DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and nid1

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_002935874.2 Gene:nid1 / 100493221 XenbaseID:XB-GENE-1003556 Length:1230 Species:Xenopus tropicalis


Alignment Length:1379 Identity:280/1379 - (20%)
Similarity:440/1379 - (31%) Gaps:530/1379 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   413 SEDDGLVYLC--TNAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRTVLVT 475
            |:.|.|..||  ||:                    ..:|...|....|:|         |:|:..
 Frog   242 SDYDSLEILCWKTNS--------------------GMQGVWIYEIGAPNL---------RSVVAA 277

  Fly   476 D-QVYHPSSVTLD----LANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVF 535
            | |:    |.|||    ..|......|.....|...|||..   :||..:..|..          
 Frog   278 DVQL----SATLDEKEQEENHFEETEDFTDHYVTEPDYENN---SLKPSIPGPTS---------- 325

  Fly   536 ENSIYLAAWMDTAIVALDKFSLKTHILQSNVSRGANLRI-FHRQKQPEVA--------------- 584
                          :::|.:..:..::..||    |.:: ...|..|:|.               
 Frog   326 --------------ISVDPYQGQKDVILGNV----NFQVPSFPQNNPQVVIVDDELEDTGVVFQY 372

  Fly   585 -----HPCRDNNAGC-NQICVPQWTKGFASAKCMCTAGYKLHNQTTCLLSALDKFLVYSDKHLAR 643
                 ..|.:|...| :|.....::.||.   |.|..||                          
 Frog   373 NTGSQQTCANNRHQCSSQAFCKDFSTGFC---CSCIPGY-------------------------- 408

  Fly   644 ISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCS 708
                                                                    :|||....:
 Frog   409 --------------------------------------------------------YGNGRQCVA 417

  Fly   709 IRS-QSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHKKMQVAPLRNLSKVLT-FNTDCDAMS 771
            ..| |.:||.|...:..|...| .|.|:.|:.|.|          .:.|..:..| .:|..|::.
 Frog   418 EGSPQRVNGKVKGKIYVGSNPV-PVVFEGIDLHSY----------VVVNDGRAYTAISTIADSLG 471

  Fly   772 LELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVD--RRTKELYW 834
            ..|.|...:            .||. .||....:.....|.|....::.|..:|.  :..|:|..
 Frog   472 YSLLPLASI------------GGII-GWMFSVQQPGYKNGFSITGGEFTRRAEVTFLQSNKKLVI 523

  Fly   835 CD----------IRLSTIELMRLDGTGREVLFKSD-QFHPYS-IVQNNGLIYWADNKNSTILRF- 886
            ..          :.:||    .|:|:..|:.:.|. ...||: :.|.:..:..:.:.....:.| 
 Frog   524 LQKFSGIDEHGHLTIST----ELEGSVPEIPYGSTVHIEPYTELYQTSSSVITSTSTREYTVEFP 584

  Fly   887 ------HAHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGA 945
                  ..:|...:.||...||             |..:..:|    |..|       |:..:..
 Frog   585 QDGSETFTYQWKQTITFKECVH-------------DTTAPTVP----AIQQ-------LSVDRVF 625

  Fly   946 ICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDP 1010
            :....|...|....|:.|..:..||:..|....|:  .|..| ||..:|...:.           
 Frog   626 VLYNRDEKILRYASSNSIGPITDSPVDTNRNPCYV--GTHVC-DTNAVCRPAQG----------- 676

  Fly  1011 KGPCNVNTCDKTHNFVCNGR-CYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSG--RCI 1072
                |..||:.|..|..:|| ||.              .|:....|:.|..|....::.|  || 
 Frog   677 ----NQYTCECTSGFRGDGRTCYD--------------IDECQEQQDICGDNAICNNQPGTFRC- 722

  Fly  1073 QLTWVNDGVVDCGPDDDSDETSETIFASKCPEFDCNNGRCRQFAD---VCDGIDNCGNNADEMEC 1134
                                             :||:|  .||.:   .|..:|           
 Frog   723 ---------------------------------ECNDG--YQFLEDGRTCAAVD----------- 741

  Fly  1135 EQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACM 1199
                       ||..     |...|.|:| |.:|.|.|..|...::         .|     ||:
 Frog   742 -----------RPTN-----HCLTGTHNC-DIADRARCIYTGGSSY---------IC-----ACL 775

