DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and Lrp1

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	XP_036011543.1	Gene:	Lrp1 / 16971	MGIID:	96828	Length:	4562	Species:	Mus musculus

Alignment Length:	4887	Identity:	1765/4887 - (36%)
Similarity:	2509/4887 - (51%)	Gaps:	631/4887 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 APK-CNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDELN--CPNGDTPKCRAFEGQCRNGD-C 183
            ||| |:..||.|.....||...|.||||.||..|  |||..  ||.....:|...|..|...: |
Mouse    24 APKTCSPKQFACRDQITCISKGWRCDGERDCPDG--SDEAPEICPQSKAQRCPPNEHSCLGTELC 86

  Fly   184 LELSRFCDGRWDC--DNDE-LQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCV 245
            :.:||.|:|..||  .:|| ..|.:..|.|:.:.|..:|..||.|..|||......::...| |.
Mouse    87 VPMSRLCNGIQDCMDGSDEGAHCRELRANCSRMGCQHHCVPTPSGPTCYCNSSFQLQADGKT-CK 150

  Fly   246 DYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGT 309
            |:||||..|||.|:|.||.||:.|.||.||.....|| |:|.|.|...|..|:..:...:.:...
Mouse   151 DFDECSVYGTCSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYL 215

  Fly   310 NGTEV--IGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSW------ 366
            :|.:|  |.|...:...                        |.:..:.|.|:|     |
Mouse   216 SGAQVSTITPTSTRQTT------------------------AMDFSYANETVC-----WVHVGDS 251

  Fly   367 -PELQMRCQR-------VDDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCT 423
             .:.|::|.|       ||:..:|.:|..       ....::.:|||:||:|.|.:.|..:::|.
Mouse   252 AAQTQLKCARMPGLKGFVDEHTINISLSL-------HHVEQMAIDWLTGNFYFVDDIDDRIFVCN 309

  Fly   424 NAMTYCRVI--LQQVDPLSSLDLDPTKGFMFYTDW--TPSLSRSLLDGSNRTVLVTDQVYHPSSV 484
            .....|..:  |:..:| ..:.|||..|.:|:||:  .|.:.|..:||.|||.||..::..|..:
Mouse   310 RNGDTCVTLLDLELYNP-KGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 373

  Fly   485 TLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLA------A 543
            ||||.:.||||.|.|.|.:..|||||:.|.|:.:    .:.::.::.:.||||.:|..      .
Mouse   374 TLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQ----GILIEHLYGLTVFENYLYATNSDNANT 434

  Fly   544 WMDTAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEV-AHPCRDNN----AGCNQICVPQWT 603
            ...|:::.:::|:...:.:.:.|.:|..|.|:|:::||.| :|.|.::.    .||:.||:  ..
Mouse   435 QQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL--LA 497

  Fly   604 KGFASAKCMCTAGYKLHNQ-TTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDV- 666
            ....:..|.|.:|:.|.:. .:|.....:.||||.......|.|:.:.          .:.||.
Mouse   498 NSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMG----------AKVPDEH 552

  Fly   667 MVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSV-SRLLAQGLKRVH 730
            |:|:.|:....|:|.:.....:::  ||:         .|..|..|.::|:. ..:|..|:..|.
Mouse   553 MIPIENLMNPRALDFHAETGFIYF--ADT---------TSYLIGRQKIDGTERETILKDGIHNVE 606

  Fly   731 AVAFDWINDHLYWTS---HKKMQVAPLRNLS---KVLTFNTDCDAMSLELDPTTGLLYWSQWE-- 787
            .||.||:.|:||||.   .|.:.||.|...:   |.|.........::.:||..|.:||:.||
Mouse   607 GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEED 671

  Fly   788 -SQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTG 851
             ..|....:..:||||:|:::.   .:|..:.||..|.:|.....|||.|.....||.:.|:||.
Mouse   672 PKDSRRGRLERAWMDGSHRDIF---VTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTD 733

