DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and yl

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:2679 Identity:593/2679 - (22%)
Similarity:889/2679 - (33%) Gaps:1058/2679 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   888 AHQANLSSTFSSTVHLQRT-----GRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGAIC 947
            ||.::..||.|...:.|||     ||...:.:..:.             ..|.|....||..|..
  Fly    37 AHPSSGGSTSSRYGNCQRTHLIINGRHVAISLLLLV-------------GLCGGTAAGTPGSADT 88

  Fly   948 RCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKG 1012
            ||..|                         .:.||.....|..| ||||..||:|..||..    
  Fly    89 RCDAG-------------------------QFQCRDGGCILQAK-MCDGRGDCKDSSDELD---- 123

  Fly  1013 PCNVNTCDKTHNFVC---NGRCYQRSLLCSTIPYCSDGTDQANC-------------HQNTCNSN 1061
             |:...|...|.|.|   :|.|....|:|:.|..|..|.|:.||             ...:|:..
  Fly   124 -CDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKY 187

  Fly  1062 EFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFAS-KCPEFD--CNNGRC-RQFADVCDGI 1122
            ||.|.:...||.:.::.||..||  .|.|||.:....|. .||...  |.|||| |:...||||:
  Fly   188 EFMCQQDRTCIPIDFMCDGRPDC--TDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGV 250

  Fly  1123 DNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKE 1187
            |:||:.:||..|...||                                                
  Fly   251 DDCGDGSDERGCLNLCE------------------------------------------------ 267

  Fly  1188 LGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDR---LC 1249
                                                                     |.:   ||
  Fly   268 ---------------------------------------------------------PQKGKFLC 275

  Fly  1250 GFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKL-CDRGHECS--HRCHNTP-EGYICSCPDHLYL 1310
            ...:.|:|:.::|||.:||.|.:||..||..|. || ..:|:  .:||..| .|..|.||....|
  Fly   276 RNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCD-AKKCALGAKCHMMPASGAECFCPKGFRL 339

  Fly  1311 QPNGKRCSMQHAC-DHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKS----TAPDEPYVIFT 1370
            .....:|.....| :..|.|||.||::..||.|.|..|:.|..|..||::    :...:|.:::|
  Fly   340 AKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYT 404

  Fly  1371 NRQDIKGINLKTLNVGNFY----SSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESL- 1430
            .:..|.|::|:..||.|..    .:|..:|.:.:     ....||||::.::        .||: 
  Fly   405 TQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAY-----DGSHIYWTNIQNE--------AESIV 456

  Fly  1431 ------RNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRA 1489
                  .|.|.::.|||...|.|||||:.:|:|:.|:.:..|.|...:|.....|:..::..||:
  Fly   457 KANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRS 521

  Fly  1490 IALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKS 1554
            :|:.|::||:|||||.: .|.|.||||.|...|.|.:.   :..||||:.||..|:|:||||||.
  Fly   522 LAVWPQKGLMFWTDWGE-KPMIGRASMDGSRSRPIVSD---NIEWPNGIALDMHQQRIYWVDAKL 582

  Fly  1555 DSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQS 1619
            .|:.:...||:....||..  :|.||:.:::||:.:||:||.|.||...:|::|.|.::|.:.::
  Fly   583 GSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT 645

  Fly  1620 QPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGR--GTFKCECPHVMRLDPANERNCVPNEQV 1682
             .:.:.:.|.::||  .:|.|..|..|||||||:..  |...|.||..|||.| :.|.|:..|: 
  Fly   646 -IYAVHIYHPAKQP--NSPHGCENATCSHLCLLAEPEIGGHSCACPDGMRLAP-DHRRCMLMEK- 705

  Fly  1683 LLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGL 1747
                                     ||                 |:|           .|:...|
  Fly   706 -------------------------RQ-----------------RLF-----------IGLGQVL 717

  Fly  1748 IEPIINTNIE-KPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPAN 1811
            :|      || ..:|       |:....|..:.|                    :::.:|.:..|
  Fly   718 LE------IEHTAFG-------RHQVSKSYTLPC--------------------LINEMVYNRIN 749

  Fly  1812 GKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPR 1876
            |                          |||.  .:|.|.|.::|.                  |.
  Fly   750 G--------------------------SLII--ADNDQRLILEFQ------------------PE 768

  Fly  1877 NETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYAD 1941
            :....|||.|.:.::|:|                                               
  Fly   769 SHESNVLVRSNLGNVSAL----------------------------------------------- 786

  Fly  1942 AQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVE 2006
                                     :.||:.|                                 
  Fly   787 -------------------------AFDHLSR--------------------------------- 793

  Fly  2007 MIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNL 2071
                                                                             
  Fly   794 ----------------------------------------------------------------- 793

  Fly  2072 VGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVV--VSNLEKPTALAVDPLQGLL 2134
                               |:||:||:|.:|||..|...||.::  ....|.|..|.|.|.:|.|
  Fly   794 -------------------NLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYL 839

