DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and nid-1

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_001256465.1 Gene:nid-1 / 179770 WormBaseID:WBGene00003738 Length:1584 Species:Caenorhabditis elegans


Alignment Length:1786 Identity:372/1786 - (20%)
Similarity:586/1786 - (32%) Gaps:605/1786 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1995 IFYSIDVLQGV-----EMIDPSEQFDTPSPAL--VPISRVSSASFIDYLANTDTLYWGDNELGSI 2052
            :|.|.:.:.|:     |.|.......||:.|:  ||:    ::..|||..::|       :.|.:
 Worm    62 LFLSHNGIVGLGKPTPEKIGGLMTISTPAIAVFYVPV----TSGVIDYRVSSD-------DQGLL 115

  Fly  2053 SRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDG--SHRYVV 2115
            :::.:|  .::...:|:...|      |..:.|.|..            ||.|..||  |.:..:
 Worm   116 TKLTQD--VKQVFADAVEFHG------LQAVIITWTQ------------IENAEKDGPASFQLAI 160

  Fly  2116 VSN------LEKPTALAVDPLQGLLFYVTQ----QHIGRV-------GLDGSQPFVLVNQTRANW 2163
            ||:      :.:..:|   |....:.|..|    :.||::       |.|..:...|.|....|:
 Worm   161 VSDGISTYAIFRYESL---PWSSSMGYYAQAGFVRSIGKIQTNVNSGGPDVKELVNLSNNQFGNF 222

  Fly  2164 AV----GSLVLD--IEATKVYWCERYPDALMKVDYDGNLREQLLNESL--NNPVALAKMGD---- 2216
            .:    ||.:.|  .|....|....|..     :|:|........:..  |.|.....:.|    
 Worm   223 FIFRVSGSAIEDPKDEGADDYDYNNYDQ-----EYEGEHPADCPKDKFVDNCPAECRTVRDERGC 282

  Fly  2217 -YLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKI----------------YSKH--- 2261
             ....||..:       ||.|.......:..|.:|...|.::                :.:|   
 Worm   283 ERCICAERPH-------APRAPQEPRPELENTVEDDEDDEQVDGTRYEEPARQAQEQHHQQHHQP 340

  Fly  2262 ---------LQRGSNP---CA-------HSNGACEQLCLFNGTSAVCACAHSRLASDGYSC---- 2303
                     .|.||.|   |:       |:|..|:.   |.|  ..|....:....:|..|    
 Worm   341 DQPQQQPQRSQEGSLPKMSCSQRDDKSCHANSVCQD---FEG--GFCCNCDTGFYGNGKECLPKG 400

  Fly  2304 EPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVY---------Y 2359
            ||..  :..|:...|..|.:.......:......|.....:.|.....:..:.:|         :
 Worm   401 EPQR--ISGSFEGVINRIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLF 463

  Fly  2360 SDVQLSTINQVHFNG---TG----HRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHL 2417
            :|||...:    :||   ||    ..|.|..:|.     |.:..:|.|...|.:...:|    ||
 Worm   464 ADVQSPNV----YNGFQLTGGLFNRTVALHIEQN-----YYVTIKQEFSGRNIHDYFKS----HL 515

  Fly  2418 SEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDI 2482
            .            |.....|..|....:.|        ::.|.....:|.|||......:|..|.
 Worm   516 F------------VSGTLPDIAPGSEVIFP--------DYEEEYVRERRGYLTSKAAFDVIVRDG 560

  Fly  2483 KMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAM-AVYGDLLFWTDWVLH 2546
            .......:.::||..:      ::.....:|..      ||...|...: .||.|     |   .
 Worm   561 GNVQTYRMSVDQQITF------EECPNKEFDRD------HSMKLHVKRINVVYND-----D---E 605

  Fly  2547 AVVR------ANKYTGTDV-------LFLREH------VTRPMGIVAVQNTSINCDA------NQ 2586
            .|||      |.:..|..|       ...|:|      ..||:.|.: |:.||:.|:      :|
 Worm   606 GVVRYGAKNFATRSVGPAVSAPSGGHFDRRQHGQSNMASERPIEIPS-QSESISTDSVCAPGRHQ 669

