DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp12

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_001128355.1 Gene:Lrp12 / 314941 RGDID:1304943 Length:858 Species:Rattus norvegicus


Alignment Length:536 Identity:136/536 - (25%)
Similarity:184/536 - (34%) Gaps:215/536 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  3416 GNPCLA--------ANCSTLCVLSPEEPYYKCMCPTNFILADDGRT-------C----RAN---- 3457
            ||..||        :..||.|..:||:    ...||..|.:....:       |    |||    
  Rat    27 GNGALAELSENVHISGVSTACGETPEQ----IRGPTGIITSPGWPSDYPAKINCSWLIRANPGEI 87

  Fly  3458 ---------------CTAAHFECVNTYKCIPFYWRCDT------------------QDDC----- 3484
                           || ..:..:.|||.|..|..|.:                  .||.     
  Rat    88 ITISFQDFDIQGSRRCT-LDWLTIETYKNIESYRACGSTIPPPYISSQDHVWIRFHSDDSVSRKG 151

  Fly  3485 ------GDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHM 3543
                  ...|:||      ||...|::|.|.||...:..|:.:::|||.|||..|.:    |.| 
  Rat   152 FRLAYFSGKSEEP------HCACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVCVQ----DAH- 205

  Fly  3544 KCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNN-----RCMPFVWVCDG 3603
                ...::||                       .|  |..:||||.:.     .|:|....|||
  Rat   206 ----PPTTTAF-----------------------QP--CAYNQFQCLSRFTKVYTCLPESLKCDG 241

  Fly  3604 DIDCPDKSDEANCDNVSCG------------PN--DFQCDSGRCIPLAWRCD-DDH--------- 3644
            :|||.|..||.:||..:||            ||  ||......|   .|..| .||         
  Rat   242 NIDCLDLGDEIDCDMPTCGQWLKYFYGTFSSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTD 303

  Fly  3645 ------------DCPNG-EDEP------ASCFSSKATCD--------PTYF---KCNNSK----- 3674
                        ...:| |:.|      .:.|.|.|...        ..:|   |.|.::     
  Rat   304 FKLDGTGYGDYVKIYDGLEENPRKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNAT 368

  Fly  3675 ------CIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDE 3733
                  |:|      :|..||                    |...|.....||||..||.:..||
  Rat   369 YQVDGFCLP------WEIPCG--------------------GNWGCYTEQQRCDGYWHCPNGRDE 407

  Fly  3734 INCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC-TCHSDHFSCGNGKCIMSRWKCD 3797
            |||.: |::.:|.|:....|..:..:|:..:.||:||||.|| .|...:|.|.|.:|:...|.||
  Rat   408 INCTM-CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCD 471

  Fly  3798 GWDDCLDGSDESLETC 3813
            ..|||.|||||  |:|
  Rat   472 SQDDCGDGSDE--ESC 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060 11/60 (18%)
LDLa 3499..3533 CDD:238060 13/33 (39%)
LDLa 3582..3616 CDD:238060 16/38 (42%)
LDLa 3621..3652 CDD:197566 13/67 (19%)
LDLa 3663..3697 CDD:238060 8/55 (15%)
LDLa 3702..3736 CDD:238060 11/33 (33%)
LDLa 3776..3808 CDD:197566 14/31 (45%)
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp12NP_001128355.1 CUB 47..158 CDD:238001 20/115 (17%)
LDLa 166..200 CDD:238060 13/33 (39%)
LDLa 215..254 CDD:238060 16/38 (42%)
CUB 267..371 CDD:238001 18/106 (17%)
LDLa 375..410 CDD:238060 16/60 (27%)
LDLa 413..448 CDD:238060 11/34 (32%)
LDLa 451..485 CDD:238060 17/35 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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