DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and Lrp4

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:2033 Identity:550/2033 - (27%)
Similarity:901/2033 - (44%) Gaps:298/2033 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   743 WTSHKKM----QVAPLR--NLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMD 801
            |..||::    ::..|.  |.|:....:.:......:|.|.:....:.|....|.|  ::.|...
  Fly    49 WNKHKQLHSDARIGHLEAGNESREDQLSEELSKFGEKLFPVSNYPPYQQNNEDSQE--VHHSGEG 111

  Fly   802 GTH--------KELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKS 858
            ..|        |..::.||:|......|::...|...|:  ..||    |..|:...||:     
  Fly   112 RLHTMESSVPSKTRISGGTNSNDTPKFRNIGAQRGRTEI--AGIR----ETDRISSRGRD----- 165

  Fly   859 DQFHPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLP 923
                        |.|....||....      :.||:                 :.:.|..||| .
  Fly   166 ------------GFIGGPSNKQKPF------RVNLA-----------------VLVQDDPSQP-G 194

  Fly   924 QTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSP-IRPNCTS---GYMCRST 984
            :|.|.|..|                       |.:..:|.|:....| ::.:|..   ..||..|
  Fly   195 ETYSNCQNS-----------------------NESDENCNPEEDAVPNLQRDCEKTGIHVMCPRT 236

  Fly   985 RQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGT 1048
            .:|:....:|||.:||.|..||:.     |...|......|.| ||.|..|:.:|.....|.|.:
  Fly   237 FRCISKYWLCDGDDDCGDYSDETH-----CGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFS 296

  Fly  1049 DQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCP--EFDCN--- 1108
            |:.:|::.||....|||: .|.||.|.:..||..||  :|:|||.......:.||  ||.|.   
  Fly   297 DETHCNRTTCTDEHFTCN-DGYCISLAFRCDGEHDC--NDNSDELKCAAVINSCPEGEFKCRGGL 358

  Fly  1109 ------NGRCRQFADVCDGIDNCGNNADEMECEQE---CEHGEKYCRPIGCYGEMHMCDGIHDCL 1164
                  :|:|......|||.::||:.:||..|.|:   |...|..|....|..:...||...||.
  Fly   359 GGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCD 423

  Fly  1165 DFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHI 1229
            ...||.:|....|: ||:|       |...||.|. ...||.....|||...|....||..| |:
  Fly   424 GGEDENDCGSLGSE-HPLT-------CGSDEFTCN-NGRCILKTWLCDGYPDCAAGEDEVEC-HL 478

  Fly  1230 NTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCH 1294
               :.|:.: .:|.....|... |.||....:|||.|:|....||.....::.|.....|...|.
  Fly   479 ---QCDLGQ-FLCPTKQNLTNL-KICVHQKHICDGHNECPAGEDEADCPKERKCSEPSPCEQLCI 538

  Fly  1295 NTPEG-YICSCPDHLYLQPNGKRCSMQHACDHWDT--CSQVCESSGKGYDCRCLDGFDLGFDRFT 1356
            .|..| ..|:|.....:..|...|:....|.:..:  |||.|.::...:.|.|..|:.|..|..:
  Fly   539 ETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRS 603

  Fly  1357 CKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIY 1421
            ||:.. ....::..||.||:.:.|...........|.|.|||||.:....   ::|:||..|.|.
  Fly   604 CKALG-GAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGL---MFWSDVSTDVIK 664

  Fly  1422 RGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMES 1486
            ..::.|..:|:   ||..||.:..|:||||:...|:|.||...::||:...|:.|..:.:.:::.
  Fly   665 MVYMNGTRVRD---VIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDK 726

  Fly  1487 PRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAG--WPNGLTLDYTQKRVYW 1549
            ||||.:.|.|.|.||:||..| |:||||.|.|..|::|     :|.|  |||||.:|:...::||
  Fly   727 PRAIVVHPGEALAFWSDWGPN-PKIERAYMDGTQRKVI-----ISKGVTWPNGLAIDFPNSKIYW 785

  Fly  1550 VDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVL 1614
            .|||..:|..:..|||:.:.:|...  |.||||:::||:.:|||||.|.:|..|:|..|.:.:.:
  Fly   786 ADAKQHAIECSNLDGSDRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAV 848

