DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp2

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_001074557.1 Gene:Lrp2 / 14725 MGIID:95794 Length:4660 Species:Mus musculus


Alignment Length:4779 Identity:1493/4779 - (31%)
Similarity:2207/4779 - (46%) Gaps:785/4779 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKS--- 64
            |.|.:|:|||.:...:...|....|..|.|..:.......|:.......|....:.|...:|   
Mouse     5 AAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGS 69

  Fly    65 -------RNRIKPTVFI---------RPNAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKADCP 113
                   .....|:.::         ..:......|..|.:...||::|.|:|:.::||..:|||
Mouse    70 GFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCP 134

  Fly   114 DMSDE------------------------------------GSECAPKCNEGQFRCGVSRHCIPN 142
            |.|||                                    .:.|...|::.:|:|| |..||..
Mouse   135 DGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDSSDEANCTTLCSQKEFQCG-SGECILR 198

  Fly   143 NWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDN--DELQC-- 203
            .::||.:.||  .|.|||.|| |.||  |...:..|.||.|:..:..|||..||.:  ||..|  
Mouse   199 AYVCDHDNDC--EDNSDEHNC-NYDT--CGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCES 258

  Fly   204 -------------------------------------DKQNAA---------CAALNCSFNCKLT 222
                                                 |:.||.         |:.|||.:.|..|
Mouse   259 NQRHHTCYPREWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQT 323

  Fly   223 PQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAIN 287
            |.|..|:||...:..|::|..|:|:|:|...|.|||.|.:..|.::|.|..||...:|..|::.:
Mouse   324 PYGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSND 388

  Fly   288 VPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEV 352
              .....::||          :||.:::          |.|..|   ....:|::          
Mouse   389 --SFSAASIIF----------SNGRDLL----------VGDLHG---RNFRILAE---------- 418

  Fly   353 WHRNRTLCSLLFSWPELQMRCQRVD----DARVNWTLPFSSFV--------SPQQFFT------- 398
             .:||.:             ...||    ..||.||.|..:.|        :.|:...       
Mouse   419 -SKNRGI-------------VMGVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDAPE 469

  Fly   399 ELRLDWLSGNWYLVS-----------EDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKGFMF 452
            .|.:||::...|||.           |.:..|.|.|..:.:.|          .:.||||.|::|
Mouse   470 NLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITENLGHPR----------GIALDPTVGYLF 524

  Fly   453 YTDW-----TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRN 512
            ::||     .|.:.|:.:|||||..|||.::..|:.:||||.::.|||:|...|.:..|.|:|..
Mouse   525 FSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQ 589

  Fly   513 RWTLKRPLDSPVPLKTIH--AVEVFENSIYLAAWMDTAIVALDKFS-LKTHILQSNVSRGANLRI 574
            |.|:.|. .|.||    |  .:.:||..::...|...|::..:||: ....:...:......:.:
Mouse   590 RKTVARG-GSLVP----HPFGISLFEEHVFFTDWTKMAVMKANKFTDTNPQVYHQSSLTPFGVTV 649

  Fly   575 FHRQKQPEVAHPCRDNNAGCNQICV--PQWTKGFASAKCMCTAGYKLH-NQTTCLLSALDKFLVY 636
            :|..:||...:||.:||.||.||||  .:...|....:|.|..|::|. ::..|:  |:..||::
Mouse   650 YHALRQPNATNPCGNNNGGCAQICVLSHRTDNGGLGYRCKCEFGFELDADEHHCV--AVKNFLLF 712

  Fly   637 SDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVY-NVSKTLAIDVNVRGKAVFYVVADSGASPF 700
            |.:...|  |||.         .:..|.||||||. :.|..:.||.:.:...:||  :|...:  
Mouse   713 SSQTAVR--GIPF---------TLSTQEDVMVPVTGSPSFFVGIDFDAQHSTIFY--SDLSKN-- 762

  Fly   701 GNGEPSCSIRSQSLNGSVSRLL-AQGLKRVHAVAFDWINDHLYWT--SHKKMQVAPLRNLSKVLT 762
                   .|..|.::|:...:: |..|:.|..::||||:.:||||  ..|.:.|..|.:.|:...
Mouse   763 -------IIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQI 820

  Fly   763 FNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMP-----MQWPRS 822
            .:...:..|:.:.|..|.::.|.|..   .|.|..:|.||:|         .||     :.||..
Mouse   821 ISNLNNPRSIVVHPAAGYMFLSDWFR---PAKIMRAWSDGSH---------LMPIVNTSLGWPNG 873

