DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and sorl1

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_031762503.1 Gene:sorl1 / 100490681 XenbaseID:XB-GENE-995776 Length:2199 Species:Xenopus tropicalis


Alignment Length:1379 Identity:400/1379 - (29%)
Similarity:579/1379 - (41%) Gaps:342/1379 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  2997 IFKNQTCDGKPDCGDGSD----ETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSD 3057
            :||.:|...  .|.:|.|    .|.|.|:.||     :||.|..|..:..||            .
 Frog   641 VFKRRTAHA--TCFNGEDFDRPITVSNCSCTR-----EDFECDFGFKLSKDL------------S 686

  Fly  3058 EELCNVNECLIPDICEHECEDKVVGYQCHCRPGY--KVLPKSPHLCTDIDECDEQQPCSQTCINT 3120
            .|||      :||                  |.:  |:.| .|..|          |...|...|
 Frog   687 SELC------VPD------------------PEFAGKLYP-IPIPC----------PVGTTYTRT 716

  Fly  3121 YGSYKCLCAKGYALVDHHTC------------KATSNVSME---LIFSNRYYIRQVDMTG--NGS 3168
                     |||..|...||            :....|..|   ::::.|..|.:.|::.  |..
 Frog   717 ---------KGYRKVSGDTCSGGDVENRLQGEEVPCPVGEENEFILYAMRNSIYRYDLSSGINEE 772

  Fly  3169 ILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNP----DGLAVDW 3229
            :.:..|.:|||||:|:.|.||||:||  |:.||:|.|...:.:|   :.:::|.    :.||.|.
 Frog   773 LPLKGLHDAVALDFDYQSNCLYWADV--TLETIQRLCLNGSSSQ---EVIVRNGLETIESLAFDP 832

  Fly  3230 VAKNLYWCDKGLDTIEVSQLDGKYRKVLINE-YLREPRGIALHPYQQHIFWSDWGDSPH-IGKAG 3292
            :::.|||.|.|:..|||:..||..|..::|. .|..||.:||.|.:..:||:||||..| |.::.
 Frog   833 LSQLLYWVDAGMKKIEVASADGDLRLTILNSTVLERPRALALVPKEGLMFWTDWGDERHGIYRSE 897

  Fly  3293 MDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHH 3357
            ||||:.|.:|.:|:.|||.:.:  :.|.::|.:|..|.|...|.:|....::|.       ||.|
 Frog   898 MDGSSVKHLIFEGIKWPNGICV--DEQWIYWTEAYMDRIERIDFNGQQRMIILD-------NLPH 953

  Fly  3358 IFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAA 3422
            .:||||::..|||.||...||...|.:||.....:|..:...||:::|:   :.:....|.|:..
 Frog   954 PYAIAVFKNEIYWDDWSQLSIFRASKYNGARMEGIIGRLTGVMDMKIFY---KDKATGHNACVLK 1015

  Fly  3423 NCSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDG 3487
            .||.||:  |:              |::.:.||         |....|..|.. ..|.|.||..|
 Frog  1016 PCSLLCL--PK--------------ANNSKICR---------CSEGVKGTPLS-SGDIQCDCPQG 1054

  Fly  3488 -SDEPETCPPFH--CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHM-KCGAT 3548
             ..:.:||....  |.|.||:|:|..|.:....||..|.|||.|||.||...||....: :|   
 Frog  1055 YLLKNKTCVKQENTCLPSQYRCSNGNCINSIWQCDTDNDCGDMSDEKNCPTTTCDPEALFRC--- 1116

  Fly  3549 ANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDE 3613
             ..|..|:....:||...||....|||.|....||:|:|.|.:..|:...||||||.||.|.|||
 Frog  1117 -QGSGACIPLSYKCDLEDDCGDNSDESHCEAHQCKEDEFNCSSGMCIRLSWVCDGDNDCRDWSDE 1180

