DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and lrp5

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_002941689.1 Gene:lrp5 / 100491803 XenbaseID:XB-GENE-485117 Length:1603 Species:Xenopus tropicalis


Alignment Length:1725 Identity:507/1725 - (29%)
Similarity:774/1725 - (44%) Gaps:273/1725 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1357 CKSTAPDEPYVIFTNRQDIK-----GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVI 1416
            |.:::...|.::|.||:|::     |..|:::.|   .|.|.:..|:||||   |...||||||.
 Frog    14 CLASSWGSPLLLFANRRDVRLVDAGGTKLESVVV---VSGLEDAAAVDFLY---SQGVIYWTDVS 72

  Fly  1417 DDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIA 1481
            ::.| :..|..:| .|::.|:.|||.:.:|||.||:||.|||.||..::|||..|||::|:.|..
 Frog    73 EESI-KQTLYNQS-SNLQTVVISGLVSPDGLACDWIGKKLYWTDSETNRIEVGNLNGTYRKVLFW 135

  Fly  1482 GNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKR 1546
            .:::.||||||||..|.::||||.| :||||||.|.|..|::|..:   ...||||||:|..:::
 Frog   136 QDLDQPRAIALDPAHGYMYWTDWGD-TPRIERAGMDGSMRKVIVDT---DIYWPNGLTIDLDEQK 196

  Fly  1547 VYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDV 1611
            :||.|||...|.....|||....|:...  |:||||:::..:.:|||||:|.|:...||..|...
 Frog   197 LYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLAGDTLYWTDWQTRSIHACNKRTGEKR 259

  Fly  1612 QVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTF-KCECPHVMRLDPANERN 1675
            :.:..:...|..|||....|||:...||.|:|||||||||||.|..| .|.||..::|....:..
 Frog   260 REILSSLYSPMDIQVFSKERQPYFPTPCDESNGGCSHLCLLSPREPFYSCTCPTGVQLTQDGKTC 324

  Fly  1676 CVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISS 1740
            ....:.|||.....::|.|.|..|:...|  :.|...:.....||:...|..|:|:|.:...|..
 Frog   325 KTGADDVLLLARRTDLRRISLDMPDFTDI--VLQIDDIRHAIAIDYDPVEGYIYWTDDEVKAIRR 387

  Fly  1741 AGISNGLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVD 1803
            |.:.....:.::.|.::.|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|:|:...
 Frog   388 AYLDGSGAQTLVTTEVQHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTSRKILISENLDEPR 450

  Fly  1804 SIVLDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA- 1863
            :|||.|..|.|||    :| |...::|.:.||||.|.::.  .::|   ..|.:|....:||:. 
 Frog   451 AIVLHPLTGYMYW----TDWGENPKIESAYLDGSERMVLV--NSSLGWPNGLALDLQDGKLYWGD 509

  Fly  1864 --YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLR 1926
              .|...:...|   ...||.|:...:..|...|:....:|:.:..:..|.:..|...|. ..:.
 Frog   510 AKTDKIEVINVD---GSNRKTLLEDKLPHIFGFTLLGDYIYWTDWQRRSIERVHKVRASR-EIII 570

  Fly  1927 VNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPR 1991
            .....:..:|........|:|.||:  ..|||..||. .|.....|.|.:|.::..:..|..:|.
 Frog   571 DQLPDLMGLKAASVSNTFGTNPCAD--NNGGCSHLCF-FSPRGVRCSCPIGLELLSDMRTCIIPE 632

  Fly  1992 AEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVK 2056
            |..:|.|...:..:.:...:      :...:|::.|..||.:|:..:.:.|||.|..|.:|||..
 Frog   633 AFLVFTSRATIHRISLETNN------NDVAIPLTGVKEASALDFDVSDNRLYWTDITLKTISRAF 691

  Fly  2057 RDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVV-SNLE 2120
            .:|:..|.::|    .|.   |:..|:|:||:..|:|||||..|.|||:||||.:|.|:| .:|:
 Frog   692 MNGSSVEHVIE----FGL---DYPEGMAVDWMGKNLYWSDTGTNRIEVSRLDGLYRQVLVWKDLD 749