  Fly  1615 QRTQSQPFGIQVLHSSRQPWDRNPCGEN----NGGCSHLCLLSGRGTFKCECPHVMRLDPANERN 1675
            ......|..|...|.:|||...:.|.::    .||||||| |..:.:.:|.||..:.| ..:.:.
  Fly   849 HENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLC-LPNKTSRRCGCPIGLSL-KEDGKT 911

  Fly  1676 CVPNEQVLLFVMVDE---IRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNE 1737
            |......|:.|...:   :|.:..:|.:.:.:..|.....|.....:|:..|...|:|:|::::.
  Fly   912 CKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERST 976

  Fly  1738 ISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFAS-IIHEDLNM 1801
            |:.|.::....:.::::|:..|.|.|:|||...:|::..... .|..:...|:..: :|.|.|..
  Fly   977 INKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTN-RIEVATTNGKMRTLLIWEKLYK 1040

  Fly  1802 VDSIVLDPANGKMYWIHSASD-GSMSQLEQSNLDG------SSRSLIYQHENNLQSLTMDFDSQR 1859
            ...||::|..|.|:|    || |....:|::|:||      :|:.|||.:     .|.:|::..:
  Fly  1041 PRDIVVNPIEGFMFW----SDWGDDPMIERANMDGHERVTITSKKLIYPN-----GLAIDYEKSK 1096

  Fly  1860 LYYA-----------YDNSGIAYYDIPRNETRKVL---VASPITSISSLTVYNGTLYFPENIQSV 1910
            :|:.           :|.||           |:|:   :..|.    .|.|..|.:::.:.....
  Fly  1097 IYFVDGGTKTLENMNFDGSG-----------RQVILNGLGHPF----GLDVNEGRVFWTDWDTKS 1146

  Fly  1911 IMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCA 1975
            :|...|....:.:.:..|:..:..:::|:...:...|.|.:  ..|||..|||...: .:.|.|.
  Fly  1147 VMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDK--LNGGCSHLCLLNPT-SYTCACT 1208

  Fly  1976 LGYDVEPNNPTGCVPRAEFIFYS--IDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLAN 2038
            :|..::.:..|......::|.::  ||:.|      .|..||.....::|:..:|:|..:|....
  Fly  1209 VGVQLKEDRHTCSEGPTQYILFAHRIDIRQ------ISLDFDHLIDVVLPLPPISNAVALDVDRK 1267

  Fly  2039 TDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIE 2103
            |..:||.|.....|.....||      |....:||...:: ..|:.:|.:...|||:|..|:.||
  Fly  1268 TGYIYWSDTIENVIMSSSPDG------LHVQKIVGDSLEN-PDGLVVDSIGRTIYWADAGRHTIE 1325

  Fly  2104 VARLDGSHRYVVV-SNLEKPTALAVDPLQGLLFYVTQQH---IGRVGLDGSQPFVLVNQTRANWA 2164
            ||.||||:|:|:. .:||.|..||:|...||||:....|   |.|..|||::...:|. ....|.
  Fly  1326 VASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVT-ANLGWP 1389

  Fly  2165 VGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGI 2229
            .| |.||:::.::||.:.....:...||.||.| :|:..||::|.|||...|.:||.:  :....
  Fly  1390 NG-LSLDLKSKRIYWVDARLKTIDSCDYTGNQR-KLIMSSLHHPYALALSDDNIYWTD--WKSKA 1450

  Fly  2230 IRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGS--NPCAHSNGACEQLCLFNGTSAVCACA 2292
            :.:....|:|..:.:: |..|.:.|:||..::..:.:  |.|.::||.|..|||.|.:...|.|.
  Fly  1451 LHMTERRNISAKRDII-TNIDGLMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQCP 1514

  Fly  2293 HS-RLASDGYS-CEPY-ENFLLFSYRSNIE--SIHMTDHADKNWPVQMISNTSLMRNVIAITYNY 2352
            .. ||..:..: |:.. |::||.:.||.|.  |::..|..|...|:..:      ...:.:.|:|
  Fly  1515 IGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGV------HGAVVLDYHY 1573

  Fly  2353 EEQLVYYSDVQLSTINQVH-FNGTGHRVLLEQQQRV-EGLAYDIVNEQLFWTSNNNATIRSVELR 2415
            .:.|::::||.|..|.:|: .|.|..:|::...... .|:|.|.:.:.|:|:..:.   :.:|:.
  Fly  1574 RKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDR---KLIEVS 1635

