DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp4

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_766256.3 Gene:Lrp4 / 228357 MGIID:2442252 Length:1905 Species:Mus musculus


Alignment Length:1739 Identity:559/1739 - (32%)
Similarity:845/1739 - (48%) Gaps:237/1739 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   987 CLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQ 1050
            |:..:..|||..||.|..||..     |.:.||... :|.| ||:|.:||.:|.....|.|.:|:
Mouse    44 CIPAQWQCDGDNDCGDHSDEDG-----CTLPTCSPL-DFHCDNGKCIRRSWVCDGDNDCEDDSDE 102

  Fly  1051 ANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKC--PEFDCNNGRCR 1113
            .:|....|..:||.| ::|.||:..|..||..|||  |:|||..:   ..||  .||.|::|.|.
Mouse   103 QDCPPRECEEDEFPC-QNGYCIRSLWHCDGDNDCG--DNSDEQCD---MRKCSDKEFRCSDGSCI 161

  Fly  1114 QFADVCDGIDNCGNNADEMEC------------EQECEHGEKYCRPIGCYGEMHMCDGIHDCLDF 1166
            .....|||..:|.:.:||..|            |.:|.:|.       |..:::.|||..||.|:
Mouse   162 AEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGR-------CILDIYHCDGDDDCGDW 219

  Fly  1167 SDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINT 1231
            |||::|    |.:.|         |...||.|.... ||....||||.:.|.|::||.|||    
Mouse   220 SDESDC----SSHQP---------CRSGEFMCDSGL-CINSGWRCDGDADCDDQSDERNCT---- 266

  Fly  1232 TRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDE--------------GFLCAD-- 1280
                   |.:|......|. |.:||.:...|||::||.|.:||              .|||.:  
Mouse   267 -------TSMCTAEQFRCR-SGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGR 323

  Fly  1281 -----KLCD--------------------RGHE--------CSHRCHNTPEGYICSCPDHLYLQP 1312
                 |||:                    .|.|        |:.:|........|:|.....|..
Mouse   324 CIGQRKLCNGINDCGDSSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTE 388

  Fly  1313 NGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKG 1377
            :|:.|...:.|.....|||.|.::...:.|.|..|::|..||.:||:..| ||.::|.||.||:.
Mouse   389 DGRTCQDVNECAEEGYCSQGCTNTEGAFQCWCEAGYELRPDRRSCKALGP-EPVLLFANRIDIRQ 452

  Fly  1378 I----NLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIH 1438
            :    :..||.:.|    |.|.|||||.:..|.   ::|:||..|:|.|.:|.|.   |||.|:.
Mouse   453 VLPHRSEYTLLLNN----LENAIALDFHHRREL---VFWSDVTLDRILRANLNGS---NVEEVVS 507

  Fly  1439 SGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTD 1503
            :||.:..|||||||...|||.||...:||||.|:|:.|:.|:..::|.||||||.|.||.::|||
Mouse   508 TGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTD 572

  Fly  1504 WDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHH 1568
            | .|:||||.:||.|.|||:|:.:...   ||||||:||..:|:||||||...|.....|||...
Mouse   573 W-GNTPRIEASSMDGSGRRIIADTHLF---WPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRK 633

  Fly  1569 VVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQP 1633
            .|:  .:.|.|||||:|||:.:|||||.|.|:..|||:.|.:.::::.....|..|..||..|||
Mouse   634 AVI--SQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQP 696

  Fly  1634 WDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPN-EQVLLFVMVDEIRGI--D 1695
            ..:|.||:|||||:||||.||: .:.|.||...|  ..|...|..: ::.|||....:||.|  |
Mouse   697 AGKNRCGDNNGGCTHLCLPSGQ-NYTCACPTGFR--KINSHACAQSLDKFLLFARRMDIRRISFD 758

  Fly  1696 LHQPNHHTIP--TIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEK 1758
            ....:...||  .:|.:..|      |:...:..::|:|:..:.||.|.......|.:::|::|.
Mouse   759 TEDLSDDVIPLADVRSAVAL------DWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLES 817

  Fly  1759 PYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDPANGKMYWIHSASD 1822
            |.|.|:||:...:|::..... .|..:|..|...:: |.|:|:....||::|..|.|||    :|
Mouse   818 PAGLAIDWVTNKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYW----TD 877

