DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and lrp5

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_002941689.1 Gene:lrp5 / 100491803 XenbaseID:XB-GENE-485117 Length:1603 Species:Xenopus tropicalis


Alignment Length:1725 Identity:507/1725 - (29%)
Similarity:774/1725 - (44%) Gaps:273/1725 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1357 CKSTAPDEPYVIFTNRQDIK-----GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVI 1416
            |.:::...|.::|.||:|::     |..|:::.|   .|.|.:..|:||||   |...||||||.
 Frog    14 CLASSWGSPLLLFANRRDVRLVDAGGTKLESVVV---VSGLEDAAAVDFLY---SQGVIYWTDVS 72

  Fly  1417 DDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIA 1481
            ::.| :..|..:| .|::.|:.|||.:.:|||.||:||.|||.||..::|||..|||::|:.|..
 Frog    73 EESI-KQTLYNQS-SNLQTVVISGLVSPDGLACDWIGKKLYWTDSETNRIEVGNLNGTYRKVLFW 135

  Fly  1482 GNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKR 1546
            .:::.||||||||..|.::||||.| :||||||.|.|..|::|..:   ...||||||:|..:::
 Frog   136 QDLDQPRAIALDPAHGYMYWTDWGD-TPRIERAGMDGSMRKVIVDT---DIYWPNGLTIDLDEQK 196

  Fly  1547 VYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDV 1611
            :||.|||...|.....|||....|:...  |:||||:::..:.:|||||:|.|:...||..|...
 Frog   197 LYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLAGDTLYWTDWQTRSIHACNKRTGEKR 259

  Fly  1612 QVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTF-KCECPHVMRLDPANERN 1675
            :.:..:...|..|||....|||:...||.|:|||||||||||.|..| .|.||..::|....:..
 Frog   260 REILSSLYSPMDIQVFSKERQPYFPTPCDESNGGCSHLCLLSPREPFYSCTCPTGVQLTQDGKTC 324

  Fly  1676 CVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISS 1740
            ....:.|||.....::|.|.|..|:...|  :.|...:.....||:...|..|:|:|.:...|..
 Frog   325 KTGADDVLLLARRTDLRRISLDMPDFTDI--VLQIDDIRHAIAIDYDPVEGYIYWTDDEVKAIRR 387

  Fly  1741 AGISNGLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVD 1803
            |.:.....:.::.|.::.|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|:|:...
 Frog   388 AYLDGSGAQTLVTTEVQHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTSRKILISENLDEPR 450

  Fly  1804 SIVLDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA- 1863
            :|||.|..|.|||    :| |...::|.:.||||.|.::.  .::|   ..|.:|....:||:. 
 Frog   451 AIVLHPLTGYMYW----TDWGENPKIESAYLDGSERMVLV--NSSLGWPNGLALDLQDGKLYWGD 509

  Fly  1864 --YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLR 1926
              .|...:...|   ...||.|:...:..|...|:....:|:.:..:..|.:..|...|. ..:.
 Frog   510 AKTDKIEVINVD---GSNRKTLLEDKLPHIFGFTLLGDYIYWTDWQRRSIERVHKVRASR-EIII 570

  Fly  1927 VNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPR 1991
            .....:..:|........|:|.||:  ..|||..||. .|.....|.|.:|.::..:..|..:|.
 Frog   571 DQLPDLMGLKAASVSNTFGTNPCAD--NNGGCSHLCF-FSPRGVRCSCPIGLELLSDMRTCIIPE 632

  Fly  1992 AEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVK 2056
            |..:|.|...:..:.:...:      :...:|::.|..||.:|:..:.:.|||.|..|.:|||..
 Frog   633 AFLVFTSRATIHRISLETNN------NDVAIPLTGVKEASALDFDVSDNRLYWTDITLKTISRAF 691

  Fly  2057 RDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVV-SNLE 2120
            .:|:..|.::|    .|.   |:..|:|:||:..|:|||||..|.|||:||||.:|.|:| .:|:
 Frog   692 MNGSSVEHVIE----FGL---DYPEGMAVDWMGKNLYWSDTGTNRIEVSRLDGLYRQVLVWKDLD 749

