Sequence 1: | NP_001260800.2 | Gene: | LRP1 / 35799 | FlyBaseID: | FBgn0053087 | Length: | 4752 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_491270.2 | Gene: | lrp-2 / 171981 | WormBaseID: | WBGene00003072 | Length: | 4858 | Species: | Caenorhabditis elegans |
Alignment Length: | 5372 | Identity: | 1506/5372 - (28%) |
---|---|---|---|
Similarity: | 2284/5372 - (42%) | Gaps: | 1170/5372 - (21%) |
- Green bases have known domain annotations that are detailed below.
Fly 11 LLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKSRNRIKPTVFIR 75
Fly 76 PNAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKADCPDMSDEGSECAPKCNEGQFRCGVSRHCI 140
Fly 141 PNNWLCDGEFDCGKGDISDELNCPNGD------TPK-------CRAFEGQC-RNGDCLELSRFCD 191
Fly 192 GRWDC---DNDELQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSE- 252
Fly 253 --PGTCDQVCR-NTPGSYECSCVS-GYAKTKGNRCRAINVPPTEPTTLI------FLSRDGVQSV 307
Fly 308 GTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWP----E 368
Fly 369 LQMRCQRV---DDARVNWTLPF--SSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTN---A 425
Fly 426 MTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRTVLVTD-------------- 476
Fly 477 --QVYHPS-------SVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAV 532
Fly 533 EVFENSIYLAAWMDTAIVALDKFSLKTHILQSNVSRGANLRIFH----RQKQP-------EVAHP 586
Fly 587 CRDNNAG------------CNQICVPQWTKGFASAKCMCTAGYKLHNQTTCLLS---ALDKFLVY 636
Fly 637 SDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVF--------YVVA 693
Fly 694 DSGASPFGNGEPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHKK--MQVAPLRN 756
Fly 757 LS--KVLTFNTDCDAMSLELDPTTGLLYWSQW-----ESQSCEAGIYSSWMDGTHKELLAKGTSS 814
Fly 815 MPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFK-SDQF-HPYSIVQNNGLIYWAD 877
Fly 878 NKNSTILRFHAHQANLSSTFSSTVH--LQRTGRAADLRIFDIASQPLPQTPSACAQSK--CPGMC 938
Fly 939 L-NTPKGAI------CRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSG---YMCRSTRQCLDTKDM 993
Fly 994 CDGFEDCEDGIDESSDPKGPC-------NVNTCDKT----HNFVCNGR--CYQ------------ 1033
Fly 1034 -------------------RSLLCSTIPYCSDGTDQANC-HQNTCNSNEFTCHKSGRCIQLTWVN 1078
Fly 1079 DGVVDCGPDDDSDETSETIFASKC---PEFDCNNGR--CRQFADVCDGIDNCGNNADEME--CE- 1135
Fly 1136 ---QECEHGEKY-CRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEF 1196
Fly 1197 ACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVI-CEHPDRLC-GFSKQCVTVD 1259
Fly 1260 QLCDGKNDCEDTTDEGFLC------ADKLCDRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCS 1318
Fly 1319 MQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTL 1383
Fly 1384 NVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLA 1448
Fly 1449 VDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIER 1513
Fly 1514 ASMSGDGRRMISTSWQLS----AGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNK 1574
Fly 1575 EILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWD-RNP 1638
Fly 1639 CGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHT 1703
Fly 1704 IPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIE-------PIINTNIEKPYG 1761
Fly 1762 FAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMS 1826
Fly 1827 QLEQSNLDGSSRSLIYQ-HENNLQSLTMD--FDSQRLYYAYDNSG-------------------- 1868
