DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp2

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_038960355.1 Gene:Lrp2 / 29216 RGDID:68407 Length:4665 Species:Rattus norvegicus


Alignment Length:4788 Identity:1512/4788 - (31%)
Similarity:2206/4788 - (46%) Gaps:798/4788 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKSRNR 67
            |.|.:|:|||.:...:|..||...|..|.|..:.......|:.......|....:.|...:|   
  Rat     5 AAAAAWMLLLAIAACLEPVSSQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRS--- 66

  Fly    68 IKPTVFIRP----------------------NAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKA 110
            .:..:|:.|                      :......|..|.|...||::|.|||..::||..:
  Rat    67 CESGLFLCPAEGTCIPSSWVCDEDKDCSDGADEQQNCAGTTCSAQQMTCSNGQCIPSEYRCDHVS 131

  Fly   111 DCPDMSDE------------------------------------GSECAPKCNEGQFRCGVSRHC 139
            ||||.|||                                    .:.|...|::.:|.|| |..|
  Rat   132 DCPDGSDERNCHYPTCDQLTCANGACYNTSQRCDQKVDCRDSSDEANCTTLCSQKEFECG-SGEC 195

  Fly   140 IPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDN--DELQ 202
            |...::||.:.||  .|.|||.|| |.||  |...:..|.||.|:..:..|||..||.:  ||..
  Rat   196 ILRAYVCDHDNDC--EDNSDERNC-NYDT--CGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDG 255

  Fly   203 C---------------------------------------DKQN---------AACAALNCSFNC 219
            |                                       |:.|         ..|:.|||.:.|
  Rat   256 CESNQSHHRCYPREWACPGSGRCISIDKVCDGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQC 320

  Fly   220 KLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCR 284
            ..||.|..|:||...:..|::|..|:|:|:|...|.|||.|.|..|.::|.|..||...:|..|:
  Rat   321 HQTPFGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCK 385

  Fly   285 AINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHA 349
            :.:            |......:.:||.:::          |.|..|   ....:|::       
  Rat   386 SSD------------SFSAASVIFSNGRDLL----------VGDLHG---RNFRILAE------- 418

  Fly   350 FEVWHRNRTLCSLLFSWPELQMRCQRVD----DARVNWTLP-----FSSFV---SPQQFFT---- 398
                .:||.:             ...||    ..||.||.|     ||:.:   :.|:...    
  Rat   419 ----SKNRGM-------------VMGVDFHYQKHRVFWTDPMQEKVFSTDINGLNTQEILNVSVD 466

  Fly   399 ---ELRLDWLSGNWYLVS-----------EDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKG 449
               .|.:||::...|||.           |.:..|.|.|..:.:.|          .:.||||.|
  Rat   467 TPENLAVDWINNKLYLVETKVNRIDVVNLEGNQRVTLITENLGHPR----------GIALDPTVG 521

  Fly   450 FMFYTDW-----TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYE 509
            ::|::||     .|.:.|:.:|||||..|||.:|..|:.:||||.::.|||:|...|.:..|.|:
  Rat   522 YLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKVGWPAGITLDLVSKRVYWVDSRYDYIETVTYD 586

  Fly   510 GRNRWTLKRPLDSPVPLKTIH--AVEVFENSIYLAAWMDTAIVALDKFS-LKTHILQSNVSRGAN 571
            |..|.|:.|. .|.||    |  .:.:||..::...|...|::...||: ....:...:..|...
  Rat   587 GIQRKTVARG-GSLVP----HPFGISLFEEHVFFTDWTKMAVMKASKFTETNPQVYHQSSLRPHG 646

  Fly   572 LRIFHRQKQPEVAHPCRDNNAGCNQICV--PQWTKGFASAKCMCTAGYKL-HNQTTCLLSALDKF 633
            :.::|..:||...:||..||.||.|:||  .:...|....:|.|..|::| .::..|:  |:..|
  Rat   647 VTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLGYRCKCEFGFELDDDEHRCV--AVKNF 709