  Fly  1200 FPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDG 1264
            ..:.  .|...|:.:..|                    ||..| |||.:                
 Frog   776 SGYS--GDGRACEDVDEC--------------------ETSQC-HPDAV---------------- 801

  Fly  1265 KNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYICSC-PDHLYLQPNGKRC----SMQHACD 1324
                                        |:|||..:.|.| |.:   :.||.:|    ..:.||.
 Frog   802 ----------------------------CYNTPGSFSCHCNPGY---RGNGFQCFPGEPEKTACQ 835

  Fly  1325 -HWDT----------------CSQVCES---------SGKGYDCRCLDGFD-------------- 1349
             |.|:                ..|..||         ||.|| |.|:|.|.              
 Frog   836 LHLDSILGSPSVRGARPVGQYIPQCDESGNYIPRQCHSGSGY-CWCVDRFGNELPGTRTGPGLSP 899

  Fly  1350 --LGFDRFTCKSTAPD-EP---------YVIFTNRQDI-----KGINLKTLNVGNFYSSLRNI-- 1395
              ||.......:..|. .|         :::|.....|     :|.|:|..:.    .:|.:|  
 Frog   900 PCLGIVTHPPPTVGPPVRPDVVPLPPGTHLLFAQSGKIEHIPLEGNNMKKTDA----KTLLHIPD 960

  Fly  1396 -----IALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKN 1455
                 :|.|.:     :..:||||:....|.|..:.|   ....|:|.:.|.:.||:|||.:|:|
 Frog   961 KVIIGVAFDCV-----DKTVYWTDITGPSISRASING---GEPTAIIKTELGSPEGIAVDHLGRN 1017

  Fly  1456 LYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDG 1520
            ::|.||.|:.|||||::||.||.|...::|:||.|..|..:|.|:||||:..:|:||.:.|.|..
 Frog  1018 IFWTDSLLNTIEVAKMDGSNRRVLFDTDLENPRGIVADAPKGNLYWTDWNRAAPKIETSYMDGTN 1082

  Fly  1521 RRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISV 1585
            ||::...   ..|.|||||:|.....:.|:||.:..:............::   |.:.:||.|:.
 Frog  1083 RRILVKD---DLGLPNGLTIDPYSSMLCWIDAGTKRMECMNPSQPARRKIV---EGIQYPFGITS 1141

  Fly  1586 FENYVYWTDWRTTSVIRANKWNGSDVQVLQ-RTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHL 1649
            :...:::|||:..:::..::....:....| ..:|:.:||...: |:.|..:|.|..|||||:||
 Frog  1142 YGKNLFYTDWKRDAIVAIDRTISKESDSYQPPKRSRLYGITTAY-SQCPQGQNYCAVNNGGCTHL 1205

  Fly  1650 CLLSGRGTFKCECP 1663
            ||.:..|. .|.||
 Frog  1206 CLATPGGR-SCLCP 1218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654 10/38 (26%)
LY 472..513 CDD:214531 13/45 (29%)
LY 817..852 CDD:214531 8/46 (17%)
LDLa 1057..1092 CDD:197566 5/36 (14%)
LDLa 1104..1134 CDD:238060 7/32 (22%)
LDLa 1191..1226 CDD:238060 6/34 (18%)
FXa_inhibition 1289..1317 CDD:464251 9/28 (32%)
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 18/43 (42%)
LY 1533..1567 CDD:214531 10/33 (30%)
LY 1568..1611 CDD:214531 7/42 (17%)
FXa_inhibition 1639..1676 CDD:464251 14/25 (56%)
LY 1751..1789 CDD:214531
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:464251
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
nid1XP_002935874.2 NIDO 105..267 CDD:214712 9/44 (20%)
EGF_3 380..415 CDD:463759 13/119 (11%)
nidG2 419..645 CDD:238158 52/277 (19%)
EGF_3 658..694 CDD:463759 13/53 (25%)
EGF_3 700..737 CDD:463759 11/72 (15%)
EGF_3 747..785 CDD:463759 12/54 (22%)
EGF_3 793..824 CDD:463759 14/78 (18%)
Thyroglobulin_1 834..901 CDD:459665 14/67 (21%)
YncE 897..1101 CDD:442618 68/218 (31%)
LY 998..1038 CDD:214531 20/39 (51%)
LY 1039..1083 CDD:214531 18/43 (42%)
LY 1084..1120 CDD:214531 11/38 (29%)
FXa_inhibition 1195..>1219 CDD:464251 14/25 (56%)
Blue background indicates that the domain is not in the aligned region.

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