Fly 1869 --------------------------IAYYDIPRNE-TRKVLVASPITSISSLTV--YNGTLYFP 1904
Fly 1905 ENIQSVIMQCEKEACSNMSYLR----VNTKSIQ-----------SMKMFYADAQ-TGSNT---CA 1950
Fly 1951 EWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSID--VLQGVEMIDPSEQ 2013
Fly 2014 FDTPSPALVPISRVSS-----------------ASFIDYLANTDTLYWGDNELGSISRVKRDGTQ 2061
Fly 2062 RETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNI--------IEVARLDGSHRYVVVSN 2118
Fly 2119 LEK-PTALAVDPLQGLLFYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCER 2182
Fly 2183 YPDALMKVDYDGNLREQLLNESLN----------NPVALAKMGDYLYWAENKYN------EGIIR 2231
Fly 2232 VAPLANLSQSKVVLQTEQD-AIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTS------AVC 2289
Fly 2290 ACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWP-VQMISNTSLMRNVIAITYNYE 2353
Fly 2354 EQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLS 2418
Fly 2419 EHADQN----QVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIK 2479
Fly 2480 TDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHST--PK-HAFAMAVYGDLLFWT 2541
Fly 2542 DWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQA 2606
Fly 2607 TCHCT-QGVLAPDGRRCIAPVN-TSCGLSQYNC-HSGECIPLELTCDNVTHCADGSDEFRSYCIF 2668
Fly 2669 RQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCG 2733
Fly 2734 SGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEK-ND--MT-FVHCGNSTICIMPRWRCDGDPDCP 2794
Fly 2795 DGTDELDC-----ANHTSL----SCD-PGQFRC-ASGNCIAGSWHCDGEKDCPDGSDEINC-RTE 2847
Fly 2848 CRHNQFACD--KTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSG----------RC 2900
Fly 2901 IPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVA-HIPDCPPPAHLCTSGLCID----SHYVCDGD 2960
Fly 2961 EDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHT-- 3023
Fly 3024 --RGCNGTDDFRCKNG--ACIHADLLCDRRNDCADFSDEELCNV--------NECLIPDICEHEC 3076
Fly 3077 EDKVVGYQ-CHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYG-SYKCLCAKGYALVDHH- 3138
Fly 3139 TCKATSNVSME--LIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVT--STVG 3199
Fly 3200 TIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLI-NEYLR 3263
Fly 3264 EPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRD-GLGWPNALTISFETQQLFWGDAR 3327
Fly 3328 EDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTL 3392
Fly 3393 I-TTIHRPMDLRVFHPYRQQQ---PMSGNPC-LAANCSTLCV------LSPEEPYYKCMCPTNFI 3446
Fly 3447 LADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDE----PETCPPFHCEPGQYQCA 3507
Fly 3508 NKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATA-NSSAFCVDNVKRCDGVKDCPGG 3571
Fly 3572 EDE--SACTPLVCKKDQFQCGN-NRCMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSG-- 3631
Fly 3632 --RCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDE 3694
Fly 3695 LNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDE-----INCNITCKENQFKCAAFNTCI 3754
Fly 3755 NKQYKCDGDDDCPDGSDEVNC---TCH------------------SDHFSCGNG------KCIM- 3791
Fly 3792 --SRWK-CDGWDDCLDGSDESLETCA--KTHCHANAFKCRNQLCVR-NSALCDGINDCGENEDES 3850
Fly 3851 DAVCAALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQICIEKKAGH 3915
Fly 3916 YNCKCADGY--HKGPE-------KNATCLASGPDQILLLASEQE----FRFILPAKQE---GTTV 3964