  Fly   634 LVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVY-NVSKTLAIDVNVRGKAVFYVVADSGA 697
            |::|.|...|  |||.         .:..|.||||||. :.|..:.||.:.:...|||  :|...
  Rat   710 LLFSSKTAVR--GIPF---------TLSTQEDVMVPVTGSPSFFVGIDFDAQHSTVFY--SDLSK 761

  Fly   698 SPFGNGEPSCSIRSQSLNGSVSRLL-AQGLKRVHAVAFDWINDHLYWTSH--KKMQVAPLRNLSK 759
            .         .|..|.::|:...:: |..|:.|..:.||||:.:||||..  |.:.|..|.:.|:
  Rat   762 D---------IIYKQKIDGTGKEVITANRLESVECLTFDWISRNLYWTDGGLKSVTVLRLADKSR 817

  Fly   760 VLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMP-----MQW 819
            ....:...:..|:.:.||.|.::.|.|..   .|.|..:|.||:|         .||     :.|
  Rat   818 RQIISNLNNPRSIVVHPTAGYMFLSDWFR---PAKIMRAWSDGSH---------LMPIVNTSLGW 870

  Fly   820 PRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNGLIYWADNKNSTI 883
            |..|.:|.....|||.|.....||...|||..|:.|...||. ||:.:......::..|.:...|
  Rat   871 PNGLAIDWSASRLYWVDAFFDKIEHSTLDGLDRKRLGHVDQMTHPFGLTVFKDNVFITDWRLGAI 935

  Fly   884 LRFHAHQAN----LSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPK- 943
            :|.......    :....||.:|::  ...|||:   ..|....||..  |...|...|...|. 
  Rat   936 IRVRKSDGGDMTVIRRGISSVMHVK--AYDADLQ---TGSNYCSQTTH--ANGDCSHFCFPVPNF 993

  Fly   944 GAICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTS-GYMCRSTRQCLDTKDMCDGFEDCEDGIDES 1007
            ..:|.||.|..|......|....|..|....|.| .:.|.:.: |:.:...|||.:||.|..||.
  Rat   994 QRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSFPCNNGK-CVPSFFRCDGVDDCHDNSDEH 1057

  Fly  1008 SDPKGPCNV--NTCDKTHNFVC--NGRCYQRSLLCSTIPYCSDGTDQANC--H--QNTCNSNEFT 1064
            .     |.|  |||..: .|.|  .|:|......|.....|.||:|:.||  |  .:||.|..||
  Rat  1058 Q-----CGVFNNTCSPS-AFACVRGGQCIPGQWHCDRQNDCLDGSDEQNCPTHATSSTCPSTSFT 1116

  Fly  1065 CHKSGRCIQLTWVNDGVVDC--GPDDDSDETSETIFASKC--PEFDCNNGRCRQFADVCDGIDNC 1125
            | .:..||...||.|...||  |.|:.:.:.|.|     |  .:|.|.:.||.....||||..:|
  Rat  1117 C-DNHVCIPKDWVCDTDNDCSDGSDEKNCQASGT-----CQPTQFRCPDHRCISPLYVCDGDKDC 1175

  Fly  1126 GNNADEMECEQECEHGEKYCRP-IGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELG 1189
            .:.:||..|...|...:..|.. ..|....:.|||::||.|.||||.|        |.   :..|
  Rat  1176 ADGSDEAGCVLNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGC--------PT---RPPG 1229

  Fly  1190 ECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEF------------------NCTH-------I 1229
            .|...||.|.....|||:...|||...|...:||.                  ||.:       .
  Rat  1230 MCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNGNCIYKAWICDGD 1294

  Fly  1230 NTTRFDMNETVICEHPDRLC--------GFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDR- 1285
            |..| ||::...|......|        |:| .|:.:..||||..||.:.|||..||.:...|: 
  Rat  1295 NDCR-DMSDEKDCPTQPFHCPSTQWQCPGYS-TCINLSALCDGVFDCPNGTDESPLCNEPQQDQD 1357

  Fly  1286 --GH---ECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCL 1345
              .|   .|:|:|...|.|..|.||....|..:.|.|...:.||....|||.|.:....:.|.|.
  Rat  1358 SCSHFNGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVNMRGSFRCACD 1422

