Protein Alignment LRP1 and lin-12

DIOPT Version :10

• Sequence 1: NP_001260800.2
• Gene: LRP1 / 35799
• FlyBaseID: FBgn0053087
• Length: 4752
• Species: Drosophila melanogaster
• Sequence 2: NP_499007.1
• Gene: lin-12 / 176282
• WormBaseID: WBGene00003001
• Length: 1429
• Species: Caenorhabditis elegans
• Alignment Length: 877
• Identity: 202/877 - (23%)
• Similarity: 282/877 - (32%)
• Gaps: 347/877 - (39%)

  Fly  3813 CAKT-HCHA-------NAFKCR------NQLCVRNSALCDGINDCGENEDESDAVCAALPKCRHD 3863
            |.:. ||||       .::.||      .:.|.:.   || ::.||.:|           ||..|
 Worm    29 CGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQ---CD-VSKCGADE-----------KCVFD 78

  Fly  3864 Q-FQCENDDCISKAFRCDGQYN------CVD--GSDEMN----CQPPVCGFGSCSQICIEKKAGH 3915
            : ::.|.  |:.|  .||...|      |..  |.|:..    |.|.||..|.   .||  .||:
 Worm    79 KDYRMET--CVCK--DCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGG---QCI--GAGN 134

  Fly  3916 -YNCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFD 3979
             ..|.|.||: ||
 Worm   135 RAKCACPDGF-KG---------------------------------------------------- 146

  Fly  3980 ILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQ 4044
                                                      |....::.|.::.|:..
 Worm   147 ------------------------------------------ERCELDVNECEENKNAC------ 163

  Fly  4045 RVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLENGILVASLDGSNKKS 4109
                    .|:....:..| .||.:...|..|.| .|:|.:.    ||:|....|..|:
 Worm   164 --------GNRSTCMNTLG-TYICVCPQGFLPPD-CLKPGNT----STVEFKQPVCFLE------ 208

  Fly  4110 LVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYI 4174
                       :|.|:|.||
 Worm   209 -----------ISADHPDGR--------------------------------------------- 217

  Fly  4175 KLYDQSIIKMNKFGNDNGTYLLK---------GYRSSDIGILHPMKQNRNISNPCAKDPCKSSRA 4230
            .:|.|           ||.:..|         ||..|...:|..       .:.||.:||  |..
 Worm   218 SMYCQ-----------NGGFCDKASSKCQCPPGYHGSTCELLEK-------EDSCASNPC--SHG 262

  Fly  4231 LCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPK--CICQPQFE 4293
            :||   ..|.|:.|.|.:||   ....|:...|  :....:|..|: |.::.|..  |.|.|:..
 Worm   263 VCI---SFSGGFQCICDDGY---SGSYCQEGKD--NCVNNKCEAGS-KCINGVNSYFCDCPPERT 318

  Fly  4294 GELCEHYRCSG---YCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPAC--QSRCHN 4353
            |..||...||.   .| |:|.|..:|.     .....:|.|..|:.|..||.....|  ::.|.|
 Worm   319 GPYCEKMDCSAIPDIC-NHGTCIDSPL-----SEKAFECQCEPGYEGILCEQDKNECLSENMCLN 377

  Fly  4354 GGSCLISETEGMKCSCPKMFTGEQCEH----CRNLTCENGGICRETLTGTPQCECPDGFTGKRCE 4414
            .|:| ::.....:|.|.:.|.|:.|:.    |::..|||.|.|..|...:|.|:|.:||.|||||
 Worm   378 NGTC-VNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCE 441

  Fly  4415 IDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFC-RNGGTCSERGGRLS--CTCP 4476
            .:                       ||.|:.|..|:.......| |.||.|...|..||  |.||
 Worm   442 KE-----------------------CPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCP 483

  Fly  4477 PRYIGESCESDL--CKTSSPPHFCDNTKVPTRDPCTLMICQNAGTC-----HIIKGVALCNCTDQ 4534
            |.:.|..||.:.  .|:|...:.|      ..||     |.|..||     ||  |.| |.|...
 Worm   484 PDFTGNQCEVNRKNGKSSLSENLC------LSDP-----CMNNATCIDVDAHI--GYA-CICKQG 534

  Fly  4535 WNGDLCT--LPVTDDNPCARYCANGGVCHLDEYRLP-HCSCIGEWQGNACEMPP--HCVGGECNV 4594
            :.||:|.  ..:..:||    |:||||||  ::|.. .|.|...:.||.||...  .|:...|.
 Worm   535 FEGDICERHKDLCLENP----CSNGGVCH--QHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQ- 592

  Fly  4595 CRPGSSINECLCENNRVVPCLSDSADALKEEQ 4626
             ..|..|||  .|..|...|....:.|..||:
 Worm   593 -NGGVCINE--EEKGRKCECSYGFSGARCEEK 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:459654
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		LDLa	1191..1226	CDD:238060
		FXa_inhibition	1289..1317	CDD:464251
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:464251
		LY	1751..1789	CDD:214531
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:464251
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060
		LDLa	2887..2916	CDD:197566
		LDLa	2938..2969	CDD:197566
		LDLa	2989..3015	CDD:197566
		LDLa	3030..3061	CDD:238060
		EGF_CA	3062..>3091	CDD:214542
		EGF_CA	3103..3141	CDD:214542
		LY	3212..3254	CDD:214531
		Ldl_recept_b	3275..3314	CDD:459654
		LY	3299..3340	CDD:214531
		LY	3354..3389	CDD:214531
		LDLa	3458..3490	CDD:238060
		LDLa	3499..3533	CDD:238060
		LDLa	3582..3616	CDD:238060
		LDLa	3621..3652	CDD:197566
		LDLa	3663..3697	CDD:238060
		LDLa	3702..3736	CDD:238060
		LDLa	3776..3808	CDD:197566
		LDLa	3818..3849	CDD:197566	11/43 (26%)
		LDLa	3860..3894	CDD:238060	11/46 (24%)
		YncE	3935..4148	CDD:442618	22/212 (10%)
		LY	4108..4150	CDD:214531	5/41 (12%)
		EGF_CA	<4386..4414	CDD:238011	14/27 (52%)
		EGF_CA	4415..4450	CDD:238011	4/34 (12%)
lin-12	NP_499007.1	EGF_CA	152..189	CDD:238011	9/52 (17%)
		EGF_2	220..245	CDD:400365	8/35 (23%)
		EGF_CA	252..285	CDD:238011	13/40 (33%)
		EGF_CA	293..323	CDD:238011	8/30 (27%)
		EGF_CA	365..401	CDD:238011	9/36 (25%)
		EGF_CA	505..541	CDD:238011	15/49 (31%)
		EGF_CA	545..579	CDD:238011	14/39 (36%)
		NL	635..668	CDD:197463
		Notch	675..709	CDD:459658
		Notch	715..750	CDD:459658
		NOD	753..807	CDD:462014
		NODP	842..898	CDD:462229
		ANK repeat	1052..1091	CDD:293786
		ANKYR	1070..1295	CDD:440430
		ANK repeat	1093..1124	CDD:293786
		ANK repeat	1126..1160	CDD:293786
		ANK repeat	1162..1201	CDD:293786
		ANK repeat	1203..1238	CDD:293786
		ANK repeat	1240..1271	CDD:293786