  Fly  2587 CKILNGQCE-------------------------------DVC------------ILNKSGQATC 2608
            |.:.|.:|.                               |.|            ..|:.|..:|
 Worm   670 CTLPNMKCRVVDPSYRCECEPGYQAAHDASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGSFSC 734

  Fly  2609 HCTQGVLAPDGRRCI----------------------APVNTSCGLSQYNCHS-GECI-----PL 2645
            .|.||... |||.||                      |.....| .:...||. |||:     |.
 Worm   735 QCLQGYQG-DGRSCIREHQASHHEHNQQTPQEMAGVGATTEGFC-TAHNQCHQWGECVFTSEHPT 797

  Fly  2646 -ELTC------DNVTHCADGSDEFRSYCIFRQCPET------HFMCQ-NHRCIPKEHKCDGEQQC 2696
             ...|      |.|.||....:....:  ....|:.      .::|. |..|:| |.....|..|
 Worm   798 GRCKCRGWYVGDGVNHCGPPEENMPKH--NANIPQRGGQACGSYVCDVNAECMP-EPSGGSECVC 859

  Fly  2697 GDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAP 2761
            ..|.....:.|:...:|...|.|:|..::.......|.        :|.|..:|   |:...|| 
 Worm   860 KAGFSGNGVTCESLLDDRHAHSSHNRHEQQQQTGSLGK--------VCRSHDEC---SEHGSCA- 912

  Fly  2762 IPCEKNDMTFVHC-------GNSTICIM-------PRWRCDGDPDCPDGTDELDCANHTSLSCDP 2812
               ..:.:.:..|       ||...|.:       |...||...||   ::..||....|.:  .
 Worm   913 ---YHHSLGYYQCACTEPYVGNGVECTLPGSSASAPELGCDVTRDC---SEFADCVYERSST--G 969

  Fly  2813 GQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSD 2877
            ..|||.   |.:| :..||:              .|..:|.|....                 |.
 Worm   970 ATFRCV---CQSG-YTGDGK--------------YCMQSQLAISAI-----------------SP 999

  Fly  2878 EGPQCPNRP-------CRPHLFQCKSSGRCI----PQKWVCDGEKDCPSG-LGDEGSEDEGPQCG 2930
            ..||.|:.|       |.|:   |....:|:    .:::.|    :|.:. :||      |..|.
 Worm  1000 SVPQLPSEPAVLSTASCNPN---CGPDAQCVYDDHNRQYRC----ECYAAFMGD------GYNCV 1051

  Fly  2931 GVAHIPDCPPPAHLCT-------SGLC-IDSH----YVC--------DGDEDCPGGDDEYEGCVP 2975
            .:|.....|.....|.       :|.| |:.|    |:|        ||..:|.|.|.    |.|
 Worm  1052 PLAKPNMVPAQPKTCVESSDCHINGHCVINEHGAGEYICQCLPGFSGDGFINCRGADQ----CNP 1112

  Fly  2976 AFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACI 3040
            : .|.:|        .|:..|::                 .:.|.||  .|...|.|:....:|:
 Worm  1113 S-NPSAC--------YQNAHCVY-----------------DAILNAH--ACKCVDGFKGDGTSCV 1149

  Fly  3041 ---------------HADLLCDRRND-------CADFSDEE---LCNVNE------CLIPDICEH 3074
                           ||:..|...:|       |...|..:   .|:|.|      |.|...|  
 Worm  1150 PYAPATNCNLEPRICHANAQCVMHHDTNAYECICKPGSSGDGYTKCDVIETPRCTNCSIHAYC-- 1212

  Fly  3075 ECEDKVVG-YQCHCRPGYKVLPKSPHLCTDIDEC-DEQQPCSQT--CI-NTYGSYKCLCAKGYAL 3134
             .::...| |||.|..||.   .:.|||..:..| |::..|.:.  |: ...|.|.|.|..||. 
 Worm  1213 -AQNPTSGAYQCKCNAGYN---GNGHLCVSMSSCLDDRSLCDENADCVPGEAGHYVCNCHYGYH- 1272

  Fly  3135 VDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINELSN---------------AVALDYDW 3184
            .|..:|...|:...:.:           :...|..:....:|               .|.:|:|.
 Worm  1273 GDGRSCSPESSTRSDKL-----------LVARGMAIFERSTNPDEYGKQLIVIPHHIPVGIDFDC 1326

