DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and yl

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_310672.6 Gene:yl / 1271818 VectorBaseID:AGAMI1_010770 Length:1906 Species:Anopheles gambiae


Alignment Length:2499 Identity:563/2499 - (22%)
Similarity:828/2499 - (33%) Gaps:959/2499 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1092 ETSETIFASKC--PEFDCNNGRCRQFADVCDGIDNCGNNADEMECE---------QECEHGEKYC 1145
            |...|..:..|  .||.|.||.|...|..|:.|.:|.:.:||..|:         ..|.|...  
Mosquito    75 EKKSTAASKSCGAHEFQCENGACIPAAGHCNDIQDCADGSDESGCDYFLCRAPFWYRCRHEST-- 137

  Fly  1146 RPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLR 1210
                |......|||..|||...||.||     ||:.|.....|  |:..||.|. ...|||..|.
Mosquito   138 ----CISGSSRCDGQRDCLGGDDEENC-----DNYEVPHRAPL--CSKAEFTCT-DRACIPADLV 190

  Fly  1211 CDGISHCFDKTDE-------------FNCTHINTTRF------------DMNETVIC------EH 1244
            |||:.||.|.:||             |.|.:.:..:.            |.::...|      ||
Mosquito   191 CDGVQHCLDGSDETIGCIDIAGKCKGFLCRNKHCLQSHHWVCDGLDDCGDGSDEEHCLSECTLEH 255

  Fly  1245 PDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLC---ADKLCDRGHECSHRCHNTPEGY-ICSCP 1305
            ....|..:..||.|.|:|:|.:||.|.:|||..|   ||. |...|.....|...|:|. :|.|.
Mosquito   256 GKYECANNHTCVDVTQVCNGADDCGDGSDEGPGCKVPADG-CKALHCAPQTCKVLPDGKPVCLCG 319

  Fly  1306 DHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFT 1370
            .....:|:..||...:.|..:..|||.|.::...:.|.|:|.|.|..|..||:.::..|..:::|
Mosquito   320 VGFRFEPSAGRCVDVNECARYGLCSQGCINTPGSFRCTCIDQFHLMRDGRTCELSSGTEALMLYT 384

  Fly  1371 NRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVE- 1434
            .::.:..:.|.:|:.......|..:|.:.:     ....:||||:       .|......|::| 
Mosquito   385 TQKAVGAMYLTSLHQYYVAKELSQVIGVAY-----DGSHVYWTDI-------SHKTESIERSLED 437

  Fly  1435 -----AVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDP 1494
                 .::.:||.:.|.:|:||:..|:|:.||....|.|...:|...|.::...:..||.|||.|
Mosquito   438 GSDRVQLLTAGLISPEDIALDWLTGNIYFSDSGQMHIAVCSSDGYHCRAIVQDELHKPRGIALLP 502

  Fly  1495 REGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAG--WPNGLTLDYTQKRVYWVDAKSDSI 1557
            :.|.||::||.:|: .|.||.|.|..::::     :|.|  ||||||||:..:|:||:|||...|
Mosquito   503 QNGTLFYSDWGNNA-MIGRARMDGTEQQVV-----VSDGIHWPNGLTLDWPNQRLYWIDAKLKRI 561

  Fly  1558 SSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPF 1622
            .|..:||::..|||  .::|.|||:|:||.:.:||:||.|.|:...:|:.|...|.|...: ..|
Mosquito   562 ESMHFDGTDRVVVL--DDVLKHPFSIAVFNDRLYWSDWDTKSIQSCDKFTGKMRQTLVHDR-MIF 623

  Fly  1623 GIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVM 1687
            .:.|.|||.||...:.|.  |..|:|||||:...|:.|.||                        
Mosquito   624 DVHVYHSSIQPKVSHACA--NHTCTHLCLLTSNATYACACP------------------------ 662

  Fly  1688 VDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPII 1752
                :|::|.:..|        |...|| :|.|.|:                  ||.:.|:    
Mosquito   663 ----QGMELSRDKH--------SCASVA-KRQDILL------------------GIGHYLV---- 692

  Fly  1753 NTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWI 1817
             |....|:|                                                       .
Mosquito   693 -TLKHHPFG-------------------------------------------------------R 701

  Fly  1818 HSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNETRKV 1882
            |:...|.                                                          
Mosquito   702 HATGRGE---------------------------------------------------------- 708

  Fly  1883 LVASPITSISSLTVYN---GTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQT 1944
              ..|:.:||.| .:|   |.|:..:|.:..|                                 
Mosquito   709 --PLPVATISRL-AFNSLTGELFVADNSRRAI--------------------------------- 737

  Fly  1945 GSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEMID 2009
                                                                |::          
Mosquito   738 ----------------------------------------------------YTV---------- 740