  Fly  1346 DGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRN---IIALDFLYNNESN 1407
            ..:.|..|..|||.|..:.|.::..:|..|...|: |.:..|.||.:::   ::||||   :...
  Rat  1423 PEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNI-TAHTHNLYSLVQDVSFVVALDF---DSVT 1483

  Fly  1408 VEIYWTDVIDDKIYRGHLVGESLRNVEAVIH-SGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKL 1471
            ..::|:|::..|.:.....|...|    |:| ||||.||.:||||:|:||||.|..|:.|||:|:
  Rat  1484 GRVFWSDLLQGKTWSVFQNGTDKR----VVHDSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKI 1544

  Fly  1472 NGSFRRTLIAGNMESPRAIALDPREG--LLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGW 1534
            :||.|..||:.|:..||.:|||||.|  ::||:|| .:.||||||||.|..|.:|.   |....|
  Rat  1545 DGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDW-GHHPRIERASMDGTMRTVIV---QEKIYW 1605

  Fly  1535 PNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTS 1599
            |.||::||..:.:|::||..|.|....|||.....|:.:..:|.||.|:::||::|||||..|..
  Rat  1606 PCGLSIDYPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYWTDRGTRQ 1670

  Fly  1600 VIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGT--FKCEC 1662
            |::||||:|.:..|:..:..||.||..:|.||||..||||.  :..||||||||.:..  :.|.|
  Rat  1671 VMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCA--SASCSHLCLLSAQAPRHYSCAC 1733

  Fly  1663 PHVMRLDPANERNCVPNEQVLLFVMVDE-IRGIDLHQPNHHTIPTIRQSPRLVAPQRI----DFL 1722
            |....|.. :..|||..:|..|..:.|. |.||.|.       |.::.:..:|....|    |..
  Rat  1734 PSGWNLSD-DSVNCVRGDQPFLMSVRDNIIFGISLD-------PEVKSNDAMVPISGIQHGYDVE 1790

  Fly  1723 VDESR--IFWSDI--QQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNIL 1783
            .|:|.  |:|.:.  :.:.:.:.|.:..:..|:  :.:....|.|:||::||:|:::...: :|.
  Rat  1791 FDDSEQFIYWVENPGEIHRVKTDGSNRTVFAPL--SLLGSSLGLALDWVSRNIYYTTPASR-SIE 1852

  Fly  1784 ASNLKGEF---ASIIHED-----LNMVDSIVLDPANGKMYWI-HSASDGSMSQLEQSNLDGSSRS 1839
            ...|||:.   .::|..|     :.....|.:|||.||:||. |....|..:::..:|:||:|..
  Rat  1853 VLTLKGDTRYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLK 1917

  Fly  1840 LIY----QHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNE---TRKVLVASPITSISSLTVY 1897
            :::    ||   |:.:|:|...|:||:|..:.|:    |.|..   |.::::...:.....|.||
  Rat  1918 ILFTGNLQH---LEVVTLDIQEQKLYWAVTSRGV----IERGNVDGTERMILVHHLAHPWGLVVY 1975

  Fly  1898 NGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFY-ADAQTGSNTCAEWAYRGGCQQL 1961
            ...||:.:....||.:.:|.:.:|...||.|...::.::::: .:|...||.|:.  ....|||:
  Rat  1976 GSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGLRVYHRRNAADSSNGCSN--NPNACQQI 2038

  Fly  1962 CLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYS-IDVLQG--VEMIDPSEQFDTPSPALVP 2023
            ||........|.||.|:.:.|:. ..|.|...|:..| :..::|  :|:.|.||       |:||
  Rat  2039 CLPVPGGMFSCACASGFKLSPDG-RSCSPYNSFMVVSMLPAVRGFSLELSDHSE-------AMVP 2095

  Fly  2024 IS----RVSSASFIDYLANTDTLYWGD-----NELGSISRVKRDGTQRETILEALNLVGYK-QQD 2078
            ::    .|..|. :| :|| ..:||.|     .....|.|:|.||:      ...|:|.|. ..:
  Rat  2096 VAGQGRNVLHAD-VD-VAN-GFIYWCDFSSSVRSSNGIRRIKPDGS------NFTNVVTYGIGAN 2151