  Fly  2121 KPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLVNQT-RANWAVGSLVLDIEATKVYWCE 2181
            .|.:||:||.:|.:::..   :..|.|..:||:...:||::. |||    .|.:|....::||  
 Frog   750 NPRSLALDPAKGYMYWTEWGGKPRIVRAYMDGTNSIILVDKVGRAN----DLTIDYADQRLYW-- 808

  Fly  2182 RYPDALMKVDYDGNLREQ---------LLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLAN 2237
                    .|.|.|:.|.         ::.:.|.:|..|.:..||:||.:  :|...|..|...|
 Frog   809 --------TDLDTNMIESSNMLGAERVIIADDLPHPFGLTQYSDYIYWTD--WNLHSIERADKLN 863

  Fly  2238 LSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCAC-AHSRLASDGY 2301
             ..::.::|...|.:.|:.::....|.|.|.|..:||.|.||||.......|:| :|..|.|:..
 Frog   864 -GNNRTLIQDHLDFVMDILVFHSSRQDGLNDCMQNNGHCSQLCLAVPKGYKCSCSSHYTLDSNNR 927

  Fly  2302 SCEPYENFLLFSYRSNIESIHMTDH--ADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQL 2364
            :|.|..||||||.::.|..:.:.:.  .|...|:..      :|||.|::|:..::|:|:.|.:.
 Frog   928 NCSPPSNFLLFSQKTAINRMLLDEQQSPDITLPIHG------LRNVKAVSYDPLDKLIYWVDGRQ 986

  Fly  2365 STINQVHFNGTGHRVLL---EQQQRVE----GLAYDIVNEQLFWTSNNNATIRSVELRHLSEHAD 2422
            :.|.:...:||...|::   .|.|..|    .|:.||.:..|:||.....||.:           
 Frog   987 NIIKRAKDDGTQPFVVVSTPNQSQTPEKQPHDLSIDIYSHTLYWTCEGTNTINA----------- 1040

  Fly  2423 QNQVHVKKV-LSLRED-DKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMP 2485
             |:::.:.: :.||.| ||||.|||....|.:|:||..|.||.|:|:...|...||:..|.:..|
 Frog  1041 -NKLNGESIGVVLRGDHDKPRAIAVNAERGYLYFTNMQERSPKIERAAFDGTEREVLFSTGLIRP 1104

  Fly  2486 NALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVR 2550
            .||.:|.:..||:|.||.|.:||.::..|:|||.|..|.......:.:.||.|:|.|.....:.|
 Frog  1105 VALVVDNKLGKLFWVDADLKRIESSDLSGANRVTLEDSNILQPMGLTILGDHLYWIDKQQQMIER 1169

  Fly  2551 ANKYTGTDVLFLREHVTRPMGIVAVQNTSIN-CDANQCKILNGQCEDVCILNKSGQATCHC-TQG 2613
            ..|..|.....::..:..|.||.||::..:| ..|:.|...||.|..:||....|...|.| ...
 Frog  1170 VEKTNGIRRTKIQGRIAHPTGIHAVESVDMNEFSAHPCSRNNGGCSHICITKGDGTPRCSCPVHL 1234

  Fly  2614 VLAPDGRRCIAPVNTSCGLSQYNCHSG--ECIPLELTCDNVTHCADGSDEFRSYCIFRQCP---E 2673
            ||..:...|..|  .:|...|:.|.:|  :|||:...||..:.|.|.|||       ..||   .
 Frog  1235 VLLQNLLTCGEP--PTCSPEQFTCATGDIDCIPMAWRCDGFSECDDNSDE-------ENCPVCSS 1290

  Fly  2674 THFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECI 2738
            ..|.|:..:||....||:||..|.|.|||......|                :||.|||.:|:||
 Frog  1291 NQFQCEKGQCIDARQKCNGEIDCQDKSDELDCDSIC----------------LPDQFRCANGQCI 1339

  Fly  2739 PRKFLCDSLKDCRDFSDEKMCAPIPCEKND--------------MTFVHCGNSTIC---IMPRWR 2786
            .....||:..||.|.|||.:|...|.||..              ..||..|...:|   :..|:.
 Frog  1340 MMSQQCDTFPDCSDSSDELICDKPPSEKTPSHSSAIGPVIGIILSVFVMGGLYFVCQRVVCHRYT 1404