  Fly  3614 ANCDNVS--CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCI 3676
            |||..:|  |....|||....|||..|.||.|.||.:|.||..|....|  |:.  |:|.|..||
 Frog  1181 ANCTAISHTCEATSFQCHDSHCIPQKWVCDGDTDCQDGSDEDHSICEKK--CNG--FQCQNGSCI 1241

  Fly  3677 PGRWRCDYENDCGDGSDELNCQMRNCSESEFRC-GTGKCIKHNYRCDGEIHCDDNSDE----INC 3736
            |....||..|||.||:||..|:.......:|.| ...:|:.|:..|||...|.|.|||    ..|
 Frog  1242 PSVKHCDGVNDCPDGADEQQCEPLCTRYMDFVCRNRQQCLFHSMVCDGVKQCRDGSDEDPQYAGC 1306

  Fly  3737 N------ITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC-------TCHSDH-FSCGNG 3787
            :      .||..:.|.|.. ..||:..:||||.|||.|.|||.||       ||...: |.|.||
 Frog  1307 SQGPEFQRTCDPHSFLCQN-GVCISLVWKCDGMDDCGDYSDEANCENPTDIPTCSRYYQFPCQNG 1370

  Fly  3788 KCIMSRWKCDGWDDCLDGSDESLETCAKT---------HCHANAFKCRNQLCVRNSALCDGINDC 3843
            .||.:|||||..:||.|.|||  :.|.:|         .|.:|.|:|.|.:|:.|:.:|||..||
 Frog  1371 HCIPTRWKCDHENDCGDWSDE--KDCGETIPQTTSRPATCPSNHFRCDNGVCILNTWVCDGYKDC 1433

  Fly  3844 GENEDESDAVCAA--------LP--KCRHDQFQCEN-DDCISKAFRCDGQYNCVDGSDEMNC--- 3894
            ....||.....:|        ||  :|...:|:|:. .|||.....|||..:|.||:||:||   
 Frog  1434 IHGSDEEGCPASANKTVVPTILPHGQCSQFEFECKKWKDCIPSWRHCDGNRDCRDGTDELNCPTH 1498

  Fly  3895 QPPVCGFGSCSQICIEKKAGHYNC-----------KCADGYHKGPEKNATCLASGPDQILLLASE 3948
            :|.:|..||   :|.:.:|    |           .|:||   ..|.|.|     .|.|:.....
 Frog  1499 KPSLCVNGS---LCEDGEA----CIALLDFCDGFLDCSDG---SDENNCT-----DDTIVQKVQN 1548

  Fly  3949 QEFRFILPAKQEGTTVVGFFQTDSLKID----VFDILIR--PKDTLLFW--IDSHHGK-VHTMKI 4004
            .::      ..:.|..:....|...|:.    |::|..|  .:.|   |  :::|..| |:.:||
 Frog  1549 LQW------TADFTGNITLMWTRPKKMPQSSCVYNIYYRIVGEST---WKSLETHSNKTVYVLKI 1604

  Fly  4005 ATP------HVEGTGVRVRRDLKELTAFNIPE--LDDPKSLAV------------DWISQ----- 4044
            ..|      .|:...:|...:..::.....||  .|.|:.|.:            .|.:.     
 Frog  1605 LKPDTTYQAKVQVQCLRKAYNTNDIITLRTPEGVPDPPQHLQLSIMKDEFGNIFGSWTAPANAHG 1669

  Fly  4045 --RVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLEN---GILVASL-- 4102
              |.||::...:.:       |::.||..|..|           ::|.:...|   .:.||::  
 Frog  1670 LIREYIVEYSMSGV-------KEWTSLSVTSNN-----------VLIKNLPRNTMYAVRVAAVTS 1716