  Fly  2079 WLGGIAIDWVAGNIYWSD--TKRNIIEVARLDGSHRYVVVS-NLEKPTALAVDPLQGLLF---YV 2137
            .:.|:|:||.|||:|:::  ....:|||.|::.::|.|::. :::.|..:.|||....||   |.
  Rat  2152 GIRGVALDWAAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFWADYG 2216

  Fly  2138 TQQHIGRVGLDGSQPFVLVNQTRANWAVG-----SLVLDIEATKVYWCERYPDALMKVDYDGNLR 2197
            .:..|.|..||.:...|||::       |     .|.:|.:...:||.:...|.:.::..||. .
  Rat  2217 QKPKIERSFLDCTNRTVLVSE-------GIVTPRGLAMDHDTGYIYWVDDSLDLIARIHLDGG-E 2273

  Fly  2198 EQLL--NESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSK 2260
            .|::  ......|..:...|:.:.|.:....: :.:.:.....:...||::.:.:.:||:.|:.:
  Rat  2274 SQVVRYGSRYPTPYGITVFGESIIWVDRNLKK-VFQASKQPGNTDPPVVIRDKINLLRDVTIFDE 2337

  Fly  2261 HLQ------RGSNPCAHSNGACEQLC--LFNGTSAVCACAHSRLASDGYSC-EPYENFLLFSYRS 2316
            |.|      ..:|||..|||.|...|  |....:..|.||...|.:||.|| ...|:||::|..:
  Rat  2338 HAQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNN 2402

  Fly  2317 NIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHF-----NGTG 2376
            ::.|:|. |..|.:.|.|:|   |:....||:.|:.....::::....|...|:.:     ..:.
  Rat  2403 SLRSLHF-DPRDHSLPFQVI---SVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSSS 2463

  Fly  2377 HRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPR 2441
            ..|||......:|:|:|.:|.:::::..:|.||.|     ::|.. .|:..:.:|      .|||
  Rat  2464 PTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINS-----MAEDG-SNRAVIARV------SKPR 2516

  Fly  2442 GIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDK 2506
            .|.::||.|.:|||:|...:. |:|:.|.|.....|:.|.:..||.|.||||...||||||.|.|
  Rat  2517 AIVLDPCRGYMYWTDWGTNAK-IERATLGGNFRVPIVNTSLVWPNGLALDLETDLLYWADASLQK 2580

  Fly  2507 IERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHV-TRPM 2570
            |||:...|:||.|:. ||..|:|.:.|||..::|||.....:.|||||.|:|::.:...: |:|.
  Rat  2581 IERSTLTGTNREVVV-STAFHSFGLTVYGQYIYWTDLYTRKIYRANKYDGSDLVAMTTRLPTQPS 2644

  Fly  2571 GIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCT-QG--VLAPDGRRCIAPVNTSCGL 2632
            ||..|..|.....:|.|...||.|..:|....:| |.|.|. :|  .||.|.:.|:....|.|..
  Rat  2645 GISTVVKTQRQQCSNPCDQFNGGCSHICAPGPNG-AECQCPHEGNWYLANDNKYCVVDTGTRCNQ 2708

  Fly  2633 SQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCG 2697
            .|:.|.:|.||..:..|||...|.|||||..:.|.|..|..|.|.|.|.||:|..::||....||
  Rat  2709 LQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYHYRCDYYNDCG 2773

  Fly  2698 DGSDETPLLCK-CQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDC--RDFSDEKMC 2759
            |.|||...|.: |           |:|.|    |.|.:|.|||..::|:.:.:|  .|.||||.|
  Rat  2774 DNSDEAGCLFRNC-----------NSTTE----FTCSNGRCIPLSYVCNGINNCHDNDTSDEKNC 2823

  Fly  2760 APIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDE--LDCANHTSLSCDPGQFRCAS-GN 2821
            .|..|..:   |..|..:.||:...:.||||.||.||:||  :.||:||   |...:|:|.| ..
  Rat  2824 PPHTCPPD---FTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHT---CRSNEFQCLSPQR 2882

