DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Lrp4

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_061518363.1 Gene:Lrp4 / 1272241 VectorBaseID:AGAMI1_014848 Length:2063 Species:Anopheles gambiae


Alignment Length:1817 Identity:540/1817 - (29%)
Similarity:814/1817 - (44%) Gaps:252/1817 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   907 GRA---ADLRIFDIASQPLPQT-PSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHC--IPQ 965
            |:|   |.:...||..:|...| ..:||   |..|.|:....|.|      .|.....:|  :.|
Mosquito   239 GKADGLAGIESCDIKCEPREFTCDKSCA---CIHMDLHCDGQADC------VLTEDEQNCEIVHQ 294

  Fly   966 LAPSPIRPNC-TSG--YMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHN--- 1024
            .....|:.|| |||  .:|.:|..|:....:|||.:||.|..||:.          |...|:   
Mosquito   295 RLAQQIKDNCETSGTHVICATTHTCISRDWLCDGDDDCGDYTDETH----------CGNRHDCTE 349

  Fly  1025 --FVC-NGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGP 1086
              |.| ||.|..|..:|.....|:|.:|:.||.:. |..:||.| |.|.||..::..||..||  
Mosquito   350 EKFECQNGMCIPRDWVCDGDNDCNDLSDEKNCTKQ-CTRDEFRC-KDGSCISASFQCDGETDC-- 410

  Fly  1087 DDDSDETSETIFASKCP--EFDCN---------NGRCRQFADVCDGIDNCGNNADEMEC---EQE 1137
            .|:|||.:.......||  ||.|.         .|||......|||.::||:.:||..|   :.:
Mosquito   411 IDESDEANCDRPMQSCPEGEFKCKGALGGMGGPGGRCVLMRFRCDGDNDCGDWSDEENCAKKQVD 475

  Fly  1138 CEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGE-CAPLEFACMFP 1201
            |...|..|....|......||...||.:..||.||        ||.  :..|. |:|.|:.|. .
Mosquito   476 CMINEFKCDDGDCIPLQWRCDDKQDCNNGEDEKNC--------PVD--RIAGRTCSPDEYTCK-D 529

  Fly  1202 FECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGF--------SKQCVTV 1258
            ..||.....|||.:.|....||.:|            .:.||....||..        |..|:..
Mosquito   530 GRCILRSWVCDGSADCRRGEDEQDC------------DIKCELNQFLCPSGSRNSTRDSSVCINQ 582

  Fly  1259 DQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEG-YICSCPDHLYLQPNGKRCSMQHA 1322
            ..:|||..||.:..||........|.....|...|.....| ..|.|.....|..||..|:....
Mosquito   583 KHVCDGHTDCANGEDEMRCPIVHPCGAHSRCEQLCITAYSGREECMCRPGYLLHGNGYNCTDIDE 647

  Fly  1323 CDHWD--TCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNV 1385
            |....  .|||.|.:....:.|.|..|:.|..|:.|||:.. ....::..||.||:.::|.....
Mosquito   648 CSITSNPVCSQECLNVAGSFRCSCQPGYVLRPDQRTCKAVG-GSVKLLMANRADIRQVSLSNNQY 711

  Fly  1386 GNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVD 1450
            .:....|.|.||||:.|..:.   ::||||..|.|.|.||.|..:|:   ||..||.:..|||||
Mosquito   712 TSIAKGLPNAIALDYHYRQDL---LFWTDVSIDVIKRSHLNGSGVRD---VIKWGLESPGGLAVD 770

  Fly  1451 WVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERAS 1515
            |:...|:|.||...::||:.|:|..|..:.|.:::.|||||:.|...|:||||| ..:|:||||.
Mosquito   771 WIHDLLFWTDSGTRRVEVSTLDGQMRAVIAASDLDKPRAIAVHPGRALVFWTDW-GTAPKIERAF 834

