DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and Lrp6

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_032540.2 Gene:Lrp6 / 16974 MGIID:1298218 Length:1613 Species:Mus musculus


Alignment Length:1746 Identity:512/1746 - (29%)
Similarity:783/1746 - (44%) Gaps:310/1746 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1365 PYVIFTNRQDIK------GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRG 1423
            |.:::.||:|::      |....|:.||    .|.:..|:||::.:..   |||:||.::.|.|.
Mouse    21 PLLLYANRRDLRLVDATNGKENATIVVG----GLEDAAAVDFVFGHGL---IYWSDVSEEAIKRT 78

  Fly  1424 HLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPR 1488
            ..  ....:|:.|:.|||.:.:|||.||:|:.|||.||..::|||:.|:||.|:.|....::.||
Mouse    79 EF--NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPR 141

  Fly  1489 AIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAK 1553
            ||||||..|.::||||.: .|:||||.|.|..|.:|..:   ...|||||||||.::::||.|||
Mouse   142 AIALDPSSGFMYWTDWGE-VPKIERAGMDGSSRFVIINT---EIYWPNGLTLDYQERKLYWADAK 202

  Fly  1554 SDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQ 1618
            .:.|..:..||:....|::..  |.||||:::||:.:|||||.|.|::..||:.|..::.:....
Mouse   203 LNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNI 265

  Fly  1619 SQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSG-RGTFKCECPHVMRLDPANERNCVPN-EQ 1681
            ..|..|......|||...||||.:|||||||||:|. :..::|.||..::| ..|.:.|... .:
Mouse   266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKL-LENGKTCKDGATE 329

  Fly  1682 VLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNG 1746
            :||.....::|.|.|..|:...|  :.|...:.....||:...|..|:|:|.:...|..:.|...
Mouse   330 LLLLARRTDLRRISLDTPDFTDI--VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS 392

  Fly  1747 LIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDP 1809
            ..:.::...|..|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|||....:|||||
Mouse   393 GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRKILISEDLEEPRAIVLDP 455

  Fly  1810 ANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA------- 1863
            ..|.|||    :| |.:.::|::.||||.|.::.  ..:|   ..|.:|:|...:|:.       
Mouse   456 MVGYMYW----TDWGEIPKIERAALDGSDRVVLV--NTSLGWPNGLALDYDEGTIYWGDAKTDKI 514

  Fly  1864 ----YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSY 1924
                .|.:|           |:|||...|..|...|:....:|:.:..:..|.:..|.: :....
Mouse   515 EVMNTDGTG-----------RRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREV 567

  Fly  1925 LRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCV 1989
            :......:..:|........|||.|||  ..|||..|||.... ...|.|.:|:::..:..|..|
Mouse   568 IIDQLPDLMGLKATSVHRIIGSNPCAE--DNGGCSHLCLYRPQ-GLRCACPIGFELISDMKTCIV 629

  Fly  1990 PRAEFIFYSIDVLQGVEMIDPSEQFDTPSPAL--------VPISRVSSASFIDYLANTDTLYWGD 2046
            |.|..:|              |.:.|....:|        :|::.|..||.:|:....:.:||.|
Mouse   630 PEAFLLF--------------SRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTD 680

  Fly  2047 NELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSH 2111
            ..|.:|||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.|||::|||.|
Mouse   681 ISLKTISRAFMNGSALEHVVE----FGL---DYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738

  Fly  2112 RYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLV-NQTRANWAVGSLVLD 2171
            |.|:| .:|:.|.|||:||.:|.:::..   :..|.|..:|||:...|| |..|||    .|.:|
Mouse   739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRAN----GLTID 799

  Fly  2172 IEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLA 2236
            ....::||.:...:.:...|..| |..:::.:.|.:|..|.:..||:||.:  ::...|..|...
Mouse   800 YAKRRLYWTDLDTNLIESSDMLG-LNREVIADDLPHPFGLTQYQDYIYWTD--WSRRSIERANKT 861

  Fly  2237 NLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSA-VCAC-AHSRLASD 2299
            : .|::.::|...|.:.|:.::....|.|.|.||.|||.|..|||...... ||.| ||..|.:|
Mouse   862 S-GQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNAD 925

  Fly  2300 GYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQL 2364
            ..:|.....|||||.:|.|..:.:    |:.....:|.....:|||.||.|:..::.:|:.|.:.
Mouse   926 NRTCSAPTTFLLFSQKSAINRMVI----DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQ 986

  Fly  2365 STINQVHFN-GTGHRVLLEQ--QQRVE----GLAYDIVNEQLFWTSNNNATIRSVELRHLSEHAD 2422
            ::|.:.|.: |.|..|:...  .|.:|    .|:.||.:..::||......|....|       |
Mouse   987 NSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRL-------D 1044

  Fly  2423 QNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNA 2487
            ...|.|  ||. .|.|:||.|.|.|..|.:|:||..|.||.|:|:.|.|...||:..:.:..|.|
Mouse  1045 GRSVGV--VLK-GEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIA 1106

  Fly  2488 LTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRAN 2552
            |.||.:..||:|||:.|.:||.::..|:||:||..|.......:.|:.:.|:|.|.....:.:.:
Mouse  1107 LALDSKLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKID 1171

  Fly  2553 KYTGTDVLFLREHVTRPMGIVAVQNTSINC---------DANQCKILNGQCEDVCILNKSGQATC 2608
             .||      ||..|:....:| |.:.|:.         ..:.|...||.|..:|::...|...|
Mouse  1172 -MTG------REGRTKVQARIA-QLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRC 1228