  Fly  2822 CIAGSWHCDGEKDCPDGSDE-------INCRTECRHNQFACDK-TCIPASWQCDGKSDCEDGSDE 2878
            ||...|.||||.||.|||||       :|   .||.:||.||. .||..:|.|||.:||.|.|||
  Rat  2883 CIPSYWFCDGEADCADGSDEPDTCGHSVN---TCRASQFQCDNGRCISGNWVCDGDNDCGDMSDE 2944

  Fly  2879 GPQ--CPNRPCRPHLFQCKSS----GRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPD 2937
            ..:  |..:.|....|.|.:|    .|||||.|||||:.||...|      ||...|    .:..
  Rat  2945 DQRHHCELQNCSSTQFTCVNSRPPNRRCIPQYWVCDGDADCSDAL------DELQNC----TMRT 2999

  Fly  2938 CPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQT 3002
            |......|.:|.|:...:.||...||....|| .||  ::.|  |.....  .||:|.||.:...
  Rat  3000 CSAGEFSCANGRCVRQSFRCDRRNDCGDYSDE-RGC--SYPP--CHANQF--TCQNGRCIPRFFV 3057

  Fly  3003 CDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECL 3067
            ||...||||||||...||...........|||.||.||....:|:..:||:|.|||:.|.:||||
  Rat  3058 CDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGINECL 3122

  Fly  3068 IPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQ-QPCSQTCINTYGSYKCLCA 3129
            ...|  |:|.|.|.:..:.|.|.||||:: .....|.|||||.|. |.|||.|.|..|||.|.||
  Rat  3123 DSSISRCDHNCTDTITSFYCSCLPGYKLM-SDKRSCVDIDECKESPQLCSQKCENVVGSYICKCA 3186

  Fly  3130 KGYAL-VDHHTCKATSNVSMELIFSNRYYIRQVDMTGNG-SILINELSNAVALDYDWDSQCLYWS 3192
            .||.. .|..:|:..||:...||||||||||.:...|:. |:::..|.|.||||:|...:.|||.
  Rat  3187 PGYIREPDGKSCRQNSNIEPYLIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWI 3251

  Fly  3193 DVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVL 3257
            |....:  |:|....:...:|:....|:..:.||||||::.|||.|..||.:.||.|:|::||::
  Rat  3252 DAEKQI--IERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRKMI 3314

  Fly  3258 I-------NEYLRE-PRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTI 3314
            .       |.:..| ||||.|||.:.|::|:|||...:||:.||||:|..:||...:.||||:||
  Rat  3315 AQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTNKSVIISTKIEWPNAITI 3379

  Fly  3315 SFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIE 3379
            .:....|:|.||....|..|||:|:|...:...|      |.|.||:.::|..::|:||.|:::|
  Rat  3380 DYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGS------LPHPFALTIFEDTVFWTDWNTRTVE 3438

  Fly  3380 YCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCP 3442
            ..:.::|.....|:.|.|:|.|:.|:||||  ||:..|||...|  ||.||::......:.|.||
  Rat  3439 KGNKYDGSGRVVLVNTTHKPFDIHVYHPYR--QPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACP 3501

  Fly  3443 TNF--ILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQ 3505
            .:|  :...|...|...|::..|.|.|..||||.:|:||.|.||.||||||:.||...|..||:|
  Rat  3502 DDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRLGQFQ 3566

  Fly  3506 CANKKCTHPSNLCDGINQCGDGSDE--LNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDC 3568
            |.:..||.|..||:....|.|||||  :.|:...|..|..:|   ||..  |:....:||.|.||
  Rat  3567 CRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQC---ANKR--CIPQSWQCDSVNDC 3626

  Fly  3569 --PGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEA---------NCDNVSCG 3622
              ...||.|.|....|:..||:|.|.||:|..|.||.|.||.|.|||.         ||||    
  Rat  3627 LDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIDECTTAAYNCDN---- 3687

  Fly  3623 PNDFQCDSG-RCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPT-YFKCNNSKCIPGRWRCDYE 3685
            ..:|.|.:. ||||....|:...||.:..|| ..|.|  ..|.|: .|:|.|..|||.||:||..
  Rat  3688 HTEFSCKTNYRCIPQWAVCNGFDDCRDNSDE-QGCES--VPCHPSGDFRCANHHCIPLRWKCDGT 3749

