Protein Alignment LRP1 and lrpc-1

DIOPT Version :10

• Sequence 1: NP_001260800.2
• Gene: LRP1 / 35799
• FlyBaseID: FBgn0053087
• Length: 4752
• Species: Drosophila melanogaster
• Sequence 2: NP_001343649.1
• Gene: lrpc-1 / 187424
• WormBaseID: WBGene00019756
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 238
• Identity: 72/238 - (30%)
• Similarity: 96/238 - (40%)
• Gaps: 56/238 - (23%)

  Fly  3583 KKDQFQCGNNRCMP-FVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDDDHDC 3646
            :.|.|:....:|.| .|:...|..:|....:..:|...|.||  .||:.           .|..|
 Worm    73 QSDGFRTYRKKCKPGLVYDVLGTQNCNYDYNVKSCGVRSGGP--VQCNG-----------TDFHC 124

  Fly  3647 PNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGT 3711
            |..|                       :|:|...|||...||....||.||.:  |:..||.|..
 Worm   125 PLSE-----------------------QCVPMSSRCDGHYDCSMEEDEQNCPL--CTAGEFACKV 164

  Fly  3712 G-KCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC 3775
            . :||..:.||:|.|.|||.:||.:|:: |....|.|...|.||....:|||...||.|.||:.|
 Worm   165 SEQCISLDRRCNGLIECDDGTDERDCDV-CGHGLFHCGKSNECIPMDERCDGRRQCPHGEDEMLC 228

  Fly  3776 ---------TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDES 3809
                     ||.|..:.      |.:...|||...|.|||||:
 Worm   229 KKPETEKKFTCQSRDYE------IPTNQVCDGMPQCPDGSDEA 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:459654
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		LDLa	1191..1226	CDD:238060
		FXa_inhibition	1289..1317	CDD:464251
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:464251
		LY	1751..1789	CDD:214531
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:464251
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060
		LDLa	2887..2916	CDD:197566
		LDLa	2938..2969	CDD:197566
		LDLa	2989..3015	CDD:197566
		LDLa	3030..3061	CDD:238060
		EGF_CA	3062..>3091	CDD:214542
		EGF_CA	3103..3141	CDD:214542
		LY	3212..3254	CDD:214531
		Ldl_recept_b	3275..3314	CDD:459654
		LY	3299..3340	CDD:214531
		LY	3354..3389	CDD:214531
		LDLa	3458..3490	CDD:238060
		LDLa	3499..3533	CDD:238060
		LDLa	3582..3616	CDD:238060	7/33 (21%)
		LDLa	3621..3652	CDD:197566	8/30 (27%)
		LDLa	3663..3697	CDD:238060	9/33 (27%)
		LDLa	3702..3736	CDD:238060	15/34 (44%)
		LDLa	3776..3808	CDD:197566	11/31 (35%)
		LDLa	3818..3849	CDD:197566
		LDLa	3860..3894	CDD:238060
		YncE	3935..4148	CDD:442618
		LY	4108..4150	CDD:214531
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
lrpc-1	NP_001343649.1	LDLa	117..152	CDD:238060	14/68 (21%)
		LDLa	155..190	CDD:238060	15/34 (44%)
		LDLa	193..228	CDD:238060	14/34 (41%)
		LDLa	233..267	CDD:238060	13/39 (33%)
		PHA03247	<353..496	CDD:223021