  Fly  2609 HCTQG-VLAPDGRRCIAPVNTSCGLSQYNCHSG--ECIPLELTCDNVTHCADGSDEFRSYCIFRQ 2670
            .|... ||..|...|..|  .:|...|:.|.:|  :|||:...||..|.|.|.|||..  |  ..
Mouse  1229 SCPMHLVLLQDELSCGEP--PTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELN--C--PV 1287

  Fly  2671 CPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE--TPLLCKCQSEDIDMHPSNNNTKEMPDMFRCG 2733
            |.|:.|.|.:.:||....:|:|:..|.|.|||  ..:||                  :.|.|||.
Mouse  1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLC------------------LIDQFRCA 1334

  Fly  2734 SGECIPRKFLCDSLKDCRDFSDEKMC----APIPCEKNDM---------TFVHCGNSTIC---IM 2782
            :|:|:.:...||...||.|.|||..|    .|.|...|.:         .||......||   :.
Mouse  1335 NGQCVGKHKKCDHSVDCSDRSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTIYFICQRMLC 1399

  Fly  2783 PRWRCDGDPDCPD------GTDELDCANH-TSLSCD-PGQFRCASGNCIAGSWHCDGEKDCPDGS 2839
            ||.:.||:....|      .:..|....| :|||.. ||..|   |..:..|....|....|   
Mouse  1400 PRMKGDGETMTNDYVVHSPASVPLGYVPHPSSLSGSLPGMSR---GKSMISSLSIMGGSSGP--- 1458

  Fly  2840 DEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCP--------------------- 2883
                          ..|:..:      .|.|.....|.:|...|                     
Mouse  1459 --------------PYDRAHV------TGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFG 1503

  Fly  2884 ---NRPC-------RPHLFQ--------CKSSGRCIPQKWVCDGEKDCPS----------GLGDE 2920
               |.|.       ||:.::        |.:.        |||.:. .||          |...:
Mouse  1504 YSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTD--------VCDSDY-APSRRMTSVATAKGYTSD 1559

  Fly  2921 GSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPA 2976
            .:.|..|       :|..|.|.          |.|:        ..::.||.|.|:
Mouse  1560 VNYDSEP-------VPPPPTPR----------SQYL--------SAEENYESCPPS 1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 21/43 (49%)
LY 1533..1567 CDD:214531 17/33 (52%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:291342 17/37 (46%)
LY 1794..1838 CDD:214531 21/45 (47%)
LY 2078..2112 CDD:214531 17/33 (52%)
NHL <2082..>2152 CDD:302697 33/73 (45%)
NHL repeat 2082..2120 CDD:271320 20/38 (53%)
FXa_inhibition 2269..2303 CDD:291342 16/35 (46%)
LY 2430..2471 CDD:214531 19/40 (48%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 13/32 (41%)
LDLa 2671..2702 CDD:238060 11/30 (37%)
LDLa 2727..2759 CDD:238060 14/31 (45%)
LDLa 2773..2802 CDD:238060 8/37 (22%)
LDLa 2810..2844 CDD:238060 7/34 (21%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 8/53 (15%)
LDLa 2938..2969 CDD:197566 4/30 (13%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp6NP_032540.2 Beta-propeller 1 20..275 102/268 (38%)
NHL 55..272 CDD:302697 92/227 (41%)
NHL repeat 55..93 CDD:271320 12/42 (29%)
LY 89..127 CDD:214531 19/37 (51%)
NHL repeat 97..132 CDD:271320 18/34 (53%)
NHL repeat 140..176 CDD:271320 21/36 (58%)
Ldl_recept_b 150..190 CDD:278487 20/43 (47%)
LY 175..216 CDD:214531 18/43 (42%)
NHL repeat 181..217 CDD:271320 17/35 (49%)
NHL repeat 226..253 CDD:271320 14/26 (54%)
LDL-receptor class B 5 236..277 12/40 (30%)
FXa_inhibition 286..323 CDD:291342 17/37 (46%)
Beta-propeller 2 328..589 70/282 (25%)
LY 353..393 CDD:214531 9/39 (23%)
LY 397..437 CDD:214531 14/41 (34%)
LY 438..481 CDD:214531 21/46 (46%)
LY 483..524 CDD:214531 7/53 (13%)
LY 525..558 CDD:214531 8/32 (25%)
FXa_inhibition 592..627 CDD:291342 12/37 (32%)
Beta-propeller 3 631..890 82/287 (29%)
LY 656..694 CDD:214531 12/37 (32%)
LY 697..739 CDD:214531 20/48 (42%)
LY 740..783 CDD:214531 15/42 (36%)
LY 783..825 CDD:214531 13/46 (28%)
LY 827..866 CDD:214531 10/41 (24%)
FXa_inhibition 893..929 CDD:291342 16/35 (46%)
Beta-propeller 4 933..1202 87/290 (30%)
LY 958..998 CDD:214531 11/39 (28%)
LY 1050..1093 CDD:214531 21/45 (47%)
LY 1094..1136 CDD:214531 16/41 (39%)
FXa_inhibition 1207..1243 CDD:291342 11/35 (31%)
LDLa 1249..1285 CDD:238060 15/37 (41%)
LDLa 1288..1322 CDD:238060 13/33 (39%)
LDLa 1326..1360 CDD:238060 15/51 (29%)
PPPSP motif A 1487..1493 0/5 (0%)
PPPSP motif B 1527..1534 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613 11/60 (18%)
PPPSP motif C 1568..1575 3/16 (19%)
PPPSP motif D 1588..1593 1/3 (33%)
PPPSP motif E 1603..1610
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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