| Sequence 1: | NP_001260800.2 | Gene: | LRP1 / 35799 | FlyBaseID: | FBgn0053087 | Length: | 4752 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_320185.5 | Gene: | LRP1 / 1280340 | VectorBaseID: | AGAMI1_005394 | Length: | 4869 | Species: | Anopheles gambiae |
| Alignment Length: | 4954 | Identity: | 2322/4954 - (46%) |
|---|---|---|---|
| Similarity: | 3101/4954 - (62%) | Gaps: | 389/4954 - (7%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 2 PATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKSRN 66
Fly 67 RIKPTVFIRPNAALTAGGGPCPASYFTC-NDGFCIPMRWKCDSKADCPDMSDE-GSECAPKCNEG 129
Fly 130 QFRCGVSRHCIPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAF------EGQCRNGDCLELSR 188
Fly 189 FCDGRWDCDNDELQCDKQN--------AACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCV 245
Fly 246 DYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVG-T 309
Fly 310 NGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQ 374
Fly 375 RVDDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQQVDPL 439
Fly 440 ---SSLDLDPTKGFMFYTDW---TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDI 498
Fly 499 YKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALDKFSLKTHILQ 563
Fly 564 SNVSRGANLRIFHRQKQPEVAHPCRDNNAGCNQICVPQWTK-GFASAKCMCTAGYKLHNQTTCLL 627
Fly 628 SALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVV 692
Fly 693 ADSGASPFGNG---EPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWT----SH---- 746
Fly 747 ----KKMQVAPLRNLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKEL 807
Fly 808 LAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLF--KSDQFHPYSIVQNN 870
Fly 871 GLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRT-----GRAADLRIFDIASQPLPQTPSACA 930
Fly 931 QSKCPGMCLNTPKG-AICRCPDGFTLN----GTGSHCIP-QLAPSPIRPNCTSGYMCRSTRQCLD 989
Fly 990 TKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVCN-GRCYQRSLLCSTIPYCSDGTDQ--A 1051
Fly 1052 NCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCPEFDCNNGRCRQFA 1116
Fly 1117 DVCDGIDNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCD-------GIHDCLDFSDEANCNQ 1174
Fly 1175 TKSDNHPVTEWKELGECA--PLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMN 1237
Fly 1238 ETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYIC 1302
Fly 1303 SCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYV 1367
Fly 1368 IFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRN 1432
Fly 1433 VEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREG 1497
Fly 1498 LLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMY 1562
Fly 1563 DGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVL 1627
Fly 1628 HSSRQP-WDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEI 1691
Fly 1692 RGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNI 1756
Fly 1757 EKPYGFAVDWIARNMYFSSG-QIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSA 1820
Fly 1821 SDGSMSQLEQSNLDGSSRSLIYQHE-NNLQSLTMDFDSQRLYYAYDNSG-IAYYDIPRNETRKVL 1883
Fly 1884 VASPIT-SISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSN 1947
Fly 1948 TCAEWAYRG---GCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSI-DVLQGVEMI 2008
Fly 2009 DPSEQFDTPS----PALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEAL 2069
Fly 2070 -NLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLEKPTALAVDPLQGL 2133
Fly 2134 LFYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLRE 2198
Fly 2199 QLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQT-EQDAIRDLKIYSKHL 2262
Fly 2263 QRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLAS-DGYSCEPYENFLLFSYRSNIESIHMTDH 2326
Fly 2327 ADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLA 2391
Fly 2392 YDIVNEQLFWTSNNNATIRSVELR--HLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYW 2454
Fly 2455 TNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVV 2519
Fly 2520 LAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDA 2584
Fly 2585 NQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTC 2649
Fly 2650 DNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDI 2714
Fly 2715 DMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKN-DMTFVHCGNST 2778
Fly 2779 ICIMPRWRCDGDPDCPDGTDELDCANHTSL-SCDPGQFRCASGNCIAGSWHCDGEKDCPD----- 2837
Fly 2838 -GSDEINCRTECRHNQFACDKT--CIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGR 2899
Fly 2900 CIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCP 2964
Fly 2965 GGD-------------DEYEGCVPAFQPHSC--PGGSLMH-QCQDGLCIFKNQTCDGKPDCGDGS 3013
Fly 3014 DETSSLCAHTR-GCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNEC-LIPDICEHEC 3076
Fly 3077 EDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQ--PCSQTCINTYGSYKCLCAKGYALVDHHT 3139
Fly 3140 CKATSN--VSMELIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIK 3202
Fly 3203 RYCP--KENK-TQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLRE 3264
Fly 3265 PRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDARED 3329