  Fly  1823 -GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYAYDNSGIAYYDIP--RNETRK 1881
             |:..::|::.:|.|||.:|.  .:||   ..|.:|:.|||||:|  ::|:...:..  ....||
Mouse   878 WGASPKIERAGMDASSRQVII--SSNLTWPNGLAIDYGSQRLYWA--DAGMKTIEFAGLDGSKRK 938

  Fly  1882 VLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGS 1946
            ||:.|.:.....||:|...:|:.:.....|...::....:...|:.|.:::..:.:|:......:
Mouse   939 VLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRQRPPVT 1003

  Fly  1947 NTCAEWAYRGGCQQLCL-ATSSIDHVCRCALGYDVEPNNPTGCVP-RAEFIFYS--IDVLQGVEM 2007
            ..||  ...|||..||| :.:.....|.|..|.::..:..| |.| ...|:.::  ||    |.|
Mouse  1004 TLCA--VENGGCSHLCLRSPNPSGFSCTCPTGINLLRDGKT-CSPGMNSFLIFARRID----VRM 1061

  Fly  2008 IDPSEQFDTP--SPALVPIS---RVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILE 2067
            :    ..|.|  :..:|||:   :.:.|..:|.|..  .:||.|:.|..|||...||:|.|.|: 
Mouse  1062 V----SLDIPYFADVVVPINMTMKNTIAIGVDPLEG--KVYWSDSTLHRISRASLDGSQHEDII- 1119

  Fly  2068 ALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVV-SNLEKPTALAVDPLQ 2131
               ..|.:..|   |:|:|.:...:||:||..|.|||..||||.|.|:| .||:.|.|:.:....
Mouse  1120 ---TTGLQTTD---GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM 1178

  Fly  2132 GLLFYV---TQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYD 2193
            |.:::.   ....:.|.|:|||...||:| ....|..| |.:|..::::.|.:.:.:.:...|.:
Mouse  1179 GFMYWTDWGENAKLERSGMDGSDRTVLIN-NNLGWPNG-LTVDKTSSQLLWADAHTERIEVADLN 1241

  Fly  2194 GNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIY 2258
            |..|..|:: .:.:|..|..:..|:||.:  :....|..|. .:...:.:::::....:.|::..
Mouse  1242 GANRHTLVS-PVQHPYGLTLLDSYIYWTD--WQTRSIHRAD-KSTGSNVILVRSNLPGLMDIQAV 1302

  Fly  2259 SKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHS-RLASDGYSCEPY-ENFLLFSYRSNIE-- 2319
            .:....|.|.|...||.|..|||...:...|||... :|..|..:|:|. |.:||||.|.:|.  
Mouse  1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTCDPSPETYLLFSSRGSIRRI 1367

  Fly  2320 SIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGT------GHR 2378
            |:...||.|.:.||..::      |||::.|:.....|||:||.|..|.:...||:      ||.
Mouse  1368 SLDTDDHTDVHVPVPGLN------NVISLDYDSVHGKVYYTDVFLDVIRRADLNGSNMETVIGHG 1426

  Fly  2379 VLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGI 2443
            :     :..:|||.|.|...|:||.....||.:..|          ....:|||.....|:||.|
Mouse  1427 L-----KTTDGLAVDWVARNLYWTDTGRNTIEASRL----------DGSCRKVLINNSLDEPRAI 1476

  Fly  2444 AVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIE 2508
            ||.|..|.::||:|...:. |:|:.|.|...:|:|.||:..||.||||.:.:::||.||.||:||
Mouse  1477 AVFPRKGYLFWTDWGHIAK-IERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIE 1540

  Fly  2509 RTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIV 2573
            ..:.:|..|.||. |...|.||:......::||||...::.|.:||:|.:...:..:|...|.|:
Mouse  1541 SADLNGKLRQVLV-SHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDII 1604