  Fly   852 REVLFKSDQF-HPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAA--DLR 913
            |:::::..:. |.:.:..:...::|.:.::.::.|.....|..    ..||.|.|:.|..  ::|
Mouse   734 RKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVAGA----PPTVTLLRSERPPIFEIR 794

  Fly   914 IFDIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCI--PQLAPSPIRPNCT 976
            ::|...|.:...........|..:||.||....|.|.:...|:..|..|:  |...|.   |.|.
Mouse   795 MYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTCLANPSYVPP---PQCQ 856

  Fly   977 SGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCST 1040
            .|....:..:|:..:..|||..||   :|.|.:....|:.:|| .:..|.| |.||.....||..
Mouse   857 PGEFACANNRCIQERWKCDGDNDC---LDNSDEAPALCHQHTC-PSDRFKCENNRCIPNRWLCDG 917

  Fly  1041 IPYCSDGTDQAN--CHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCP 1103
            ...|.:..|::|  |...||..|:|:| .|||||.::|..|...|||  |.|||::...:.:..|
Mouse   918 DNDCGNSEDESNATCSARTCPPNQFSC-ASGRCIPISWTCDLDDDCG--DRSDESASCAYPTCFP 979

  Fly  1104 --EFDCNNGRCRQF-------ADVCDGID----------NCGNNADEMECEQECEHGEKYCRPIG 1149
              :|.||||||...       .|..||.|          :||:|:||..|...|...:..|....
Mouse   980 LTQFTCNNGRCININWRCDNEKDCGDGSDEKTCPEPADNDCGDNSDEAGCSHSCSSTQFKCNSGR 1044

  Fly  1150 CYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGI 1214
            |..|...|||.:||.|:|||.:.|.|.....|.      |.|...||.|.....|||...||||.
Mouse  1045 CIPEHWTCDGDNDCGDYSDETHANCTNQATRPP------GGCHSDEFQCRLDGLCIPLRWRCDGD 1103

  Fly  1215 SHCFDKTDEFNC---THI--NTTRFDMN---------------------------ETVICEHPDR 1247
            :.|.|.:||.:|   ||:  ...:|...                           |.:.|..|..
Mouse  1104 TDCMDSSDEKSCEGVTHVCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALACRPPSH 1168

  Fly  1248 LCGFSKQ-CVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTP-EGYICSCPDHLYL 1310
            .|..:.. |:..|:|||||:||.|.:|||.|| |:.......|||.|...| ||.:||||..:.|
Mouse  1169 PCANNTSVCLPPDKLCDGKDDCGDGSDEGELC-DQCSLNNGGCSHNCSVAPGEGIVCSCPLGMEL 1232

  Fly  1311 QPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDI 1375
            ..:...|.:|..|.....|||.|:.:.....|.|.:|:.|..|..:|:|..|.:|::||:||.:|
Mouse  1233 GSDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEI 1297

  Fly  1376 KGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGE-SLRNVEAVIHS 1439
            :.|:|...:.......|||.|||||   :.|...:|||||::||||||.|:.. :|.:.|.||..
Mouse  1298 RRIDLHKGDYSVLVPGLRNTIALDF---HLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQY 1359

  Fly  1440 GLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDW 1504
            ||:|.|||||||:..|:||::|||||||||||:|:.|.||:||::|.|||||||||:|:||||||
Mouse  1360 GLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDW 1424

  Fly  1505 DDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHV 1569
            |.:.||||.|||||.|||.|..... |.|||||||:||.:||:.|:||:||:|.|..||||.|..
Mouse  1425 DASLPRIEAASMSGAGRRTIHRETG-SGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHME 1488

  Fly  1570 VLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPW 1634
            |||..|.||||||::::...||||||||.::.:||||.|.:|.|:|||.:|||.:||.|.||||.
Mouse  1489 VLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPM 1553