  Fly  3686 NDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNI-TCKENQFKCAA 3749
            :||||.|||.||..|.||||||||...:||...:.||.|..|.|||||.:|.: ||....|:|.:
  Rat  3750 DDCGDNSDEENCVPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTS 3814

  Fly  3750 FNTCINKQYKCDGDDDCPDGSDEVNCT--------CHSDHFSCGNGKCIMSRWKCDGWDDCLDGS 3806
             ..|:.|...|||..||.|.|||..|.        |.:..|.|.|..||.|.|.|||.:||:|||
  Rat  3815 -GHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGS 3878

  Fly  3807 DESLETCAKTHCHA-NAFKCRNQLCVRNSALCDGINDCGENEDESDAVC--AALPKCRHDQFQCE 3868
            ||.:..|....|.: ..|:|.|..||....||:|::|||:..||.:..|  .....|...:::|.
  Rat  3879 DEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCS 3943

  Fly  3869 NDDCISKAFRCDGQYNCVDGSDEMNCQ--------PPVC-------------------------- 3899
            |.:|||:.:.||...:|.|.|||..|.        ..:|                          
  Rat  3944 NGNCISQHYVCDNVNDCGDLSDETGCNLGDNRTCAENICEQNCTQLSSGGFICSCRPGFKPSTLD 4008

  Fly  3900 -----------GFGSCSQICIEKKAGHYNCKCADGY-----HKGPEKNATCLASGPDQILLL--- 3945
                       .||.|.|.|...| |.|.|.|.||:     |.|..    |.|.|...:|||   
  Rat  4009 KNSCQDINECEEFGICPQSCRNSK-GSYECFCVDGFKSMSTHYGER----CAADGSPPLLLLPEN 4068

  Fly  3946 -------ASEQEFRFILPAKQEGTTVVGFFQTDSLKIDV--FDILIRPKDTLLFWIDSHHGKVHT 4001
                   .|.::|...|..::...|:...:..:.:.:.|  :.:|.:         .|..|.:..
  Rat  4069 VRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTVLAQ---------GSQFGAIKR 4124

  Fly  4002 MKIATPHVE-GTGVRVRR-DLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGK 4064
            ..|  |:.| |:...:|. ||      .:..|..|..|||||:.:.:|..|::..:|....::|:
  Rat  4125 AYI--PNFESGSNNPIREVDL------GLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGR 4181

  Fly  4065 KYISLVSTGMN-PTDIVLEPESRIMIWSTLENG----ILVASLDGSNKKSLVERDVGWPISLSMD 4124
            ....|::|.:: |..|.:.|:..:|.|:  :.|    |..|.::|.::..||..::|||..||:|
  Rat  4182 YRKWLITTQLDQPAAIAVNPKLGLMFWT--DQGKQPKIESAWMNGEHRSVLVSENLGWPNGLSID 4244

  Fly  4125 Y-PTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLY-IKLYDQSIIKMNKF 4187
            | ...|:||:|.::..||..:.:|.||.::  .....||..:|:|||.|| :......:.:.|||
  Rat  4245 YLNDDRVYWSDSKEDVIEAIKYDGTDRRLI--INEAMKPFSLDIFEDKLYWVAKEKGEVWRQNKF 4307

  Fly  4188 GNDN-GTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEG-- 4249
            |.:| ...|:.....:.:.|.|.::.|:::|||| |..|..   ||:|...   ||||.|.:|  
  Rat  4308 GKENKEKVLVVNPWLTQVRIFHQLRYNQSVSNPC-KQVCSH---LCLLRPG---GYSCACPQGSD 4365

  Fly  4250 YVMTDDGVCKAHADIPDYCPLQCNL---GTCKIVDH-VPKCICQPQFEGELCE------------ 4298
            :|......|.|.:::|...|..|..   |.|...:: :|||.|...:.||.||            
  Rat  4366 FVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGYSGEYCEVGLSRGIPPGTT 4430