  Fly   823 LDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNGLIYWADNKNSTILRF 886
            |.:|..|..|||.|.....||...|||..|:.|...||. ||:.:......::..|.:...|:|.
Mouse   874 LAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVDQMTHPFGLTVFKDNVFLTDWRLGAIIRV 938

  Fly   887 HAHQAN----LSSTFSSTVHLQRTGRAADLRIFDIASQPLPQT-PSACAQS-----KCPGMCLNT 941
            ......    :....||.:|::  ...|||           || .:.|:|:     .|...|...
Mouse   939 RKSDGGDMTVVRRGISSIMHVK--AYDADL-----------QTGTNYCSQTTHPNGDCSHFCFPV 990

  Fly   942 PK-GAICRCPDGFTLNGTGSHCIPQLAPSPIRPNC-TSGYMCRSTRQCLDTKDMCDGFEDCEDGI 1004
            |. ..:|.||.|..|......|....|..|....| :|.:.|.:.: |:.:...|||.:||.|..
Mouse   991 PNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSSSFPCNNGK-CVPSIFRCDGVDDCHDNS 1054

  Fly  1005 DESSDPKGPCNV--NTCDKTHNFVC--NGRCYQRSLLCSTIPYCSDGTDQANC----HQNTCNSN 1061
            ||..     |..  |||..: .|.|  .|:|......|.....|.||:|:.||    ..:||...
Mouse  1055 DEHQ-----CGALNNTCSSS-AFTCVHGGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSSTCPPT 1113

  Fly  1062 EFTCHKSGRCIQLTWVNDGVVDC--GPDDDSDETSETIFASKCPEFDCNNGRCRQFADVCDGIDN 1124
            .||| .:..||...||.|...||  |.|:.:.:.|.|...:   :|.|.:.||.....||||..:
Mouse  1114 SFTC-DNHMCIPKEWVCDTDNDCSDGSDEKNCQASGTCHPT---QFRCPDHRCISPLYVCDGDKD 1174

  Fly  1125 CGNNADEMECEQECEHGEKYCRP-IGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKEL 1188
            |.:.:||..|...|...:..|.. ..|....:.|||::||.|.||||.|        |.   :..
Mouse  1175 CVDGSDEAGCVLNCTSSQFKCADGSSCINSRYRCDGVYDCKDNSDEAGC--------PT---RPP 1228

  Fly  1189 GECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFN-------------------------CTH 1228
            |.|.|.||.|.....|||:...|||...|...:||.|                         |..
Mouse  1229 GMCHPDEFQCQGDGTCIPNTWECDGHPDCIQGSDEHNGCVPKTCSPSHFLCDNGNCIYNSWVCDG 1293

  Fly  1229 INTTRFDMNETVICEHPDRLC--------GFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLC-- 1283
            .|..| ||::...|......|        |:| .||.:..||||..||.:.|||..||....|  
Mouse  1294 DNDCR-DMSDEKDCPTQPFHCPSSQWQCPGYS-ICVNLSALCDGVFDCPNGTDESPLCNQDSCLH 1356

  Fly  1284 -DRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDG 1347
             :.|  |:|||...|.|..|.||....|..:.|.|...:.||....|||.|.:....:.|.|...
Mouse  1357 FNGG--CTHRCIQGPFGATCVCPIGYQLANDTKTCEDVNECDIPGFCSQHCVNMRGSFRCACDPE 1419

  Fly  1348 FDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRN---IIALDFLYNNESNVE 1409
            :.|..|..|||.||.:...::..:|..|...|: |.:..|.||.:::   ::||||   :.....
Mouse  1420 YTLESDGRTCKVTASENLLLVVASRDKIIMDNI-TAHTHNIYSLVQDVSFVVALDF---DSVTGR 1480

  Fly  1410 IYWTDVIDDKIYRGHLVGESLRNVEAVIH-SGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNG 1473
            ::|:|:::.|.:.....|...|    |:| ||||.||.:||||:|:|:||.|..|:.|||:|::|
Mouse  1481 VFWSDLLEGKTWSAFQNGTDKR----VVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDG 1541

  Fly  1474 SFRRTLIAGNMESPRAIALDPREG--LLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPN 1536
            |.|..||:.|:..||.:|||||.|  ::||:|| .:.||||||||.|..|.:|.   |....||.
Mouse  1542 SHRTVLISKNVTKPRGLALDPRMGDNVMFWSDW-GHHPRIERASMDGTMRTVIV---QEKIYWPC 1602

