CDD:197566 6/30 (20%)
LDLa 2989..3015 CDD:197566 6/27 (22%)
LDLa 3030..3061 CDD:238060 3/30 (10%)
EGF_CA 3062..>3091 CDD:214542 11/29 (38%)
EGF_CA 3103..3141 CDD:214542 10/46 (22%)
LY 3212..3254 CDD:214531 15/42 (36%)
LY 3255..3297 CDD:214531 21/42 (50%)
LY 3299..3340 CDD:214531 8/41 (20%)
LY 3354..3389 CDD:214531 11/35 (31%)
LDLa 3458..3490 CDD:238060 4/8 (50%)
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
NdgNP_610575.1 NIDO 108..262 CDD:214712 43/212 (20%)
EGF_3 285..320 CDD:372403 10/44 (23%)
G2F 322..549 CDD:214774 46/288 (16%)
EGF_CA 591..627 CDD:311536 11/37 (30%)
EGF_3 797..828 CDD:372403 14/79 (18%)
EGF_3 836..873 CDD:372403 11/48 (23%)
EGF_3 963..995 CDD:372403 13/42 (31%)
EGF_3 1001..1036 CDD:372403 6/35 (17%)
NHL 1059..>1275 CDD:302697 71/227 (31%)
NHL repeat 1067..1103 CDD:271320 11/39 (28%)
Ldl_recept_b 1084..1123 CDD:393440 10/42 (24%)
LY 1107..1145 CDD:214531 13/37 (35%)
NHL repeat 1117..1154 CDD:271320 17/36 (47%)
LY 1152..1195 CDD:214531 21/42 (50%)
NHL repeat 1161..1198 CDD:271320 17/36 (47%)
NHL repeat 1204..1245 CDD:271320 9/48 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461704
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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