DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and lrp1

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	XP_002939758.3	Gene:	lrp1 / 100485788	XenbaseID:	XB-GENE-479843	Length:	4543	Species:	Xenopus tropicalis

Alignment Length:	4888	Identity:	1776/4888 - (36%)
Similarity:	2554/4888 - (52%)	Gaps:	613/4888 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CPASYFTCNDGF-CIPMRWKCDSKADCPDMSDEGSECAP-----KCNEGQFRCGVSRHCIPNNWL 145
            |....|.|.|.. ||...|:||.:.||||.|||..|..|     ||...:..|..:..|||...|
Frog    35 CSPKQFACKDQVTCISKGWRCDGEKDCPDGSDEAPEICPQSKISKCQPNEHNCLGTEICIPMGKL 99

  Fly   146 CDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAAC 210
            |:|..||..|  |||       .|.||.:...                                |
Frog   100 CNGHHDCSDG--SDE-------GPFCREYAHN--------------------------------C 123

  Fly   211 AALNCSFNCKLTPQGARCYCPKD-QVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSG 274
            ..|.|..:|..|..|..|||... |:.|...:  |.|:|||:..|||.|.|.|..|||.||||.|
Frog   124 TELGCQHHCARTVTGPVCYCNTSYQLVEDGKT--CKDFDECTVYGTCSQTCFNMEGSYSCSCVEG 186

  Fly   275 YAKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGTNGTEV--IGPPGAKDNDKVTDKDGVGSEE 336
            |.....|: |:|.|.|...||.|:..|...:.:...||..|  |.|...|   :.|..|...:||
Frog   187 YLLQPDNKSCKAKNEPVDRPTILLIASTQNILATYLNGAAVTTIVPTSTK---QTTAMDFNYAEE 248

  Fly   337 ELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQRVDDARVNWTLPFSSFVSPQQFFTELR 401
            .:.      ::|..|...:....|:.:   |.|:   ..|::..:|.:|..       ....::.
Frog   249 TVC------WIHMGESPSQTMLNCAKI---PNLK---GFVEERSINISLSL-------HHVEQMA 294

  Fly   402 LDWLSGNWYLVSEDDGLVYLCT-NAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDW--TPSLSRS 463
            :|||:||:|.|.:.|..:::|. |..|...::.:::.....:.||||.|.:|:||:  .|.:.|.
Frog   295 IDWLTGNFYFVDDIDDRIFVCNRNGDTCVNLLDRELYNPKGIALDPTMGKLFFTDYGQIPKVERC 359

  Fly   464 LLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKT 528
            .:||.|||.||..::..|..:||||.:.||||.|.|.|.:..|||||:||.|:.:.|    .::.
Frog   360 DMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKNRHTIIQGL----LIEH 420

  Fly   529 IHAVEVFENSIYLA------AWMDTAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEV-AHP 586
            ::.:.||||.:|..      ....|:::.:::|:...:.:.:.|.:|..|.|:|:::||.| :|.
Frog   421 LYGLTVFENYLYATNTDHANTQQKTSVIRVNRFNSSDYNVVTRVDKGGALHIYHQRRQPTVRSHA 485

  Fly   587 CRDNN----AGCNQICVPQWTKGFASAKCMCTAGYKLHNQ-TTCLLSALDKFLVYSDKHLARISG 646
            |..:.    .||:.||:  ......:..|.|.:|:.|.:. .:|.....:.||||.......|.|
Frog   486 CEPDQYKKPGGCSDICL--LANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGRGRPGIIRG 548

  Fly   647 IPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRS 711
            :.:..:         .|.:.|:|:.|:....|:|.:.....|::  ||:         .|..|..
Frog   549 MDIGAK---------VQDEHMIPIENLMNPRALDFHAEYGFVYF--ADT---------TSYLIGR 593

  Fly   712 QSLNGSV-SRLLAQGLKRVHAVAFDWINDHLYWTS---HKKMQVAPLRNLS---KVLTFNTDCDA 769
            |.::||. ..:|.:|:..|..:|.||:.::||||.   .|.:.||.|...|   |.:........
Frog   594 QKIDGSARETILKEGIHNVEGIAVDWMGNNLYWTDDGPKKTISVARLEKASQTRKTIVEGKMTHP 658