Fly 3965 VGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIP 4029
Fly 4030 ELDDPKSLAVDWISQRVYIID-SRHNQILATDIEGKKYIS----------LVSTGMNPTDIVLEP 4083
Fly 4084 ESRIMIWSTLE--NGILVASLDG-----------SNKKSLVERDVGWPISLSMDYPTGRLYWADY 4135
Fly 4136 RKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYLLKGYR 4200
Fly 4201 SS---DIGILHPMKQN----RNISNPCAKDPCKSSRALCILSSESSVGY---SCKCAEG-YVMTD 4254
Fly 4255 DGVCKAHADIPDYCPLQC------NLGTCKIVDHVPK--CICQPQFEGELCEHYRCSGYCQNYGV 4311
Fly 4312 CSV------------------------------------APALPGSQEPPPLK----CTCTAGWS 4336
Fly 4337 GARCETSMPA--CQSRCHNGGSCLISETEG---MKCSCPKMFTGEQCEHCRNLTCENGGIC--RE 4394
Fly 4395 TLTGTPQCECPDGFTGKRCEIDECAD--------------------------------------- 4420
Fly 4421 ----FCKNGGSCVISTKGQRQCKCPSGYFGEHCE-SNSCRDFCRNGGTCS-ERGGRLSCTCPPRY 4479
Fly 4480 IGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQ-------------NAGTCHIIK----GVA 4527
Fly 4528 L------------CNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNA 4580
Fly 4581 CEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVL--VLA 4643
Fly 4644 VILLVFALFAG-----AVYFLKKHRIAQ-------PFSH-ARLTD--NVEIMLTNAMYRGDADEA 4693
Fly 4694 PTFASEDDKGNFANPVYESMYADAIPEPVSTEITHSTAPDER 4735 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRP1 | NP_001260800.2 | LDLa | 87..118 | CDD:197566 | 9/30 (30%) |
LDLa | 126..163 | CDD:238060 | 12/36 (33%) | ||
EGF_CA | 246..283 | CDD:214542 | 11/41 (27%) | ||
Ldl_recept_b | 449..487 | CDD:278487 | 10/60 (17%) | ||
LY | 472..513 | CDD:214531 | 13/63 (21%) | ||
LY | 817..852 | CDD:214531 | 12/34 (35%) | ||
LDLa | 1057..1092 | CDD:197566 | 12/34 (35%) | ||
LDLa | 1104..1134 | CDD:238060 | 11/33 (33%) | ||
FXa_inhibition | 1289..1317 | CDD:291342 | 17/27 (63%) | ||
LY | 1434..1476 | CDD:214531 | 18/41 (44%) | ||
LY | 1477..1521 | CDD:214531 | 22/43 (51%) | ||
LY | 1533..1567 | CDD:214531 | 22/33 (67%) | ||
LY | 1568..1611 | CDD:214531 | 19/42 (45%) | ||
FXa_inhibition | 1639..1676 | CDD:291342 | 8/36 (22%) | ||
LY | 1794..1838 | CDD:214531 | 13/43 (30%) | ||
LY | 2078..2112 | CDD:214531 | 8/41 (20%) | ||
NHL | <2082..>2152 | CDD:302697 | 21/78 (27%) | ||
NHL repeat | 2082..2120 | CDD:271320 | 10/45 (22%) | ||
FXa_inhibition | 2269..2303 | CDD:291342 | 12/39 (31%) | ||
LY | 2430..2471 | CDD:214531 | 15/40 (38%) | ||
LY | 2475..2517 | CDD:214531 | 16/41 (39%) | ||
LDLa | 2630..2661 | CDD:238060 | 11/31 (35%) | ||
LDLa | 2671..2702 | CDD:238060 | 9/30 (30%) | ||
LDLa | 2727..2759 | CDD:238060 | 16/31 (52%) | ||
LDLa | 2773..2802 | CDD:238060 | 14/28 (50%) | ||
LDLa | 2810..2844 | CDD:238060 | 18/35 (51%) | ||
LDLa | 2848..2878 | CDD:238060 | 14/31 (45%) | ||
LDLa | 2887..2916 | CDD:197566 | 13/38 (34%) | ||
LDLa | 2938..2969 | CDD:197566 | 8/34 (24%) | ||
LDLa | 2989..3015 | CDD:197566 | 11/25 (44%) | ||
LDLa | 3030..3061 | CDD:238060 | 11/32 (34%) | ||
EGF_CA | 3062..>3091 | CDD:214542 | 7/37 (19%) | ||
EGF_CA | 3103..3141 | CDD:214542 | 11/39 (28%) | ||
LY | 3212..3254 | CDD:214531 | 14/41 (34%) | ||
LY | 3255..3297 | CDD:214531 | 20/42 (48%) | ||
LY | 3299..3340 | CDD:214531 | 16/41 (39%) | ||
LY | 3354..3389 | CDD:214531 | 15/34 (44%) | ||