  Fly  4299 ----------------------HYRCSGYCQNYGVCSVAPALP 4319
                                  |||.:|        |:.|.||
  Rat  4431 MAVLLTFVIVIIVGALVLVGLFHYRKTG--------SLLPTLP 4465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566 15/30 (50%)
LDLa 126..163 CDD:238060 15/36 (42%)
EGF_CA 246..283 CDD:214542 15/36 (42%)
Ldl_recept_b 449..487 CDD:278487 17/42 (40%)
LY 472..513 CDD:214531 17/40 (43%)
LY 817..852 CDD:214531 13/34 (38%)
LDLa 1057..1092 CDD:197566 15/36 (42%)
LDLa 1104..1134 CDD:238060 11/29 (38%)
FXa_inhibition 1289..1317 CDD:291342 10/27 (37%)
LY 1434..1476 CDD:214531 25/42 (60%)
LY 1477..1521 CDD:214531 24/45 (53%)
LY 1533..1567 CDD:214531 14/33 (42%)
LY 1568..1611 CDD:214531 19/42 (45%)
FXa_inhibition 1639..1676 CDD:291342 13/38 (34%)
LY 1794..1838 CDD:214531 15/49 (31%)
LY 2078..2112 CDD:214531 12/35 (34%)
NHL <2082..>2152 CDD:302697 25/75 (33%)
NHL repeat 2082..2120 CDD:271320 14/40 (35%)
FXa_inhibition 2269..2303 CDD:291342 13/35 (37%)
LY 2430..2471 CDD:214531 15/40 (38%)
LY 2475..2517 CDD:214531 21/41 (51%)
LDLa 2630..2661 CDD:238060 13/30 (43%)
LDLa 2671..2702 CDD:238060 14/30 (47%)
LDLa 2727..2759 CDD:238060 13/33 (39%)
LDLa 2773..2802 CDD:238060 13/30 (43%)
LDLa 2810..2844 CDD:238060 18/41 (44%)
LDLa 2848..2878 CDD:238060 16/30 (53%)
LDLa 2887..2916 CDD:197566 16/32 (50%)
LDLa 2938..2969 CDD:197566 8/30 (27%)
LDLa 2989..3015 CDD:197566 13/25 (52%)
LDLa 3030..3061 CDD:238060 14/30 (47%)
EGF_CA 3062..>3091 CDD:214542 12/30 (40%)
EGF_CA 3103..3141 CDD:214542 21/39 (54%)
LY 3212..3254 CDD:214531 18/41 (44%)
LY 3255..3297 CDD:214531 21/49 (43%)
LY 3299..3340 CDD:214531 17/40 (43%)
LY 3354..3389 CDD:214531 11/34 (32%)
LDLa 3458..3490 CDD:238060 17/31 (55%)
LDLa 3499..3533 CDD:238060 16/35 (46%)
LDLa 3582..3616 CDD:238060 18/42 (43%)
LDLa 3621..3652 CDD:197566 9/31 (29%)
LDLa 3663..3697 CDD:238060 19/34 (56%)
LDLa 3702..3736 CDD:238060 19/33 (58%)
LDLa 3776..3808 CDD:197566 16/39 (41%)
LDLa 3818..3849 CDD:197566 12/31 (39%)
LDLa 3860..3894 CDD:238060 13/33 (39%)
NHL 4029..>4158 CDD:302697 40/134 (30%)
NHL repeat 4034..4074 CDD:271320 12/39 (31%)
NHL repeat 4076..4115 CDD:271320 11/42 (26%)
LY 4108..4150 CDD:214531 16/42 (38%)
NHL repeat 4121..4158 CDD:271320 13/37 (35%)
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp2XP_038960355.1 LDLa 28..62 CDD:238060 5/33 (15%)
LDLa 67..103 CDD:238060 2/35 (6%)
LDLa 108..142 CDD:238060 17/33 (52%)
LDLa 148..179 CDD:238060 0/30 (0%)
LDLa 183..217 CDD:238060 15/36 (42%)
LDLa 222..256 CDD:238060 12/33 (36%)
LDLa 265..299 CDD:238060 1/33 (3%)
LY 460..500 CDD:214531 7/39 (18%)