  Fly  1537 GLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVI 1601
            ||::||..:.:|::||..|.|....|||.....|:.:..:|.||.|:::||:.|:|||..|..|:
Mouse  1603 GLSIDYPNRLIYFMDAYLDYIEFCDYDGQNRRQVIASDLVLHHPHALTLFEDSVFWTDRGTHQVM 1667

  Fly  1602 RANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGT--FKCECPH 1664
            :||||:|.:..|:..:..||.||..:|.||||...|||.  :..||||||||.:..  :.|.||.
Mouse  1668 QANKWHGRNQSVVMYSVPQPLGIIAIHPSRQPSSPNPCA--SATCSHLCLLSAQEPRHYSCACPS 1730

  Fly  1665 VMRLDPANERNCVPNEQ-VLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRI----DFLVD 1724
            ...|.. :..|||..:| .|:.|..:.|.||.|.       |.::.:..:|....|    |...|
Mouse  1731 GWNLSD-DSVNCVRGDQPFLISVRENVIFGISLD-------PEVKSNDAMVPISGIQHGYDVEFD 1787

  Fly  1725 ESR--IFWSDI--QQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILAS 1785
            :|.  |:|.:.  :.:.:.:.|.:.....|:  :.:....|.|:||::||:|:::...: :|...
Mouse  1788 DSEQFIYWVENPGEIHRVKTDGSNRTAFAPL--SLLGSSLGLALDWVSRNIYYTTPASR-SIEVL 1849

  Fly  1786 NLKGEF---ASIIHED-----LNMVDSIVLDPANGKMYWI-HSASDGSMSQLEQSNLDGSSRSLI 1841
            .|:|:.   .::|..|     :.....|.:|||.||:||. |....|..:::..:|:||:|..::
Mouse  1850 TLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKIL 1914

  Fly  1842 YQ-HENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNE---TRKVLVASPITSISSLTVYNGTLY 1902
            :. :..:|:.:|:|...|:||:|..:.|:    |.|..   |.::::...:.....|.|:...||
Mouse  1915 FTGNMEHLEVVTLDIQEQKLYWAVTSRGV----IERGNVDGTERMILVHHLAHPWGLVVHGSFLY 1975

  Fly  1903 FPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMF-YADAQTGSNTCAEWAYRGGCQQLCLATS 1966
            :.:....||.:.:|.:.||....|.|...::.:::: :.:|...||.|:.  ....|||:||...
Mouse  1976 YSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGLRVYHHRNAADSSNGCSN--NPNACQQICLPVP 2038

  Fly  1967 SIDHVCRCALGYDVEPNNPTGCVPRAEFIFYS-IDVLQG--VEMIDPSEQFDTPSPALVPIS--- 2025
            .....|.||.|:.:.|:. ..|.|...||..| :..::|  :|:.|.||       |:||::   
Mouse  2039 GGMFSCACASGFKLSPDG-RSCSPYNSFIVVSMLPAVRGFSLELSDHSE-------AMVPVAGQG 2095

  Fly  2026 -RVSSASFIDYLANTDTLYWGD-----NELGSISRVKRDGTQRETILEALNLVGYK-QQDWLGGI 2083
             .|..|. :| :|| ..:||.|     .....|.|:|.:|:      ...|:|.|. ..:.:.|:
Mouse  2096 RNVLHAD-VD-VAN-GFIYWCDFSSSVRSSNGIRRIKPNGS------NFTNIVTYGIGANGIRGV 2151

  Fly  2084 AIDWVAGNIYWSD--TKRNIIEVARLDGSHRYVVVS-NLEKPTALAVDPLQGLLF---YVTQQHI 2142
            |:||||||:|:::  ....:|||.|::.::|.|::. :::.|..:.|||....||   |..:..|
Mouse  2152 AVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMPRHIVVDPKHRYLFWADYGQKPKI 2216

  Fly  2143 GRVGLDGSQPFVLVNQTRANWAVG-----SLVLDIEATKVYWCERYPDALMKVDYDGNLREQLL- 2201
            .|..||.:...|||::       |     .|.:|.:...:||.:...|.:.::..||. ..|:: 
Mouse  2217 ERSFLDCTNRTVLVSE-------GIVTPRGLAVDHDTGYIYWVDDSLDIIARIHRDGG-ESQVVR 2273

