Protein Alignment LRP1 and LpR1

DIOPT Version :10

• Sequence 1: NP_001260800.2
• Gene: LRP1 / 35799
• FlyBaseID: FBgn0053087
• Length: 4752
• Species: Drosophila melanogaster
• Sequence 2: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Alignment Length: 866
• Identity: 309/866 - (35%)
• Similarity: 429/866 - (49%)
• Gaps: 129/866 - (14%)

  Fly  2626 VNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQ--CPETHFMCQNHRCIPKEH 2688
            :...|...|:.||||:|||:...||....|.|.|||....|.|.:  |....|.|.|..|||.:.
  Fly   132 LEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNKW 196

  Fly  2689 KCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGS-GECIPRKFLCDSLKDCRD 2752
            :||.|..|.|||||...||        |:...||.      |:|.: .:||||.:|||...||||
  Fly   197 RCDQESDCADGSDEANELC--------MNACPNNE------FKCQTVDQCIPRSWLCDGSNDCRD 247

  Fly  2753 FSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRC 2817
            .|||               .||...|                               |.|.::.|
  Fly   248 KSDE---------------AHCRART-------------------------------CSPDEYAC 266

  Fly  2818 AS--GNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFAC-DKTCIPASWQCDGKSDCEDGSDEG 2879
            .|  |.|:..:|.||..|||.|||||.||...||.::|.| :..||...|:||...||.|||||
  Fly   267 KSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDE- 330

  Fly  2880 PQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAH-IPDCPPPAH 2943
            .:||..||........::|.||.::|||||:.||..| .||.|      |..|.. ...|....:
  Fly   331 KECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDG-SDERS------CANVTKTTTPCLSHEY 388

  Fly  2944 LCTSGL-CIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSL---MHQCQDGLCIFKNQTCD 3004
            .|...: |:...::||||.|||.||||:..        :|...:.   ..||.|..||..:.||:
  Fly   389 QCKDRITCLHHSWLCDGDRDCPDGDDEHTA--------NCKNVTCRADQFQCGDRSCIPGHLTCN 445

  Fly  3005 GKPDCGDGSDE-----TSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEEL--CN 3062
            |..||.|||||     :.||..:..|||.|.:|.|..|.|:....:||:|.||.|..||..  |.
  Fly   446 GDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCG 510

  Fly  3063 VNECLIPD-ICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKC 3126
            :|||...: .|.|:|.|..||:.|.|..|||:.|...: |.||:||:....|||.|:|..|.:||
  Fly   511 INECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRN-CQDINECEVPGKCSQICVNEIGGFKC 574

  Fly  3127 LCAKGYAL--VDHHTCKATSNVSMELIFSNRYYIRQV-----DMTGNGSILINELSNAVALDYDW 3184
            .|..||..  .:|..||| |.....|:.:.|:.||::     :||.    ::|....|.|||:.:
  Fly   575 ECEAGYMRDPKNHTRCKA-SEGHASLLLARRHDIRKIALDHMEMTS----IVNSTKAATALDFVF 634

  Fly  3185 DSQCLYWSDVTSTVGTIKRYCPKEN-KTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQ 3248
            .:..::||||| |....|....:.| ||..|.::.:.: |||||||:..::|:.|....|||::.
  Fly   635 RTGMIFWSDVT-TQSIYKAPIDEGNEKTVVLTKSSVTS-DGLAVDWIYNHVYFTDTHKCTIELTN 697

  Fly  3249 LDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALT 3313
            .:|...|||:.:.|..||.|||.|.:..::|||||.||.|.:||||||:...||...:.|||.:|
  Fly   698 FEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGIT 762

  Fly  3314 ISFETQQLFWGDAREDTISVSDLDGN-HTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKS 3377
            :....::::|.|.:.:.||.::.||: .:::|.:...     |.|.|:|..:|.::||:||:.::
  Fly   763 LDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEY-----LRHPFSITTFEDNVYWTDWDKQA 822

  Fly  3378 IEYCSIFNGQNCTTLITTIH---RPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSP----E 3433
            :...:.|.|::... :|.:|   .||.:.|:||||  ||...|.|.:.|  ||.||:.:|    .
  Fly   823 VFKANKFTGEDVEP-VTAMHMLQHPMVVHVYHPYR--QPDGVNHCQSVNGHCSHLCLPAPRINER 884

  Fly  3434 EPYYKCMCPTNFILADDGRTC 3454
            .|...|.|||...|..||..|
  Fly   885 SPRISCACPTGLKLMVDGLMC 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:459654
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		LDLa	1191..1226	CDD:238060
		FXa_inhibition	1289..1317	CDD:464251
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:464251
		LY	1751..1789	CDD:214531
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:464251
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060	14/30 (47%)
		LDLa	2671..2702	CDD:238060	14/30 (47%)
		LDLa	2727..2759	CDD:238060	16/32 (50%)
		LDLa	2773..2802	CDD:238060	3/28 (11%)
		LDLa	2810..2844	CDD:238060	17/35 (49%)
		LDLa	2848..2878	CDD:238060	14/30 (47%)
		LDLa	2887..2916	CDD:197566	11/28 (39%)
		LDLa	2938..2969	CDD:197566	12/31 (39%)
		LDLa	2989..3015	CDD:197566	13/25 (52%)
		LDLa	3030..3061	CDD:238060	12/32 (38%)
		EGF_CA	3062..>3091	CDD:214542	11/29 (38%)
		EGF_CA	3103..3141	CDD:214542	16/39 (41%)
		LY	3212..3254	CDD:214531	14/41 (34%)
		Ldl_recept_b	3275..3314	CDD:459654	19/38 (50%)
		LY	3299..3340	CDD:214531	12/41 (29%)
		LY	3354..3389	CDD:214531	11/34 (32%)
		LDLa	3458..3490	CDD:238060
		LDLa	3499..3533	CDD:238060
		LDLa	3582..3616	CDD:238060
		LDLa	3621..3652	CDD:197566
		LDLa	3663..3697	CDD:238060
		LDLa	3702..3736	CDD:238060
		LDLa	3776..3808	CDD:197566
		LDLa	3818..3849	CDD:197566
		LDLa	3860..3894	CDD:238060
		YncE	3935..4148	CDD:442618
		LY	4108..4150	CDD:214531
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	14/31 (45%)
		LDLa	178..210	CDD:197566	14/31 (45%)
		LDLa	219..254	CDD:238060	18/55 (33%)
		LDLa	259..295	CDD:238060	17/35 (49%)
		LDLa	343..373	CDD:238060	14/36 (39%)
		LDLa	383..415	CDD:197566	12/31 (39%)
		Ldl_recept_a	423..459	CDD:395011	15/35 (43%)
		LDLa	476..504	CDD:197566	10/27 (37%)
		FXa_inhibition	514..549	CDD:464251	13/35 (37%)
		EGF_CA	551..581	CDD:214542	14/29 (48%)
		LY	662..702	CDD:214531	14/40 (35%)
		LY	704..747	CDD:214531	24/42 (57%)
		LY	749..790	CDD:214531	12/40 (30%)
		Ldl_recept_b	769..815	CDD:459654	12/50 (24%)
		FXa_inhibition	864..905	CDD:464251	15/40 (38%)