DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and lrp6

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_031754428.1 Gene:lrp6 / 100489328 XenbaseID:XB-GENE-481820 Length:1612 Species:Xenopus tropicalis


Alignment Length:1508 Identity:475/1508 - (31%)
Similarity:727/1508 - (48%) Gaps:203/1508 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly  1365 PYVIFTNRQDIKGINLKTLNVGN---FYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYR--GH 1424
            |.:::.||:|::.::...:. ||   ..|.|.:..|:||::....   |||:||.::.|.|  .:
 Frog    21 PLLLYANRRDLRLVDAAGMK-GNSTVVVSGLEDAAAVDFVFFRGL---IYWSDVSEEAIKRIDFN 81

  Fly  1425 LVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRA 1489
            ..|.|    ..|:.|||.:.:|||.||:|:.|||.||..::|||:.|:||.|:.|....::.|||
 Frog    82 KTGSS----HDVVISGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRA 142

  Fly  1490 IALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKS 1554
            |||||..|.::||||.| .|:||||.|.|..|.:|..|   ...|||||||||.::::||.|||.
 Frog   143 IALDPTRGYMYWTDWGD-VPKIERAGMDGSLRSVIIDS---DIYWPNGLTLDYDEQKLYWADAKL 203

  Fly  1555 DSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQS 1619
            ..|.....|||....|::..  |:||||:::|.:.:|||||.|.|::..||:.|.|.:.:.....
 Frog   204 SFIHKANLDGSHRQTVIKGS--LAHPFALTLFGDTIYWTDWTTRSILACNKYTGEDRREVDSDIF 266

  Fly  1620 QPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTF-KCECPHVMRLDPANERNCVPN-EQV 1682
            .|..|.|....|||...|||..:|||||||||:|....| :|.||..:|| ..:.:.|:.. .::
 Frog   267 SPMDIHVFSRLRQPNATNPCAVHNGGCSHLCLMSPMEPFYQCACPTGVRL-MEDGKMCMHGATEL 330

  Fly  1683 LLFVMVDEIRGIDLHQPNHHTI----PTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGI 1743
            ||.|...::|.|.|..|:...|    ..||.:   :|   ||:...|..|:|:|.:...|....|
 Frog   331 LLLVRRTDLRRISLDTPDFTDIVLPLDDIRHA---IA---IDYDPVEGYIYWTDDEVRAIRRTQI 389

  Fly  1744 SNGLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIV 1806
            .....:.|:.:.:..|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|||:...:||
 Frog   390 DGSSSQYIVTSQVAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRKILISEDLDEPRAIV 452

  Fly  1807 LDPANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYY----- 1862
            |||.||.|||    :| |.:.::|::.:|||.|.::.  ..:|   ..|.:|:...::|:     
 Frog   453 LDPMNGYMYW----TDWGEIPKIERAAMDGSDRIILV--NTSLGWPNGLALDYAEGKIYWGDAKT 511

  Fly  1863 ------AYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPE----NIQSVIMQC-EK 1916
                  ..|.:|           |:|||...:..|...|:....:|:.:    :|:.|..:. |:
 Frog   512 DKIEVMTTDGTG-----------RRVLVEDKLPHIFGFTLLGDYVYWTDWQRRSIERVHKRTGER 565

  Fly  1917 EACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVE 1981
            |...:.....:..|:....||      :|:|.|||  ..|||..|||....... |.|.:|.::.
 Frog   566 EVIIDQLPDLMGLKATNIHKM------SGTNGCAE--NNGGCSHLCLFRPQGPR-CACPIGLELI 621

  Fly  1982 PNNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGD 2046
            .:..|..||.|..:|.....::.:.:...:      |...:|::.|..||.:|:....:.:||.|
 Frog   622 SDMKTCIVPEAFLLFSRRADIRRISLETSN------SHVAIPLTGVKEASALDFDVTDNRIYWTD 680

  Fly  2047 NELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSH 2111
            ..|.:|||...:|:..|.:::    .|.   |:..|:|:||:..|:||:||..|.|||::|||.|
 Frog   681 VSLKTISRAFMNGSALEHVVQ----FGL---DYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738

  Fly  2112 RYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLVNQT-RANWAVGSLVLD 2171
            |.::| .:|:.|.|||:||.:|.:::..   :..|.|..:|||....||... |||    .|.:|
 Frog   739 RQILVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRTAMDGSGRITLVPDVGRAN----GLTID 799

  Fly  2172 IEATKVYWCERYPDALMKVDYDGNLREQ---------LLNESLNNPVALAKMGDYLYWAENKYNE 2227
            ....::||          .|.|.||.|.         ::.:.|.:|..|.:..||:||.:  :::
 Frog   800 YAERRLYW----------TDLDTNLIESSNMLGLDRVVIADDLPHPFGLTQYQDYIYWTD--WSQ 852

  Fly  2228 GIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSA-VCAC 2291
            ..|..|...: .|::.::|.:.|.:.|:.::....|.|.|.||.|||.|..|||....|. .|.|
 Frog   853 RSIERANKTS-GQNRTMIQNDLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLATPVSGYTCGC 916

  Fly  2292 -AHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQ 2355
             .|..|.:|..:|.|..:|||||.::.|..:.:    |:.....:|.....:|||.||.|:..|:
 Frog   917 PVHHSLNADNKTCSPPSSFLLFSQKNAINRMVI----DEQQSPDIILPIHNLRNVRAIDYDPLEK 977

