DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and R11G1.1

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_001361923.1 Gene:R11G1.1 / 187815 WormBaseID:WBGene00020010 Length:1745 Species:Caenorhabditis elegans


Alignment Length:1330 Identity:233/1330 - (17%)
Similarity:358/1330 - (26%) Gaps:560/1330 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  3621 CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYE 3685
            |...|:.|..|:|:|::...|...||.:|.||  .||..:.:|.|.|                  
 Worm    33 CMLGDYDCGLGQCVPISQFRDGKPDCMDGSDE--WCFIGQVSCGPVY------------------ 77

  Fly  3686 NDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNY-RCDGEIHCDDNSDEINCNITCKENQFKCAA 3749
              |.|..|.|.|.:                   | :|||      :|.::....|.||.  .|| 
 Worm    78 --CADYKDALPCIV-------------------YPKCDG------SSKQLPWCSTSKEK--LCA- 112

  Fly  3750 FNTCINKQYKCDGDDDCPDGSDEVNCTCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDES----- 3809
                                 ||.:..|.      |.|:|::..|..||..||.|||||.     
 Worm   113 ---------------------DETSFPCK------GYGECVLWEWLLDGKKDCNDGSDEDENYVM 150

  Fly  3810 -LETCAKTHCHANAFKC-RNQLCV------------RNSALCDGINDCGENE----DESDAVCAA 3856
             ||         :|::| |||..:            ..|...:|.:.|.:..    ..:..:...
 Worm   151 PLE---------HAYRCARNQSGLYLPKPVPPPPEDHPSLYVEGCSMCSKPSTVTLPSNPVIDYT 206

  Fly  3857 LPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQICIEKKAGHY----- 3916
            .||                       |..:......|.:||:..|.....  .|.|.|.:     
 Worm   207 TPK-----------------------YPFITSPLLGNTKPPLSNFPVFPS--EESKLGDFFPEPS 246

  Fly  3917 --NCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFD 3979
              ......|:||..|                                 .:..||.|.|      .
 Worm   247 GVEISRVTGFHKPNE---------------------------------PIGDFFPTHS------S 272

  Fly  3980 ILIRPKDTLLFWIDSHHGKVHTMKIAT-PHVEGT----------GVRVRRDLKELTAFNIPELDD 4033
            ..:.|.:.:.        :.||.::.| |.:..|          |   |.||..:||        
 Worm   273 TPVPPTEAVT--------QSHTFRLITIPSISQTQFPQAPLIFPG---RPDLPPITA-------- 318

  Fly  4034 PKSLAVDWISQRVYIIDSRHNQ------ILATDIEGKKYISLVS--------------------- 4071
            |..|. :|....|......|:|      ...|..||.:.|..:.                     
 Worm   319 PSPLN-NWPIPIVTTTPDPHHQGPLPPITYPTIEEGSEKIPPIKPGIIISRPVTSRKPDLPSEFE 382

  Fly  4072 ------------TGMNPTDIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGWPISLSMD 4124
                        .||||.|::..|.                          |......|..:..:
 Worm   383 YGGGTGDGISQPPGMNPFDMLTRPS--------------------------VPMTTPGPFDMFPN 421

  Fly  4125 YPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGN 4189
            .|.     .|.|..|                     :|.:.:..:.|..:.:.|:     .|.|.
 Worm   422 VPP-----VDLRPVT---------------------RPWESEKTKPYPGVTIPDE-----QKSGT 455

  Fly  4190 DNGTYLLKGYRSSDIGILHPMKQNRNISNP-------------CAKDPCKSSRALCILSSE---- 4237
            |....|:.|      .||......|.:|.|             ..::|...:....|..:|    
 Worm   456 DTLIPLIPG------RILPTFATPRPLSIPSFFTTPQSPHRPFVTQNPPHGALPTLIPQAEIEKY 514

  Fly  4238 ----------------------SSVGYSCKCAEGYV-------MTDDGVCKAHAD---IPDYCPL 4270
                                  |.:.:..|..||::       .:.:.......|   .|....|
 Worm   515 VQTEVPPHSGFEIPGGGFTTPGSHITHPSKVPEGFIEEKTLLTPSTNNAQTTQIDRNLTPKTTTL 579