  Fly  2202 -NESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQ-- 2263
             ......|..:...|:.:.|.:....: :.:.:.....:....|::...:.:||:.|:.:|:|  
Mouse  2274 YGSRYPTPYGITVFGESIIWVDRNLRK-VFQASKQPGNTDPPTVIRDSINLLRDVTIFDEHVQPL 2337

  Fly  2264 ----RGSNPCAHSNGACEQLC--LFNGTSAVCACAHSRLASDGYSC-EPYENFLLFSYRSNIESI 2321
                ..:|||..|||.|...|  |....:..|.||...|..||.:| ...|:||::|..:::.|:
Mouse  2338 SPAELNNNPCLQSNGGCSHFCFALPELPTPKCGCAFGTLEDDGKNCATSREDFLIYSLNNSLRSL 2402

  Fly  2322 HMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDV------QLSTINQVHFNGTGHRVL 2380
            |. |..|.|.|.|.||...:   .||:.|:.....::::..      |:|.:| ::...:...:|
Mouse  2403 HF-DPQDHNLPFQAISVEGM---AIALDYDRRNNRIFFTQKLNPIRGQISYVN-LYSGASSPTIL 2462

  Fly  2381 LEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAV 2445
            |......:|:|:|.:|.:::::..:|.||.|     ::|.. .|:..:.:|      .|||.|.:
Mouse  2463 LSNIGVTDGIAFDWINRRIYYSDFSNQTINS-----MAEDG-SNRAVIARV------SKPRAIVL 2515

  Fly  2446 EPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERT 2510
            :||.|.:|||:|...:. |:|:.|.|.....|:.|.:..||.||||||...||||||.|.||||:
Mouse  2516 DPCRGYMYWTDWGTNAK-IERATLGGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKIERS 2579

  Fly  2511 NYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHV-TRPMGIVA 2574
            ...||||.|:. ||..|:|.:.|||..::|||:....:.|||||.|:|::.:...: |:|.||..
Mouse  2580 TLTGSNREVVI-STAFHSFGLTVYGQYIYWTDFYTKKIYRANKYDGSDLIAMTTRLPTQPSGIST 2643

  Fly  2575 VQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCT-QG--VLAPDGRRCIAPVNTSCGLSQYN 2636
            |..|.....:|.|...||.|..:|....:| |.|.|. :|  .||.|.:.|:......|...|:.
Mouse  2644 VVKTQQQQCSNPCDQFNGGCSHICAPGPNG-AECQCPHEGSWYLANDNKYCVVDTGARCNQFQFT 2707

  Fly  2637 CHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSD 2701
            |.:|.||..:..|||...|.|||||..:.|.|..|..|.|.|.|.||:|..::||....|||.||
Mouse  2708 CLNGRCISQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCANGRCVPYHYRCDFYNDCGDNSD 2772

  Fly  2702 ETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDC--RDFSDEKMCAPIPC 2764
            |...|.:          |.|:|.|    |.|.:|.|||..::|:.:.:|  .|.||||.|.||.|
Mouse  2773 EAGCLFR----------SCNSTTE----FTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPITC 2823

  Fly  2765 EKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDE--LDCANHTSLSCDPGQFRCASGN-CIAGS 2826
            :.:   |..|..:.||:...:.||||.||.||:||  :.||:||   |...:|:|.|.: ||...
Mouse  2824 QPD---FAKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHT---CRSNEFQCVSPHRCIPSY 2882

  Fly  2827 WHCDGEKDCPDGSDEIN-C---RTECRHNQFACDK-TCIPASWQCDGKSDCEDGSDEGPQ--CPN 2884
            |.||||.||.|.|||.: |   ...|..|||.||. .||.:||.|||.:||.|.|||..:  |..
Mouse  2883 WFCDGEADCVDSSDEPDTCGHSLNSCSANQFHCDNGRCISSSWVCDGDNDCGDMSDEDQRHHCEL 2947

  Fly  2885 RPCRPHLFQCKSS----GRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLC 2945
            :.|....|.|.:|    .|||||.|||||:.||...|      ||...|...|    |......|
Mouse  2948 QNCSSTEFTCINSRPPNRRCIPQHWVCDGDADCADAL------DELQNCTMRA----CSTGEFSC 3002

  Fly  2946 TSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCG 3010
            .:|.||...:.||...||....|| .||  ::.|  |.....  .||:|.||.|...||...|||
Mouse  3003 ANGRCIRQSFRCDRRNDCGDYSDE-RGC--SYPP--CRDDQF--TCQNGQCITKLYVCDEDNDCG 3060

