DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp6

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_017448147.1 Gene:Lrp6 / 312781 RGDID:1304749 Length:1613 Species:Rattus norvegicus


Alignment Length:1762 Identity:512/1762 - (29%)
Similarity:780/1762 - (44%) Gaps:342/1762 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1365 PYVIFTNRQDIK------GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRG 1423
            |.:::.||:|::      |....|:.||    .|.:..|:||::.:..   |||:||.::.|.|.
  Rat    21 PLLLYANRRDLRLVDATNGKENATIVVG----GLEDAAAVDFVFGHGL---IYWSDVSEEAIKRT 78

  Fly  1424 HLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPR 1488
            ..  ....:|:.|:.|||.:.:|||.||:|:.|||.||..::|||:.|:||.|:.|....::.||
  Rat    79 EF--NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPR 141

  Fly  1489 AIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAK 1553
            ||||||..|.::||||.: .|:||||.|.|..|.:|..:   ...|||||||||.::::||.|||
  Rat   142 AIALDPSSGFMYWTDWGE-VPKIERAGMDGSSRFVIINT---EIYWPNGLTLDYEERKLYWADAK 202

  Fly  1554 SDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQ 1618
            .:.|..:..||:....|::..  |.||||:::||:.:|||||.|.|::..||:.|..::.:....
  Rat   203 LNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNI 265

  Fly  1619 SQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSG-RGTFKCECPHVMRL--------DPANER 1674
            ..|..|......|||...||||.:|||||||||:|. :..::|.||..::|        |.|.| 
  Rat   266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATE- 329

  Fly  1675 NCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEIS 1739
                   :||.....::|.|.|..|:...|  :.|...:.....||:...|..::|:|.:...|.
  Rat   330 -------LLLLARRTDLRRISLDTPDFTDI--VLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIR 385

  Fly  1740 SAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMV 1802
            .:.|.....:.::...|..|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|||...
  Rat   386 RSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRKILISEDLEEP 448

  Fly  1803 DSIVLDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA 1863
            .:|||||..|.|||    :| |.:.::|::.||||.|.::.  ..:|   ..|.:|:|...:|:.
  Rat   449 RAIVLDPMAGYMYW----TDWGEIPKIERAALDGSDRVVLV--NTSLGWPNGLALDYDEGTIYWG 507

  Fly  1864 -----------YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKE 1917
                       .|.:|           |:|||...|..|...|:....:|:.:..:..|.:..|.
  Rat   508 DAKTDKIEVMNTDGTG-----------RRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKR 561

  Fly  1918 ACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEP 1982
            : :....:......:..:|........|||.|||  ..|||..|||.... ...|.|.:|:::..
  Rat   562 S-AEREVIIDQLPDLMGLKATSVHRVIGSNPCAE--ENGGCSHLCLYRPQ-GLRCACPIGFELIS 622

  Fly  1983 NNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPAL--------VPISRVSSASFIDYLANT 2039
            :..|..||.|..:|              |.:.|....:|        :|::.|..||.:|:....
  Rat   623 DMKTCIVPEAFLLF--------------SRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTD 673

  Fly  2040 DTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEV 2104
            :.:||.|..|.:|||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.|||
  Rat   674 NRIYWTDISLKTISRAFMNGSALEHVVE----FGL---DYPEGMAVDWLGKNLYWADTGTNRIEV 731

  Fly  2105 ARLDGSHRYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLV-NQTRANWA 2164
            ::|||.||.|:| .:|:.|.|||:||.:|.:::..   :..|.|..:|||:...|| |..|||  
  Rat   732 SKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRAN-- 794

  Fly  2165 VGSLVLDIEATKVYWCERYPDALMKVDYDGNLRE---------QLLNESLNNPVALAKMGDYLYW 2220
              .|.:|....::||          .|.|.||.|         :::.:.|.:|..|.:..||:||
  Rat   795 --GLTIDYAKRRLYW----------TDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYW 847

  Fly  2221 AENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGT 2285
            .:  ::...|..|...: .|::.::|...|.:.|:.::....|.|.|.||.|||.|..|||....
  Rat   848 TD--WSRRSIERANKTS-GQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPV 909

  Fly  2286 SA-VCAC-AHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAI 2348
            .. ||.| ||..|.:|..:|.....|||||.:|.|..:.:    |:.....:|.....:|||.||
  Rat   910 GGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI----DEQQSPDIILPIHSLRNVRAI 970

  Fly  2349 TYNYEEQLVYYSDVQLSTINQVHFN-GTGHRVLLEQ--QQRVE----GLAYDIVNEQLFWTSNNN 2406
            .|:..::.:|:.|.:.:.|.:...: |.|..|::..  .|.:|    .|:.||.:..::||....
  Rat   971 DYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEAT 1035

  Fly  2407 ATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTG 2471
            ..|....|       |...|.|  ||. .|.|:||.|.|.|..|.:|:||..|.||.|:|:.|.|
  Rat  1036 NVIDVTRL-------DGRSVGV--VLK-GEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDG 1090

  Fly  2472 YGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGD 2536
            ...||:..:.:..|.||.||.:..:|:|||:.|.:||.::..|:||:||..|.......:.|:.:
  Rat  1091 TEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFEN 1155