  Fly  2416 HLSEHADQNQVHVKKVLSLREDD--KPRGIAVEPCLGMIYWTNWNEGSPC-IQRSYLTGYGTEVI 2477
            .|.....:..|         ||:  .||.:.|.|....::|::|:  ||. |:||||.|....||
  Fly  1636 RLDGSCRKRIV---------EDNLGDPRSLIVHPKKAYLFWSDWS--SPAKIERSYLDGSNRTVI 1689

  Fly  2478 IKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTD 2542
            |.:.|..|..||:|...::|.||||..|.|.:.:::|..|..:....| |.|.:.::.:.:||||
  Fly  1690 ITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAP-HPFGLTLFENSIFWTD 1753

  Fly  2543 WVLHAVVRANKYTGT---DVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSG 2604
            |...:|.|:.|...:   :...:|:.::..:.|.||..:......|.|...||.|..:| ||::.
  Fly  1754 WYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLC-LNRNV 1817

  Fly  2605 QATCHCTQGVLAPDGRRCIAPVNTSCG---------------LSQYNCHS-GECIPLELTCDNVT 2653
            ...|.|      ||   .:.|.:.:|.               |.:|:..| .:..|.||..::..
  Fly  1818 DYVCAC------PD---VMDPKDVACSIKPKVLVHANLENDQLLEYSDESTDDSTPPELLGESND 1873

  Fly  2654 HCADG----SDEFRSYCI 2667
            |..||    ||:.|.:.:
  Fly  1874 HGDDGHTKKSDQEREFFV 1891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531 7/34 (21%)
LDLa 1057..1092 CDD:197566 15/34 (44%)
LDLa 1104..1134 CDD:238060 12/38 (32%)
FXa_inhibition 1289..1317 CDD:291342 7/28 (25%)
LY 1434..1476 CDD:214531 16/41 (39%)
LY 1477..1521 CDD:214531 19/43 (44%)
LY 1533..1567 CDD:214531 16/35 (46%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:291342 13/40 (33%)
LY 1794..1838 CDD:214531 16/50 (32%)
LY 2078..2112 CDD:214531 15/33 (45%)
NHL <2082..>2152 CDD:302697 33/73 (45%)
NHL repeat 2082..2120 CDD:271320 17/38 (45%)
FXa_inhibition 2269..2303 CDD:291342 12/35 (34%)
LY 2430..2471 CDD:214531 15/43 (35%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 11/50 (22%)
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 10/33 (30%)
LDLa 306..340 CDD:238060 16/36 (44%)
LDLa 347..390 CDD:238060 14/42 (33%)
LDLa 397..431 CDD:238060 10/33 (30%)
LDLa 442..476 CDD:238060 12/34 (35%)
LDLa 480..521 CDD:238060 13/42 (31%)
FXa_inhibition 576..604 CDD:291342 9/27 (33%)
LY 634..671 CDD:214531 12/39 (31%)
NHL <656..793 CDD:302697 57/145 (39%)
LY 680..714 CDD:214531 13/33 (39%)
NHL repeat 681..722 CDD:271320 14/40 (35%)
NHL repeat 726..760 CDD:271320 19/34 (56%)
LY 761..803 CDD:214531 18/46 (39%)
NHL repeat 769..793 CDD:271320 11/23 (48%)
FXa_inhibition 882..912 CDD:291342 12/31 (39%)
LY 946..985 CDD:214531 9/38 (24%)
NHL <967..1142 CDD:302697 47/199 (24%)
LY 988..1030 CDD:214531 10/42 (24%)
NHL repeat 998..1037 CDD:271320 10/39 (26%)
NHL repeat 1038..1080 CDD:271320 14/45 (31%)
NHL repeat 1084..1119 CDD:271320 8/50 (16%)
FXa_inhibition 1185..1220 CDD:291342 10/37 (27%)
NHL 1260..>1445 CDD:302697 67/194 (35%)
NHL repeat 1260..1296 CDD:271320 9/41 (22%)
NHL repeat 1302..1337 CDD:271320 16/34 (47%)
NHL repeat 1345..1383 CDD:271320 14/37 (38%)
FXa_inhibition <1499..1525 CDD:291342 8/25 (32%)
LY 1600..1640 CDD:214531 8/42 (19%)
LY 1643..1686 CDD:214531 17/53 (32%)
LY 1688..1729 CDD:214531 16/40 (40%)
FXa_inhibition 1801..>1825 CDD:291342 9/30 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461701
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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