  Fly  2135 FYVTQ----QHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGN 2195
            :.|.:    .||.::.|.|....|.|.:.........||.|.|...::|.:   ..|.::.| .|
  Fly   840 YVVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSD---SDLGRISY-SN 900

  Fly  2196 LR---EQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKI 2257
            .|   .|:....|..|.:||.:...|:|.|                                   
  Fly   901 YRVPHSQIFRGKLRRPYSLAMVHHDLFWNE----------------------------------- 930

  Fly  2258 YSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIH 2322
                                                                             
  Fly   931 ----------------------------------------------------------------- 930

  Fly  2323 MTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRV 2387
                                                     |.|                     
  Fly   931 -----------------------------------------LGT--------------------- 933

  Fly  2388 EGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMI 2452
                     .:::||..:|                   :..:||:.:.|.|.|..|         
  Fly   934 ---------PRIYWTHKSN-------------------MGPRKVIDIMEKDDPAAI--------- 961

  Fly  2453 YWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNR 2517
                                           ||..                              
  Fly   962 -------------------------------MPYV------------------------------ 965

  Fly  2518 VVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINC 2582
                                                           .|..|.||....::.:..
  Fly   966 -----------------------------------------------PVATPNGIPLAASSPVGQ 983

  Fly  2583 DANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPD--GRRCIAPVNTSCGLSQYNCHSGECIPL 2645
            :::.|:..||.|..:|:......:.|.|..|.:..|  .|.|:..::  |   ::.||||||:.:
  Fly   984 ESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALD--C---EFRCHSGECLTM 1043

  Fly  2646 ELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQ 2710
            ...|:....|.|.|||.       .|.|      .||..||                  :||.  
  Fly  1044 NHRCNGRRDCVDNSDEM-------NCDE------EHRRKPK------------------VLCS-- 1075

  Fly  2711 SEDIDMHPSNNNTKEMPDMFRCGSGE-CIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVH- 2773
                            |:.|.|.||| |:.::..||:.|||.|.|||:.|...  :|:....|| 
  Fly  1076 ----------------PNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKF--DKSKKCHVHQ 1122

  Fly  2774 --CGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCP 2836
              |.|.. |:.....|||..||.|.:|||.|  ..:..|:||.|:|.||:||||           
  Fly  1123 HGCDNGK-CVDSSLVCDGTNDCGDNSDELLC--EATSRCEPGMFQCGSGSCIAG----------- 1173

  Fly  2837 DGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCI 2901
                                      ||:|||:.||.|||||..:|.:|.|.|.:.:| ..|:|:
  Fly  1174 --------------------------SWECDGRIDCSDGSDEHDKCVHRSCPPDMQRC-LLGQCL 1211

  Fly  2902 PQKWVCDGEKDCPSGLGDEGSEDEGPQCG---GVAHIPDCPPPAHLCTSGL--CIDSHYVCDGDE 2961
            .:..||||..||    ||:..|   ..||   ...:| .|....:.|||.|  |:.|...|:|..
  Fly  1212 DRSLVCDGHNDC----GDKSDE---LNCGTDSSTMNI-SCAEDQYQCTSNLKICLPSTVRCNGTT 1268

  Fly  2962 DCPGGDDEYE-GCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRG 3025
            :||.|:||.: |.|.:.....|..|.        .||.:...|||:.||||||||.|  |...:|
  Fly  1269 ECPRGEDEADCGDVCSIYEFKCRSGR--------ECIRREFRCDGQKDCGDGSDELS--CELEKG 1323

  Fly  3026 CNGTDD---------------FRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIP---DIC 3072
            .:....               |.|::|.|:....:|:...||.:..||.......|...   .:|
  Fly  1324 HHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGRQVC 1388

  Fly  3073 EHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYAL-VD 3136
            :|:|.....|..|.|..||: |......|.|||||.|||||:|.|.||.|.|:|.|...:.| .|
  Fly  1389 QHKCRATPAGAVCSCFDGYR-LDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLRQD 1452

  Fly  3137 HHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINEL-----SNAVALDYDWDSQCLYWSDVTS 3196
            ..:||:..: ...|:||:...:|.:   ....:::|..     |.....|.....|..|:|  ..
  Fly  1453 RVSCKSLQS-GATLLFSSFNEVRNL---SEQPVMLNVAWSANDSRITGFDLAMHRQMGYFS--AE 1511

  Fly  3197 TVGTIKRYCPKENKTQTLHQAM-LKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINE 3260
            ..|.:.:.   :.:|:.:.:|: |..|..|:||||..|:|.. .|...|:.....|:....::  
  Fly  1512 DEGIVYQI---DLQTKVIVRALGLPAPTKLSVDWVTGNVYVL-SGAQEIQACSFVGRMCGRIV-- 1570