  Fly  2010 PSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSI--SRVKRDGTQRETILEALNLV 2072
                                                  ||||:  .|:.|.|..|.|.|      
Mosquito   741 --------------------------------------ELGSLRTQRLVRSGIGRITAL------ 761

  Fly  2073 GYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNL--EKPTALAVDPLQGLLF 2135
                       |.|:::..:||||.:|:.||:..|...||.::...|  :.|.|||:.|..|.:|
Mosquito   762 -----------AFDYLSNTLYWSDAERSTIEIYSLQTRHRSIIQHYLGDDAPVALALIPETGKMF 815

  Fly  2136 YVTQQ-----HIGRVGLDGSQPFVLVNQTR--ANWAVGSLVLDIEATKVYWCERYPDALMKVDYD 2193
            ...:.     ||.|..:.|..|...|.:.|  :|..: |..:|.:...|:|.:...:.:....::
Mosquito   816 VALRSPSGHTHIDRQDMTGRGPHTHVIEERLGSNGTI-SFAVDQDLRSVFWSDSGTNRIEITSFE 879

  Fly  2194 GNLREQLLNESLNNPVALAKMGDYLYWA---------ENKYNEGIIRVAPLANLSQSKVVLQTEQ 2249
            |:.| .|..|.|..||:||.:|..|:|.         .:|:|.|          :..::.:|...
Mosquito   880 GDTR-HLFREYLREPVSLAIIGSELFWTCRGSQRLYWSDKHNVG----------ATKRISVQLPP 933

  Fly  2250 D-AIRD---LKIYSKHLQRGSNPCAHSNGACEQLCLFNG--TSAVCACAHSRLASDGYSCEPYEN 2308
            | |:.|   :.......:|..:||..|||.|..:|:..|  ||| |.|                 
Mosquito   934 DLAVPDEMPIAASQPTTRRPDHPCTRSNGGCSHICVAGGLYTSA-CVC----------------- 980

  Fly  2309 FLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFN 2373
                                   |..|:.||:|.|                              
Mosquito   981 -----------------------PTGMVFNTTLAR------------------------------ 992

  Fly  2374 GTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDD 2438
                                                                             
Mosquito   993 ----------------------------------------------------------------- 992

  Fly  2439 KPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADAR 2503
                                                                             
Mosquito   993 ----------------------------------------------------------------- 992

  Fly  2504 LDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTR 2568
                                                                             
Mosquito   993 ----------------------------------------------------------------- 992

  Fly  2569 PMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLS 2633
                                        |||                  |...|           
Mosquito   993 ----------------------------VCI------------------DAAAC----------- 1000

  Fly  2634 QYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGD 2698
            .:.|.||||:...|.|:....|.|.||                          |..|:.:...|.
Mosquito  1001 AFRCASGECLARGLRCNGRVDCMDQSD--------------------------EQGCESKTPAGA 1039

  Fly  2699 GSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSG-ECIPRKFLCDSLKDCRDFSDEKMCAPI 2762
            |:      ..|:..:                |||..| .||.....|||..||.|.|||..|...
Mosquito  1040 GT------TGCRWNE----------------FRCADGSRCIAATSRCDSRPDCADRSDEANCEGY 1082

  Fly  2763 PCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCA------NHTSLSCDPGQFRCASGN 2821
            ....|...:........|:....|||..||||||:||.:||      ...:.:|..|.|||.||.
Mosquito  1083 NRRTNCTRYQFSCADGFCVDATARCDQVPDCPDGSDEQECAGVGGKGGVAATTCAAGMFRCNSGQ 1147

  Fly  2822 CIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRP 2886
            |:.|||.|||..||.|.|||              .::|.||          |...:||.......
Mosquito  1148 CVPGSWECDGSPDCHDASDE--------------HESCQPA----------EKKQEEGKGKEQER 1188

  Fly  2887 CRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDE---------GPQCG--GVAHIPDCPP 2940
            |....|:| ..|.||....||||..||    || |:::|         ..||.  .:|:     .
Mosquito  1189 CGEGRFRC-GVGFCISSALVCDGNDDC----GD-GTDEEHCVGRIGATAAQCSEQAIAN-----G 1242

  Fly  2941 PAHLCT-SGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCD 3004
            .|:.|. ||.|:.:...|:|..:||.|:|| .||      .:|  |....||.||.||.:...||
Mosquito  1243 TAYRCARSGACLPAAARCNGTTECPHGEDE-TGC------SNC--GLREFQCADGQCIRQEWRCD 1298

  Fly  3005 GKPDCGDGSDETSSLC------AHTRGCN-GTDDFRCKNGACIHADLLCDRRNDCADFSDEELCN 3062
            ...||.|||||.:...      |||...: |.|.|.|..|.||....|||.|.||.:..|||...
Mosquito  1299 HDQDCDDGSDERNCTAGADGSTAHTHAIDCGRDTFECGPGECIPVAKLCDGRRDCTNGHDEEGAC 1363

