DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp5

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_001099791.2 Gene:Lrp5 / 293649 RGDID:1309329 Length:1600 Species:Rattus norvegicus


Alignment Length:1759 Identity:512/1759 - (29%)
Similarity:760/1759 - (43%) Gaps:337/1759 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1357 CKSTAP--DEPYVIFTNRQDIK-----GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTD 1414
            |.|..|  ..|.::|.||:|::     |:.|::..|.   |.|.:..|:||.:   |...:||||
  Rat    23 CCSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVA---SGLEDAAAVDFQF---SKGAVYWTD 81

  Fly  1415 VIDDKIYRGHL--VGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRR 1477
            |.::.|.:.:|  .|.:.:|   ::.|||.:.:|||.|||||.|||.||..::||||.|||:.|:
  Rat    82 VSEEAIKQTYLNQTGAAAQN---IVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRK 143

  Fly  1478 TLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDY 1542
            .|...:::.||||||||..|.::||||.: :||||||.|.|..|::|..|   ...||||||:|.
  Rat   144 VLFWQDLDQPRAIALDPAHGYMYWTDWGE-APRIERAGMDGSTRKIIVDS---DIYWPNGLTIDL 204

  Fly  1543 TQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWN 1607
            .::::||.|||...|.....|||....|:...  |:||||:::..:.:|||||:|.|:...|||.
  Rat   205 EEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKWT 267

  Fly  1608 GSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTF-KCECPHVMRLDPA 1671
            |...:.:......|..||||...|||....||.|.|||||||||||.|..| .|.||..::|.. 
  Rat   268 GEKRKEILSALYSPMDIQVLSQERQPPFHTPCEEGNGGCSHLCLLSPREPFYSCACPTGVQLQD- 331

  Fly  1672 NERNCVPN-EQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQ 1735
            |.:.|... |:|||.....::|.|.|..|:...|  :.|...:.....||:...|..::|:|.:.
  Rat   332 NGKTCKAGAEEVLLLARRTDLRRISLDTPDFTDI--VLQVGDIRHAIAIDYDPLEGYVYWTDDEV 394

  Fly  1736 NEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHED 1798
            ..|..|.:.....:.::||.|..|.|.||||:|||:|:: :|..:..:  :.|.|....| :.||
  Rat   395 RAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTSRKILVSED 457

  Fly  1799 LNMVDSIVLDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQR 1859
            |:...:|||.|..|.|||    :| |...::|.:||||..|.::.  ..:|   ..|.:|....:
  Rat   458 LDEPRAIVLHPVMGLMYW----TDWGENPKIECANLDGRDRHVLV--NTSLGWPNGLALDLQEGK 516

  Fly  1860 LYYA---YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSN 1921
            ||:.   .|...:...|   ...|:.|:...:..|...|:....:|:.:..:..|.:..|...|.
  Rat   517 LYWGDAKTDKIEVINID---GTKRQTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR 578

  Fly  1922 ----------MSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHV--CRC 1974
                      |....||...:           .|:|.||:.  .|||..||..|   .|.  |.|
  Rat   579 DVIIDQLPDLMGLKAVNVAKV-----------VGTNPCADG--NGGCSHLCFFT---PHATKCGC 627

  Fly  1975 ALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANT 2039
            .:|.::..:..|..:|.|..:|.|...:..:.:...:      :...:|::.|..||.:|:..:.
  Rat   628 PIGLELLSDMKTCIIPEAFLVFTSRATIHRISLETNN------NDVAIPLTGVKEASALDFDVSN 686

  Fly  2040 DTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEV 2104
            :.:||.|..|.:|||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.|||
  Rat   687 NHIYWTDVSLKTISRAFMNGSSVEHVIE----FGL---DYPEGMAVDWMGKNLYWADTGTNRIEV 744

  Fly  2105 ARLDGSHRYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLVNQT-RANWA 2164
            |||||..|.|:| .:|:.|.:||:||.:|.:::..   :..|.|..:||:....||::. |||  
  Rat   745 ARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRAN-- 807

  Fly  2165 VGSLVLDIEATKVYWCERYPDALMKVDYDGNLRE---------QLLNESLNNPVALAKMGDYLYW 2220
              .|.:|....::||          .|.|.|:.|         .::.:.|..|..|.:..||:||
  Rat   808 --DLTIDYADQRLYW----------TDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYW 860

  Fly  2221 AENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGT 2285
            .:  :|...|..|...: .:::.::|...|.:.|:.::....|.|.|.|.||||.|.||||....
  Rat   861 TD--WNLHSIERADKTS-GRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPG 922

  Fly  2286 SAVCACA-HSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAIT 2349
            ...|.|| |..|.....:|.|...|||||.:..|..:...|....:    :|.....:|||.||.
  Rat   923 GHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPD----LILPLHGLRNVKAIN 983

  Fly  2350 YNYEEQLVYYSDVQLSTINQVHFNGTGHRVL------LEQQQRVEGLAYDIVNEQLFWTSNNNAT 2408
            |:..::.:|:.|.: ..|.:...:||...:|      |...::...|:.||.:..||||.....|
  Rat   984 YDPLDKFIYWVDGR-QNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNT 1047

  Fly  2409 IRSVELRHLSEHADQNQVHVKKVLSLRED-DKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGY 2472
            |....|       |.:.:.|    .||.| |:||.|||....|.:|:||..:.:..|:|:.|.|.
  Rat  1048 INVHRL-------DGDAMGV----VLRGDRDRPRAIAVNAERGYMYFTNMQDHAAKIERASLDGT 1101

