DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and gldi-2

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_872023.2 Gene:gldi-2 / 174116 WormBaseID:WBGene00020481 Length:911 Species:Caenorhabditis elegans


Alignment Length:1003 Identity:290/1003 - (28%)
Similarity:432/1003 - (43%) Gaps:262/1003 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  2669 RQCPETH-FMCQNHRCIPKEHKCDGEQQCGDGSDE--TPLLCKCQSEDIDMHPSNNNTKEMPDMF 2730
            |:|..|: |.||:.||||...:|||:..|.:..||  .|:...|.:|:                .
 Worm    30 RKCDATNSFQCQDGRCIPMSWRCDGDIDCQNEEDEKNCPISEVCGAEE----------------H 78

  Fly  2731 RCGS----------GECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHC----GNSTICI 2781
            :||.          .:|||.|::||...||.|.|||..|..:.|::...   .|    |:.::||
 Worm    79 KCGEVKSARSSLERFKCIPNKWVCDGEFDCEDKSDEFQCKNVSCQEKQF---QCEELSGDYSLCI 140

  Fly  2782 MPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEI---- 2842
            ...|.|||..||.:|.||.:|.:.|| .|....|:|::||||..:|.||||:||.|||||:    
 Worm   141 PETWVCDGQRDCTNGKDEQNCTSKTS-KCPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDELLTAP 204

  Fly  2843 -NC-RT--ECRHNQ-FACDK-TCIPASWQCDGKSDCEDGSDEGPQCP--NRPCR-PHLFQCKSSG 2898
             || ||  :|...: :.|.. .|||:.|:||.:.||:|.||| ..|.  ...|: ...|.||:|.
 Worm   205 SNCNRTVNQCPPGEMWKCGSGECIPSRWRCDAEVDCKDHSDE-KNCTAIQHTCKLAEEFACKASH 268

  Fly  2899 RCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDC 2963
            .||.:.:|||||.||     .:||:::           ||......|.|           |:..|
 Worm   269 NCINKAFVCDGELDC-----SDGSDED-----------DCADVRTECKS-----------GERTC 306

  Fly  2964 P------GGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAH 3022
            |      |.:..:..|:||                       :..|:|:.||.||.||       
 Worm   307 PASYGAYGAESGHVVCIPA-----------------------SSWCNGEEDCPDGGDE------- 341

  Fly  3023 TRGCNGTDDFRCKNGA----------CIHADLLC-DRRNDCADFSDEELCNVNECLIPDICEHEC 3076
             :.||.|....|:.|.          ||....|| ..:.||.| .:..:|:..:  |.::|:...
 Worm   342 -KECNMTAPVTCQKGTEYECPSTPLQCIEMSKLCASAQFDCGD-GNMSVCSQKK--IIEMCKPSS 402

  Fly  3077 EDKVV-------GYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYAL 3134
            |..|.       ...|||:.|||:   ....|.||:||:....|.|.|:|..|||:|.|..||.:
 Worm   403 EGCVCRPSFVRGNNVCHCKDGYKL---ENGQCIDINECEIAGVCDQICLNIPGSYRCACHAGYQI 464

  Fly  3135 VDHHT----------CKATSNVSMELIFSNRYYIRQVDMTGNGSILINEL--------SNAVALD 3181
            ....|          |:|.....:.|: :||:.|||.|       |:|::        .:|||:|
 Worm   465 SFGDTKIGSGRIANKCRAMGGDPLVLL-TNRHTIRQFD-------LVNKMHFPVSSSPGSAVAMD 521

  Fly  3182 YDWDSQCLYWSDVTS------TVGTIKR------YCPKENKTQTLHQAMLKNPDGLAVDWVAKNL 3234
            :...:..|.||||.|      ::|.:..      .|.|:::. .|....:..|||||||||...|
 Worm   522 FHILNGTLIWSDVLSKQILKCSIGNVSNAFLGTDMCDKKHEI-VLTGDKIHTPDGLAVDWVHDLL 585