  Fly  3011 DGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDI--CE 3073
            |||||...||...........|||.||.||....:|:..:||:|.|||:.|.:|||....|  |:
Mouse  3061 DGSDEQEHLCHTPEPTCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGCGINECQDSSISHCD 3125

  Fly  3074 HECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDE-QQPCSQTCINTYGSYKCLCAKGYAL-VD 3136
            |.|.|.:..:.|.|.||||:: .....|.|||||.| .|.|||.|.|..|||.|.||.||.. .|
Mouse  3126 HNCTDTITSFYCSCLPGYKLM-SDKRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPD 3189

  Fly  3137 HHTCKATSNVSMELIFSNRYYIRQVDMTGNG-SILINELSNAVALDYDWDSQCLYWSDVTSTVGT 3200
            ..:|:..||:...|:||||||||.:.:.|.. |:::..|.|.||||:|...:.|||.|....:  
Mouse  3190 GKSCRQNSNIEPYLVFSNRYYIRNLTIDGTSYSLILQGLGNVVALDFDRVEERLYWIDAEKQI-- 3252

  Fly  3201 IKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLI------- 3258
            |:|....:...:|:....|:..:.||||||::.|||.|..||.:.||.|:|:.||:|.       
Mouse  3253 IERMFLNKTNQETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQRKMLAQHCVDAN 3317

  Fly  3259 NEYLRE-PRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLF 3322
            |.:..| ||||.|||.:.:::|:||||..:|.:.||||:|..:||...:.||||:||.:....|:
Mouse  3318 NTFCFENPRGIVLHPQRGYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDYTNDLLY 3382

  Fly  3323 WGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQ 3387
            |.||....|..|||:|:|...:...:      |.|.||:.::|..::|:||.|:::|..:.::|.
Mouse  3383 WADAHLGYIEFSDLEGHHRHTVYDGT------LPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGS 3441

  Fly  3388 NCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCPTNF--ILA 3448
            ....|:.|.|:|.|:.|.||||  ||:..|||...|  ||.||::......:.|.||.:|  :..
Mouse  3442 GRVVLVNTTHKPFDIHVLHPYR--QPIMSNPCATNNGGCSHLCLIKAGGRGFTCECPDDFQTVQL 3504

  Fly  3449 DDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTH 3513
            .|...|...|::..|.|.|..||||.:|:||.|.||.|||||.:.||...|..||:||.:..||.
Mouse  3505 RDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDESDLCPHRFCRLGQFQCRDGNCTS 3569

  Fly  3514 PSNLCDGINQCGDGSDE--LNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDC--PGGEDE 3574
            |..||:....|.|||||  :.|:...|..|..:|   ||..  |:....:||.|.||  ...||.
Mouse  3570 PQALCNARQDCADGSDEDRVLCEHHRCEANEWQC---ANKR--CIPEYWQCDSVDDCLDNSDEDP 3629

  Fly  3575 SACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEA---------NCDNVSCGPNDFQCDS 3630
            |.|....|:..||:|.|.||:|..|.||.|.||.|.|||.         ||||    ..:|.|.:
Mouse  3630 SHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIHECMTAAYNCDN----HTEFSCKT 3690

  Fly  3631 G-RCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPT-YFKCNNSKCIPGRWRCDYENDCGDGSD 3693
            . ||||....|:...||.:..|| ..|.|  ..|.|: .|:|.|..|||.||:||..:||||.||
Mouse  3691 NYRCIPQWAVCNGFDDCRDNSDE-QGCES--VPCHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSD 3752

  Fly  3694 ELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNI-TCKENQFKCAAFNTCINKQ 3757
            |.:|..|.|:||||||...:||...:.||.|..|.|||||.:|.: ||....|:|.: ..|:.|.
Mouse  3753 EESCVPRECTESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTS-GHCVPKA 3816

  Fly  3758 YKCDGDDDCPDGSDEVNCT--------CHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCA 3814
            ..|||..||.|.|||..|.        |.:..|.|.|..||.|.|.|||.:||:|||||.:..|.
Mouse  3817 LACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCF 3881

  Fly  3815 KTHCHA-NAFKCRNQLCVRNSALCDGINDCGENEDESDAVC--AALPKCRHDQFQCENDDCISKA 3876
            ...|.: ..|:|.|..|:....||:|::|||:..||.:..|  .....|...:::|.|.:|:|:.
Mouse  3882 NVPCESPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCVSQH 3946