  Fly  1635 DRNPCGENNGG---CSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDL 1696
            ..||| |.|||   ||||||::...|..|.|||:|:|...| ..|...::.||:....||||:||
Mouse  1554 APNPC-EANGGRGPCSHLCLINYNRTVSCACPHLMKLHKDN-TTCYEFKKFLLYARQMEIRGVDL 1616

  Fly  1697 HQPNHH-----TIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNI 1756
            ..|.::     |:|.|.....|      |:...|.|::|||::...|..|.|:...:|.:::.::
Mouse  1617 DAPYYNYIISFTVPDIDNVTVL------DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADL 1675

  Fly  1757 EKPYGFAVDWIARNMYFSSGQI-KCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSA 1820
            ...:|.||||::||::::|... |..|..:.|.|.|.:.:.:.|.....:|:.|..||:||
Mouse  1676 PNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYW---- 1736

  Fly  1821 SDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYA-----------YDNSGIAYYDI 1874
            :||  ..:..:|:|||:.:|::..:.....|.:||...:||:.           .|.|.:...|.
Mouse  1737 TDG--DNISMANMDGSNHTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDT 1799

  Fly  1875 PRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFY 1939
            .|::..|.         ::|.:....|::.:.:...:..|.|...|....||.:|..:..||::.
Mouse  1800 MRSQLGKA---------TALAIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYD 1855

  Fly  1940 ADAQ---TGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSI-D 2000
            ...|   .|:|.|:  ...|.|.||||.||.....|.|..||.:. :....|.....|:.||: :
Mouse  1856 ESIQLEHEGTNPCS--VNNGDCSQLCLPTSETTRSCMCTAGYSLR-SGQQACEGVGSFLLYSVHE 1917

  Fly  2001 VLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETI 2065
            .::|:. :||:::.|    ||||:|..|.|..||:.|..||:||.|..|.:|||.|||.|.||.:
Mouse  1918 GIRGIP-LDPNDKSD----ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDV 1977

  Fly  2066 LEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVS-NLEKPTALAVDP 2129
            :  .|.:|..:     |||:||:||||||:|...::||||||:||.||||:| .|:||.|:.|.|
Mouse  1978 V--TNGIGRVE-----GIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHP 2035

  Fly  2130 LQGLLFYVTQQH---IGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVD 2191
            .:|.||:....|   |.|..|||::..|||| ...:|..| :.:|.:..|:|||:...|.:.::|
Mouse  2036 EKGYLFWTEWGHYPRIERSRLDGTERVVLVN-VSISWPNG-ISVDYQGGKLYWCDARMDKIERID 2098

  Fly  2192 YD-GNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDA-IRD 2254
            .: |..||.:|:.:..:..:::...|::||::..:..|.|:.....|.:.| |.|:|.... ::|
Mouse  2099 LETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDS-VPLRTGIGVQLKD 2162

  Fly  2255 LKIYSKHLQRGSNPCAHSNGACEQLCLF-NGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNI 2318
            :|::::..|:|:|.||.:||.|:||||: .|....|||||..||.||.||..|..:||:|.|:.:
Mouse  2163 IKVFNRDRQKGTNVCAVANGGCQQLCLYRGGGQRACACAHGMLAEDGASCREYAGYLLYSERTIL 2227

  Fly  2319 ESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYE-------EQLVYYSDVQLSTINQVHFNGTG 2376
            :|||::|..:.|.|||...:...|:||||:.::|.       ...:::||:....|.|::.:|:|
Mouse  2228 KSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSG 2292

  Fly  2377 HRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPR 2441
            ...::|....||||||....:.|:|||...:||    .||..:.........:.|:::..||.||
Mouse  2293 RTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTI----TRHTVDQTRPGAFERETVITMSGDDHPR 2353

  Fly  2442 GIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDK 2506
            ...::.|..:::||||||..|.|.|:.|:|.....:|:.||:.||.|.:|...:|||::||.|||
Mouse  2354 AFVLDECQNLMFWTNWNELHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK 2418