  Fly  3235 YWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPK 3299
            :|.|.|||.|.|..:....::||.:..|.|||.||:.|....|||:|||....|.::||||.:..
 Worm   586 FWTDGGLDQINVLDMKNGKQRVLYSSDLEEPRAIAVDPEVGLIFWTDWGKKARIERSGMDGQHRT 650

  Fly  3300 MIIR-DGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLH----HIF 3359
            :|:. |.:.|||.|.:.:..::::|.||:..:|...|..|        ::|..:|:.|    |.|
 Worm   651 VIVEGDRVVWPNGLALDYVDKRVYWADAKIKSIFSCDYWG--------KNIKTVLHSHQYLRHPF 707

  Fly  3360 AIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANC 3424
            ::||:|..::::|||...:...:.|.|.:..|::..:..||.:|::|  :|.||:..|.|..:.|
 Worm   708 SMAVFEDRLFYTDWEHDGVITVNKFTGADIRTVMDQVKSPMTVRIYH--KQAQPLMQNKCENSEC 770

  Fly  3425 STLCVLSPEEPY---------------YKCMCP-----------------------TNFILADDG 3451
            ..||:  |...|               :.|.|.                       |.|:|    
 Worm   771 DHLCL--PRAVYREKERVHEKTWHDRPFSCACEGTTASDVLECFADLETKSGISMFTIFLL---- 829

  Fly  3452 RTCRANCTAAHFECV------NTYKCI----PFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQC 3506
             .|.....||.|..|      .|:..:    |.|.|  |.::.....::|...|  ..||...:.
 Worm   830 -LCVGGVVAAGFVIVRRKMGPRTFTALNFDNPIYRR--TTEEADHQMEDPFRDP--FAEPRNGRG 889

  Fly  3507 ANKKCTHPSNLCDGINQCGDGSDELNCD 3534
            .|          ||:.......:|...|
 Worm   890 RN----------DGLPTLASADNETRAD 907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:464251
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060 13/31 (42%)
LDLa 2727..2759 CDD:238060 14/41 (34%)
LDLa 2773..2802 CDD:238060 13/32 (41%)
LDLa 2810..2844 CDD:238060 19/38 (50%)
LDLa 2848..2878 CDD:238060 12/31 (39%)
LDLa 2887..2916 CDD:197566 14/29 (48%)
LDLa 2938..2969 CDD:197566 7/36 (19%)
LDLa 2989..3015 CDD:197566 6/25 (24%)
LDLa 3030..3061 CDD:238060 9/41 (22%)
EGF_CA 3062..>3091 CDD:214542 7/35 (20%)
EGF_CA 3103..3141 CDD:214542 16/47 (34%)
LY 3212..3254 CDD:214531 18/41 (44%)
Ldl_recept_b 3275..3314 CDD:459654 17/39 (44%)
LY 3299..3340 CDD:214531 12/41 (29%)
LY 3354..3389 CDD:214531 11/38 (29%)
LDLa 3458..3490 CDD:238060 9/41 (22%)
LDLa 3499..3533 CDD:238060 6/33 (18%)
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
gldi-2NP_872023.2 LDLa 36..67 CDD:238060 13/30 (43%)
LDLa 73..117 CDD:238060 16/59 (27%)
LDLa 122..161 CDD:238060 14/41 (34%)
LDLa 167..199 CDD:197566 17/31 (55%)
LDLa 214..249 CDD:238060 14/35 (40%)
LDLa 261..292 CDD:238060 15/46 (33%)
LDLa <322..344 CDD:238060 11/52 (21%)
EGF_CA 433..463 CDD:214542 14/29 (48%)
LY 564..606 CDD:214531 18/41 (44%)
LY 606..649 CDD:214531 20/42 (48%)
LY 649..692 CDD:214531 12/50 (24%)
LY 696..736 CDD:214531 12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

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