  Fly  3185 DSQCLYWSDV------TSTV-GT-IKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGL 3241
            ..:.:.|||:      ||:: || .|.|..||          |.:|:|:||||.::|:|:.|...
 Worm  1327 KEEKIVWSDMSGHSIRTSSLNGTEHKSYFNKE----------LSSPEGIAVDWSSRNVYYADSMN 1381

  Fly  3242 DTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDW-GDSPHIGKAGMDGSNPKMIIRDG 3305
            |.|.|:.|:||::|.|:.|.|..||.:.|..|.:|:::||| .::|:||:..|||.|.::.:.:.
 Worm  1382 DEIGVASLNGKFKKSLVTEGLVNPRSVVLDLYGRHLYYSDWHRENPYIGRVDMDGKNNRVFLNED 1446

  Fly  3306 LGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIA-VWEGHIY 3369
            :..||.|||....::|.|.||....:|....:|...|.:.:       :|.:.|.:. ..|...|
 Worm  1447 VHLPNGLTILPNRRELCWVDAGNHRLSCIQYNGAGRRTVFS-------SLQYPFGLTHDEEQKFY 1504

  Fly  3370 WSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQ---------------PMS---- 3415
            |:||:...|....:: |:.                   ||..|               |.|    
 Worm  1505 WTDWKDNRIHSVGVY-GEG-------------------YRSFQISLGGSGKVFGILAVPKSCVGP 1549

  Fly  3416 GNPCLAAN--CSTLCVLSPEEPYYKCMCPTN 3444
            ..||...|  |..||:  |.:....|.||.|
 Worm  1550 STPCSEDNGGCQHLCL--PGQNGAVCECPDN 1578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:464251
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531 9/35 (26%)
NHL <2082..>2152 CDD:302697 18/88 (20%)
NHL repeat 2082..2120 CDD:271320 10/45 (22%)
FXa_inhibition 2269..2303 CDD:464251 8/40 (20%)
LY 2430..2471 CDD:214531 8/40 (20%)
LY 2475..2517 CDD:214531 5/41 (12%)
LDLa 2630..2661 CDD:238060 12/43 (28%)
LDLa 2671..2702 CDD:238060 9/37 (24%)
LDLa 2727..2759 CDD:238060 5/31 (16%)
LDLa 2773..2802 CDD:238060 9/42 (21%)
LDLa 2810..2844 CDD:238060 7/33 (21%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 6/32 (19%)
LDLa 2938..2969 CDD:197566 13/50 (26%)
LDLa 2989..3015 CDD:197566 2/25 (8%)
LDLa 3030..3061 CDD:238060 9/55 (16%)
EGF_CA 3062..>3091 CDD:214542 10/35 (29%)
EGF_CA 3103..3141 CDD:214542 11/41 (27%)
LY 3212..3254 CDD:214531 16/41 (39%)
Ldl_recept_b 3275..3314 CDD:459654 14/39 (36%)
LY 3299..3340 CDD:214531 11/40 (28%)
LY 3354..3389 CDD:214531 9/35 (26%)
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
nid-1NP_001256465.1 NIDO 93..232 CDD:214712 34/172 (20%)
EGF_3 368..396 CDD:463759 7/32 (22%)
G2F 398..629 CDD:214774 52/285 (18%)
EGF_3 712..747 CDD:463759 10/35 (29%)
EGF_3 841..870 CDD:463759 8/29 (28%)
EGF_3 952..987 CDD:463759 12/57 (21%)
EGF_3 1205..1236 CDD:463759 11/36 (31%)
EGF_3 1242..1278 CDD:463759 11/36 (31%)
NHL <1319..1513 CDD:302697 68/210 (32%)
NHL repeat 1319..1354 CDD:271320 11/34 (32%)
NHL repeat 1362..1399 CDD:271320 17/36 (47%)
NHL repeat 1402..1445 CDD:271320 16/42 (38%)
NHL repeat 1450..1482 CDD:271320 11/31 (35%)
NHL repeat 1490..1513 CDD:271320 6/22 (27%)
FXa_inhibition 1553..>1577 CDD:464251 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

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