  Fly  1516 MSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHP 1580
            |.|..|:.|...   :..||||||:|||..|:||.||| ..|.|..:||.....:|.|.  |.||
Mosquito   835 MDGSDRQTIIAE---AIFWPNGLTIDYTSSRIYWADAK-HVIESANFDGRARRKILSNN--LPHP 893

  Fly  1581 FAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGEN--- 1642
            ||:::||:.:|||||.|.::..|:|.||...:|:......|.|||..|.||||...|.|..:   
Mosquito   894 FALALFEDSMYWTDWHTKTISTASKVNGRGFRVVHEGLHFPMGIQSYHPSRQPDFTNRCAADKNG 958

  Fly  1643 -NGGCSHLCLLSGRGTFKCECPHVMRLDPANERNC--VPNEQVLLFVMVD-EIRGIDLHQPNHHT 1703
             .||||||| |..|...:|.||..:.|.| :::.|  ||::.:|:....| .:|.:|...|....
Mosquito   959 RKGGCSHLC-LPARTHRRCACPIGLTLRP-DQKTCSTVPDKLLLIARKKDVRVRQLDAANPVDMV 1021

  Fly  1704 IPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIA 1768
            :|.    ..:.:...:|:....:.|:|:|:.::.||.|.|:....|.|:..|:..|.|.|:||:.
Mosquito  1022 LPL----DGIKSTVAVDWCSRTNVIYWTDVGKSMISRAFINGSQQEAIVKANLISPAGLALDWVT 1082

  Fly  1769 RNMYFSSGQIKCNILASNLKG-EFASIIHEDLNMVDSIVLDPANGKMYWIHSASD-GSMSQLEQS 1831
            ..:|::..... .|.|:...| :.|.:|.|.|:....||:.|..|.|:|    || ||...:|::
Mosquito  1083 DKIYWTDPGTN-RIEAATTDGRQRALLIWERLDKPRDIVVHPGEGYMFW----SDWGSNPLIERA 1142

  Fly  1832 NLDGSSRSLIYQHENNLQ---SLTMDFDSQRLYYA-----------YDNSGIAYYDIPRNETRKV 1882
            .:||:.|..:.  ..|||   .|.:|.|.||||:.           ||.:|           |..
Mosquito  1143 GMDGTGRFTLV--SENLQWPNGLALDVDKQRLYFLDGGTKSLEYVNYDGTG-----------RNR 1194

  Fly  1883 LVASPITSISSLTVYNGTLYFPE----NIQSVIMQCEKEACSNM------SYLRVNTKSIQSMKM 1937
            |:...:.....|.||...:|:.:    :||          .:||      ..:..|...:..:::
Mosquito  1195 LITEGLKHPFGLDVYEKRVYWTDWDTHSIQ----------VANMYNGHDRRTILANNTDLMDIRV 1249

  Fly  1938 FYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCV--PRAEFIF-YSI 1999
            |:.:.:...|.||.  ..|||..:||...: .:.|.|.:|..::.|..| |.  |....:| :..
Mosquito  1250 FHRNRRDSRNPCAH--KNGGCSYICLLNPT-SYSCACPIGIQLKDNGKT-CKSGPSNYLVFAHRT 1310

  Fly  2000 DVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQ-RE 2063
            :|.|  ..:|...|.|...| |.|||.|.:   :|....|..:||.|.....|.|...||.: ::
Mosquito  1311 EVRQ--VSLDSDYQIDVVLP-LPPISNVVT---LDVDRRTGEIYWADTIEDVIMRSTPDGMRIKQ 1369

  Fly  2064 TILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARL-DGSHRYVVVSNLEKPTALAV 2127
            ...|::..|        .|:.||.:...:||:|..|.::||:.| :|....:|..:||:|..:|:
Mosquito  1370 IYSESMTSV--------DGLVIDSIGRKLYWTDAGRKVLEVSDLEEGIRSALVWKDLEQPRGIAL 1426

