Protein Alignment LRP1 and egg-2

DIOPT Version :10

• Sequence 1: NP_001260800.2
• Gene: LRP1 / 35799
• FlyBaseID: FBgn0053087
• Length: 4752
• Species: Drosophila melanogaster
• Sequence 2: NP_498537.1
• Gene: egg-2 / 187510
• WormBaseID: WBGene00019811
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 453
• Identity: 148/453 - (32%)
• Similarity: 195/453 - (43%)
• Gaps: 99/453 - (21%)

  Fly  3456 ANCTAAHFECVNTY-KCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQC-------ANKK-- 3510
            :.|:...|.|..:. ..||...|||...||.||||| |.|.  .|: ..|.|       :.||
 Worm   121 STCSGFGFACTGSIDMIIPSSKRCDGLKDCSDGSDE-ENCK--ECQ-SIYSCRAHIEEESEKKDK 181

  Fly  3511 --------CTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKD 3567
                    |.....||:|:..|.|||||.:| :..|..:..||    :.|..|:....:||||.|
 Worm   182 TSVLPTLICLTAEKLCNGVENCPDGSDEASC-RSKCSKDQFKC----SGSDACLPISVKCDGVSD 241

  Fly  3568 CPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVSC-GPNDFQCDSG 3631
            |....|||.|..  |:|...:||.| |:....||||..||.|.|||..||..:| |.....|:.|
 Worm   242 CENESDESNCNK--CQKGAHKCGKN-CIKASKVCDGIPDCDDGSDEHQCDCKTCSGSEKALCEDG 303

  Fly  3632 RCIPLAWRCDDDHDCPNGEDE---PASC----FSSK----------------------------- 3660
            .||..:..||..|||.:|.||   |.||    ||||
 Worm   304 TCIMRSQVCDGKHDCLDGIDEENCPGSCSNERFSSKLKLLTCDDGNQYSEVEACSGLVEACELNC 368

  Fly  3661 ATCDPTY-FKCN-----NSKCIPGRWRCDYENDCGDGSDELNC-QMRNC---SESEFRCGTGKCI 3715
            ..|||.: |.|.     ::|||.....||...||.||:||..| .::.|   |..:|.| ..||:
 Worm   369 PKCDPKHTFTCPAVGGIHNKCIKRSKVCDGIFDCEDGADEKKCTPVKECVVESSIQFTC-DNKCL 432

  Fly  3716 KHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCTC--- 3777
            :.:.||||...|:|.|||..|: .|....|||:|...|:....:|:|..:|.|||||..|:|
 Worm   433 ESSRRCDGVWDCEDKSDEKGCD-KCPSRSFKCSADKKCLPFHTRCNGVAECSDGSDEHKCSCQEC 496

  Fly  3778 ---HSDHFSCG-NGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQLCVRNSAL 3836
               |.|.:.|. :.:|:.....|..:..|.:.:......||             .|.::||.|
 Worm   497 LGTHHDTYMCSESNRCLKRGEVCSPYSMCPNATYIDKAYCA-------------SLALKNSGL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:459654
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		LDLa	1191..1226	CDD:238060
		FXa_inhibition	1289..1317	CDD:464251
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:464251
		LY	1751..1789	CDD:214531
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:464251
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060
		LDLa	2887..2916	CDD:197566
		LDLa	2938..2969	CDD:197566
		LDLa	2989..3015	CDD:197566
		LDLa	3030..3061	CDD:238060
		EGF_CA	3062..>3091	CDD:214542
		EGF_CA	3103..3141	CDD:214542
		LY	3212..3254	CDD:214531
		Ldl_recept_b	3275..3314	CDD:459654
		LY	3299..3340	CDD:214531
		LY	3354..3389	CDD:214531
		LDLa	3458..3490	CDD:238060	13/32 (41%)
		LDLa	3499..3533	CDD:238060	15/50 (30%)
		LDLa	3582..3616	CDD:238060	16/33 (48%)
		LDLa	3621..3652	CDD:197566	12/31 (39%)
		LDLa	3663..3697	CDD:238060	16/39 (41%)
		LDLa	3702..3736	CDD:238060	15/36 (42%)
		LDLa	3776..3808	CDD:197566	7/38 (18%)
		LDLa	3818..3849	CDD:197566	4/19 (21%)
		LDLa	3860..3894	CDD:238060
		YncE	3935..4148	CDD:442618
		LY	4108..4150	CDD:214531
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
egg-2	NP_498537.1	LDLa	123..159	CDD:238060	16/36 (44%)
		LDLa	216..251	CDD:238060	14/38 (37%)
		LDLa	254..287	CDD:238060	16/33 (48%)
		LDLa	300..327	CDD:238060	12/26 (46%)
		LDLa	373..411	CDD:238060	14/37 (38%)
		LDLa	424..453	CDD:238060	13/29 (45%)
		LDLa	456..491	CDD:238060	14/34 (41%)