DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and Gm19410

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_006509297.1 Gene:Gm19410 / 100502846 MGIID:5011595 Length:2104 Species:Mus musculus


Alignment Length:2214 Identity:561/2214 - (25%)
Similarity:890/2214 - (40%) Gaps:556/2214 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 PNAALTAGGGPCP--------------ASYFTCNDGFCIPMRWKCDSKADCPDMSDE-------- 118
            |.|.|..|...||              ...:.|::|.|||..|.||..:||.|.|||        
Mouse    45 PVAWLCNGEQECPDGTDELCEQTCLGHLQAWQCDNGRCIPASWLCDGASDCLDGSDEVNCESLTA 109

  Fly   119 -----------------GSEC--------------AP--KCNEGQFRCGVSRHCIPNNWLCDGEF 150
                             |..|              .|  :|..||::| .:|.||.::|.|||..
Mouse   110 CPDYKIRCPGKAQCLDAGEPCDAQQSCEDGSIKAYCPHIRCLAGQWQC-QNRACIMDSWRCDGID 173

  Fly   151 DCGKGDISDE---LNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDN--DELQ-CDKQNAA 209
            .|  ||.|||   .:||.|..        .|.:|.|:..|..|:||.||.:  ||.: |.|.   
Mouse   174 HC--GDASDERDCASCPEGTV--------SCDSGKCIPESLMCNGRADCTDGADEPRTCGKN--- 225

  Fly   210 CAALN--CSFNCKLTPQGARCYC-PKDQVPESSNSTRCVDYDECSEP-GTCDQVCRNTPGSYECS 270
            |:.||  |...|..|..|.||.| |..|:.....|  |.|.||||.| |.|.|:|.||||||.|.
Mouse   226 CSLLNGGCEGPCSDTHWGVRCSCTPGWQLQPDGWS--CGDVDECSLPYGPCGQLCHNTPGSYSCG 288

  Fly   271 CVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSE 335
            |:.|:....|..||.     |:....|.::.|         .|:          ::.|: ..||.
Mouse   289 CIQGHQLYNGTDCRV-----TDDDVKILIATD---------KEL----------RILDR-RTGSH 328

  Fly   336 EELL--LSQPLRFVHAFEVWHRN------RTLCSLLFS-------WPELQMRCQRVDDARVNWTL 385
            |.|:  .|:|....:..:   ||      :.|...:|.       :|||.               
Mouse   329 EMLIPVKSRPSSVAYDLD---RNMYFWVDKVLNVFVFGKPNSVHLYPELP--------------- 375

  Fly   386 PFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLC---TNAMTYCRVILQQVDPLSSLDLDPT 447
            |.||          :.|||::|..|..|....::  |   ::...|.:::.:.:.| ..|.:.|.
Mouse   376 PVSS----------ISLDWVTGQLYWASSSGRVI--CAGLSDGRGYVKILEKDLVP-EELVVFPA 427

  Fly   448 KGFMFYTDWTPSLSRSL----LDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDY 508
            |.::::.|.:.:..:::    :|||:|.:|.......|..:|||.....:|||..||:.:..|:.
Mouse   428 KRYLYWVDRSENGVKTIETAGMDGSDRKMLAVVTAEEPLGLTLDHVTGRLYWISGYKESIETVNV 492

  Fly   509 EGRNRWTLKRPL---DSPVPLKTIHAVEVFENSIYLAAWMD-TAIVALDKFSLKTH--ILQSNVS 567
            :...|:|..|..   :.||.|      .||||:.:   |.: |.::.....|.|..  :|.:::|
Mouse   493 DSSGRYTFPRVFFEDEHPVGL------AVFENAFF---WANQTQLIRTSPSSPKEREVLLHASIS 548

  Fly   568 RGANLRIFHRQKQPEVAH-PCRDNNAGCNQICV--PQWTKGFASAKCMCTAGYKLHNQTTCLLSA 629
            .   ..:.|:.:||:..| .|...:  |:.:|:  |...||:   ||:|..|..|....||    
Mouse   549 A---FSVLHKTQQPKSRHSACVPGS--CSHLCLLSPIHPKGY---KCVCPEGLFLLPSGTC---- 601