  Fly   770 MSLELDPTTGLLYWSQWE---SQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKE 831
            .::.:||..|.:||:.||   .:|....|..:||||:::.:.   .:|..:.||..|.:|...|.
Frog   659 RAIVVDPLYGWMYWTDWEEDPKESKRGKIEKAWMDGSNRNVF---VTSKTVLWPNGLSIDIPNKI 720

  Fly   832 LYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNGLIYWADNKNSTILRFHAHQANLSS 895
            |||.|.....||::..:|:.|:.:::..:. |.:.:......::|.:.::.:|.|.        .
Frog   721 LYWVDAFYDRIEMIYTNGSSRKPVYEGQELNHAFGLCHYGSYLFWTEYRSGSIYRL--------D 777

  Fly   896 TFSSTVHLQRTGRAA--DLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGT 958
            ..|.||.|.|..|..  ::|::|...|.:...........|..:||..|....|.|.:...|:..
Frog   778 QVSKTVTLLRNERPPIFEIRMYDAQQQQVGSNACRVNNGGCSSLCLAVPGSRQCACAEDQILDDD 842

  Fly   959 GSHCIPQLAPSPI-RPNCTSG-YMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDK 1021
            |..|  :..||.| .|.|..| :.|:::| |:..:..|||..||.|..||:.:   .|:.:|| .
Frog   843 GVTC--KANPSYIPPPQCQPGEFACKNSR-CIQERWKCDGDNDCLDNSDEAPE---LCHQHTC-P 900

  Fly  1022 THNFVC-NGRCYQRSLLCSTIPYCSDGTDQAN--CHQNTCNSNEFTCHKSGRCIQLTWVNDGVVD 1083
            :..|.| |.||.....||.....|.:..|::|  |...||.||:|:| .|||||.|:|..|...|
Frog   901 SDRFKCENNRCIPNRWLCDGDNDCGNSEDESNSTCSARTCPSNQFSC-ASGRCIPLSWTCDLDDD 964

  Fly  1084 CGPDDDSDETSETIFASKCP--EFDCNNGRCRQFADVCDGIDNCGNNADEMECEQECEHGEKYCR 1146
            ||  |.|||:|:..:.:..|  :|.||:|||......||..::||:|:||..|...|...:..|.
Frog   965 CG--DRSDESSKCAYPTCFPLTQFTCNSGRCININWRCDNDNDCGDNSDEDGCSHSCSSTQFKCN 1027

  Fly  1147 PIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRC 1211
            ...|..|...|||.:||.|:|||.:.|.|.....|.      |.|...||.|.....|||:..||
Frog  1028 SGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP------GGCHTDEFQCRLDGLCIPNRWRC 1086

  Fly  1212 DGISHCFDKTDEFNCTHINTTRFDMN---------------------------------ETVICE 1243
            ||.:.|.|.:||.||.. .|...|.|                                 |:::|:
Frog  1087 DGDTDCMDTSDEKNCDG-ETRPCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCESLVCK 1150

  Fly  1244 HPDRLCGFSKQ-CVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTP-EGYICSCPD 1306
            .|...|..:.. |:..::||||.:||.|.:|||.|| |:.......|||.|...| ||.:||||.
Frog  1151 SPSHTCANNTSICLPPEKLCDGNDDCGDGSDEGDLC-DQCSLNNGGCSHNCTVAPGEGIVCSCPL 1214

  Fly  1307 HLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTN 1371
            .:...|:.|.|.:|..|.....|||.||.......|.|.:|:.|..|:.:|:|..|.:|::||:|
Frog  1215 GMEPGPDNKTCQIQSYCAKHLRCSQRCEQEKNTVKCSCYEGWMLEADKESCRSLDPFKPFIIFSN 1279

  Fly  1372 RQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGES--LRNVE 1434
            |.:|:.|:|...:.......|||.|||||..|..:   :|||||::||||||.| .||  |.|.|
Frog  1280 RHEIRRIDLNKWDYSVLVPGLRNTIALDFHLNQST---LYWTDVVEDKIYRGKL-SESGALTNFE 1340

  Fly  1435 AVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLL 1499
            .:|..||:|.|||||||:..|:||::|||||||||||||:.|.||:||::|.|||||||||.|:|
Frog  1341 VIIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLNGTMRTTLLAGDIEHPRAIALDPRNGIL 1405