  Fly  2787 CDGDP---DCPDGTDELDCANHTSLSCDPGQFRCAS-GNCIAGSW---------------HCDGE 2832
            ....|   :...||..:.....|:.|..|..:...| |..:.||.               |..|.
 Frog  1405 GPNGPFPHEYISGTPHVPLNFITTRSSQPNTYTGISYGKPMIGSMSIMGGSSGAPLYDRNHVTGA 1469

  Fly  2833 KDCPDGSDEIN--------------------------------------------------CRTE 2847
            ......|.:..                                                  |.|:
 Frog  1470 SSSSSSSTKATLYPQILNPPPSPATDRSLYNTEVFYSSNSPSTTRSYRPYLIRGIAPPTTPCSTD 1534

  Fly  2848 CRHNQFACDKTCIPASWQCDG-KSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEK 2911
                  .||.....:.|:.:. ..|....||..|..|.                 |:......|:
 Frog  1535 ------VCDSDYTTSRWKANKYYMDLNSDSDPYPPPPT-----------------PRSQYMSAEE 1576

  Fly  2912 DCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCT 2946
            .||.....|.|         ..|:  .|||...||
 Frog  1577 SCPPSPTTERS---------YFHL--YPPPPSPCT 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531 22/41 (54%)
LY 1477..1521 CDD:214531 23/43 (53%)
LY 1533..1567 CDD:214531 16/33 (48%)
LY 1568..1611 CDD:214531 16/42 (38%)
FXa_inhibition 1639..1676 CDD:291342 19/37 (51%)
LY 1794..1838 CDD:214531 19/45 (42%)
LY 2078..2112 CDD:214531 19/33 (58%)
NHL <2082..>2152 CDD:302697 32/73 (44%)
NHL repeat 2082..2120 CDD:271320 21/38 (55%)
FXa_inhibition 2269..2303 CDD:291342 13/34 (38%)
LY 2430..2471 CDD:214531 19/42 (45%)
LY 2475..2517 CDD:214531 16/41 (39%)
LDLa 2630..2661 CDD:238060 12/32 (38%)
LDLa 2671..2702 CDD:238060 13/33 (39%)
LDLa 2727..2759 CDD:238060 16/31 (52%)
LDLa 2773..2802 CDD:238060 6/34 (18%)
LDLa 2810..2844 CDD:238060 8/99 (8%)
LDLa 2848..2878 CDD:238060 5/30 (17%)
LDLa 2887..2916 CDD:197566 4/28 (14%)
LDLa 2938..2969 CDD:197566 5/9 (56%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
LY 3255..3297 CDD:214531
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
NHL 4029..>4158 CDD:302697
NHL repeat 4034..4074 CDD:271320
NHL repeat 4076..4115 CDD:271320
LY 4108..4150 CDD:214531
NHL repeat 4121..4158 CDD:271320
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
lrp5XP_002941689.1 LY 88..130 CDD:214531 22/41 (54%)
LY 131..174 CDD:214531 23/43 (53%)
LY 175..217 CDD:214531 17/44 (39%)
LY 218..252 CDD:214531 13/35 (37%)
FXa_inhibition 287..324 CDD:373209 19/36 (53%)
LY 354..394 CDD:214531 9/39 (23%)
LY 396..438 CDD:214531 14/43 (33%)
LY 439..482 CDD:214531 19/46 (41%)
LY 484..525 CDD:214531 7/45 (16%)
LY 526..559 CDD:214531 6/32 (19%)
FXa_inhibition 593..628 CDD:373209 11/37 (30%)
LY 657..697 CDD:214531 14/39 (36%)
LY 698..740 CDD:214531 22/48 (46%)
LY 741..783 CDD:214531 13/41 (32%)
LY 785..826 CDD:214531 13/54 (24%)
LY 826..867 CDD:214531 11/43 (26%)
FXa_inhibition 894..929 CDD:373209 13/34 (38%)
LY 958..998 CDD:214531 11/45 (24%)
LY 1050..1093 CDD:214531 20/42 (48%)
LY 1094..1136 CDD:214531 16/41 (39%)
FXa_inhibition 1207..1243 CDD:373209 11/35 (31%)
LDLa 1249..1285 CDD:238060 14/42 (33%)
LDLa 1288..1322 CDD:238060 13/33 (39%)
LDLa 1326..1360 CDD:238060 17/49 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.