  Fly  2121 KPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLVNQT-RANWAVGSLVLDIEATKVYWCE 2181
            .|.:||:||.:|.:::..   :..|.|..:||:...:||::. |||    .|.:|....::||  
 Frog   750 NPRSLALDPAKGYMYWTEWGGKPRIVRAYMDGTNSIILVDKVGRAN----DLTIDYADQRLYW-- 808

  Fly  2182 RYPDALMKVDYDGNLREQ---------LLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLAN 2237
                    .|.|.|:.|.         ::.:.|.:|..|.:..||:||.:  :|...|..|...|
 Frog   809 --------TDLDTNMIESSNMLGAERVIIADDLPHPFGLTQYSDYIYWTD--WNLHSIERADKLN 863

  Fly  2238 LSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCAC-AHSRLASDGY 2301
             ..::.::|...|.:.|:.::....|.|.|.|..:||.|.||||.......|:| :|..|.|:..
 Frog   864 -GNNRTLIQDHLDFVMDILVFHSSRQDGLNDCMQNNGHCSQLCLAVPKGYKCSCSSHYTLDSNNR 927

  Fly  2302 SCEPYENFLLFSYRSNIESIHMTDH--ADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQL 2364
            :|.|..||||||.::.|..:.:.:.  .|...|:..      :|||.|::|:..::|:|:.|.:.
 Frog   928 NCSPPSNFLLFSQKTAINRMLLDEQQSPDITLPIHG------LRNVKAVSYDPLDKLIYWVDGRQ 986

  Fly  2365 STINQVHFNGTGHRVLL---EQQQRVE----GLAYDIVNEQLFWTSNNNATIRSVELRHLSEHAD 2422
            :.|.:...:||...|::   .|.|..|    .|:.||.:..|:||.....||.:           
 Frog   987 NIIKRAKDDGTQPFVVVSTPNQSQTPEKQPHDLSIDIYSHTLYWTCEGTNTINA----------- 1040

  Fly  2423 QNQVHVKKV-LSLRED-DKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMP 2485
             |:::.:.: :.||.| ||||.|||....|.:|:||..|.||.|:|:...|...||:..|.:..|
 Frog  1041 -NKLNGESIGVVLRGDHDKPRAIAVNAERGYLYFTNMQERSPKIERAAFDGTEREVLFSTGLIRP 1104

  Fly  2486 NALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVR 2550
            .||.:|.:..||:|.||.|.:||.::..|:|||.|..|.......:.:.||.|:|.|.....:.|
 Frog  1105 VALVVDNKLGKLFWVDADLKRIESSDLSGANRVTLEDSNILQPMGLTILGDHLYWIDKQQQMIER 1169

  Fly  2551 ANKYTGTDVLFLREHVTRPMGIVAVQNTSIN-CDANQCKILNGQCEDVCILNKSGQATCHC-TQG 2613
            ..|..|.....::..:..|.||.||::..:| ..|:.|...||.|..:||....|...|.| ...
 Frog  1170 VEKTNGIRRTKIQGRIAHPTGIHAVESVDMNEFSAHPCSRNNGGCSHICITKGDGTPRCSCPVHL 1234

  Fly  2614 VLAPDGRRCIAPVNTSCGLSQYNCHSG--ECIPLELTCDNVTHCADGSDEFRSYCIFRQCP---E 2673
            ||..:...|..|  .:|...|:.|.:|  :|||:...||..:.|.|.|||       ..||   .
 Frog  1235 VLLQNLLTCGEP--PTCSPEQFTCATGDIDCIPMAWRCDGFSECDDNSDE-------ENCPVCSS 1290

  Fly  2674 THFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECI 2738
            ..|.|:..:||....||:||..|.|.|||......|                :||.|||.:|:||
 Frog  1291 NQFQCEKGQCIDARQKCNGEIDCQDKSDELDCDSIC----------------LPDQFRCANGQCI 1339

  Fly  2739 PRKFLCDSLKDCRDFSDEKMCAPIPCEKND--------------MTFVHCGNSTIC---IMPRWR 2786
            .....||:..||.|.|||.:|...|.||..              ..||..|...:|   :..|:.
 Frog  1340 MMSQQCDTFPDCSDSSDELICDKPPSEKTPSHSSAIGPVIGIILSVFVMGGLYFVCQRVVCHRYT 1404