  Fly  3877 FRCDGQYNCVDGSDEMNCQ--------PPVC---------------------------------- 3899
            :.||...:|.|.|||..|.        ..:|                                  
Mouse  3947 YVCDNVDDCGDLSDETGCNLGENRTCAEKICEQNCTQLSNGGFICSCRPGFKPSTLDKNSCQDIN 4011

  Fly  3900 ---GFGSCSQICIEKKAGHYNCKCADGY-----HKGPEKNATCLASGPDQILLL----------A 3946
               .||.|.|.|...| |.|.|.|.||:     |.|..    |.|.|...:|||          .
Mouse  4012 ECEEFGICPQSCRNSK-GSYECFCVDGFKSMSTHYGER----CAADGSPPLLLLPENVRIRKYNI 4071

  Fly  3947 SEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIA-TPHVE 4010
            |.::|...|..::....:...:..:.:.:.|          :.:.:.|...:...:|.| .|..|
Mouse  4072 SSEKFSEYLEEEEHIQAIDYDWDPEGIGLSV----------VYYTVLSQGSQFGAIKRAYLPDFE 4126

  Fly  4011 -GTGVRVRR-DLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTG 4073
             |:...||. ||      .:..|..|..|||||:.:.:|..|::..:|....::|:....|::|.
Mouse  4127 SGSNNPVREVDL------GLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQ 4185

  Fly  4074 MN-PTDIVLEPESRIMIWSTLENG----ILVASLDGSNKKSLVERDVGWPISLSMDYPTG-RLYW 4132
            :: |..|.:.|:..:|.|:  :.|    |..|.::|.::..|...::|||..||:||..| |:||
Mouse  4186 LDQPAAIAVNPKLGLMFWT--DQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDYLNGDRIYW 4248

  Fly  4133 ADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLY-IKLYDQSIIKMNKFGNDNGTYLL 4196
            :|.::..||:.:.:|.||.::  ..:..||..:|:|||.|| :......:.:.||||..|...||
Mouse  4249 SDSKEDVIESIKYDGTDRRLI--INDAMKPFSLDIFEDQLYWVAKEKGEVWRQNKFGKGNKEKLL 4311

  Fly  4197 -KGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEG--YVMTDDGVC 4258
             .....:.:.|.|.::.|:::|||| |..|..   ||:|...   ||||.|.:|  :|......|
Mouse  4312 VVNPWLTQVRIFHQLRYNQSVSNPC-KQVCSH---LCLLRPG---GYSCACPQGSDFVTGSTVEC 4369

  Fly  4259 KAHADIPDYCPLQCNL---GTCKIVDH-VPKCICQPQFEGELCE--------------------- 4298
            .|.:::|...|..|..   |:|...:: :|||.|...:.||.||                     
Mouse  4370 DAASELPITMPSPCRCMHGGSCYFDENDLPKCKCSSGYSGEYCEIGLSRGIPPGTTMALLLTFAM 4434