  Fly  2574 AVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRC 2622
            .| :.......|.|.:.||.|..:|.. ::....|.|..   .|||..|
Mouse  1605 VV-SPQRQTGTNACGVNNGGCTHLCFA-RASDFVCACPD---EPDGHPC 1648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566 15/34 (44%)
LDLa 1104..1134 CDD:238060 11/29 (38%)
LDLa 1191..1226 CDD:238060 14/34 (41%)
FXa_inhibition 1289..1317 CDD:464251 6/27 (22%)
LY 1434..1476 CDD:214531 22/41 (54%)
LY 1477..1521 CDD:214531 23/43 (53%)
LY 1533..1567 CDD:214531 19/33 (58%)
LY 1568..1611 CDD:214531 21/42 (50%)
FXa_inhibition 1639..1676 CDD:464251 18/36 (50%)
LY 1751..1789 CDD:214531 10/37 (27%)
LY 1794..1838 CDD:214531 15/45 (33%)
LY 2078..2112 CDD:214531 16/33 (48%)
NHL <2082..>2152 CDD:302697 28/73 (38%)
NHL repeat 2082..2120 CDD:271320 19/38 (50%)
FXa_inhibition 2269..2303 CDD:464251 12/34 (35%)
LY 2430..2471 CDD:214531 17/40 (43%)
LY 2475..2517 CDD:214531 19/41 (46%)
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp4NP_766256.3 LDLa 27..66 CDD:238060 9/26 (35%)
Ldl_recept_a 70..105 CDD:395011 13/35 (37%)
LDLa 110..142 CDD:238060 16/34 (47%)
LDLa 148..182 CDD:238060 12/33 (36%)
LDLa 231..265 CDD:238060 14/34 (41%)
LDLa 270..304 CDD:238060 13/34 (38%)
LDLa 311..343 CDD:197566 6/31 (19%)
FXa_inhibition 358..393 CDD:464251 6/34 (18%)
EGF_CA 395..434 CDD:214542 11/38 (29%)
LY 460..502 CDD:214531 19/51 (37%)
LDL-receptor class B 1 480..522 21/47 (45%)
LY 505..545 CDD:214531 21/39 (54%)
LDL-receptor class B 2 523..565 21/41 (51%)
LDL-receptor class B 3 566..609 25/46 (54%)
Ldl_recept_b 566..607 CDD:459654 23/44 (52%)
LY 590..632 CDD:214531 21/44 (48%)
LDL-receptor class B 4 610..652 21/43 (49%)
LY 633..673 CDD:214531 21/41 (51%)
LDL-receptor class B 5 653..693 15/39 (38%)
FXa_inhibition 702..>729 CDD:464251 16/27 (59%)
YncE 749..982 CDD:442618 65/247 (26%)
LDL-receptor class B 6 785..827 13/41 (32%)
LY 808..850 CDD:214531 12/42 (29%)
LDL-receptor class B 7 828..870 10/42 (24%)
LDL-receptor class B 8 871..914 16/48 (33%)
Ldl_recept_b 871..912 CDD:459654 15/46 (33%)
LY 895..937 CDD:214531 12/45 (27%)
LDL-receptor class B 9 915..956 14/42 (33%)
LDL-receptor class B 10 957..998 5/40 (13%)
FXa_inhibition 1006..1043 CDD:464251 12/39 (31%)
NHL <1085..1277 CDD:302697 63/205 (31%)
NHL repeat 1085..1123 CDD:271320 15/43 (35%)
LDL-receptor class B 11 1093..1135 17/50 (34%)
NHL repeat 1128..1161 CDD:271320 16/32 (50%)
LDL-receptor class B 12 1136..1178 19/41 (46%)
NHL repeat 1166..1203 CDD:271320 9/36 (25%)
LDL-receptor class B 13 1179..1222 13/44 (30%)
Ldl_recept_b 1179..1219 CDD:459654 12/41 (29%)
NHL repeat 1212..1244 CDD:271320 7/32 (22%)
LDL-receptor class B 14 1223..1263 7/40 (18%)
NHL repeat 1253..1277 CDD:271320 6/25 (24%)
LDL-receptor class B 15 1264..1306 6/44 (14%)
FXa_inhibition 1313..1348 CDD:464251 12/34 (35%)
Vgb 1359..1583 CDD:443399 84/246 (34%)
LDL-receptor class B 16 1397..1439 15/46 (33%)
LDL-receptor class B 17 1440..1482 16/51 (31%)
LDL-receptor class B 18 1483..1526 18/43 (42%)
Ldl_recept_b 1483..1524 CDD:459654 17/41 (41%)
LY 1507..1547 CDD:214531 18/39 (46%)
LDL-receptor class B 19 1527..1568 16/41 (39%)
LDL-receptor class B 20 1569..1610 12/41 (29%)
FXa_inhibition 1617..1648 CDD:464251 10/34 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.

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