  Fly  1500 FWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDG 1564
            ||||||.:.||||.|||||:|||.|..... |.|||||||:||.::|:.|:||:||:|.|..|||
Frog  1406 FWTDWDSSMPRIEAASMSGEGRRTIHKETG-SGGWPNGLTVDYLEERILWIDARSDAIYSAKYDG 1469

  Fly  1565 SEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHS 1629
            |....||:..|.||||||::::...||||||||.::.:||||.|.:|:|:|||.:|||.:||.|.
Frog  1470 SGLIEVLKGNEYLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVRVVQRTNTQPFDLQVYHP 1534

  Fly  1630 SRQPWDRNPCGENN--GGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIR 1692
            ||||...|||..|:  |.||||||::...:|.|.|||:|:|.| :::.|:.....||:....|||
Frog  1535 SRQPQAPNPCAANDGRGPCSHLCLITYNQSFSCACPHLMKLSP-DKKTCLEFRNFLLYARQMEIR 1598

  Fly  1693 GIDLHQPNHH-----TIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPII 1752
            |:|:..|.::     |:|.|..      ...:|:...|.||:|||::...|..|.|:...:|.::
Frog  1599 GVDIDNPYYNYIISFTVPDIDN------VTVVDYDALEQRIYWSDVRTQTIKRAFINGTGVETVV 1657

  Fly  1753 NTNIEKPYGFAVDWIARNMYFSSGQI-KCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYW 1816
            :.::...:|.||||::||::::|... |..|..:.|.|.|.:.:.:.|:....:|:.|..||:||
Frog  1658 SADLPNAHGLAVDWVSRNLFWTSYDANKKQINVARLDGSFKNAVIQGLDKPHCLVVHPLKGKLYW 1722

  Fly  1817 IHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPR---NE 1878
                :||  ..:..:|:||:...:::.::.....|::||...:||:.  :||.:  .|.|   |.
Frog  1723 ----TDG--DNISIANMDGNDHKVLFTNQKGPVGLSIDFIDNKLYWI--SSGAS--TINRCNLNG 1777

  Fly  1879 TRKVLVASP---ITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYA 1940
            |...::.:.   :...::|.:....|::.::....:..|.|:..|:...||.||..:..||::..
Frog  1778 TGLEVIGTMKAYLGKATALAIMGNKLWWADHASDKMGTCNKKDGSDPRVLRQNTNQVMHMKVYDE 1842

  Fly  1941 DAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSI-DVLQG 2004
            :.|.|:|.|:  ...|.|.||||.||.....|.|..||.::....| |.....|:.||: :.::|
Frog  1843 EIQKGTNNCS--VNNGDCSQLCLPTSETTRSCMCTAGYSLKSGQKT-CEGVGSFLLYSVHEGIRG 1904

  Fly  2005 VEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEAL 2069
            :. :||:::.|    ||||:|..|.|..:|:.|..||:||.|..|.:|||.|||.|.||.:|  .
Frog  1905 IP-LDPNDKSD----ALVPVSGTSLAVGMDFHAENDTIYWVDMGLSTISRAKRDQTWREDVL--T 1962

  Fly  2070 NLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVS-NLEKPTALAVDPLQGL 2133
            |.:|..:     |||:||:||||||:|...::||||||:||.||||:| .|:||.|:.|.|.:|.
Frog  1963 NGIGRVE-----GIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGY 2022

  Fly  2134 LFYVT-QQH--IGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYD-G 2194
            ||:.. .||  |.|..||||:..:|| ||..:|..| :.:|.|..|:|||:...|.:.::|.: |
Frog  2023 LFWTEWGQHPRIERSRLDGSERSILV-QTSISWPNG-VSIDYEEGKLYWCDARTDKIERIDLETG 2085

  Fly  2195 NLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDA-IRDLKIY 2258
            ..||.:|:.:..:..:::...||:||::..:..|.|:.....|.:.| |.|:|.... ::|:|::
Frog  2086 KNREVVLSSNNMDMFSVSVFEDYIYWSDRTHANGSIKRGNKDNATDS-VSLRTGIGVQLKDIKVF 2149