Fly 3330 TISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLIT 3394
Fly 3395 TIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCT 3459
Fly 3460 AAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQC 3524
Fly 3525 GDGSDELNCDKFTCFDNHMKCGATA--NSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQF 3587
Fly 3588 QCGN-NRCMPFVWVCDGDIDCPDKSDEANC-DNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGE 3650
Fly 3651 DEPASCFSSKA-TCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKC 3714
Fly 3715 IKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCTCHS 3779
Fly 3780 DHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQLCVRNSALCDGINDCG 3844
Fly 3845 ENEDESDAVCAALPKCRHDQFQCENDD-CISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQIC 3908
Fly 3909 IEKKAGHYNCKCADGYHK-GPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDS 3972
Fly 3973 LKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIAT-----------PHVEGTGVRVRRDLKELTA- 4025
Fly 4026 ---FNIPELD-------------DPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGM 4074
Fly 4075 NPTDIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGT 4139
Fly 4140 IETC-RLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYL-------- 4195
Fly 4196 -LKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEG---YVMTDDG 4256
Fly 4257 VCKAHADIP---DYCPLQCNLGTCKI-VDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPA 4317
Fly 4318 LPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEG--MKCSCPKMFTGEQCEH 4380
Fly 4381 CRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYF 4445
Fly 4446 GEHCESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDLCK--TSSPPHFCDNTKVPTRDP 4508
Fly 4509 --------CTLMICQNAGTCHIIKGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLD-- 4563
Fly 4564 ------EYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRV-VPCLSDSADA 4621
Fly 4622 LKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRIAQPFSHARLTDNVEIMLTNAMY 4686
Fly 4687 RGDADEAPTFASEDDKGNFANPVYESMYADAI-------------PEPVSTEITHSTAPDERKGL 4738
Fly 4739 LQHTHDENHTPDIL 4752 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP1 | NP_001260800.2 | LDLa | 87..118 | CDD:197566 | 18/31 (58%) |
| LDLa | 126..163 | CDD:238060 | 19/36 (53%) | ||
| EGF_CA | 246..283 | CDD:214542 | 20/36 (56%) | ||
| Ldl_recept_b | 449..487 | CDD:459654 | 16/40 (40%) | ||
| LY | 472..513 | CDD:214531 | 15/40 (38%) | ||
| LY | 817..852 | CDD:214531 | 18/34 (53%) | ||
| LDLa | 1057..1092 | CDD:197566 | 18/34 (53%) | ||
| LDLa | 1104..1134 | CDD:238060 | 15/29 (52%) | ||
| LDLa | 1191..1226 | CDD:238060 | 4/36 (11%) | ||
| FXa_inhibition | 1289..1317 | CDD:464251 | 21/27 (78%) | ||
| LY | 1434..1476 | CDD:214531 | 34/41 (83%) | ||
| LY | 1477..1521 | CDD:214531 | 29/43 (67%) | ||
| LY | 1533..1567 | CDD:214531 | 21/33 (64%) | ||
| LY | 1568..1611 | CDD:214531 | 29/42 (69%) | ||
| FXa_inhibition | 1639..1676 | CDD:464251 | 22/36 (61%) | ||
| LY | 1751..1789 | CDD:214531 | 18/38 (47%) | ||
| LY | 1794..1838 | CDD:214531 | 14/43 (33%) | ||
| LY | 2078..2112 | CDD:214531 | 27/33 (82%) | ||
| NHL | <2082..>2152 | CDD:302697 | 49/69 (71%) | ||
| NHL repeat | 2082..2120 | CDD:271320 | 28/37 (76%) | ||
| FXa_inhibition | 2269..2303 | CDD:464251 | 18/34 (53%) | ||
| LY | 2430..2471 | CDD:214531 | 26/40 (65%) | ||
| LY | 2475..2517 | CDD:214531 | 29/41 (71%) | ||
| LDLa | 2630..2661 | CDD:238060 | 16/30 (53%) | ||
| LDLa | 2671..2702 | CDD:238060 | 17/30 (57%) | ||
| LDLa | 2727..2759 | CDD:238060 | 14/31 (45%) | ||
| LDLa | 2773..2802 | CDD:238060 | 16/28 (57%) | ||
| LDLa | 2810..2844 | CDD:238060 | 18/39 (46%) | ||
| LDLa | 2848..2878 | CDD:238060 | 19/31 (61%) | ||
| LDLa | 2887..2916 | CDD:197566 | 18/28 (64%) | ||
| LDLa | 2938..2969 | CDD:197566 | 12/43 (28%) | ||
| LDLa | 2989..3015 | CDD:197566 | 13/26 (50%) | ||
| LDLa | 3030..3061 | CDD:238060 | 18/30 (60%) | ||
| EGF_CA | 3062..>3091 | CDD:214542 | 19/29 (66%) | ||
| EGF_CA | 3103..3141 | CDD:214542 | 23/39 (59%) | ||
| LY | 3212..3254 | CDD:214531 | 30/41 (73%) | ||
| Ldl_recept_b | 3275..3314 | CDD:459654 | 24/38 (63%) | ||
| LY | 3299..3340 | CDD:214531 | 31/40 (78%) | ||
| LY | 3354..3389 | CDD:214531 | 24/34 (71%) | ||
| LDLa | 3458..3490 | CDD:238060 | 25/31 (81%) | ||
| LDLa | 3499..3533 | CDD:238060 | 21/33 (64%) | ||
| LDLa | 3582..3616 | CDD:238060 | 17/34 (50%) | ||
| LDLa | 3621..3652 | CDD:197566 | 17/30 (57%) | ||
| LDLa | 3663..3697 | CDD:238060 | 28/33 (85%) | ||
| LDLa | 3702..3736 | CDD:238060 | 20/33 (61%) | ||
| LDLa | 3776..3808 | CDD:197566 | 18/31 (58%) | ||
| LDLa | 3818..3849 | CDD:197566 | 14/30 (47%) | ||
| LDLa | 3860..3894 | CDD:238060 | 15/34 (44%) | ||
| YncE | 3935..4148 | CDD:442618 | 86/241 (36%) | ||
| LY | 4108..4150 | CDD:214531 | 23/42 (55%) | ||
| EGF_CA | <4386..4414 | CDD:238011 | 14/27 (52%) | ||
| EGF_CA | 4415..4450 | CDD:238011 | 14/34 (41%) | ||
| LRP1 | XP_320185.5 | None | |||