  Fly  2473 GTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDL 2537
            ..||:..|.:..|.||.:|....||:|.||.|.:||..:..|:||:.|..:.......:.|.|..
  Rat  1102 EREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRH 1166

  Fly  2538 LFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSI-NCDANQCKILNGQCEDVCILN 2601
            |:|.|.....:.|..|.||.....::..||...||.||:..|: ...|:.|...||.|..:||..
  Rat  1167 LYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAK 1231

  Fly  2602 KSGQATCHC-TQGVLAPDGRRCIAPVNTSCGLSQYNCHSGE--CIPLELTCDNVTHCADGSDEFR 2663
            ..|...|.| ...||..:...|..|  .:|...|:.|.:||  |||....||....|||.|||  
  Rat  1232 GDGTPRCSCPVHLVLLQNLLTCGEP--PTCSPDQFACATGEIDCIPGAWRCDGFPECADQSDE-- 1292

  Fly  2664 SYCIFRQCP---ETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKE 2725
                 ..||   .:.|.|...:|:....:||.             :|                  
  Rat  1293 -----EGCPVCSASQFPCARGQCVDLRLRCDA-------------VC------------------ 1321

  Fly  2726 MPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCA-------PIPCEKNDM---------TFVHC 2774
            :|:.|||.||:|:..|..|||..||.|.|||.||.       .:|...:.:         .||..
  Rat  1322 LPNQFRCASGQCVLIKQQCDSFPDCADGSDELMCEINKPPSDDVPAHSSAIGPVIGIILSLFVMG 1386

  Fly  2775 GNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGS 2839
            |...:|                 ..:.|..:|..|   |.|   ....:.|:.|           
  Rat  1387 GVYFVC-----------------QRVMCQRYTGAS---GPF---PHEYVGGTPH----------- 1417

  Fly  2840 DEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPC----------------- 2887
                                :|.::...|      ||..|| .|..||                 
  Rat  1418 --------------------VPLNFIAPG------GSQHGP-FPGIPCSKSMMSSVSLVGGRGSV 1455

  Fly  2888 ----RPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGV-----AHIPD------ 2937
                |.|:....||.....:..:      .|..|....|....|....:     ::||.      
  Rat  1456 PLYDRNHVTGASSSSSSSTKATL------YPPILNPPPSPATDPSLYNMDMFYSSNIPSTARPYR 1514

  Fly  2938 ------CPPPAHLCTSGLCID---------SHYVCDGDEDCPGGDDEYEGCVPAFQPH------- 2980
                  ..||...|::.:|..         |.|..|.:.|    .|.|.   |...||       
  Rat  1515 PYIIRGMAPPTTPCSTDVCDSDYSTSRWKTSKYYLDLNSD----SDPYP---PPPTPHSQYLSAE 1572

  Fly  2981 -SCP 2983
             |||
  Rat  1573 DSCP 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 23/41 (56%)
LY 1477..1521 CDD:214531 22/43 (51%)
LY 1533..1567 CDD:214531 16/33 (48%)
LY 1568..1611 CDD:214531 17/42 (40%)
FXa_inhibition 1639..1676 CDD:291342 20/37 (54%)
LY 1794..1838 CDD:214531 19/45 (42%)
LY 2078..2112 CDD:214531 19/33 (58%)
NHL <2082..>2152 CDD:302697 32/73 (44%)
NHL repeat 2082..2120 CDD:271320 21/38 (55%)
FXa_inhibition 2269..2303 CDD:291342 15/34 (44%)
LY 2430..2471 CDD:214531 16/41 (39%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 14/32 (44%)
LDLa 2671..2702 CDD:238060 7/33 (21%)
LDLa 2727..2759 CDD:238060 17/31 (55%)
LDLa 2773..2802 CDD:238060 2/28 (7%)
LDLa 2810..2844 CDD:238060 4/33 (12%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 6/49 (12%)
LDLa 2938..2969 CDD:197566 8/39 (21%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp5NP_001099791.2 NHL <37..>169 CDD:302697 57/140 (41%)
NHL repeat 65..104 CDD:271320 13/44 (30%)
LY 102..142 CDD:214531 23/39 (59%)
NHL repeat 107..148 CDD:271320 23/40 (58%)
Ldl_recept_b 163..203 CDD:278487 22/43 (51%)
LY 187..229 CDD:214531 18/44 (41%)
LY 230..271 CDD:214531 17/42 (40%)
FXa_inhibition 299..336 CDD:291342 20/37 (54%)
LY 366..406 CDD:214531 8/39 (21%)
LY 408..450 CDD:214531 16/43 (37%)
LY 451..494 CDD:214531 19/46 (41%)
LY 495..537 CDD:214531 7/46 (15%)
LY 538..571 CDD:214531 5/32 (16%)
FXa_inhibition 605..640 CDD:291342 12/39 (31%)
NHL 685..878 CDD:302697 67/216 (31%)
LY 710..752 CDD:214531 22/48 (46%)
NHL repeat 720..756 CDD:271320 20/35 (57%)
NHL repeat 763..802 CDD:271320 12/38 (32%)
NHL repeat 808..843 CDD:271320 8/44 (18%)
NHL repeat 847..871 CDD:271320 8/25 (32%)
FXa_inhibition 906..941 CDD:291342 15/34 (44%)
LY 1060..1103 CDD:214531 18/46 (39%)
LY 1104..1146 CDD:214531 16/41 (39%)
FXa_inhibition 1217..1253 CDD:291342 11/35 (31%)
LDLa 1259..1295 CDD:238060 16/42 (38%)
LDLa 1321..1355 CDD:238060 18/51 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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