  Fly  2259 SKHLQRGSNPCAHSNGACEQLCLFNG-TSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIH 2322
            :|..|:|:|.||.:||.|:||||:.| .:..|||||..||.:|.:|..|:.:||:|.|:.::|||
Frog  2150 NKDRQKGTNICAVNNGGCQQLCLYRGNNNRTCACAHGMLAENGLNCRNYDGYLLYSERTILKSIH 2214

  Fly  2323 MTDHADKNWPVQMISNTSLMRNVIAITYNYEEQ-----LVYYSDVQLSTINQVHFNGTGHRVLLE 2382
            ::|.:..|.||:...:...|:||||:.::|.|.     .::|||:....|.|::.:|||.:.::|
Frog  2215 LSDESSLNAPVKPFEDHEHMKNVIALAFHYRESSQGGIRIFYSDIHFGNIQQINHDGTGRKTVVE 2279

  Fly  2383 QQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEP 2447
            ....||||||....:.|:|||...:||    .||..:.:.......:.|:::..||.||...::.
Frog  2280 NVGSVEGLAYHRGWDTLYWTSYTTSTI----TRHTVDQSRLGAYDRETVVTMSGDDHPRAFVLDE 2340

  Fly  2448 CLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNY 2512
            |..:::||||||..|.|.|:.|||....:||..||:.||.|.:|.:.:|||::||.||||||..|
Frog  2341 CQNLMFWTNWNEQHPSIMRATLTGGNVLIIIDKDIRTPNGLAIDHKSEKLYFSDATLDKIERCEY 2405

  Fly  2513 DGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHV-TRPMGIVAVQ 2576
            ||:.|..:..:.|.|.|.:||||:.:||||||..||.|||||.|:|:..||..: .:||||:||.
Frog  2406 DGTKRYSILKTDPVHPFGLAVYGEYIFWTDWVRRAVHRANKYLGSDLKILRGDIPQQPMGIIAVA 2470

  Fly  2577 NTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGL-SQYNCHSG 2640
            |.:.:|:.:.|:..||.|:|:|:|...|:..|.|....:..:...|.:| |::|.: .::.|.:|
Frog  2471 NDTNSCELSPCQTNNGGCQDICVLTAEGRINCTCRGDRIIQEDFTCKSP-NSTCNMYDEFECGNG 2534

  Fly  2641 ECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPL 2705
            :||...:|||.|.||.|.:||..|||..|.|.:....|.|.|||.....|:....|||.|||  :
Frog  2535 DCINYSMTCDGVPHCKDKADEKLSYCRTRHCRKGFKHCMNGRCISSSSWCNELDDCGDNSDE--I 2597

  Fly  2706 LCK---CQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEK- 2766
            .||   |.||:                :||..|.||.....|:...||.|.|||..|....|..
Frog  2598 ACKKTNCTSEE----------------YRCRDGTCIGNSSRCNQFIDCEDASDEMNCNITDCSSY 2646

  Fly  2767 -----NDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGS 2826
                 ..:||.:|..:::|..|.|.|||..||.|.:||.:|.......|....|.|.:|:||..|
Frog  2647 FKLGVKGVTFKNCERTSLCYAPSWVCDGSNDCGDFSDEKNCPGVRKPKCPVNYFACPNGHCIPMS 2711

  Fly  2827 WHCDGEKDCPDGSDEINCRTECRHNQFAC-DKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPH 2890
            |.||.|.||.:|:||::|...|...||.| :..||...|.|||..||.|.||||..|.:..|.|.
Frog  2712 WTCDKESDCENGADEMHCDKFCTSMQFECSNHRCISKHWVCDGSDDCGDKSDEGAICQSNTCSPE 2776

  Fly  2891 LFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHY 2955
            .|:|.|:..|||::|:|||:.||..|      .||....|.:.: ..|.....:|.:..||...:
Frog  2777 SFRCPSTHVCIPRRWLCDGDIDCQDG------ADESVNVGCLFN-NTCDAKEFMCQNRQCIPKQF 2834

  Fly  2956 VCDGDEDCPGGDDEYEGC-VPAFQPHSCPGGSLMHQCQDGLCIFKNQ-TCDGKPDCGDGSDET-- 3016
            |||.|.||..|.||...| .|...|..       .:|.:|.|:...| .|||:.||.|.|||.
Frog  2835 VCDHDADCSDGSDESPECEYPTCGPDE-------FRCANGRCLVNKQWECDGEFDCHDKSDEAPK 2892

