DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and ldlr

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_002942891.1 Gene:ldlr / 100495826 XenbaseID:XB-GENE-962372 Length:894 Species:Xenopus tropicalis


Alignment Length:749 Identity:255/749 - (34%)
Similarity:374/749 - (49%) Gaps:95/749 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly  2730 FRCGSGECIPRKFLCDSLKDCRDFSDE--KMCAPIPCEKNDMTFVHCGNS-TICIMPRWRCDGDP 2791
            |:||.|:|||.|::||...:|:|.|||  :.|..:.|..:..:   ||.. ..||...|:|||..
 Frog    34 FQCGDGKCIPYKWICDGSAECKDGSDESPETCKVVTCGADHFS---CGGRLNRCIPLLWKCDGQT 95

  Fly  2792 DCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACD 2856
            ||.:|:||.||   |...|...||.|.||.||:..:.||.:.||.|||||               
 Frog    96 DCENGSDENDC---TRKVCADDQFTCRSGKCISLDFVCDEDLDCDDGSDE--------------- 142

  Fly  2857 KTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEG 2921
                                   ..||...|.|.:||||..|.|||:.|.|||:.||..|..::.
 Frog   143 -----------------------SYCPAPTCNPAMFQCKDKGICIPKLWACDGDPDCEDGSDEQH 184

  Fly  2922 SEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGS 2986
            .|...|    :.....|.|....|.||.||...:.|||..||....||.:...|..:|..     
 Frog   185 CEGREP----IKTDKPCSPLEFHCGSGECIHMSWKCDGGYDCKDKSDEKDCVKPTCRPDE----- 240

  Fly  2987 LMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRND 3051
              .||.||.||..::.||.:.||.|.|||..  |.:...|.|.|.|:|::|.||..|.:|:::.|
 Frog   241 --FQCNDGTCIHGSRQCDREYDCKDLSDEEG--CVNVTKCEGPDVFKCRSGECITMDKVCNKKRD 301

  Fly  3052 CADFSDEEL--CNVNECLIPD-ICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPC 3113
            |.|:|||.:  |..|||:..: .|.|.|.|..:||:|.|..||:::.|.  .|.||:||:....|
 Frog   302 CRDWSDEPIKECGENECMRNNGGCAHICNDLKIGYECLCNEGYRLVDKK--RCEDINECENPNTC 364

  Fly  3114 SQTCINTYGSYKCLCAKGYALVDHHT--CKATSNVSMELIFSNRYYIRQVDM-TGNGSILINELS 3175
            ||.|||..|.|||.|.:||.: |..|  ||:...|:. |.|:||:.:|::.: ....:..|..|.
 Frog   365 SQICINLDGGYKCECREGYQM-DPVTASCKSIGTVAY-LFFTNRHEVRKMTLDRSEYTSFIPRLK 427

  Fly  3176 NAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKT------QTLHQAMLKNPDGLAVDWVAKNL 3234
            |.||||.:..|..:||||:|..    |.|....:|.      :|:..:.::.|||:||||:..|:
 Frog   428 NVVALDMEIASNKIYWSDLTQR----KIYSASMDKADNTSHHETVISSQIQAPDGIAVDWIHGNI 488

  Fly  3235 YWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPK 3299
            ||.|....||.|:..:|..||.|.::.|.:||.|.:.|.|..::|:|||....|.|.|::|.:..
 Frog   489 YWTDSKFSTISVANTEGSKRKTLFSDDLAKPRDIVVDPSQGFMYWTDWGLPAKIEKGGLNGVDRY 553

  Fly  3300 MIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVW 3364
            .::.:.:.|||.:|:....|:|:|.|::..::|..|:.|.: |:.:   |:...:|.|.|.:.|:
 Frog   554 PLVTENIEWPNGITLDLTNQRLYWVDSKLHSLSCIDVTGQN-RITV---ISDETHLAHPFGLTVF 614

  Fly  3365 EGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLA-----ANC 3424
            |..::|:|.|.::|...:...|.|.|.:...:..|.|:.::|..|  ||.:.|.|.:     ..|
 Frog   615 EDLVFWTDIENEAIFSANRLTGSNITKVAEDLLSPEDIVLYHNLR--QPKAENWCESHHLGNGGC 677

  Fly  3425 STLCVLSP----EEPYYKCMCPTNFILADDGRTC 3454
            ..||:.:|    ..|.:.|.||....|..|.|:|
 Frog   678 EYLCLPAPLITSRSPKFTCACPDGMHLGADMRSC 711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:464251
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060 15/30 (50%)
LDLa 2773..2802 CDD:238060 13/29 (45%)
LDLa 2810..2844 CDD:238060 17/33 (52%)
LDLa 2848..2878 CDD:238060 0/29 (0%)
LDLa 2887..2916 CDD:197566 16/28 (57%)
LDLa 2938..2969 CDD:197566 12/30 (40%)
LDLa 2989..3015 CDD:197566 12/25 (48%)
LDLa 3030..3061 CDD:238060 14/32 (44%)
EGF_CA 3062..>3091 CDD:214542 11/29 (38%)
EGF_CA 3103..3141 CDD:214542 19/39 (49%)
LY 3212..3254 CDD:214531 16/41 (39%)
Ldl_recept_b 3275..3314 CDD:459654 11/38 (29%)
LY 3299..3340 CDD:214531 11/40 (28%)
LY 3354..3389 CDD:214531 10/34 (29%)
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
ldlrXP_002942891.1 Ldl_recept_a 27..60 CDD:395011 13/25 (52%)
Ldl_recept_a 68..106 CDD:395011 14/40 (35%)
LDLa 111..145 CDD:238060 17/71 (24%)
LDLa 150..185 CDD:238060 17/34 (50%)
Ldl_recept_a 195..231 CDD:395011 14/35 (40%)
Ldl_recept_a 235..270 CDD:395011 15/43 (35%)
Ldl_recept_a 278..308 CDD:395011 13/29 (45%)
FXa_inhibition 318..352 CDD:464251 12/35 (34%)
EGF_CA 354..384 CDD:214542 16/29 (55%)
LY 419..457 CDD:214531 15/41 (37%)
Ldl_recept_b 439..483 CDD:459654 14/47 (30%)
Ldl_recept_b 486..526 CDD:459654 15/39 (38%)
Ldl_recept_b 529..569 CDD:459654 12/39 (31%)
LY 555..595 CDD:214531 11/40 (28%)
Ldl_recept_b 616..656 CDD:459654 9/39 (23%)
FXa_inhibition 674..711 CDD:464251 11/36 (31%)
Blue background indicates that the domain is not in the aligned region.

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