LY 502..547 CDD:214531 16/54 (30%)
LY 550..590 CDD:214531 17/39 (44%)
LY 775..817 CDD:214531 14/41 (34%)
Ldl_recept_b 837..877 CDD:423042 14/51 (27%)
LY 863..903 CDD:214531 13/39 (33%)
LDLa 1025..1059 CDD:238060 12/39 (31%)
Ldl_recept_a 1065..1101 CDD:395011 11/36 (31%)
LDLa 1110..1144 CDD:238060 14/34 (41%)
LDLa 1150..1184 CDD:238060 12/33 (36%)
LDLa 1188..1223 CDD:238060 13/34 (38%)
LDLa 1231..1263 CDD:197566 11/31 (35%)
LDLa 1272..1306 CDD:238060 6/34 (18%)
LDLa 1313..1345 CDD:197566 11/32 (34%)
FXa_inhibition 1359..1394 CDD:405372 11/34 (32%)
EGF_CA 1396..1435 CDD:214542 11/38 (29%)
LY 1507..1549 CDD:214531 26/45 (58%)
LY 1551..1595 CDD:214531 24/44 (55%)
LY 1597..1638 CDD:214531 16/43 (37%)
FXa_inhibition 1715..1746 CDD:405372 12/31 (39%)
Ldl_recept_b 1889..1933 CDD:395012 14/46 (30%)
LY 1917..1959 CDD:214531 13/48 (27%)
FXa_inhibition 2028..2064 CDD:405372 11/38 (29%)
YncE 2115..>2307 CDD:225926 51/206 (25%)
LY 2188..2231 CDD:214531 12/42 (29%)
LY 2233..2273 CDD:214531 11/47 (23%)
FXa_inhibition 2352..2388 CDD:405372 13/35 (37%)
LY 2465..2506 CDD:214531 12/46 (26%)
Ldl_recept_b 2525..2565 CDD:395012 14/40 (35%)
LY 2551..2591 CDD:214531 21/39 (54%)
LY <2600..2631 CDD:214531 14/30 (47%)
FXa_inhibition 2661..2698 CDD:405372 13/37 (35%)
LDLa 2705..2737 CDD:197566 13/31 (42%)
LDLa 2747..2781 CDD:238060 16/33 (48%)
exchanger_TraA <2748..3136 CDD:411343 166/428 (39%)
LDLa 2912..2944 CDD:197566 16/31 (52%)
LDLa 3000..3034 CDD:238060 10/34 (29%)
LDLa 3039..3070 CDD:197566 14/32 (44%)
LDLa 3082..3116 CDD:238060 14/33 (42%)
cEGF 3139..3162 CDD:403760 9/23 (39%)
EGF_CA 3159..3198 CDD:214542 21/38 (55%)
LY 3226..3268 CDD:214531 14/43 (33%)
LY 3269..3311 CDD:214531 18/41 (44%)
Ldl_recept_b 3340..3380 CDD:395012 19/39 (49%)
LY 3365..3406 CDD:214531 17/40 (43%)
LY 3407..3448 CDD:214531 12/46 (26%)
FXa_inhibition 3476..>3505 CDD:405372 9/28 (32%)
LDLa 3519..3553 CDD:238060 19/33 (58%)
LDLa 3560..3591 CDD:197566 14/30 (47%)
LDLa 3600..3632 CDD:197566 11/36 (31%)
LDLa 3641..3673 CDD:197566 16/31 (52%)
LDLa 3689..3721 CDD:238060 11/32 (34%)
LDLa 3728..3761 CDD:238060 18/32 (56%)
LDLa 3766..3800 CDD:238060 19/33 (58%)
LDLa 3805..3839 CDD:238060 14/34 (41%)
LDLa 3849..3881 CDD:238060 17/31 (55%)
LDLa 3892..3922 CDD:197566 11/29 (38%)
LDLa 3935..3969 CDD:238060 13/33 (39%)
EGF_CA 4014..4054 CDD:214542 14/44 (32%)
LY 4148..4183 CDD:214531 11/34 (32%)
Ldl_recept_b 4204..4244 CDD:395012 13/41 (32%)
LY 4229..4271 CDD:214531 16/41 (39%)
FXa_inhibition 4345..>4363 CDD:405372 9/23 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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