DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and EGF

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_016863334.1 Gene:EGF / 1950 HGNCID:3229 Length:1223 Species:Homo sapiens


Alignment Length:1792 Identity:340/1792 - (18%)
Similarity:560/1792 - (31%) Gaps:754/1792 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  2290 ACAHSRLASDGYS-CEPYE--------NFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNV 2345
            :|....||.:|.| |..:.        .||:||:.:   ||...|....|:. |::.:..:.   
Human    27 SCPEGTLAGNGNSTCVVWSLSSHPGPAPFLIFSHGN---SIFRIDTEGTNYE-QLVVDAGVS--- 84

  Fly  2346 IAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIR 2410
            :.:.::|.|:.:|:.|::...:.:|..||:....:...::.|.|:|.:.:||::.|::.....|.
Human    85 VIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIIT 149

  Fly  2411 SVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTE 2475
            ..:::..:.|           :.|.....|..:||:|....|:|::...||  :.|:.|.|.|.:
Human   150 VTDMKGNNSH-----------ILLSALKYPANVAVDPVERFIFWSSEVAGS--LYRADLDGVGVK 201

  Fly  2476 VIIKTDIKMPNALTLDLEQQKLYW----ADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGD 2536
            .:::|..|: .|::||:..::|:|    .:.....|...:|||.:..:..|.|..:.|||:::||
Human   202 ALLETSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGD 265

  Fly  2537 LLFWTDWVLHAVVRANKYTGTDVLFLREHVT-RPMGIVAVQNTSINCDANQCKILNGQCEDVCIL 2600
            .:|::.|.:..:..|||:||.|::.:..|.: .|:|              :.|:::...:.    
Human   266 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLG--------------ELKVVHPLAQP---- 312

  Fly  2601 NKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSY 2665
             |:...|..               |....|.|.:.||.|..|               |.|     
Human   313 -KAEDDTWE---------------PEQKLCKLRKGNCSSTVC---------------GQD----- 341

  Fly  2666 CIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMF 2730
                        .|:|.|:                                              
Human   342 ------------LQSHLCM---------------------------------------------- 348

  Fly  2731 RCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPD 2795
             |..|..:.|              |.|.|..:    |:..|.:.|                 |  
Human   349 -CAEGYALSR--------------DRKYCEDV----NECAFWNHG-----------------C-- 375

  Fly  2796 GTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDG----SDEINCR--TECRHNQFA 2854
               .|.|.|      .||.:.|.                ||.|    .|...|.  ..|..|...
Human   376 ---TLGCKN------TPGSYYCT----------------CPVGFVLLPDGKRCHQLVSCPRNVSE 415

  Fly  2855 CDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGD 2919
            |...|:..|                                                        
Human   416 CSHDCVLTS-------------------------------------------------------- 424

  Fly  2920 EGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPG 2984
                 |||.|                                                   .||.
Human   425 -----EGPLC---------------------------------------------------FCPE 433

  Fly  2985 GSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRR 3049
            ||::.  :||      :||.                    ||:..|     ||.|          
Human   434 GSVLE--RDG------KTCS--------------------GCSSPD-----NGGC---------- 455

  Fly  3050 NDCADFSDEELCNVNECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCS 3114
                    .:||                                :|.||                
Human   456 --------SQLC--------------------------------VPLSP---------------- 464

  Fly  3115 QTCINTYGSYKCLCAKGYAL-VDHHTCKATSNVSMELIFSNRYYIRQV--DMTGNGSILINELSN 3176
                   .|::|.|..||.| :|..:| |.|.....|:|:|...||.:  |.|..|::|..::..
Human   465 -------VSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGM 521

  Fly  3177 AVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKN----PDGLAVDWVAKNLYWC 3237
            ..|||:|.....:|::.      |..::..:.|...:..:.:::.    |:||||||:.:..||.
Human   522 VYALDHDPVENKIYFAH------TALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWT 580

  Fly  3238 DKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMII 3302
            |:|...|..|.|:||..|::..|.:.:|||||:||..:.:||:|.|.:|.|..:.:.|....:|.
Human   581 DRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIA 645

  Fly  3303 RDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGH 3367
            ...|.||:.:||.|.|.:|:|.||::..|.:::|||:..|.|....:.      |.||:||:|.:
Human   646 SSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVG------HPFAVAVFEDY 704

  Fly  3368 IYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVL 3430
            :::|||...|:...:...|::...|..::.:|..|.|.||..:.   ..:|||..|  |..:|..
Human   705 VWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP---GADPCLYQNGGCEHICKK 766