  Fly  4103 ----DGSNKKSLVE---RDVGWPI-------------------SLSMDYPTGRLYWA-DYRKGTI 4140
                |.|..||:..   :|:..|.                   .:|::|......|. |......
 Frog  1717 RGVGDWSETKSITTVQGKDIPVPTIKILSFNEDSITFNLKVDSEISVNYYFVSFVWEFDTHVQER 1781

  Fly  4141 ETCRLNGKDRNVVRRFGNREKPQKIDV--------------FEDY-----------LYIKLYDQS 4180
            .|.:.:||.::.  :.||.......::              ||.:           |..|..:|:
 Frog  1782 RTLKFDGKTKDF--KVGNLTAQTSYEISAWITTIIGDSSVSFEHFVTQGLKPAAPSLKAKAINQT 1844

  Fly  4181 IIKMNKFGNDNGTY 4194
            .|:.|..|..|.||
 Frog  1845 TIECNWSGVKNVTY 1858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531
LY 2475..2517 CDD:214531
LDLa 2630..2661 CDD:238060
LDLa 2671..2702 CDD:238060
LDLa 2727..2759 CDD:238060
LDLa 2773..2802 CDD:238060
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566 6/21 (29%)
LDLa 3030..3061 CDD:238060 7/30 (23%)
EGF_CA 3062..>3091 CDD:214542 3/28 (11%)
EGF_CA 3103..3141 CDD:214542 9/49 (18%)
LY 3212..3254 CDD:214531 15/45 (33%)
LY 3255..3297 CDD:214531 18/43 (42%)
LY 3299..3340 CDD:214531 13/40 (33%)
LY 3354..3389 CDD:214531 17/34 (50%)
LDLa 3458..3490 CDD:238060 8/32 (25%)
LDLa 3499..3533 CDD:238060 16/33 (48%)
LDLa 3582..3616 CDD:238060 19/33 (58%)
LDLa 3621..3652 CDD:197566 14/30 (47%)
LDLa 3663..3697 CDD:238060 16/33 (48%)
LDLa 3702..3736 CDD:238060 12/38 (32%)
LDLa 3776..3808 CDD:197566 17/32 (53%)
LDLa 3818..3849 CDD:197566 12/30 (40%)
LDLa 3860..3894 CDD:238060 14/34 (41%)
NHL 4029..>4158 CDD:302697 31/181 (17%)
NHL repeat 4034..4074 CDD:271320 10/58 (17%)
NHL repeat 4076..4115 CDD:271320 8/50 (16%)
LY 4108..4150 CDD:214531 11/64 (17%)
NHL repeat 4121..4158 CDD:271320 7/37 (19%)
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
sorl1XP_031762503.1 VPS10 115..744 CDD:214740 36/165 (22%)
LY 777..812 CDD:214531 19/36 (53%)
LY 815..854 CDD:214531 12/38 (32%)
Ldl_recept_b 879..920 CDD:395012 18/42 (43%)
LY 904..944 CDD:214531 13/41 (32%)
LY 944..982 CDD:214531 16/44 (36%)
LDLa 1069..1103 CDD:238060 16/33 (48%)
LDLa 1114..1144 CDD:238060 10/33 (30%)
Ldl_recept_a 1148..1183 CDD:395011 19/34 (56%)
LDLa 1189..1221 CDD:197566 14/31 (45%)
LDLa 1231..1262 CDD:238060 15/32 (47%)
LDLa 1272..1299 CDD:197566 10/26 (38%)
LDLa 1316..1350 CDD:238060 16/34 (47%)
LDLa 1363..1394 CDD:238060 17/32 (53%)
LDLa 1408..1442 CDD:238060 14/33 (42%)
LDLa 1460..1495 CDD:238060 14/34 (41%)
LDLa 1509..1537 CDD:238060 7/34 (21%)
FN3 1546..1617 CDD:214495 15/79 (19%)
FN3 1639..1730 CDD:238020 20/108 (19%)
FN3 1922..2003 CDD:214495
FN3 2013..2100 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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