  Fly  2507 IERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHV-TRPM 2570
            |||..||||:|.|:..|.|.|.|.:||||:.:||||||..||.|||||.|:|:..||..: .:||
Mouse  2419 IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPM 2483

  Fly  2571 GIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSC-GLSQ 2634
            ||:||.|.:.:|:.:.|:|.||.|:|:|:|...|...|.|..|.:..:...|.| ||:|| ...:
Mouse  2484 GIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQEDFTCRA-VNSSCRAQDE 2547

  Fly  2635 YNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDG 2699
            :.|.:||||...||||.|:||.|.|||..|||..|:|.:|...|.|.||:.....|:|...||||
Mouse  2548 FECANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDG 2612

  Fly  2700 SDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPC 2764
            |||.|    |           |.|......|||..|.||.....|:...||.|.|||..|:...|
Mouse  2613 SDEIP----C-----------NKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSTTDC 2662

  Fly  2765 EK------NDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCI 2823
            ..      ..:.|..|..:::|..|.|.|||..||.|.:||.||.......|....|.|.||.||
Mouse  2663 SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCI 2727

  Fly  2824 AGSWHCDGEKDCPDGSDEINCRTECRHNQFAC-DKTCIPASWQCDGKSDCEDGSDEGPQCPNRPC 2887
            ..||.||.|.||.:|.||.:|...|...||.| :..||...|.|||..||.|||||...|..:.|
Mouse  2728 PMSWTCDKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTC 2792

  Fly  2888 RPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCID 2952
            .|..|.|..:..|:|::|:|||:|||..| .||.      ...|..:...|.....:|.:.|||.
Mouse  2793 GPSSFSCPGTHVCVPERWLCDGDKDCTDG-ADES------VTAGCLYNSTCDDREFMCQNRLCIP 2850

  Fly  2953 SHYVCDGDEDCPGGDDEYEGC-VPAFQPHSCPGGSLMHQCQDGLCIFKNQ-TCDGKPDCGDGSDE 3015
            .|:|||.|.||..|.||...| .|...|:.       .:|.:|.|:...| .|||:.||.|.|||
Mouse  2851 KHFVCDHDRDCADGSDESPECEYPTCGPNE-------FRCANGRCLSSRQWECDGENDCHDHSDE 2908

  Fly  3016 TSS---LCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDI--CEHE 3075
            ...   ..:....||.:..|.|.:|.|:...|||:.::||.|.|||..|:|||||...:  |..:
Mouse  2909 APKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQD 2973

  Fly  3076 CEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYAL--VDHH 3138
            |||..:|::|.||||:: |......|.|:|||....||||.||||:|||||||.:|||.  .|.|
Mouse  2974 CEDLKIGFKCRCRPGFR-LKDDGRTCADLDECSTTFPCSQLCINTHGSYKCLCVEGYAPRGGDPH 3037

  Fly  3139 TCKATSNVSMELIFSNRYYIRQVDMTGNGSILINE-LSNAVALDYDWDSQCLYWSDVTSTVGTIK 3202
            :|||.::....|||:||||:|::::.|:...|:.: |:||||||:|:..|.:||:|||:....|:
Mouse  3038 SCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIR 3102

  Fly  3203 RYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRG 3267
            |.....:..|.||:..|.||||||||||..||||||||.||||||:|:|.||.||::..|||||.
Mouse  3103 RMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRA 3167

  Fly  3268 IALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTIS 3332
            :.:.....:::|:||||...||:.|||||...:|:...:.|||.||:.:.|::::|.|||||.|.
Mouse  3168 LVVDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIE 3232

  Fly  3333 VSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIH 3397
            .:.|||::..::|::.|      .||||:.::|.::||:|||||||.......|.|.|.||:|:|
Mouse  3233 FASLDGSNRHVVLSQDI------PHIFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLISTLH 3291