  Fly  2128 DPLQGLLFYV---TQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMK 2189
            |...|.||:.   ....|.|..:||.....|:.: ...|..| |.:|..|.::||.:.....:..
Mosquito  1427 DYESGYLFWSDWGANPRIERADMDGENRVDLITE-GLGWPNG-LAVDRAAKRIYWADAQMKTIES 1489

  Fly  2190 VDYDGNLREQLLNESLNNPVALAKMGDYLYWAE---------NKYNEGIIR--VAPLANLSQSKV 2243
            ....|..|.::: |:|.:|.|||..|..:||.:         .|.|...||  ...|..|...||
Mosquito  1490 CTLSGGARTKVV-ENLPHPYALAVTGRTIYWTDWITKALHSVPKGNPAHIRNVTHGLEGLMDVKV 1553

  Fly  2244 VLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLASDGYS--CEPY 2306
            |.:.::          :||:   |.|...||.|..|||.|.|...|.|.......:|.:  |:..
Mosquito  1554 VQEDDE----------RHLE---NVCGAGNGGCSHLCLRNPTGYSCKCPTGLTMREGSTTDCKTL 1605

  Fly  2307 -ENFLLFSYRSNIE--SIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTIN 2368
             :.:||.:.||.|.  |:...|..|...|::.:      ...:.:.|:::...|:|:||.:..|.
Mosquito  1606 PDEYLLIALRSGIGRISLDTPDLFDVVLPIEGV------HGAVVLDYHFDSMYVFYADVNVDAIR 1664

  Fly  2369 QVHF-NGTGHRVLLEQQQRV-EGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKV 2431
            :|:. |.:..:|::...... .|:|.|.:.:.|:||   :..::.:|:..|.....      |.:
Mosquito  1665 RVNMHNYSDTQVIVSSGLNTPNGIAVDWLADNLYWT---DTALKKIEVARLDGSCR------KAI 1720

  Fly  2432 LSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQK 2496
            |:...|| ||.|.:.|..|.::|.:|.: :|.|:|:|:.|.....|:..::..|..|.:|.:.:|
Mosquito  1721 LTDGLDD-PRSIILYPKRGFVFWADWGQ-TPKIERAYMDGSERRSIVDFELGFPTGLAIDFDAKK 1783

  Fly  2497 LYWADARLDKIERTNYDGSNR-VVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVL 2560
            ||||||..|:||..::||..| .|::|:|  |.|...:....|:||||...:|:||.|::.:.|.
Mosquito  1784 LYWADALQDRIELCDFDGRRRQQVVSHAT--HPFGFTLTATHLYWTDWYNKSVLRAPKHSVSSVE 1846

  Fly  2561 FLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRC 2622
            ..|..:...:.|.||.......|.|.|:..||.|..:|:..:: :..|.|..   .||...|
Mosquito  1847 VARFSLRGALEIRAVSGQRQPHDWNPCRSDNGGCSHLCLYAET-RYVCGCPD---IPDAHHC 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566 14/34 (41%)
LDLa 1104..1134 CDD:238060 13/38 (34%)
LDLa 1191..1226 CDD:238060 12/34 (35%)
FXa_inhibition 1289..1317 CDD:464251 8/28 (29%)
LY 1434..1476 CDD:214531 18/41 (44%)
LY 1477..1521 CDD:214531 20/43 (47%)
LY 1533..1567 CDD:214531 19/33 (58%)
LY 1568..1611 CDD:214531 19/42 (45%)
FXa_inhibition 1639..1676 CDD:464251 15/40 (38%)
LY 1751..1789 CDD:214531 10/37 (27%)
LY 1794..1838 CDD:214531 16/44 (36%)
LY 2078..2112 CDD:214531 11/34 (32%)
NHL <2082..>2152 CDD:302697 24/73 (33%)
NHL repeat 2082..2120 CDD:271320 12/38 (32%)
FXa_inhibition 2269..2303 CDD:464251 12/35 (34%)
LY 2430..2471 CDD:214531 14/40 (35%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Lrp4XP_061518363.1 None
Blue background indicates that the domain is not in the aligned region.

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