  Fly   630 LDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVAD 694
                                     .:|:.:                                  
Mouse   602 -------------------------SELKVV---------------------------------- 607

  Fly   695 SGASPFGNGEPSCSIRSQSLNGSVSR-LLAQGLKRVHAVAFDWINDHLYWTS---HKKMQVAPLR 755
                 |.:|:....::..|:..::.| |:.:....::.:..||..:.:||.:   |.........
Mouse   608 -----FSSGKRLYLLKVSSMGRAIERTLIEEHAGNLYLLDIDWKRNFIYWANAQGHLVYSAGYSG 667

  Fly   756 NLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAG-IYSSWMDGTHKELLAKGTSSMPMQ- 818
            ...::.|..|.|.|   .:|..||.|:|     ..|..| |..:.|.|.....| ..|.::.:| 
Mouse   668 EKQEIWTQQTVCSA---NVDIPTGNLFW-----VPCNRGTIQKTRMPGAESFTL-YSTQNIILQL 723

  Fly   819 ---WPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLF-----------------------K 857
               |||.:        |||.:.. :.::.|.|||..|:.::                       |
Mouse   724 LLDWPRRM--------LYWVESG-TPLQRMTLDGKNRQEVWRGTWAADTRMALDLGSASILWTTK 779

  Fly   858 SDQFHPYSIVQNN--------------------------GLIYWADNKN-----STILRFHAHQA 891
            ....|..||::|.                          .|:.|  |:.     ||:...|    
Mouse   780 GVGLHSLSILKNRTCSLNTSWSDVVMVAHAPYLVTADKAALVLW--NRKTLEPFSTLKEPH---- 838

  Fly   892 NLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPS----ACAQSKCPGMCLNTPKGAICRCPDG 952
                 ....:.|......:|..:    .:|:|.|||    .||:|..|             |.| 
Mouse   839 -----IKKMIILAENQEVSDPGL----KEPVPTTPSLPPVLCARSSVP-------------CQD- 880

  Fly   953 FTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVN 1017
                  |..|||:                         :.:|:|..||:||.||.:     |: .
Mouse   881 ------GKGCIPR-------------------------ESLCNGEADCQDGSDEKN-----CS-Q 908

  Fly  1018 TCDKTHNFVC--NGRCYQRSLLCSTIPYCSDGTDQANCHQ--NTCNSNEFTCHKSGRCIQLTWVN 1078
            .|.:...|.|  ..||.:....|....:||||:|:.:|.:  :.|:.:   |....|||..:|..
Mouse   909 ICHQPGVFQCLDGSRCIEERYHCDGAQHCSDGSDELDCWRPADDCSMH---CDNKTRCIPKSWRC 970

  Fly  1079 DGVVDCGPDDDSDETSETIFASKC--PEFDCNNGRCRQFADVCDGIDNCGNNADEMEC----EQE 1137
            ||..||  .|..||  :..|..||  |||.|.||:|...:..|||..:|.:::||..|    ..:
Mouse   971 DGKPDC--LDRRDE--QGCFHEKCSSPEFQCENGQCISSSLRCDGDRDCLDHSDEEGCPVAWSLQ 1031

  Fly  1138 CEHGEKYCRPIG-CYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFP 1201
            |..||..|...| |.....:||...||.|.:||.:|.            .::..|.|.::||...
Mouse  1032 CPEGEMKCPKSGECVLAEWICDHDVDCKDGTDEKDCG------------LKVISCGPRQWACDSG 1084

  Fly  1202 FECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKN 1266
            .:|:|||..|||.|.|.|.:||..|....           |:..:..|. :..|::...:|||:.
Mouse  1085 DQCVPDFWHCDGQSDCRDGSDEAGCAPQK-----------CQDSEFQCA-TGACLSFSMVCDGRE 1137