  Fly  3398 RPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTA 3460
            |||||.|||..||.. :..:||...|  ||.||:|||... :||.|||||.|..|||||.:||||
Mouse  3292 RPMDLHVFHALRQPD-VPNHPCKVNNGGCSNLCLLSPGGG-HKCACPTNFYLGGDGRTCVSNCTA 3354

  Fly  3461 AHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCG 3525
            :.|.|.|. |||||:|:|||:|||||.||||..||.|.|.|||:||:...||:|:.:|||.|.|.
Mouse  3355 SQFVCKND-KCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQ 3418

  Fly  3526 DGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCG 3590
            |.|||.|||...|..:..||..|..    |:..:.||:|..:|..||||..|..:.|..:||||.
Mouse  3419 DNSDEANCDIHVCLPSQFKCTNTNR----CIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCS 3479

  Fly  3591 -NNRCMPFVWVCDGDIDCPDKSDE-ANCDNVSCGPNDFQC-DSGRCIPLAWRCDDDHDCPNGEDE 3652
             ..||:|.|||||.|.||.|.||| |||..::||.::|:| |||||||..|:||.:.||.:|.||
Mouse  3480 ITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3544

  Fly  3653 P-ASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIK 3716
            | ..|  .:.||:|..|:|.|::|:||||:|||:|||||.|||.:|..|.||||||.|..|:||.
Mouse  3545 PKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIA 3607

  Fly  3717 HNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC-----T 3776
            ..::|||:..|.|.|||.:|...|..:||:|.: ..||..:::||.|.||.|||||..|     |
Mouse  3608 GRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS-GHCIPLRWRCDADADCMDGSDEEACGTGVRT 3671

  Fly  3777 CHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHAN-AFKCRN-QLCVRNSALCDG 3839
            |..|.|.|.|..|....|||||.|||.|.|||:.|.||:..|..| .|:|:| ::|:.....|||
Mouse  3672 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFICPPNRPFRCKNDRVCLWIGRQCDG 3736

  Fly  3840 INDCGENEDESDAVC----AALPKCR-HDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC----- 3894
            :::||:..||.|  |    |..|.|: ..:|.|.|..|:|.:.||:...:|.|||||.:|
Mouse  3737 VDNCGDGTDEED--CEPPTAQNPHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPK 3799

  Fly  3895 ------QPPVCG-------------------------------------FGSCSQICIEKKAGHY 3916
                  ...:||                                     ||:|||:|...|.||.
Mouse  3800 LTSCATNASMCGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHL 3864

  Fly  3917 NCKCADGYHKGPEKNATCLASGPD-QILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDI 3980
             |.||..:.|   .:.||.|.|.: |:|.:|.:.|.|.:.|..........|...:|::||..|:
Mouse  3865 -CSCARNFMK---THNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQTFQGDESVRIDAMDV 3925

  Fly  3981 LIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDL-KELTAFNIPELDDPKSLAVDWISQ 4044
            .:  |...::|.:.|.|.:....:.......|..|.||.: :.:|..||..|..|:.:|:||::.
Mouse  3926 HV--KAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAG 3988

  Fly  4045 RVYIIDSRHNQILATDIEGKKYISLVSTGM--NPTDIVLEPESRIMIWSTLEN--GILVASLDGS 4105
            .||..||..:.|....::|:...:|:| ||  .|..||::|....|.||...|  .|..|::||:
Mouse  3989 NVYWTDSGRDVIEVAQMKGENRKTLIS-GMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGT 4052

  Fly  4106 NKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNR--EKPQKIDVF 4168
            .:::||:.::.||..|::||...||||||.:...|.:.||||.| .:|.....|  ..|..||||
Mouse  4053 LRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD-PIVAADSKRGLSHPFSIDVF 4116

  Fly  4169 EDYLY-IKLYDQSIIKMNKFGNDNGTYLLKGY-RSSDIGILHPMKQNRNISNPCAKDPCKSSRAL 4231
            |||:| :...:..:.|::|||:.....|..|. .:||:.:.|..|| ..::|||.:..|:   .|
Mouse  4117 EDYIYGVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQ-PEVTNPCDRKKCE---WL 4177