  Fly  4299 -------------HYRCSGYCQNYGVCSVAPALP 4319
                         |||.:|        |:.|:||
Mouse  4435 VIIVGALVLVGFFHYRKTG--------SLLPSLP 4460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566 13/30 (43%)
LDLa 126..163 CDD:238060 15/36 (42%)
EGF_CA 246..283 CDD:214542 14/36 (39%)
Ldl_recept_b 449..487 CDD:459654 16/42 (38%)
LY 472..513 CDD:214531 16/40 (40%)
LY 817..852 CDD:214531 14/34 (41%)
LDLa 1057..1092 CDD:197566 14/36 (39%)
LDLa 1104..1134 CDD:238060 11/29 (38%)
LDLa 1191..1226 CDD:238060 15/59 (25%)
FXa_inhibition 1289..1317 CDD:464251 11/27 (41%)
LY 1434..1476 CDD:214531 24/42 (57%)
LY 1477..1521 CDD:214531 24/45 (53%)
LY 1533..1567 CDD:214531 14/33 (42%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:464251 13/38 (34%)
LY 1751..1789 CDD:214531 9/37 (24%)
LY 1794..1838 CDD:214531 15/49 (31%)
LY 2078..2112 CDD:214531 13/35 (37%)
NHL <2082..>2152 CDD:302697 26/75 (35%)
NHL repeat 2082..2120 CDD:271320 15/40 (38%)
FXa_inhibition 2269..2303 CDD:464251 13/35 (37%)
LY 2430..2471 CDD:214531 15/40 (38%)
LY 2475..2517 CDD:214531 23/41 (56%)
LDLa 2630..2661 CDD:238060 13/30 (43%)
LDLa 2671..2702 CDD:238060 14/30 (47%)
LDLa 2727..2759 CDD:238060 13/33 (39%)
LDLa 2773..2802 CDD:238060 13/30 (43%)
LDLa 2810..2844 CDD:238060 17/35 (49%)
LDLa 2848..2878 CDD:238060 17/30 (57%)
LDLa 2887..2916 CDD:197566 16/32 (50%)
LDLa 2938..2969 CDD:197566 9/30 (30%)
LDLa 2989..3015 CDD:197566 14/25 (56%)
LDLa 3030..3061 CDD:238060 14/30 (47%)
EGF_CA 3062..>3091 CDD:214542 11/30 (37%)
EGF_CA 3103..3141 CDD:214542 21/39 (54%)
LY 3212..3254 CDD:214531 18/41 (44%)
Ldl_recept_b 3275..3314 CDD:459654 17/38 (45%)
LY 3299..3340 CDD:214531 17/40 (43%)
LY 3354..3389 CDD:214531 11/34 (32%)
LDLa 3458..3490 CDD:238060 17/31 (55%)
LDLa 3499..3533 CDD:238060 16/35 (46%)
LDLa 3582..3616 CDD:238060 18/42 (43%)
LDLa 3621..3652 CDD:197566 9/31 (29%)
LDLa 3663..3697 CDD:238060 19/34 (56%)
LDLa 3702..3736 CDD:238060 18/33 (55%)
LDLa 3776..3808 CDD:197566 16/39 (41%)
LDLa 3818..3849 CDD:197566 11/31 (35%)
LDLa 3860..3894 CDD:238060 12/33 (36%)
YncE 3935..4148 CDD:442618 56/231 (24%)
LY 4108..4150 CDD:214531 16/42 (38%)
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp2NP_001074557.1 LDLa 28..62 CDD:238060 5/33 (15%)
LDLa 67..99 CDD:197566 1/31 (3%)
LDLa 108..142 CDD:238060 15/33 (45%)
LDLa 148..179 CDD:238060 0/30 (0%)
LDLa 183..217 CDD:238060 15/36 (42%)
LDLa 222..256 CDD:238060 12/33 (36%)
LDLa 265..299 CDD:238060 1/33 (3%)
YncE <427..576 CDD:442618 47/158 (30%)
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 435..477 10/41 (24%)
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 478..520 11/51 (22%)
LY 502..547 CDD:214531 16/54 (30%)
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 521..567 19/45 (42%)
LY 550..590 CDD:214531 16/39 (41%)
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 568..612 17/48 (35%)
FXa_inhibition 662..703 CDD:464251 14/40 (35%)
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 752..794 12/52 (23%)
LY 775..817 CDD:214531 14/41 (34%)
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 795..836 10/40 (25%)
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 837..880 15/54 (28%)
Ldl_recept_b 837..878 CDD:459654 14/52 (27%)
LY 863..903 CDD:214531 14/39 (36%)
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 881..924 15/42 (36%)
FXa_inhibition 980..1012 CDD:464251 8/31 (26%)
LDLa 1025..1059 CDD:238060 12/39 (31%)
Ldl_recept_a 1065..1101 CDD:395011 11/36 (31%)
LDLa 1110..1144 CDD:238060 13/34 (38%)
LDLa 1150..1184 CDD:238060 11/36 (31%)
LDLa 1188..1223 CDD:238060 13/34 (38%)
LDLa 1231..1263 CDD:197566 12/31 (39%)
LDLa 1272..1306 CDD:238060 5/34 (15%)
LDLa 1313..1345 CDD:197566 12/32 (38%)
FXa_inhibition 1354..1389 CDD:464251 13/36 (36%)
EGF_CA 1391..1430 CDD:214542 11/38 (29%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1479..1521 17/45 (38%)
LY 1502..1544 CDD:214531 25/45 (56%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1522..1564 21/41 (51%)
LY 1546..1590 CDD:214531 24/44 (55%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1567..1610 22/46 (48%)
LY 1592..1633 CDD:214531 16/43 (37%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1611..1655 15/43 (35%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1656..1696 17/39 (44%)
