DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and LRP12

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	NP_038465.1	Gene:	LRP12 / 29967	HGNCID:	31708	Length:	859	Species:	Homo sapiens

Alignment Length:	541	Identity:	135/541 - (24%)
Similarity:	179/541 - (33%)	Gaps:	225/541 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  3416 GNPCLA--------ANCSTLCVLSPEE----------PYYKCMCPTN-----FILADDG------ 3451
            ||..||        :..||.|..:||:          |.:....|..     ||.|:.|
Human    27 GNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITIS 91

  Fly  3452 ---------RTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPP----------- 3496
                     |.|..:     :..:.|||.|..|..|        ||..|   ||
Human    92 FQDFDIQGSRRCNLD-----WLTIETYKNIESYRAC--------GSTIP---PPYISSQDHIWIR 140

  Fly  3497 FH-----------------------CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTC 3538
            ||                       |...|::|.|.||...:..|:.:::|||.|||..|.|
Human   141 FHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK--- 202

  Fly  3539 FDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNN-----RCMPFV 3598
                     .||...                    .:|..|  |..:||||.:.     .|:|..
Human   203 ---------EANPPT--------------------AAAFQP--CAYNQFQCLSRFTKVYTCLPES 236

  Fly  3599 WVCDGDIDCPDKSDEANCDNVSCG------------PN--DFQCDSGRCIPLAWRCD-DDH---- 3644
            ..|||:|||.|..||.:||..:||            ||  ||......|   .|..| .||
Human   237 LKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC---TWLIDTGDHRKVI 298

  Fly  3645 -----------------DCPNG-EDEP------ASCFSSKATCD--------PTYF---KCNNSK 3674
                             ...:| |:.|      .:.|.|.|...        ..:|   |.|.::
Human   299 LRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAAR 363

  Fly  3675 -----------CIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCD 3728
                       |:|      :|..||                    |...|.....||||..||.
Human   364 GFNATYQVDGFCLP------WEIPCG--------------------GNWGCYTEQQRCDGYWHCP 402

  Fly  3729 DNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC-TCHSDHFSCGNGKCIMS 3792
            :..||.||.: |::.:|.|:....|..:..:|:..:.||:||||.|| .|...:|.|.|.:|:..
Human   403 NGRDETNCTM-CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFE 466

  Fly  3793 RWKCDGWDDCLDGSDESLETC 3813
            .|.||..|||.|||||  |.|
Human   467 SWVCDSQDDCGDGSDE--ENC 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:278487
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		FXa_inhibition	1289..1317	CDD:291342
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:291342
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:291342
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060
		LDLa	2887..2916	CDD:197566
		LDLa	2938..2969	CDD:197566
		LDLa	2989..3015	CDD:197566
		LDLa	3030..3061	CDD:238060
		EGF_CA	3062..>3091	CDD:214542
		EGF_CA	3103..3141	CDD:214542
		LY	3212..3254	CDD:214531
		LY	3255..3297	CDD:214531
		LY	3299..3340	CDD:214531
		LY	3354..3389	CDD:214531
		LDLa	3458..3490	CDD:238060	8/31 (26%)
		LDLa	3499..3533	CDD:238060	13/33 (39%)
		LDLa	3582..3616	CDD:238060	16/38 (42%)
		LDLa	3621..3652	CDD:197566	13/67 (19%)
		LDLa	3663..3697	CDD:238060	8/55 (15%)
		LDLa	3702..3736	CDD:238060	10/33 (30%)
		LDLa	3776..3808	CDD:197566	14/31 (45%)
		LDLa	3818..3849	CDD:197566
		LDLa	3860..3894	CDD:238060
		NHL	4029..>4158	CDD:302697
		NHL repeat	4034..4074	CDD:271320
		NHL repeat	4076..4115	CDD:271320
		LY	4108..4150	CDD:214531
		NHL repeat	4121..4158	CDD:271320
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
LRP12	NP_038465.1	CUB	47..158	CDD:238001	24/126 (19%)
		LDLa	166..200	CDD:238060	13/33 (39%)
		LDLa	215..254	CDD:238060	16/38 (42%)
		CUB	267..371	CDD:238001	18/106 (17%)
		LDLa	375..410	CDD:238060	15/60 (25%)
		LDLa	413..448	CDD:238060	11/34 (32%)
		LDLa	451..485	CDD:238060	17/35 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..678
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910