  Fly  4232 CILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGEL 4296
            |:||....|   |.|..|..: |:|.|                        ||
Mouse  4178 CLLSPSGPV---CTCPNGKRL-DNGTC------------------------VP------------ 4202

  Fly  4297 CEHYRCSGYCQNYGVCSVAPALPGSQEPP--PLKCTCTAGWSGARCETSMPACQSRCHNGGSCLI 4359
                                 :|....||  |...|||.                :|.|||||.:
Mouse  4203 ---------------------VPSPTPPPDAPRPGTCTL----------------QCFNGGSCFL 4230

  Fly  4360 SETEGMKCSCPKMFTGEQCE--HCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFC 4422
            :.....||.|...:||::||  .|... |.|||.|..:.:|.|.|.||.||||.:|....||.:|
Mouse  4231 NARRQPKCRCQPRYTGDKCELDQCWEY-CHNGGTCAASPSGMPTCRCPTGFTGPKCTAQVCAGYC 4294

  Fly  4423 KNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCS-ERGGRLSCTCPPRYIGESCES 4486
            .|..:|.::...|.||:|..|:.|:.|:...|..||.|.|||. ...|...|.|...:.|..||.
Mouse  4295 SNNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSRQCRCTVYFEGPRCEV 4359

  Fly  4487 DLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIK--GVALCNCTDQWNGDLCTLPVTDDNP 4549
            :.|..                 |.      .|.|.:.|  |...|||||......|.       .
Mouse  4360 NKCSR-----------------CL------QGACVVNKQTGDVTCNCTDGRVAPSCL-------T 4394

  Fly  4550 CARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPC 4614
            |..:|:|||.|.::...:|.|.|           |||..|..|.
Mouse  4395 CIDHCSNGGSCTMNSKMMPECQC-----------PPHMTGPRCE--------------------- 4427

  Fly  4615 LSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKH-RIAQPFSHARLTD--- 4675
                 :.:..:|:|   |.:.|:::.:|.::||:  |.||.|::.|:. |.|:.|.|.|:|:
Mouse  4428 -----EQVVSQQQP---GHMASILIPLLLLLLLL--LVAGVVFWYKRRVRGAKGFQHQRMTNGAM 4482

  Fly  4676 NVEI-MLTNAMYRG----------DADEAPTFASEDDK-GNFANPVYESMYADAIPEPVSTEITH 4728
            |||| ..|..||.|          |||    ||.:.|| .||.||||.::|......      .|
Mouse  4483 NVEIGNPTYKMYEGGEPDDVGGLLDAD----FALDPDKPTNFTNPVYATLYMGGHGS------RH 4537

