DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and Lrp5

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_032539.2 Gene:Lrp5 / 16973 MGIID:1278315 Length:1614 Species:Mus musculus


Alignment Length:1741 Identity:516/1741 - (29%)
Similarity:760/1741 - (43%) Gaps:312/1741 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1361 APDEPYVIFTNRQDIK-----GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKI 1420
            |...|.::|.||:|::     |:.|::..|.   |.|.:..|:||.:   |...:|||||.::.|
Mouse    28 AAASPLLLFANRRDVRLVDAGGVKLESTIVA---SGLEDAAAVDFQF---SKGAVYWTDVSEEAI 86

  Fly  1421 YRGHL--VGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGN 1483
            .:.:|  .|.:.:|   ::.|||.:.:|||.|||||.|||.||..::||||.|||:.|:.|...:
Mouse    87 KQTYLNQTGAAAQN---IVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQD 148

  Fly  1484 MESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVY 1548
            ::.||||||||..|.::||||.: :||||||.|.|..|::|..|   ...||||||:|..::::|
Mouse   149 LDQPRAIALDPAHGYMYWTDWGE-APRIERAGMDGSTRKIIVDS---DIYWPNGLTIDLEEQKLY 209

  Fly  1549 WVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQV 1613
            |.|||...|.....|||....|:...  |:||||:::..:.:|||||:|.|:...|||.|...:.
Mouse   210 WADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQRKE 272

  Fly  1614 LQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTF-KCECPHVMRLDPANERNCV 1677
            :......|..||||...|||....||.|:|||||||||||.|..| .|.||..::|.. |.:.|.
Mouse   273 ILSALYSPMDIQVLSQERQPPFHTPCEEDNGGCSHLCLLSPREPFYSCACPTGVQLQD-NGKTCK 336

  Fly  1678 PN-EQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSA 1741
            .. |:|||.....::|.|.|..|:...|  :.|...:.....||:...|..::|:|.:...|..|
Mouse   337 TGAEEVLLLARRTDLRRISLDTPDFTDI--VLQVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRA 399

  Fly  1742 GISNGLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDS 1804
            .:.....:.::||.|..|.|.||||:|||:|:: :|..:..:  :.|.|....| :.|||:...:
Mouse   400 YLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTSRKILVSEDLDEPRA 462

  Fly  1805 IVLDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA-- 1863
            |||.|..|.|||    :| |...::|.:||||..|.::.  ..:|   ..|.:|....:||:.  
Mouse   463 IVLHPVMGLMYW----TDWGENPKIECANLDGRDRHVLV--NTSLGWPNGLALDLQEGKLYWGDA 521

  Fly  1864 -YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSN------ 1921
             .|...:...|   ...||.|:...:..|...|:....:|:.:..:..|.:..|...|.      
Mouse   522 KTDKIEVINID---GTKRKTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQ 583

  Fly  1922 ----MSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEP 1982
                |....||...:           .|:|.||:.  .|||..||..|..... |.|.:|.::..
Mouse   584 LPDLMGLKAVNVAKV-----------VGTNPCADG--NGGCSHLCFFTPRATK-CGCPIGLELLS 634

  Fly  1983 NNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDN 2047
            :..|..:|.|..:|.|...:..:.:...:      :...:|::.|..||.:|:..:.:.:||.|.
Mouse   635 DMKTCIIPEAFLVFTSRATIHRISLETNN------NDVAIPLTGVKEASALDFDVSNNHIYWTDV 693

  Fly  2048 ELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHR 2112
            .|.:|||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.||||||||..|
Mouse   694 SLKTISRAFMNGSSVEHVIE----FGL---DYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 751

  Fly  2113 YVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLVNQT-RANWAVGSLVLDI 2172
            .|:| .:|:.|.:||:||.:|.:::..   :..|.|..:||:....||::. |||    .|.:|.
Mouse   752 QVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRAN----DLTIDY 812