  Fly  3063 VNEC---LIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSY 3124
            .:.|   |.|  |...|:....|..|.|..||: |......|||::||...|||:|.|.|.:|||
Mosquito  1364 ASACTGGLGP--CAQICQKSPAGSICACLEGYE-LAGDRKTCTDVNECARGQPCAQQCANVHGSY 1425

  Fly  3125 KCLCAKGYAL-VDHHTCKATSNVSMELIFSNRYYIRQVDMTGN---GSILINELSNAVALDYDWD 3185
            :|.|..|:.| .|..:||:. ..:..|:::....:||:.:...   .::|....|...|||.|..
Mosquito  1426 RCACHDGFMLRPDKASCKSV-GPAPHLLYTALDQVRQLTLQQPPRIDTVLRTNGSRITALDLDVR 1489

  Fly  3186 SQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLD 3250
            .:.||::  ......:..:..:.|:|:.|  |.:..||.|||||||.|:|:.|....:::|....
Mosquito  1490 QRRLYYA--AENGAALYEHDLRTNETRVL--ANVGRPDRLAVDWVAGNVYFADATEPSLKVCHFG 1550

  Fly  3251 -GKYRKVLINEYLREPRGIALHPYQQHIFWS---DW-GDSPH--IGKAGMDGSNPKMIIRDGLGW 3308
             |...:|.........:.:|:.|..:::|::   .| ...||  :.:|.:|||..:::.:.. |.
Mosquito  1551 RGACARVASFSQRNYVKAVAVDPVNRYLFYALLFSWIFQVPHTIVYRARLDGSLQEIVTKQA-GI 1614

  Fly  3309 PNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGH-IYWSD 3372
            .:||.:..:.|.|::.:...:|:...|..|...|:|  ....|.| ||....::|:|.. :..:.
Mosquito  1615 VSALAVDPQAQLLYYTELAGNTLRRVDYLGQGQRVL--AEDQPGL-LHQPVQLSVYENQALVVNR 1676

  Fly  3373 WETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYR--------------QQQPMSGNPCLAAN 3423
            ....||..|.::....|                .|||              .:|||..|.|..||
Mosquito  1677 APPGSIGQCQLYGQYRC----------------EPYRVNVPPTGLLLVVQESRQPMVPNVCDRAN 1725

  Fly  3424 CSTLCVLSPEEPYYKCMCPTNFILADDGR 3452
            |:.|||  ...|..:|:|.....:|:..|
Mosquito  1726 CTHLCV--AVGPVARCICENGLEIAEGDR 1752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566 563/2499 (23%)
LDLa 1104..1134 CDD:238060 12/29 (41%)
LDLa 1191..1226 CDD:238060 17/47 (36%)
FXa_inhibition 1289..1317 CDD:464251 6/28 (21%)
LY 1434..1476 CDD:214531 14/47 (30%)
LY 1477..1521 CDD:214531 18/43 (42%)
LY 1533..1567 CDD:214531 19/35 (54%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:464251 12/36 (33%)
LY 1751..1789 CDD:214531 3/37 (8%)
LY 1794..1838 CDD:214531 2/43 (5%)
LY 2078..2112 CDD:214531 10/33 (30%)
NHL <2082..>2152 CDD:302697 24/76 (32%)
NHL repeat 2082..2120 CDD:271320 13/39 (33%)
FXa_inhibition 2269..2303 CDD:464251 12/35 (34%)
LY 2430..2471 CDD:214531 0/40 (0%)
LY 2475..2517 CDD:214531 0/41 (0%)
LDLa 2630..2661 CDD:238060 10/30 (33%)
LDLa 2671..2702 CDD:238060 4/30 (13%)
LDLa 2727..2759 CDD:238060 15/32 (47%)
LDLa 2773..2802 CDD:238060 12/28 (43%)
LDLa 2810..2844 CDD:238060 20/33 (61%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 12/28 (43%)
LDLa 2938..2969 CDD:197566 10/31 (32%)
LDLa 2989..3015 CDD:197566 13/25 (52%)
LDLa 3030..3061 CDD:238060 15/30 (50%)
EGF_CA 3062..>3091 CDD:214542 8/31 (26%)
EGF_CA 3103..3141 CDD:214542 17/38 (45%)
LY 3212..3254 CDD:214531 16/42 (38%)
Ldl_recept_b 3275..3314 CDD:459654 11/44 (25%)
LY 3299..3340 CDD:214531 8/40 (20%)
LY 3354..3389 CDD:214531 7/35 (20%)
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
ylXP_310672.6 None
Blue background indicates that the domain is not in the aligned region.

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