LDLa | 3458..3490 | CDD:238060 | 19/31 (61%) | ||
LDLa | 3499..3533 | CDD:238060 | 3/33 (9%) | ||
LDLa | 3582..3616 | CDD:238060 | 16/34 (47%) | ||
LDLa | 3621..3652 | CDD:197566 | 14/34 (41%) | ||
LDLa | 3663..3697 | CDD:238060 | 17/33 (52%) | ||
LDLa | 3702..3736 | CDD:238060 | 11/38 (29%) | ||
LDLa | 3776..3808 | CDD:197566 | 15/59 (25%) | ||
LDLa | 3818..3849 | CDD:197566 | 10/31 (32%) | ||
LDLa | 3860..3894 | CDD:238060 | 14/33 (42%) | ||
NHL | 4029..>4158 | CDD:302697 | 43/152 (28%) | ||
NHL repeat | 4034..4074 | CDD:271320 | 8/50 (16%) | ||
NHL repeat | 4076..4115 | CDD:271320 | 15/51 (29%) | ||
LY | 4108..4150 | CDD:214531 | 19/41 (46%) | ||
NHL repeat | 4121..4158 | CDD:271320 | 17/36 (47%) | ||
EGF_CA | <4386..4414 | CDD:238011 | 13/29 (45%) | ||
EGF_CA | 4415..4450 | CDD:238011 | 11/77 (14%) | ||
lrp-2 | NP_491270.2 | LDLa | 80..119 | CDD:197566 | 16/47 (34%) |
LDLa | 130..162 | CDD:197566 | 11/31 (35%) | ||
LY | 668..702 | CDD:214531 | 9/33 (27%) | ||
LY | 707..758 | CDD:214531 | 10/50 (20%) | ||
LY | 759..801 | CDD:214531 | 14/45 (31%) | ||
LDLa | 968..1000 | CDD:197566 | 9/31 (29%) | ||
LDLa | 1013..1047 | CDD:238060 | 5/33 (15%) | ||
LDLa | 1053..1087 | CDD:238060 | 12/34 (35%) | ||
LDLa | 1098..1129 | CDD:238060 | 11/30 (37%) | ||
LDLa | 1144..1175 | CDD:238060 | 10/30 (33%) | ||
LDLa | 1182..1216 | CDD:238060 | 11/33 (33%) | ||
FXa_inhibition | 1276..1305 | CDD:291342 | 17/28 (61%) | ||
LY | 1421..1463 | CDD:214531 | 18/41 (44%) | ||
LY | 1465..1508 | CDD:214531 | 22/42 (52%) | ||
LY | 1521..1555 | CDD:214531 | 22/33 (67%) | ||
LY | 2480..2521 | CDD:214531 | 16/40 (40%) | ||
LDLa | 2681..2715 | CDD:238060 | 11/35 (31%) | ||
LDLa | 2717..2751 | CDD:238060 | 17/49 (35%) | ||
LDLa | <2774..2798 | CDD:238060 | 13/23 (57%) | ||
LDLa | 2819..2851 | CDD:238060 | 16/31 (52%) | ||
LDLa | 2856..2891 | CDD:238060 | 16/35 (46%) | ||
LDLa | 2904..2938 | CDD:238060 | 12/33 (36%) | ||
LDLa | 2988..3020 | CDD:197566 | 13/33 (39%) | ||
LY | 3231..3270 | CDD:214531 | 13/38 (34%) | ||
Ldl_recept_b | 3296..3336 | CDD:278487 | 21/39 (54%) | ||
LY | 3319..3362 | CDD:214531 | 16/42 (38%) | ||
LY | 3363..3404 | CDD:214531 | 18/46 (39%) | ||
LDLa | 3481..3514 | CDD:197566 | 19/32 (59%) | ||
LDLa | 3574..3609 | CDD:238060 | 16/34 (47%) | ||
LDLa | 3614..3649 | CDD:197566 | 14/34 (41%) | ||
LDLa | 3659..3693 | CDD:238060 | 17/33 (52%) | ||
LDLa | 3881..3912 | CDD:238060 | 14/30 (47%) | ||
LY | 4084..4125 | CDD:214531 | 10/40 (25%) | ||
LY | 4139..4181 | CDD:214531 | 19/41 (46%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 169 | 1.000 | Domainoid score | I2297 |
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 1775 | 1.000 | Inparanoid score | I25 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 1 | 1.010 | - | - | QHG46025 | |
OrthoDB | 1 | 1.010 | - | - | D1326at33208 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0002316 | |
OrthoInspector | 1 | 1.000 | - | - | oto18695 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_100345 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X1742 | |
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
10 | 9.880 |