  Fly  2173 EATKVYWCERYPDALMKVDYDGNLRE---------QLLNESLNNPVALAKMGDYLYWAENKYNEG 2228
            ...::||          .|.|.|:.|         .::.:.|..|..|.:..||:||.:  :|..
Mouse   813 ADQRLYW----------TDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYWTD--WNLH 865

  Fly  2229 IIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACA- 2292
            .|..|...: .:::.::|...|.:.|:.::....|.|.|.|.||||.|.||||.......|.|| 
Mouse   866 SIERADKTS-GRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPGGHRCGCAS 929

  Fly  2293 HSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLV 2357
            |..|.....:|.|...|||||.:..|..:...|....:    ::.....:|||.||.|:..::.:
Mouse   930 HYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPD----LVLPLHGLRNVKAINYDPLDKFI 990

  Fly  2358 YYSDVQLSTINQVHFNGTGHRVL------LEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRH 2416
            |:.|.: ..|.:...:||...:|      |...::...|:.||.:..||||.....||....|  
Mouse   991 YWVDGR-QNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL-- 1052

  Fly  2417 LSEHADQNQVHVKKVLSLRED-DKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKT 2480
                 |.:.:.|    .||.| ||||.|||....|.:|:||..:.:..|:|:.|.|...||:..|
Mouse  1053 -----DGDAMGV----VLRGDRDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTT 1108

  Fly  2481 DIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVL 2545
            .:..|.||.:|....||:|.||.|.:||..:..|:||:.|..:.......:.|.|..|:|.|...
Mouse  1109 GLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWIDRQQ 1173

  Fly  2546 HAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSI-NCDANQCKILNGQCEDVCILNKSGQATCH 2609
            ..:.|..|.||.....::..||...||.||:..|: ...|:.|...||.|..:||....|...|.
Mouse  1174 QMIERVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCS 1238

  Fly  2610 C-TQGVLAPDGRRCIAPVNTSCGLSQYNCHSGE--CIPLELTCDNVTHCADGSDEFRSYCIFRQC 2671
            | ...||..:...|..|  .:|...|:.|.:||  |||....||....|||.|||       ..|
Mouse  1239 CPVHLVLLQNLLTCGEP--PTCSPDQFACTTGEIDCIPGAWRCDGFPECADQSDE-------EGC 1294

  Fly  2672 P---ETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCG 2733
            |   .:.|.|...:|:....:||||..|.|.|||......|                :|:.|||.
Mouse  1295 PVCSASQFPCARGQCVDLRLRCDGEADCQDRSDEANCDAVC----------------LPNQFRCT 1343

  Fly  2734 SGECIPRKFLCDSLKDCRDFSDEKMCA-------PIPCEKNDM---------TFVHCGNSTICIM 2782
            ||:|:..|..|||..||.|.|||.||.       .||...:.:         .||..|...:|  
Mouse  1344 SGQCVLIKQQCDSFPDCADGSDELMCEINKPPSDDIPAHSSAIGPVIGIILSLFVMGGVYFVC-- 1406

  Fly  2783 PRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTE 2847
                           ..:.|..:|..|   |.|   ....:.|:.|.......|.||        
Mouse  1407 ---------------QRVMCQRYTGAS---GPF---PHEYVGGAPHVPLNFIAPGGS-------- 1442

  Fly  2848 CRHNQF---ACDKTCIPASWQCDGK-----------------------------------SDCED 2874
             :|..|   .|.|:.:.:.....|:                                   |...|
Mouse  1443 -QHGPFPGIPCSKSVMSSMSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATD 1506

  Fly  2875 GS--------DEGPQCPNRPCRPHLFQ--------CK--------SSGRCIPQKWVCD------- 2908
            .|        ..|.....||.||::.:        |.        |:.|....|:..|       
Mouse  1507 PSLYNVDVFYSSGIPATARPYRPYVIRGMAPPTTPCSTDVCDSDYSTSRWKSSKYYLDLNSDSDP 1571