  Fly  2787 CDGDP---DCPDGTDELDCANHTSLSCDPGQFRCAS-GNCIAGSW---------------HCDGE 2832
            ....|   :...||..:.....|:.|..|..:...| |..:.||.               |..|.
 Frog  1405 GPNGPFPHEYISGTPHVPLNFITTRSSQPNTYTGISYGKPMIGSMSIMGGSSGAPLYDRNHVTGA 1469

  Fly  2833 KDCPDGSDEIN--------------------------------------------------CRTE 2847
            ......|.:..                                                  |.|:
 Frog  1470 SSSSSSSTKATLYPQILNPPPSPATDRSLYNTEVFYSSNSPSTTRSYRPYLIRGIAPPTTPCSTD 1534

  Fly  2848 CRHNQFACDKTCIPASWQCDG-KSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEK 2911
                  .||.....:.|:.:. ..|....||..|..|.                 |:......|:
 Frog  1535 ------VCDSDYTTSRWKANKYYMDLNSDSDPYPPPPT-----------------PRSQYMSAEE 1576

  Fly  2912 DCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCT 2946
            .||.....|.|         ..|:  .|||...||
 Frog  1577 SCPPSPTTERS---------YFHL--YPPPPSPCT 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531 22/41 (54%)
LY 1477..1521 CDD:214531 23/43 (53%)
LY 1533..1567 CDD:214531 16/33 (48%)
LY 1568..1611 CDD:214531 16/42 (38%)
FXa_inhibition 1639..1676 CDD:464251 19/37 (51%)
LY 1751..1789 CDD:214531 13/38 (34%)
LY 1794..1838 CDD:214531 19/45 (42%)
LY 2078..2112 CDD:214531 19/33 (58%)
NHL <2082..>2152 CDD:302697 32/73 (44%)
NHL repeat 2082..2120 CDD:271320 21/38 (55%)
FXa_inhibition 2269..2303 CDD:464251 13/34 (38%)
LY 2430..2471 CDD:214531 19/42 (45%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 12/32 (38%)
LDLa 2671..2702 CDD:238060 13/33 (39%)
LDLa 2727..2759 CDD:238060 16/31 (52%)
LDLa 2773..2802 CDD:238060 6/34 (18%)
LDLa 2810..2844 CDD:238060 8/99 (8%)
LDLa 2848..2878 CDD:238060 5/30 (17%)
LDLa 2887..2916 CDD:197566 4/28 (14%)
LDLa 2938..2969 CDD:197566 5/9 (56%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
lrp5XP_002941689.1 YvrE 33..262 CDD:442613 101/242 (42%)
LY 88..130 CDD:214531 22/41 (54%)
Ldl_recept_b 151..191 CDD:459654 22/43 (51%)
LY 175..217 CDD:214531 17/44 (39%)
FXa_inhibition 287..324 CDD:464251 19/36 (53%)
LY 354..394 CDD:214531 9/39 (23%)
LY 396..438 CDD:214531 14/43 (33%)
Ldl_recept_b 459..499 CDD:459654 14/45 (31%)
LY 484..525 CDD:214531 7/45 (16%)
LY 526..559 CDD:214531 6/32 (19%)
FXa_inhibition 593..628 CDD:464251 11/37 (30%)
YncE <642..770 CDD:442618 46/140 (33%)
LY 698..740 CDD:214531 22/48 (46%)
LY 785..826 CDD:214531 13/54 (24%)
LY 826..867 CDD:214531 11/43 (26%)
FXa_inhibition 894..929 CDD:464251 13/34 (38%)
LY 958..998 CDD:214531 11/45 (24%)
LY 1050..1093 CDD:214531 20/42 (48%)
LY 1094..1136 CDD:214531 16/41 (39%)
FXa_inhibition 1207..1243 CDD:464251 11/35 (31%)
LDLa 1249..1285 CDD:238060 14/42 (33%)
LDLa 1288..1322 CDD:238060 13/33 (39%)
LDLa 1326..1360 CDD:238060 17/49 (35%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.