  Fly  3017 SSLCAHTRG-CNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDI--CEHECED 3078
            :..|.:|.. ||.| .|.||||.||..:||||..:||.|.|||..|.:||||...:  |..||||
Frog  2893 NPRCTNTESKCNET-FFLCKNGTCIPDNLLCDNNDDCGDGSDELNCFINECLNRKLSGCSQECED 2956

  Fly  3079 KVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDH--HTCK 3141
            :.:||:|.||||:: |......|.|:|||....||||.|:||.|||:|||.:||...|:  ::||
Frog  2957 QKIGYKCRCRPGFR-LKDDGKTCVDMDECTTTYPCSQWCLNTLGSYRCLCIEGYEARDNNSNSCK 3020

  Fly  3142 ATSNVSME---LIFSNRYYIRQVDMTG-NGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIK 3202
            .:::..:|   |||:||||:|::.:.| |.::|...|:||||||:|:..|.:||:|||:....|:
Frog  3021 VSASADVEEPFLIFANRYYLRKLSLGGTNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIR 3085

  Fly  3203 RYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRG 3267
            |.....:..|.||:..|.||||||||||..||||||||.||||||:|:|.||.||:|..|||||.
Frog  3086 RMHINGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVNSGLREPRA 3150

  Fly  3268 IALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTIS 3332
            :.:......::|:||||:..|||.||||:|..:|:...:.|||.||:.:...:::|.|||||.|.
Frog  3151 LVVDVQHGFLYWTDWGDNSLIGKIGMDGTNRSVIVDSRITWPNGLTLDYVNSRIYWADAREDYIQ 3215

  Fly  3333 VSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIH 3397
            .::|||.:...::::.|      .||||:.::|.:|||:|||||||.......|.|.|.||:|:|
Frog  3216 FANLDGTNRHTVISQDI------PHIFALTLFEDYIYWTDWETKSINRAHKTTGANKTMLISTLH 3274

  Fly  3398 RPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTA 3460
            ||||:.::|.|||.. :..:||...|  ||.||:|||... |||.|||||.|..||:||.:||||
Frog  3275 RPMDIHIYHLYRQPD-VPNHPCKMNNGGCSNLCLLSPNGG-YKCACPTNFYLGADGKTCVSNCTA 3337

  Fly  3461 AHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCG 3525
            :.|.|.|. |||||:|:|||:|||||.||||..||.|.|.|||:||:...||:|:.:|||.|.|.
Frog  3338 SQFVCKND-KCIPFWWKCDTEDDCGDRSDEPSDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQ 3401

  Fly  3526 DGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCG 3590
            |.|||.|||...|..:..||..|..    |:..:.||:|..:|..|:||..|..:.|..:||||.
Frog  3402 DNSDEANCDIHVCLPSQFKCTNTNR----CIPGIFRCNGQDNCGDGDDEKDCPEVTCAPNQFQCA 3462

  Fly  3591 -NNRCMPFVWVCDGDIDCPDKSDEA-NCDNVSCGPNDFQC-DSGRCIPLAWRCDDDHDCPNGEDE 3652
             |.||:|.|||||.|.||.|.|||. ||..::||.::|:| |||||||..|:||.:.||.:..||
Frog  3463 VNKRCIPRVWVCDRDNDCVDASDEPDNCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDSSDE 3527

  Fly  3653 P-ASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIK 3716
            | ..|  .:.||:|..|:|.|::|:||||:|||:|||||.|||..|..|.||||||.|..|:||.
Frog  3528 PKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEETCTPRPCSESEFSCANGRCIA 3590

  Fly  3717 HNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNT--CINKQYKCDGDDDCPDGSDEVNC---- 3775
            ..::|||:..|.|.|||.:|.:.|:.:||:|   |.  ||..::.||.|.||.|||||.||
Frog  3591 GRWKCDGDHDCIDGSDEKDCKVRCEPDQFQC---NNGHCIPHRWHCDADADCMDGSDEENCHNTV 3652