  Fly  4271 QCNLGTCKIVDHVPKCICQP---------QFEGELCEHYRCSGYCQNYGVCSVAPALPGSQE--- 4323
            :....| ||:...|..:.:.         :.|..|.||              ....:|||.:   
 Worm   580 KATSRT-KIIHVGPNGVVEEIDNNESTKIENETNLGEH--------------EGQIVPGSDKVIH 629

  Fly  4324 -PPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISET----EGMKCSCPKMFTGEQCEHCRN 4383
             .|.:|.|.|..                  :|.|.:::|.    |.:..|.....|         
 Worm   630 IGPTVKTTPTPS------------------SGTSTIVTENSSTFESVSTSSVPTTT--------- 667

  Fly  4384 LTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEH 4448
                       ..||.||             :|:|.....:.|..||       |.||:|.|   
 Worm   668 -----------VKTGDPQ-------------VDDCLRRMSDSGGSVI-------CDCPNGQF--- 698

  Fly  4449 CESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMI 4513
              .|:      ..|.|.|   .||.......:...|.:|.............           .|
 Worm   699 --KNT------GNGQCEE---TLSLVVVKVKVNTVCNTDKASLEQKQRILHQ-----------KI 741

  Fly  4514 CQNAGTC-----HIIKGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCI 4573
            .|:..:|     |....||:..|:|      |||...|.....|.....|..:|....|....|.
 Worm   742 GQSYKSCIRSAEHDSALVAIVQCSD------CTLQEIDRLLTTRSFGEPGNLNLTAEALGTDLCS 800

  Fly  4574 GEWQGNACEMPPHCVGGECNV-----CRPGSSINECLCENNRVVPCLSDSADALKEEQE--PTES 4631
            .. :.|.|.:...|:..:.|:     |:.|:                :||:|......|  |.||
 Worm   801 NS-EFNHCHVYSDCILDDENLRYACKCKKGT----------------TDSSDGYGRSCEGFPEES 848

  Fly  4632 GGVFSVVVLVLAVILLVFALFAGAVYFLK-----------KHRIAQPFS-HARLTDNVEIMLT-- 4682
            .     .|:|..:.|:|:.:|....:||.           :.|..:..: |....|.::.::.  
 Worm   849 D-----CVMVFGICLIVWLIFLLGSFFLSLLACIACYALCRKRCCRYIAIHPANADGLQTVVVGQ 908

  Fly  4683 ------------------NAMY--------RGDADEAPTFASEDDK-GNFANPVYESMYADAIPE 4720
                              .|::        :|....|..||..|.| ...:.|...|...:.:.|
 Worm   909 KAAKSLEMDGNREKLPHMKAIFAESLKHSAKGSTSVASAFALADFKRKKVSRPPDMSQVIEEVNE 973

  Fly  4721 PVSTEITHSTAPDERKGLLQ-HTHDENHTP 4749
            ..:..|.:|.:..:...|.: .||..|..|
 Worm   974 NPTASIHNSESLPKVSSLAKISTHTANSEP 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:464251
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566 10/30 (33%)
LDLa 3663..3697 CDD:238060 7/33 (21%)
LDLa 3702..3736 CDD:238060 5/34 (15%)
LDLa 3776..3808 CDD:197566 12/31 (39%)
LDLa 3818..3849 CDD:197566 8/47 (17%)
LDLa 3860..3894 CDD:238060 1/33 (3%)
YncE 3935..4148 CDD:442618 38/262 (15%)
LY 4108..4150 CDD:214531 6/41 (15%)
EGF_CA <4386..4414 CDD:238011 4/27 (15%)
EGF_CA 4415..4450 CDD:238011 10/34 (29%)
R11G1.1NP_001361923.1 LDLa 32..64 CDD:197566 10/30 (33%)
LDLa 113..145 CDD:238060 15/37 (41%)
PHA03247 <268..594 CDD:223021 63/415 (15%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.