  Fly  4729 STA-PDERKGLL 4739
            |.| .||::.||
Mouse  4538 SLASTDEKRELL 4549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060	17/38 (45%)
		EGF_CA	246..283	CDD:214542	21/37 (57%)
		Ldl_recept_b	449..487	CDD:278487	15/39 (38%)
		LY	472..513	CDD:214531	19/40 (48%)
		LY	817..852	CDD:214531	13/34 (38%)
		LDLa	1057..1092	CDD:197566	17/34 (50%)
		LDLa	1104..1134	CDD:238060	16/46 (35%)
		FXa_inhibition	1289..1317	CDD:291342	12/28 (43%)
		LY	1434..1476	CDD:214531	28/41 (68%)
		LY	1477..1521	CDD:214531	31/43 (72%)
		LY	1533..1567	CDD:214531	22/33 (67%)
		LY	1568..1611	CDD:214531	23/42 (55%)
		FXa_inhibition	1639..1676	CDD:291342	19/39 (49%)
		LY	1794..1838	CDD:214531	13/43 (30%)
		LY	2078..2112	CDD:214531	20/33 (61%)
		NHL	<2082..>2152	CDD:302697	40/73 (55%)
		NHL repeat	2082..2120	CDD:271320	25/38 (66%)
		FXa_inhibition	2269..2303	CDD:291342	19/34 (56%)
		LY	2430..2471	CDD:214531	16/40 (40%)
		LY	2475..2517	CDD:214531	22/41 (54%)
		LDLa	2630..2661	CDD:238060	15/31 (48%)
		LDLa	2671..2702	CDD:238060	13/30 (43%)
		LDLa	2727..2759	CDD:238060	13/31 (42%)
		LDLa	2773..2802	CDD:238060	12/28 (43%)
		LDLa	2810..2844	CDD:238060	17/33 (52%)
		LDLa	2848..2878	CDD:238060	15/30 (50%)
		LDLa	2887..2916	CDD:197566	13/28 (46%)
		LDLa	2938..2969	CDD:197566	13/30 (43%)
		LDLa	2989..3015	CDD:197566	11/26 (42%)
		LDLa	3030..3061	CDD:238060	13/30 (43%)
		EGF_CA	3062..>3091	CDD:214542	14/30 (47%)
		EGF_CA	3103..3141	CDD:214542	24/39 (62%)
		LY	3212..3254	CDD:214531	30/41 (73%)
		LY	3255..3297	CDD:214531	18/41 (44%)
		LY	3299..3340	CDD:214531	17/40 (43%)
		LY	3354..3389	CDD:214531	15/34 (44%)
		LDLa	3458..3490	CDD:238060	21/31 (68%)
		LDLa	3499..3533	CDD:238060	18/33 (55%)
		LDLa	3582..3616	CDD:238060	21/35 (60%)
		LDLa	3621..3652	CDD:197566	17/31 (55%)
		LDLa	3663..3697	CDD:238060	21/33 (64%)
		LDLa	3702..3736	CDD:238060	18/33 (55%)
		LDLa	3776..3808	CDD:197566	17/31 (55%)
		LDLa	3818..3849	CDD:197566	11/32 (34%)
		LDLa	3860..3894	CDD:238060	14/34 (41%)
		NHL	4029..>4158	CDD:302697	47/132 (36%)
		NHL repeat	4034..4074	CDD:271320	12/39 (31%)
		NHL repeat	4076..4115	CDD:271320	14/40 (35%)
		LY	4108..4150	CDD:214531	18/41 (44%)
		NHL repeat	4121..4158	CDD:271320	16/36 (44%)
		EGF_CA	<4386..4414	CDD:238011	14/27 (52%)
		EGF_CA	4415..4450	CDD:238011	11/34 (32%)
Lrp1	XP_036011543.1	LDLa	27..60	CDD:197566	15/34 (44%)
		LDLa	72..105	CDD:197566	10/32 (31%)
		FXa_inhibition	120..149	CDD:405372	9/29 (31%)
		FXa_inhibition	159..189	CDD:405372	16/29 (55%)
		LY	276..315	CDD:214531	10/45 (22%)
		LY	317..359	CDD:214531	13/42 (31%)
		LY	362..402	CDD:214531	19/39 (49%)
		FXa_inhibition	487..520	CDD:405372	8/34 (24%)
		LY	552..594	CDD:214531	11/52 (21%)
		LY	595..634	CDD:214531	15/38 (39%)
		LY	641..690	CDD:214531	14/48 (29%)
		LY	<701..734	CDD:214531	13/32 (41%)
		FXa_inhibition	808..843	CDD:405372	9/34 (26%)