  Fly  3776 -TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHA-NAFKCRN-QLCVRNSALC 3837
             ||..|.|.|.|..|....|||||.|||.|.|||..|.|.|..|.. ..|:||| ::|:..:.:|
Frog  3653 RTCPMDEFQCHNTLCKPLAWKCDGEDDCGDNSDEKPEECLKFTCPPFRQFRCRNDRVCLSMARVC 3717

  Fly  3838 DGINDCGENEDESDAVCAALPK-C--RHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQP--- 3896
            |||::||:..||..  |...|| |  ..::|||:|:.|||.:.|||...:|.|||||.:|.|
Frog  3718 DGIDNCGDGTDEEH--CDTKPKSCDMEKEEFQCKNNKCISSSRRCDLFDDCGDGSDEESCYPDLK 3780

  Fly  3897 --------PVCG-------------------------------------FGSCSQICIEKKAGHY 3916
                    .:||                                     ||:|||||...|..|.
Frog  3781 INGCHGNSTICGEEMKCVHTQTTVYCTCQNGFQKIPGSNACKDINECLTFGTCSQICNNTKGSHM 3845

  Fly  3917 NCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDIL 3981
             |.||..:.|  ..|.:|.|.|.:|:|.:|.:.|.|.:.|..........|...::::||..|:.
Frog  3846 -CTCAKNFIK--STNHSCKADGSNQVLYIADDNEIRSLYPFNPNSAYEQAFRGDENVRIDAMDVY 3907

  Fly  3982 IRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKE-LTAFNIPELDDPKSLAVDWISQR 4045
            :  |...:||.:.|.||:...::.:.....:. |.:|.:.| :|..|||.|..|:.:|:||::..
Frog  3908 V--KGNKIFWSNWHTGKISYRELHSTSSTSSN-RNKRQIDEGVTDLNIPGLKMPRGIAIDWVAGN 3969

  Fly  4046 VYIIDSRHNQILATDIEGKKYISLVSTGM--NPTDIVLEPESRIMIWSTLEN--GILVASLDGSN 4106
            :|..||..:.|....::|:...:|:| ||  .|..||::|....|.||...|  .|..|::||:.
Frog  3970 IYWTDSGRDVIEVAQMKGEHRKTLIS-GMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTL 4033

  Fly  4107 KKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNRE---KPQKIDVF 4168
            :::|||.::.||..|::||...||||||.:...|.:.||||.|..|.  ..|::   .|..||:|
Frog  4034 RETLVEDNIQWPTGLAVDYYNERLYWADAKLSIICSIRLNGTDPVVA--ISNKKGLTHPFSIDIF 4096

  Fly  4169 EDYLYIKLYDQSII-KMNKFGNDNGTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALC 4232
            |||:|...|..::| |::|||:...|.|..|.......:||...:...::|||.:..|:   .||
Frog  4097 EDYIYGVTYINNLIFKVHKFGHGPVTNLTWGINHVTDVVLHHQYKQPEVTNPCDRKKCE---WLC 4158

  Fly  4233 ILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELC 4297
            :||....|   |.|..|..:.:                    |||.::.
Frog  4159 LLSPSGPV---CTCPNGRRLDN--------------------GTCMLIP---------------- 4184

  Fly  4298 EHYRCSGYCQNYGVCSVAPAL-PGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISE 4361
                             :|.| |.:..|                    .:|...|.|||.|.::.
Frog  4185 -----------------SPTLSPDASTP--------------------ESCTLECLNGGKCFLNA 4212

  Fly  4362 TEGMKCSCPKMFTGEQCE--HCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDEC-ADFCK 4423
            .:..||.|...:.||:||  .||:. |:|||||..:|||.|.|.||:||||.:|:.:.| :|.|:
Frog  4213 RKQPKCRCSSSYDGERCEIYQCRDY-CKNGGICAPSLTGMPTCRCPNGFTGSQCQQEVCTSDHCQ 4276

  Fly  4424 NGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDL 4488
            |.|||.::...|..|:|...|.|:.|:...|:.:|.||.......|...|.|.|.|.|..||...
Frog  4277 NNGSCTVNQGNQPNCRCLPDYTGDKCQYRKCKGYCENGICQMLANGTKQCRCNPEYEGTKCEIHR 4341