  Fly  2909 -------------GEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCT 2946
                         .|..||...|.|.|         ..|:  .|||...||
Mouse  1572 YPPPPTPHSQYLSAEDSCPPSPGTERS---------YCHL--FPPPPSPCT 1611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 23/41 (56%)
LY 1477..1521 CDD:214531 22/43 (51%)
LY 1533..1567 CDD:214531 16/33 (48%)
LY 1568..1611 CDD:214531 17/42 (40%)
FXa_inhibition 1639..1676 CDD:291342 20/37 (54%)
LY 1794..1838 CDD:214531 19/45 (42%)
LY 2078..2112 CDD:214531 19/33 (58%)
NHL <2082..>2152 CDD:302697 32/73 (44%)
NHL repeat 2082..2120 CDD:271320 21/38 (55%)
FXa_inhibition 2269..2303 CDD:291342 15/34 (44%)
LY 2430..2471 CDD:214531 17/41 (41%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 14/32 (44%)
LDLa 2671..2702 CDD:238060 12/33 (36%)
LDLa 2727..2759 CDD:238060 17/31 (55%)
LDLa 2773..2802 CDD:238060 2/28 (7%)
LDLa 2810..2844 CDD:238060 7/33 (21%)
LDLa 2848..2878 CDD:238060 8/75 (11%)
LDLa 2887..2916 CDD:197566 10/64 (16%)
LDLa 2938..2969 CDD:197566 5/9 (56%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp5NP_032539.2 Beta-propeller 1 31..287 109/270 (40%)
NHL <36..>168 CDD:302697 57/140 (41%)
NHL repeat 64..103 CDD:271320 13/44 (30%)
LY 101..141 CDD:214531 23/39 (59%)
NHL repeat 106..147 CDD:271320 23/40 (58%)
Ldl_recept_b 162..202 CDD:278487 22/43 (51%)
LY 186..228 CDD:214531 18/44 (41%)
LY 229..270 CDD:214531 17/42 (40%)
LDL-receptor class B 5 247..289 16/41 (39%)
FXa_inhibition 298..335 CDD:291342 20/37 (54%)
Beta-propeller 2 340..601 72/284 (25%)
LY 365..405 CDD:214531 8/39 (21%)
LY 407..449 CDD:214531 16/43 (37%)
LY 450..493 CDD:214531 19/46 (41%)
LY 494..536 CDD:214531 7/46 (15%)
LY 537..570 CDD:214531 6/32 (19%)
FXa_inhibition 604..639 CDD:291342 11/37 (30%)
Beta-propeller 3 643..902 79/288 (27%)
NHL 684..877 CDD:302697 67/216 (31%)
LY 709..751 CDD:214531 22/48 (46%)
NHL repeat 719..755 CDD:271320 20/35 (57%)
NHL repeat 762..801 CDD:271320 12/38 (32%)
NHL repeat 807..842 CDD:271320 8/44 (18%)
NHL repeat 846..870 CDD:271320 8/25 (32%)
FXa_inhibition 905..940 CDD:291342 15/34 (44%)
Beta-propeller 4 944..1211 85/282 (30%)
LY 969..1008 CDD:214531 10/39 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1025 4/22 (18%)
LY 1059..1102 CDD:214531 19/46 (41%)
LY 1103..1145 CDD:214531 16/41 (39%)
FXa_inhibition 1216..1252 CDD:291342 11/35 (31%)
LDLa 1258..1294 CDD:238060 16/42 (38%)
LDLa 1297..1331 CDD:238060 12/33 (36%)
LDLa 1335..1369 CDD:238060 18/49 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1474..1498 0/23 (0%)
PPPSP motif A 1499..1505 1/5 (20%)
PPPSP motif B 1537..1544 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1567..1599 6/40 (15%)
PPPSP motif C 1573..1580 0/6 (0%)
PPPSP motif D 1590..1595 1/4 (25%)
PPPSP motif E 1604..1611 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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