		LDLa	854..886	CDD:197566	10/34 (29%)
		LDLa	896..929	CDD:238060	10/33 (30%)
		LDLa	936..968	CDD:197566	17/34 (50%)
		LDLa	979..1012	CDD:238060	12/32 (38%)
		LDLa	1033..1066	CDD:238060	13/32 (41%)
		LDLa	1080..1115	CDD:238060	15/34 (44%)
		LDLa	1122..1158	CDD:238060	1/35 (3%)
		LDLa	1163..1196	CDD:238060	13/32 (41%)
		FXa_inhibition	1203..1239	CDD:405372	12/35 (34%)
		LY	1354..1394	CDD:214531	27/39 (69%)
		LY	1398..1441	CDD:214531	31/42 (74%)
		LY	1442..1486	CDD:214531	25/44 (57%)
		LY	1631..1667	CDD:214531	11/41 (27%)
		LY	1668..1711	CDD:214531	13/42 (31%)
		LY	1715..1752	CDD:214531	13/42 (31%)
		LY	1752..1793	CDD:214531	7/40 (18%)
		FXa_inhibition	1868..1904	CDD:405372	13/38 (34%)
		LY	1934..1974	CDD:214531	21/39 (54%)
		LY	1977..2017	CDD:214531	22/46 (48%)
		LY	2018..2061	CDD:214531	19/42 (45%)
		LY	2063..2105	CDD:214531	14/43 (33%)
		FXa_inhibition	2177..2212	CDD:405372	19/34 (56%)
		YvrE	2271..2481	CDD:225921	87/213 (41%)
		Ldl_recept_b	2362..2403	CDD:395012	17/40 (43%)
		LY	2388..2429	CDD:214531	22/40 (55%)
		FXa_inhibition	2500..2532	CDD:405372	12/31 (39%)
		LDLa	2545..2575	CDD:238060	15/29 (52%)
		LDLa	2584..2618	CDD:238060	16/37 (43%)
		LDLa	2623..2657	CDD:238060	13/33 (39%)
		LDLa	<2684..2706	CDD:238060	11/21 (52%)
		LDLa	2714..2748	CDD:238060	17/33 (52%)
		LDLa	2752..2783	CDD:197566	15/30 (50%)
		LDLa	2791..2824	CDD:197566	14/33 (42%)
		LDLa	2835..2867	CDD:197566	13/31 (42%)
		LDLa	2875..2908	CDD:197566	12/39 (31%)
		LDLa	2925..2957	CDD:238060	13/31 (42%)
		cEGF	2980..3003	CDD:403760	9/23 (39%)
		EGF_CA	3000..>3029	CDD:214542	19/28 (68%)
		LY	3067..3111	CDD:214531	17/43 (40%)
		LY	3112..3154	CDD:214531	30/41 (73%)
		LY	3156..3198	CDD:214531	19/41 (46%)
		LY	3200..3241	CDD:214531	17/40 (43%)
		LY	3242..3282	CDD:214531	17/45 (38%)
		FXa_inhibition	3312..3348	CDD:405372	20/36 (56%)
		LDLa	3352..3383	CDD:238060	21/31 (68%)
		LDLa	3392..3426	CDD:238060	18/33 (55%)
		LDLa	3431..3466	CDD:238060	13/38 (34%)
		LDLa	3470..3503	CDD:197566	18/32 (56%)
		LDLa	3511..3544	CDD:197566	17/32 (53%)
		LDLa	3554..3588	CDD:238060	21/33 (64%)
		LDLa	3593..3627	CDD:238060	18/33 (55%)
LDLa	3631..3665	CDD:238060	16/34 (47%)
LDLa	3671..3703	CDD:197566	17/31 (55%)
LDLa	3713..3749	CDD:238060	14/37 (38%)
LDLa	3764..3794	CDD:238060	13/29 (45%)
LY	3973..4010	CDD:214531	11/36 (31%)
Ldl_recept_b	4031..4071	CDD:395012	13/39 (33%)
LY	4055..4096	CDD:214531	18/40 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3639
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1744
Inparanoid	1	1.050	2921	1.000	Inparanoid score	I18
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46025
OrthoDB	1	1.010	-	-		D1326at33208
OrthoFinder	1	1.000	-	-		FOG0002316
OrthoInspector	1	1.000	-	-		otm43231
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4848
SonicParanoid	1	1.000	-	-		X1742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.910