DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LRP1 and lrp12

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	XP_002931586.3	Gene:	lrp12 / 100491530	XenbaseID:	XB-GENE-980112	Length:	844	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	120/474 - (25%)
Similarity:	165/474 - (34%)	Gaps:	173/474 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  3421 AANCS-TLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDC 3484
            ::.|| ....:.|.:.|            |..|.| .:...|.:..:..:..|.|:
Frog    96 SSTCSFDWVTIGPSQNY------------DGARAC-GSTIPAPYTSLQDHVWIKFH--------- 138

  Fly  3485 GDGSDEPETCPPF---------HCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFD 3540
               |||..:...|         .||..:::|.|.||......|:.::.|||||||..|
Frog   139 ---SDEHVSRKGFCLSYLAEKKKCESDRFRCDNGKCIPEILRCNRMDDCGDGSDEKLC------- 193

  Fly  3541 NHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNN-----RCMPFVWV 3600
                  |.||....                    |:..|  |...||||.:.     .|:|....
Frog   194 ------AKANRPTL--------------------SSFQP--CTVSQFQCLSRFTKAYTCLPNSLK 230

  Fly  3601 CDGDIDCPDKSDEANCDNVSCG------------PN--DFQCDSGRCIPLAWRCD---------- 3641
            |||:|||.|..||.:||..|||            ||  ||......|   .|..|
Frog   231 CDGNIDCLDLGDELDCDVPSCGQSLKYFYGAFSSPNYPDFYPPGSNC---TWLIDTGDRRKVILR 292

  Fly  3642 ------------DDHDCPNG-EDEP------ASCFSSKATCD--------PTYF---KCNNSK-- 3674
                        |.....:| |:.|      .:.|.|.|...        ..:|   |.|.::
Frog   293 FTDFKLDGTGYGDYVKIYDGLEENPRNLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 357

  Fly  3675 ---------CIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDN 3730
                     |:|      :|..||                    |...|.....||||..||.:.
Frog   358 NATYQVDGFCLP------WEIPCG--------------------GNWGCYTEQQRCDGYWHCPNG 396

  Fly  3731 SDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC-TCHSDHFSCGNGKCIMSRW 3794
            .||:||.: |::::|.|:....|..:..:|:..:.||:||||.|| .|...:|.|.|.:|:...|
Frog   397 RDELNCTM-CQKDEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCYFCQPGNFHCKNNRCVFESW 460

  Fly  3795 KCDGWDDCLDGSDESLETC 3813
            .||..|||.|||||  |.|
Frog   461 VCDSQDDCGDGSDE--ENC 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:278487
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566
		LDLa	1104..1134	CDD:238060
		FXa_inhibition	1289..1317	CDD:291342
		LY	1434..1476	CDD:214531
		LY	1477..1521	CDD:214531
		LY	1533..1567	CDD:214531
		LY	1568..1611	CDD:214531
		FXa_inhibition	1639..1676	CDD:291342
		LY	1794..1838	CDD:214531
		LY	2078..2112	CDD:214531
		NHL	<2082..>2152	CDD:302697
		NHL repeat	2082..2120	CDD:271320
		FXa_inhibition	2269..2303	CDD:291342
		LY	2430..2471	CDD:214531
		LY	2475..2517	CDD:214531
		LDLa	2630..2661	CDD:238060
		LDLa	2671..2702	CDD:238060
		LDLa	2727..2759	CDD:238060
		LDLa	2773..2802	CDD:238060
		LDLa	2810..2844	CDD:238060
		LDLa	2848..2878	CDD:238060
		LDLa	2887..2916	CDD:197566
		LDLa	2938..2969	CDD:197566
		LDLa	2989..3015	CDD:197566
		LDLa	3030..3061	CDD:238060
		EGF_CA	3062..>3091	CDD:214542
		EGF_CA	3103..3141	CDD:214542
		LY	3212..3254	CDD:214531
		LY	3255..3297	CDD:214531
		LY	3299..3340	CDD:214531
		LY	3354..3389	CDD:214531
		LDLa	3458..3490	CDD:238060	4/31 (13%)
		LDLa	3499..3533	CDD:238060	14/33 (42%)
		LDLa	3582..3616	CDD:238060	16/38 (42%)
		LDLa	3621..3652	CDD:197566	12/67 (18%)
		LDLa	3663..3697	CDD:238060	8/55 (15%)
		LDLa	3702..3736	CDD:238060	10/33 (30%)
		LDLa	3776..3808	CDD:197566	14/31 (45%)
		LDLa	3818..3849	CDD:197566
		LDLa	3860..3894	CDD:238060
		NHL	4029..>4158	CDD:302697
		NHL repeat	4034..4074	CDD:271320
		NHL repeat	4076..4115	CDD:271320
		LY	4108..4150	CDD:214531
		NHL repeat	4121..4158	CDD:271320
		EGF_CA	<4386..4414	CDD:238011
		EGF_CA	4415..4450	CDD:238011
lrp12	XP_002931586.3	CUB	43..152	CDD:238001	14/80 (18%)
		LDLa	159..193	CDD:238060	14/33 (42%)
		LDLa	207..246	CDD:238060	16/38 (42%)
		CUB	251..363	CDD:238001	19/114 (17%)
		LDLa	405..440	CDD:238060	11/34 (32%)
		LDLa	443..477	CDD:238060	17/35 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910