  Fly  3431 SPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCP 3495
            .....:  |.|...|:.|.||:||.|                                       
Human   767 RLGTAW--CSCREGFMKASDGKTCLA--------------------------------------- 790

  Fly  3496 PFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVK 3560
                                  .||......|..:|. ::.|..|       ..:.:....||:.
Human   791 ----------------------LDGHQLLAGGEVDLK-NQVTPLD-------ILSKTRVSEDNIT 825

  Fly  3561 RCDGVKDCPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVSCGPND 3625
                       |.:......:...||..|....|..:.       .|..:.::|.|         
Human   826 -----------ESQHMLVAEIMVSDQDDCAPVGCSMYA-------RCISEGEDATC--------- 863

  Fly  3626 FQC-----DSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYE 3685
             ||     ..|:.      |.|..:|..|          ...|.|...||.|::   |.:.|   
Human   864 -QCLKGFAGDGKL------CSDIDECEMG----------VPVCPPASSKCINTE---GGYVC--- 905

  Fly  3686 NDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAF 3750
                                  ||..|      |:.|| |||.| .||      |:..:..|...
Human   906 ----------------------RCSEG------YQGDG-IHCLD-IDE------CQLGEHSCGEN 934

  Fly  3751 NTCINKQ--YKC-------DGDDDCPDGSDEVNCTCHSDHFSCGN--GKCIMSRWKCDGWDDCL- 3803
            .:|.|.:  |.|       :....|||.:...:......|:|..|  .:|.:|.   ||:  || 
Human   935 ASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSH---DGY--CLH 994

  Fly  3804 DGSDESLETCAKTHC----------------------HANAFKCRNQLCVRNSALC--------- 3837
            ||....:|...|..|                      ||...:.:..:.|   |:|         
Human   995 DGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVV---AVCVVVLVMLLL 1056

  Fly  3838 ---------------------------------------DGINDCGEN-----EDESDAVCAALP 3858
                                                   ||::.|.:.     ::..|......|
Human  1057 LSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQP 1121

  Fly  3859 KCRHDQFQCENDDCISKAFRCDGQY-NCVDGSDEMNC---QPPVCGF--------------GSCS 3905
            ....|            ....|||: :...||.:...   :|.:||.              |||.
Human  1122 VAGED------------GQAADGQFLSLAPGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCP 1174

  Fly  3906 QICIEKKAGH---YNCKCADGYHKGPEKNATCLASGP 3939
            |:.  :::.|   |..:..:|   |.||..:.|::.|
Human  1175 QVM--ERSFHMPSYGTQTLEG---GVEKPHSLLSANP 1206

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342 5/13 (38%)
LY 2430..2471 CDD:214531 11/40 (28%)
LY 2475..2517 CDD:214531 11/45 (24%)
LDLa 2630..2661 CDD:238060 7/30 (23%)
LDLa 2671..2702 CDD:238060 3/30 (10%)
LDLa 2727..2759 CDD:238060 5/31 (16%)
LDLa 2773..2802 CDD:238060 3/28 (11%)
LDLa 2810..2844 CDD:238060 7/37 (19%)
LDLa 2848..2878 CDD:238060 5/29 (17%)
LDLa 2887..2916 CDD:197566 0/28 (0%)
LDLa 2938..2969 CDD:197566 0/30 (0%)
LDLa 2989..3015 CDD:197566 4/25 (16%)
LDLa 3030..3061 CDD:238060 4/30 (13%)
EGF_CA 3062..>3091 CDD:214542 0/28 (0%)
EGF_CA 3103..3141 CDD:214542 7/38 (18%)
LY 3212..3254 CDD:214531 16/45 (36%)
LY 3255..3297 CDD:214531 16/41 (39%)
LY 3299..3340 CDD:214531 16/40 (40%)
LY 3354..3389 CDD:214531 11/34 (32%)
LDLa 3458..3490 CDD:238060 0/31 (0%)
LDLa 3499..3533 CDD:238060 4/33 (12%)
LDLa 3582..3616 CDD:238060 6/33 (18%)
LDLa 3621..3652 CDD:197566 7/35 (20%)
LDLa 3663..3697 CDD:238060 7/33 (21%)
LDLa 3702..3736 CDD:238060 12/33 (36%)
LDLa 3776..3808 CDD:197566 11/34 (32%)
LDLa 3818..3849 CDD:197566 9/105 (9%)
LDLa 3860..3894 CDD:238060 6/34 (18%)
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
EGFXP_016863334.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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