  Fly  1267 DCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDH--WDTC 1329
            ||.|.:|||..|:..:|..| .|.|.|:.:|.|.:|.|.....|:.||:.|...:.|..  ...|
Mouse  1138 DCVDGSDEGGECSSSVCSPG-LCYHSCYQSPTGPVCVCAPGFELESNGQICQDVNECQQPSGQPC 1201

  Fly  1330 SQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRN 1394
            ||.|.::...|.|.|..|:.||.|..|||:|.. ||            |.|.::....|.|.||:
Mouse  1202 SQTCINTEGSYICACHPGYLLGPDGHTCKATGA-EP------------ILLVSIEFNLFLSGLRS 1253

  Fly  1395 IIALDFLYNNESNVEIYWT--DVIDDKIYRGHLVGESLR------NVEAVIHSGLSTTEGLAVDW 1451
             :..|.|...:.|:.||..  |::|.||:......||:|      ..:.::..|:. .:.:.|||
Mouse  1254 -LKEDILTTADKNLAIYSVDYDLVDQKIFWADPNAESIRWTSMATKKDGIVVQGIK-PDCIGVDW 1316

  Fly  1452 VGKNLYWIDSNLDQIEVAKLNGSFR-----RTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRI 1511
            :|:||||.|....||...:|....|     ..::..::..|:::||||..||::|::..: .|||
Mouse  1317 IGRNLYWTDGRAGQILAIQLTAMGRGKSEYTVVLDDDLIRPQSLALDPLNGLMYWSETGE-EPRI 1380

  Fly  1512 ERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEI 1576
            |:|.|.|..|:::...   ..|.|..:.||....:::|.|.|...|.|...|||  .:.:.....
Mouse  1381 EQAGMDGSSRKILVNQ---GLGHPTSIALDQLSWKIFWSDEKFHCIGSVNLDGS--GISMMQLTQ 1440

  Fly  1577 LSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGE 1641
            :..||:::|||:.|:|:|.:|.::..|.|..|.|..||.:...||||::::|...||...:||.:
Mouse  1441 IKSPFSVAVFEDKVFWSDLQTRTIQHAEKMTGKDRAVLIKRSGQPFGLKIMHEVLQPRSSSPCLD 1505

  Fly  1642 NNGGCSHLCLLSGRGTFKCECPHVMRLDPANER-NCVPNEQ-----VLLFVMVDEIRGIDLHQPN 1700
            .  |||||||||.|....|.||..:.|  |::. .||..::     ::|..::.:|...:|....
Mouse  1506 I--GCSHLCLLSPRAKGSCRCPVGLLL--ADDGITCVSLQESGFVFLVLPTVLTQIYLKNLKTSQ 1566

  Fly  1701 HHTIPTIRQSPRLVAPQ--RIDFLVDESRIFWSDIQQNEI-----SSAGI-SNGLIEPIINTNIE 1757
            ..|:|..|..|.....|  .:|:||.|..::.|::..::|     ...|| |...:..:..|.|:
Mouse  1567 QTTVPEHRILPFTSVKQLASVDYLVQEKALYLSELNTSDIRLLRMKEPGILSWRRVISVKGTVID 1631

  Fly  1758 KPYGFAVDWIARNMYF-SSGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDPANGKMYW--IH 1818
                ||:||::.|:|: .:.....|:..||  |::..: :.|:|....||||.|....|..  :.
Mouse  1632 ----FALDWMSGNIYWIDTDNPYINVAFSN--GQYPIVLLSENLYRPTSIVLHPPTAAMCLADLG 1690

  Fly  1819 SASDGSM-SQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGI--------AYYDI 1874
            |..||.. |.:|.:::|||.|.:::........|.......|:|:|....|:        :.|.:
Mouse  1691 SQDDGRHGSSIECASMDGSGRKVLWLQSQVPVGLAFSDSGTRVYWADTGQGLIQSIQLDGSRYRV 1755