  Fly  3261 YLREPRGI---ALHPYQQHIFW-----SDWGD-SPHIGKAGMDGSNPKMIIRDGLGWPNALTISF 3316
            :::.||.:   |:..|...||:     ..:|. |..|..|.:|||...|:::....:..|||...
  Fly  1571 HVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDP 1635

  Fly  3317 ETQQLFWGDAREDT---ISVSDLDGNHTR--LLLARSINPLLNLHHIFAIAVWEGHIYWSDWETK 3376
            ..|.|::.|....|   ||.....|...|  ::|.:| |.|:   |...::|:|.:.:..:..:.
  Fly  1636 HQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKS-NALM---HPSGLSVYENNAFIVNLGSV 1696

  Fly  3377 SIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLCVLSPEEPY-YKCM 3440
            ....|:::..:.|..:...:....|:.|....||.|..| :||..|:|..||:   :..| |:||
  Fly  1697 EAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKAS-HPCAHAHCHGLCL---QADYGYECM 1757

  Fly  3441 CPTNFILADDGRTC 3454
            |...  |..:|..|
  Fly  1758 CGNR--LVAEGERC 1769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566 12/34 (35%)
LDLa 1104..1134 CDD:238060 15/32 (47%)
FXa_inhibition 1289..1317 CDD:291342 9/30 (30%)
LY 1434..1476 CDD:214531 16/41 (39%)
LY 1477..1521 CDD:214531 19/43 (44%)
LY 1533..1567 CDD:214531 17/33 (52%)
LY 1568..1611 CDD:214531 16/42 (38%)
FXa_inhibition 1639..1676 CDD:291342 18/38 (47%)
LY 1794..1838 CDD:214531 3/43 (7%)
LY 2078..2112 CDD:214531 10/33 (30%)
NHL <2082..>2152 CDD:302697 24/75 (32%)
NHL repeat 2082..2120 CDD:271320 12/39 (31%)
FXa_inhibition 2269..2303 CDD:291342 0/33 (0%)
LY 2430..2471 CDD:214531 6/40 (15%)
LY 2475..2517 CDD:214531 2/41 (5%)
LDLa 2630..2661 CDD:238060 11/30 (37%)
LDLa 2671..2702 CDD:238060 6/30 (20%)
LDLa 2727..2759 CDD:238060 16/32 (50%)
LDLa 2773..2802 CDD:238060 13/31 (42%)
LDLa 2810..2844 CDD:238060 11/33 (33%)
LDLa 2848..2878 CDD:238060 10/29 (34%)
LDLa 2887..2916 CDD:197566 11/28 (39%)
LDLa 2938..2969 CDD:197566 12/32 (38%)
LDLa 2989..3015 CDD:197566 11/25 (44%)
LDLa 3030..3061 CDD:238060 9/45 (20%)
EGF_CA 3062..>3091 CDD:214542 7/31 (23%)
EGF_CA 3103..3141 CDD:214542 20/38 (53%)
LY 3212..3254 CDD:214531 13/42 (31%)
LY 3255..3297 CDD:214531 12/50 (24%)
LY 3299..3340 CDD:214531 11/43 (26%)
LY 3354..3389 CDD:214531 4/34 (12%)
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
ylNP_996433.1 LDLa 90..124 CDD:238060 15/64 (23%)
LDLa 131..166 CDD:238060 11/34 (32%)
LDLa 184..216 CDD:238060 12/33 (36%)
LDLa 227..262 CDD:238060 17/34 (50%)
LDLa 271..302 CDD:238060 12/30 (40%)
FXa_inhibition 352..387 CDD:291342 14/34 (41%)
Ldl_recept_b 442..482 CDD:278487 14/47 (30%)
LY 466..508 CDD:214531 16/41 (39%)
Ldl_recept_b 529..569 CDD:278487 20/43 (47%)
LY 553..595 CDD:214531 19/44 (43%)
LY 596..637 CDD:214531 16/42 (38%)
FXa_inhibition 669..700 CDD:291342 16/31 (52%)
LY 774..815 CDD:214531 19/229 (8%)
LDLa 1032..1062 CDD:238060 12/36 (33%)
LDLa 1074..1109 CDD:238060 17/52 (33%)
LDLa 1118..1152 CDD:238060 14/34 (41%)
LDLa 1157..1189 CDD:197566 21/68 (31%)
LDLa 1198..1232 CDD:238060 14/41 (34%)
LDLa 1243..1279 CDD:238060 14/35 (40%)
LDLa 1283..1318 CDD:238060 16/44 (36%)
LDLa 1340..1371 CDD:197566 7/30 (23%)
FXa_inhibition 1388..1416 CDD:291342 9/28 (32%)
EGF_CA 1418..1452 CDD:214542 19/33 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461688
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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