Protein Alignment LRP1 and F14B4.1

DIOPT Version :10

• Sequence 1: NP_001260800.2
• Gene: LRP1 / 35799
• FlyBaseID: FBgn0053087
• Length: 4752
• Species: Drosophila melanogaster
• Sequence 2: NP_492474.2
• Gene: F14B4.1 / 172750
• WormBaseID: WBGene00008779
• Length: 722
• Species: Caenorhabditis elegans
• Alignment Length: 628
• Identity: 188/628 - (29%)
• Similarity: 290/628 - (46%)
• Gaps: 78/628 - (12%)

  Fly  2944 LCTSGL---CIDSHYVCDGDEDCPGGDDEYEG-CVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCD 3004
            :||.|:   |..|.        .|..:..||. |.|.|       .::|.:.|  .|:.:.:...
 Worm   113 MCTQGVRPDCRQSR--------APNIEFMYETICEPKF-------AAIMKEEQ--ACLLEVENDK 160

  Fly  3005 GKPDC-----GDGSDETSSLCAHTRGCNGTDDFRCKNGACIHA--DLLCDR-RNDCADF------ 3055
            ...:|     ....|||....:     |.|.::.|   ..|.|  |.|.:| ...|.|.
 Worm   161 NVKECFVNKTNTLRDETPDTVS-----NPTQNYEC---TVIQAYVDCLIEREETSCRDAEKIEIS 217

  Fly  3056 --------SDEELCNVNECLIPDICE----HECEDKVVGYQCHCR-PGYKVLPKSPHLCTDIDEC 3107
                    :.|..|.:|...|....:    .||:.:   ..|.|| ||| ....:...|.|:|||
 Worm   218 FLSMLAKRNSESRCELNTNAIKSRPKAQPLEECDTQ---GNCKCRLPGY-YYEAARKKCLDVDEC 278

  Fly  3108 DE-QQPCSQTCINTYGSYKCLC-AKGYAL-VDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSI 3169
            :. ...|||.|:|..|:::|.| .:.|.| .|:.||:......|.|.|::...:..:...|....
 Worm   279 ESLSSACSQKCVNLPGTFECTCDPRTYKLATDNKTCERIDQSPMWLFFAHGQSVWNISTDGKSFQ 343

  Fly  3170 LINE-LSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKN 3233
            |... |.....:|.|.....||::|:.:.|  |:|...:....|.:.:..:...:|:||||:.:|
 Worm   344 LQRAGLQKTAMIDIDVKENRLYYADIGANV--IERMNIEGTFPQAVQRFDVDGLEGIAVDWIGRN 406

  Fly  3234 LYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNP 3298
            ||...:  :.|.|..|||::|:.|....:..||.|.|||.:..:|.:||..:..|..|.||||:.
 Worm   407 LYSLRR--EDILVQSLDGRFRQPLYKNVMTLPRSITLHPAKGIMFVTDWSANAFIAAASMDGSHF 469

  Fly  3299 KMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAV 3363
            :.||.:.:.||||:.:....::::|.||..|||..:::||...|:::|.:    .::.|:|.:|:
 Worm   470 RKIITERITWPNAVAVDIFAEKIYWADAFLDTIESANMDGTGRRVIIADA----GSVPHVFGLAI 530

  Fly  3364 WEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLC 3428
            .:.::||:||..:.|...:..||:|.|.|..|...|..|:|||  :..||...:.|....|..||
 Worm   531 ADDYLYWTDWTYRGILRANKHNGENITVLAQTALLPYSLKVFH--KSLQPEETSTCETRGCDQLC 593

  Fly  3429 VLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNT-YKCIPFYWRCDTQDDCGDGSDEPE 3492
            :|. |.....|.|...|.|.:||:.|.:||:.:..||... .|||...:.||....|.:.:|| |
 Worm   594 LLG-ENGAATCACGEGFDLLNDGKKCSSNCSESQIECGGADPKCISKIYLCDGLAQCSNQADE-E 656

  Fly  3493 TCPPFHCEPGQYQC-ANKKCTHPSNLCDGINQCGDGSDELNCD 3534
            .|||..|.|||:|| .|.||..|..|||.:..|.|.|||:.|:
 Worm   657 KCPPRICLPGQFQCHDNHKCLPPGGLCDKVTDCSDSSDEIYCE 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:459654
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		LDLa	1191..1226	CDD:238060
		FXa_inhibition	1289..1317	CDD:464251
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:464251
		LY	1751..1789	CDD:214531
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:464251
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060
		LDLa	2887..2916	CDD:197566
		LDLa	2938..2969	CDD:197566	6/27 (22%)
		LDLa	2989..3015	CDD:197566	3/30 (10%)
		LDLa	3030..3061	CDD:238060	9/47 (19%)
		EGF_CA	3062..>3091	CDD:214542	8/33 (24%)
		EGF_CA	3103..3141	CDD:214542	16/40 (40%)
		LY	3212..3254	CDD:214531	14/41 (34%)
		Ldl_recept_b	3275..3314	CDD:459654	15/38 (39%)
		LY	3299..3340	CDD:214531	14/40 (35%)
		LY	3354..3389	CDD:214531	10/34 (29%)
		LDLa	3458..3490	CDD:238060	9/32 (28%)
		LDLa	3499..3533	CDD:238060	18/34 (53%)
		LDLa	3582..3616	CDD:238060
		LDLa	3621..3652	CDD:197566
		LDLa	3663..3697	CDD:238060
		LDLa	3702..3736	CDD:238060
		LDLa	3776..3808	CDD:197566
		LDLa	3818..3849	CDD:197566
		LDLa	3860..3894	CDD:238060
		YncE	3935..4148	CDD:442618
		LY	4108..4150	CDD:214531
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
F14B4.1	NP_492474.2	vWFA	<272..313	CDD:469594	16/40 (40%)
		LY	343..383	CDD:214531	10/41 (24%)
		LY	391..425	CDD:214531	13/35 (37%)
		Ldl_recept_b	448..487	CDD:459654	15/38 (39%)
		LY	470..512	CDD:214531	14/41 (34%)
		LY	513..549	CDD:214531	10/39 (26%)
		FXa_inhibition	588..618	CDD:464251	11/30 (37%)
		LDLa	622..658	CDD:238060	12/36 (33%)
		LDLa	663..698	CDD:238060	18/34 (53%)