FXa_inhibition 1710..1741 CDD:464251 12/31 (39%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1791..1833 8/43 (19%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1834..1883 11/49 (22%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1884..1931 13/46 (28%)
Ldl_recept_b 1884..1929 CDD:459654 12/44 (27%)
LY 1912..1954 CDD:214531 11/45 (24%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1932..1973 10/44 (23%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1974..2014 9/39 (23%)
YncE 2035..2277 CDD:442618 72/266 (27%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2108..2157 14/54 (26%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2158..2202 13/43 (30%)
LY 2183..2226 CDD:214531 12/42 (29%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2203..2246 13/49 (27%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2247..2290 8/43 (19%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2291..2333 5/42 (12%)
FXa_inhibition 2347..2383 CDD:464251 13/35 (37%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2432..2478 8/46 (17%)
LY 2460..2501 CDD:214531 11/46 (24%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2479..2519 12/51 (24%)
LY 2503..2543 CDD:214531 16/46 (35%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2520..2563 18/43 (42%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2564..2605 23/41 (56%)
LY <2595..2626 CDD:214531 14/30 (47%)
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2606..2647 15/40 (38%)
FXa_inhibition 2656..2693 CDD:464251 13/37 (35%)
LDLa 2700..2732 CDD:197566 13/31 (42%)
LDLa 2742..2776 CDD:238060 16/33 (48%)
LDLa 2783..2818 CDD:238060 15/38 (39%)
LDLa 2822..2855 CDD:197566 13/35 (37%)
LDLa 2865..2899 CDD:238060 17/33 (52%)
LDLa 2908..2939 CDD:197566 17/30 (57%)
LDLa 2950..2986 CDD:197566 17/41 (41%)
LDLa 2995..3029 CDD:238060 11/34 (32%)
LDLa 3034..3066 CDD:238060 16/33 (48%)
LDLa 3077..3111 CDD:238060 14/33 (42%)
FXa_inhibition 3124..3152 CDD:464251 10/28 (36%)
vWFA <3149..3192 CDD:469594 22/42 (52%)
LY 3221..3262 CDD:214531 14/42 (33%)
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3241..3283 13/43 (30%)
LY 3264..3306 CDD:214531 18/41 (44%)
Ldl_recept_b 3284..3332 CDD:459654 20/47 (43%)
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3284..3326 15/41 (37%)
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3335..3378 19/42 (45%)
Ldl_recept_b 3335..3376 CDD:459654 19/40 (48%)
LY 3360..3401 CDD:214531 17/40 (43%)
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3379..3421 15/47 (32%)
LY 3406..3443 CDD:214531 11/42 (26%)
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3422..3462 13/39 (33%)
FXa_inhibition 3471..>3500 CDD:464251 9/28 (32%)
LDLa 3514..3548 CDD:238060 19/33 (58%)
LDLa 3555..3586 CDD:197566 14/30 (47%)
LDLa 3595..3627 CDD:197566 11/36 (31%)
LDLa 3636..3668 CDD:197566 16/31 (52%)
LDLa 3684..3716 CDD:238060 11/32 (34%)
LDLa 3723..3756 CDD:238060 18/32 (56%)
LDLa 3761..3795 CDD:238060 18/33 (55%)
LDLa 3800..3834 CDD:238060 14/34 (41%)
LDLa 3844..3876 CDD:238060 17/31 (55%)
LDLa 3887..3917 CDD:197566 10/29 (34%)
LDLa 3930..3964 CDD:238060 12/33 (36%)
EGF_CA 4009..4049 CDD:214542 14/44 (32%)
LY 4143..4178 CDD:214531 11/34 (32%)
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4156..4198 9/41 (22%)
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4199..4242 14/44 (32%)
Ldl_recept_b 4199..4240 CDD:459654 12/42 (29%)
LY 4224..4266 CDD:214531 16/41 (39%)
LDL-receptor class B 36. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4244..4285 14/42 (33%)
FXa_inhibition 4340..>4358 CDD:464251 9/23 (39%)
SH3-binding. /evidence=ECO:0000255 4454..4463 4/7 (57%)
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4457..4462 3/4 (75%)
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4460..4465 1/1 (100%)
Endocytosis signal. /evidence=ECO:0000255 4522..4527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4558..4660
Interaction with DAB2. /evidence=ECO:0000250|UniProtKB:P98164 4597..4610
NPXY motif 4603..4606
SH2-binding. /evidence=ECO:0000255 4606..4609
SH3-binding. /evidence=ECO:0000255 4619..4630
Blue background indicates that the domain is not in the aligned region.

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