  Fly  2537 LLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINC---------DANQCKILNG 2592
            .|:|.|.....:.:.: .||      ||..|:....:| |.:.|:.         ..:.|...||
  Rat  1156 WLYWIDKQQQMIEKID-MTG------REGRTKVQARIA-QLSDIHAVKELNLQEYRQHPCAQDNG 1212

  Fly  2593 QCEDVCILNKSGQATCHCTQG-VLAPDGRRCIAPVNTSCGLSQYNCHSG--ECIPLELTCDNVTH 2654
            .|..:|::...|...|.|... ||..|...|..|  .:|...|:.|.:|  :|||:...||..|.
  Rat  1213 GCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP--PTCSPQQFTCFTGDIDCIPVAWRCDGFTE 1275

  Fly  2655 CADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE--TPLLCKCQSEDIDMH 2717
            |.|.|||..  |  ..|.|:.|.|.:.:||....:|:|:..|.|.|||  ..:||          
  Rat  1276 CEDHSDELN--C--PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLC---------- 1326

  Fly  2718 PSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC----APIPCEKNDM--------- 2769
                    :.|.|||.:|:|:.:...||...||.|.|||..|    .|.|...|.:         
  Rat  1327 --------LIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYPTEEPAPQATNTVGSVIGVIVT 1383

  Fly  2770 TFVHCGNSTIC---IMPRWRCDGDPDCPD------GTDELDCANH-TSLSCD-PGQFRCASGNCI 2823
            .||......||   :.||.:.||:....|      .:..|....| :|||.. ||..|   |..:
  Rat  1384 IFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSR---GKSM 1445

  Fly  2824 AGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCP----- 2883
            ..|....|....|                 ..|:..:      .|.|.....|.:|...|     
  Rat  1446 ISSLSIMGGSSGP-----------------PYDRAHV------TGASSSSSSSTKGTYFPAILNP 1487

  Fly  2884 -------------------NRPC-------RPHLFQ--------CKSSGRCIPQKWVCDGEKDCP 2914
                               |.|.       ||:.::        |.:.        |||.:. .|
  Rat  1488 PPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTD--------VCDSDY-AP 1543

  Fly  2915 S----------GLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE 2969
            |          |...:.:.|..|       :|..|.|.          |.|:        ..::.
  Rat  1544 SRRMTSVATAKGYTSDLNYDSEP-------VPPPPTPR----------SQYL--------SAEEN 1583

  Fly  2970 YEGCVPA 2976
            ||.|.|:
  Rat  1584 YESCPPS 1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 21/43 (49%)
LY 1533..1567 CDD:214531 17/33 (52%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:291342 19/45 (42%)
LY 1794..1838 CDD:214531 21/45 (47%)
LY 2078..2112 CDD:214531 17/33 (52%)
NHL <2082..>2152 CDD:302697 33/73 (45%)
NHL repeat 2082..2120 CDD:271320 20/38 (53%)
FXa_inhibition 2269..2303 CDD:291342 16/35 (46%)
LY 2430..2471 CDD:214531 19/40 (48%)
LY 2475..2517 CDD:214531 15/41 (37%)
LDLa 2630..2661 CDD:238060 13/32 (41%)
LDLa 2671..2702 CDD:238060 11/30 (37%)
LDLa 2727..2759 CDD:238060 14/31 (45%)
LDLa 2773..2802 CDD:238060 8/37 (22%)
LDLa 2810..2844 CDD:238060 7/34 (21%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 8/53 (15%)
LDLa 2938..2969 CDD:197566 4/30 (13%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp6XP_017448147.1 NHL 55..272 CDD:302697 92/227 (41%)
NHL repeat 55..93 CDD:271320 12/42 (29%)
LY 89..127 CDD:214531 19/37 (51%)
NHL repeat 97..132 CDD:271320 18/34 (53%)
NHL repeat 140..176 CDD:271320 21/36 (58%)
Ldl_recept_b 150..190 CDD:278487 20/43 (47%)
LY 175..216 CDD:214531 18/43 (42%)
NHL repeat 181..217 CDD:271320 17/35 (49%)
NHL repeat 226..253 CDD:271320 14/26 (54%)
FXa_inhibition 286..323 CDD:291342 16/36 (44%)
LY 353..393 CDD:214531 8/39 (21%)
LY 397..437 CDD:214531 14/41 (34%)
LY 438..481 CDD:214531 21/46 (46%)
LY 483..524 CDD:214531 7/53 (13%)
LY 525..558 CDD:214531 8/32 (25%)
FXa_inhibition 592..627 CDD:291342 12/37 (32%)
LY 656..694 CDD:214531 12/37 (32%)
LY 697..739 CDD:214531 20/48 (42%)
LY 740..783 CDD:214531 15/42 (36%)
LY 783..825 CDD:214531 15/55 (27%)
LY 827..866 CDD:214531 10/41 (24%)
FXa_inhibition 893..929 CDD:291342 16/35 (46%)
LY 958..998 CDD:214531 10/39 (26%)
LY 1001..1048 CDD:214531 11/53 (21%)
Ldl_recept_b 1069..1110 CDD:278487 16/40 (40%)
LY 1094..1136 CDD:214531 15/41 (37%)
FXa_inhibition 1207..1243 CDD:291342 11/35 (31%)
LDLa 1249..1285 CDD:238060 15/37 (41%)
LDLa 1288..1322 CDD:238060 13/33 (39%)
LDLa 1326..1360 CDD:238060 15/51 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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