  Fly  1875 PRNETRKV-LVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMF 1938
            .....:.: |.|.....:...||        ::.|...:...|...|...:.:|:.| |..:|::
Mouse  1756 DHQGLKGLHLFACGQDMMLWTTV--------DDAQITRVWYNKAQVSESQWFQVDQK-IVDLKVY 1811

  Fly  1939 YADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGY----------DVEPNNPTGCVPRAE 1993
            ...:|.|:|:|:.  ..|||..:||.... ...|.|..||          .|:.:..:.|....:
Mouse  1812 SVLSQQGNNSCSR--DNGGCSHICLPNPE-GKTCWCPNGYCLVDGHTCVEAVQCSPMSQCCKDGQ 1873

  Fly  1994 FIFYSIDVLQG-VEMIDPSEQFDTPSPALVPIS----------RVSSASFIDYLA--NTDTLYWG 2045
            .......:..| |:.:|.|::.|..:|..|..:          |:.|.:|..:.|  :|..:|.|
Mouse  1874 RCISKEQICDGHVDCLDGSDEVDCLNPGNVHSTSILKKPEARKRLISEAFKLFQATESTTNVYLG 1938

  Fly  2046 DNEL 2049
            :.|:
Mouse  1939 EEEM 1942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566 14/44 (32%)
LDLa 126..163 CDD:238060 17/39 (44%)
EGF_CA 246..283 CDD:214542 20/37 (54%)
Ldl_recept_b 449..487 CDD:459654 8/41 (20%)
LY 472..513 CDD:214531 11/40 (28%)
LY 817..852 CDD:214531 11/38 (29%)
LDLa 1057..1092 CDD:197566 11/34 (32%)
LDLa 1104..1134 CDD:238060 12/29 (41%)
LDLa 1191..1226 CDD:238060 16/34 (47%)
FXa_inhibition 1289..1317 CDD:464251 10/27 (37%)
LY 1434..1476 CDD:214531 13/41 (32%)
LY 1477..1521 CDD:214531 15/43 (35%)
LY 1533..1567 CDD:214531 12/33 (36%)
LY 1568..1611 CDD:214531 12/42 (29%)
FXa_inhibition 1639..1676 CDD:464251 16/37 (43%)
LY 1751..1789 CDD:214531 11/38 (29%)
LY 1794..1838 CDD:214531 16/47 (34%)
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Gm19410XP_006509297.1 LDLa <42..63 CDD:238060 6/17 (35%)
LDLa 75..104 CDD:238060 14/28 (50%)
LDLa 150..184 CDD:238060 17/36 (47%)
LDLa 187..218 CDD:197566 12/38 (32%)
FXa_inhibition 226..261 CDD:464251 13/36 (36%)
EGF_CA 263..301 CDD:214542 20/37 (54%)
Ldl_recept_b 429..472 CDD:459654 9/42 (21%)
LY <465..497 CDD:214531 10/31 (32%)
LDLa 871..906 CDD:238060 18/84 (21%)
LDLa 912..946 CDD:238060 10/33 (30%)
LDLa 956..985 CDD:238060 12/35 (34%)
LDLa 990..1024 CDD:238060 14/33 (42%)
LDLa 1032..1067 CDD:238060 13/34 (38%)
LDLa 1074..1109 CDD:238060 16/34 (47%)
LDLa 1114..1145 CDD:238060 9/31 (29%)
FXa_inhibition 1201..1229 CDD:464251 11/27 (41%)
LY 1302..1341 CDD:214531 13/39 (33%)
Ldl_recept_b 1367..1407 CDD:459654 13/43 (30%)
LY 1391..1432 CDD:214531 12/45 (27%)
FXa_inhibition 1507..1537 CDD:464251 15/31 (48%)
LY 1620..1658 CDD:214531 11/43 (26%)
Ldl_recept_b 1639..1679 CDD:459654 12/41 (29%)
FXa_inhibition 1822..1856 CDD:464251 10/36 (28%)
LDLa 1869..1897 CDD:238060 4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

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