  Fly  2356 LVYYSDVQLSTINQVHFNGTGHRVLLEQ---QQRVE----GLAYDIVNEQLFWTSNNNATIRSVE 2413
            .:|:.|.: ..|.:...:|:....::..   .|.::    .|:.|:.:..::||......|....
 Frog   978 QLYWIDSR-QNIRRAQEDGSQSMTVVASTVPNQNIDMQPYDLSIDVYSRLIYWTCEATNVINVTR 1041

  Fly  2414 LRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVII 2478
            |       |...:.|  ||. .|.|:||.|.|.|..|.:|:||..|.||.|:|:.|.|...||:.
 Frog  1042 L-------DGRAIGV--VLK-GEQDRPRAILVNPERGYMYFTNLQERSPKIERAALDGTEREVLF 1096

  Fly  2479 KTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDW 2543
            .|.:..|.||.||.:..||:|||:.|.:||.::..|.:|:||..|.......:.|:|:.|:|.|.
 Frog  1097 FTGLSKPVALALDNKMGKLFWADSDLRRIESSDLSGGHRIVLEDSNVLQPVGLTVFGNHLYWIDR 1161

  Fly  2544 VLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCD---ANQCKILNGQCEDVCILNKSGQ 2605
            ....:.|..|........::..:.....|.||  |.::.|   .:.|...||.|..:||:...|.
 Frog  1162 QQQMIERIEKTGRVGRTKIQARIPLLTDIHAV--TELSMDEYKEHPCSQDNGGCSHICIVKGDGT 1224

  Fly  2606 ATCHCTQG--VLAPDGRRCIAPVNTSCGLSQYNCHSGE--CIPLELTCDNVTHCADGSDEFRSYC 2666
            ..|.|...  :|..|...|..|  .:|...|:.|.:||  |||.|..||..|.|.|.|||     
 Frog  1225 TRCSCPMHLVLLQEDELSCGEP--PTCSPLQFTCFTGEVDCIPAEWRCDGFTECEDHSDE----- 1282

  Fly  2667 IFRQCP---ETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPD 2728
              :.||   :|.:.|.:.:||....:|:||..|.|.|||                .|.|....||
 Frog  1283 --QNCPMCSDTQYQCASGQCIDSSLRCNGEANCQDKSDE----------------KNCNEVCAPD 1329

  Fly  2729 MFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPI----PCEKNDM---------TFVHCGNSTIC 2780
            .|.||||:||.:...||...||.|.|||:.|.|.    |...|.:         .||..|...||
 Frog  1330 QFHCGSGQCIGKHRRCDLSPDCSDSSDEQACYPTEEPPPPSTNTIGSIIGVILTVFVVGGVYFIC 1394

  Fly  2781 ---IMPRWRCDGD 2790
               :..|.:.||:
 Frog  1395 QRVLCRRMKGDGE 1407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 22/43 (51%)
LY 1533..1567 CDD:214531 18/33 (55%)
LY 1568..1611 CDD:214531 17/42 (40%)
FXa_inhibition 1639..1676 CDD:464251 17/37 (46%)
LY 1751..1789 CDD:214531 13/38 (34%)
LY 1794..1838 CDD:214531 21/45 (47%)
LY 2078..2112 CDD:214531 17/33 (52%)
NHL <2082..>2152 CDD:302697 32/73 (44%)
NHL repeat 2082..2120 CDD:271320 19/38 (50%)
FXa_inhibition 2269..2303 CDD:464251 15/35 (43%)
LY 2430..2471 CDD:214531 19/40 (48%)
LY 2475..2517 CDD:214531 17/41 (41%)
LDLa 2630..2661 CDD:238060 15/32 (47%)
LDLa 2671..2702 CDD:238060 12/33 (36%)
LDLa 2727..2759 CDD:238060 17/31 (55%)
LDLa 2773..2802 CDD:238060 6/21 (29%)
LDLa 2810..2844 CDD:238060
LDLa 2848..2878 CDD:238060
LDLa 2887..2916 CDD:197566
LDLa 2938..2969 CDD:197566
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
lrp6XP_031754428.1 Ldl_recept_b 63..104 CDD:459654 16/47 (34%)
LY 89..127 CDD:214531 19/37 (51%)
Ldl_recept_b 150..191 CDD:459654 23/44 (52%)
LY 175..216 CDD:214531 20/43 (47%)
LY 217..258 CDD:214531 17/42 (40%)
FXa_inhibition 286..323 CDD:464251 17/37 (46%)
Vgb 339..569 CDD:443399 69/254 (27%)
FXa_inhibition 592..627 CDD:464251 12/37 (32%)
YncE <654..830 CDD:442618 62/196 (32%)
LY 697..739 CDD:214531 19/48 (40%)
LY 825..866 CDD:214531 10/43 (23%)
FXa_inhibition 893..929 CDD:464251 15/35 (43%)
LY 958..997 CDD:214531 12/39 (31%)
Ldl_recept_b 1068..1109 CDD:459654 17/40 (43%)
LY 1093..1135 CDD:214531 17/41 (41%)
FXa_inhibition 1206..1243 CDD:464251 11/36 (31%)
LDLa 1249..1285 CDD:238060 17/42 (40%)
LDLa 1288..1322 CDD:238060 12/49 (24%)
LDLa 1326..1360 CDD:238060 17/33 (52%)
Blue background indicates that the domain is not in the aligned region.

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