  Fly  4489 CKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGVALCNCTDQWNGDLCTLPVTDDNPCARY 4553
            |..      |.:.|..||:                 |..:|:|.|   |.:....:|.||    |
Frog  4342 CSR------CKDGKCDTRN-----------------GEVICSCLD---GRIAKTCLTCDN----Y 4376

  Fly  4554 CANGGVCHLD-EYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSD 4617
            |.|||||.:: :..:|.|.|..|..|..|.:   .||.|                 ||
Frog  4377 CLNGGVCTMNRQTDMPECQCPAEMTGPTCNV---FVGVE-----------------NR------- 4414

  Fly  4618 SADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRI--AQPFSHARLTD---NV 4677
                         |....|:|:.::.|||||..:..|| ||..:||:  |:.|.|.|:|:   ||
Frog  4415 -------------SSSTVSIVIPIVLVILLVLLVMVGA-YFWYRHRMSGAKGFQHQRMTNGAMNV 4465

  Fly  4678 EI-MLTNAMYRGDADE------APTFASEDDK-GNFANPVYESMYADAIPEPVSTEITHSTA-PD 4733
            || ..|..||.|:.|:      ...|..:.|| .||.||||.::|..|      ....||.| .|
Frog  4466 EIGNPTYKMYEGEQDDDGGDLLDADFTLDPDKPTNFTNPVYATLYMGA------HNSRHSLASTD 4524

  Fly  4734 ERKGLLQHTHDEN 4746
            |::.||....:::
Frog  4525 EKRELLSRGGEDD 4537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566	14/31 (45%)
		LDLa	126..163	CDD:238060	14/36 (39%)
		EGF_CA	246..283	CDD:214542	20/37 (54%)
		Ldl_recept_b	449..487	CDD:278487	15/39 (38%)
		LY	472..513	CDD:214531	19/40 (48%)
		LY	817..852	CDD:214531	12/34 (35%)
		LDLa	1057..1092	CDD:197566	19/34 (56%)
		LDLa	1104..1134	CDD:238060	13/29 (45%)
		FXa_inhibition	1289..1317	CDD:291342	13/28 (46%)
		LY	1434..1476	CDD:214531	28/41 (68%)
		LY	1477..1521	CDD:214531	31/43 (72%)
		LY	1533..1567	CDD:214531	21/33 (64%)
		LY	1568..1611	CDD:214531	22/42 (52%)
		FXa_inhibition	1639..1676	CDD:291342	17/38 (45%)
		LY	1794..1838	CDD:214531	12/43 (28%)
		LY	2078..2112	CDD:214531	20/33 (61%)
		NHL	<2082..>2152	CDD:302697	42/73 (58%)
		NHL repeat	2082..2120	CDD:271320	25/38 (66%)
		FXa_inhibition	2269..2303	CDD:291342	18/34 (53%)
		LY	2430..2471	CDD:214531	16/40 (40%)
		LY	2475..2517	CDD:214531	22/41 (54%)
		LDLa	2630..2661	CDD:238060	12/31 (39%)
		LDLa	2671..2702	CDD:238060	11/30 (37%)
		LDLa	2727..2759	CDD:238060	12/31 (39%)
		LDLa	2773..2802	CDD:238060	12/28 (43%)
		LDLa	2810..2844	CDD:238060	16/33 (48%)
		LDLa	2848..2878	CDD:238060	14/30 (47%)
		LDLa	2887..2916	CDD:197566	14/28 (50%)
		LDLa	2938..2969	CDD:197566	11/30 (37%)
		LDLa	2989..3015	CDD:197566	11/26 (42%)
		LDLa	3030..3061	CDD:238060	17/30 (57%)
		EGF_CA	3062..>3091	CDD:214542	15/30 (50%)
		EGF_CA	3103..3141	CDD:214542	20/39 (51%)
		LY	3212..3254	CDD:214531	30/41 (73%)
		LY	3255..3297	CDD:214531	20/41 (49%)
		LY	3299..3340	CDD:214531	16/40 (40%)
		LY	3354..3389	CDD:214531	16/34 (47%)
		LDLa	3458..3490	CDD:238060	21/31 (68%)
		LDLa	3499..3533	CDD:238060	18/33 (55%)
		LDLa	3582..3616	CDD:238060	21/35 (60%)
		LDLa	3621..3652	CDD:197566	16/31 (52%)
		LDLa	3663..3697	CDD:238060	21/33 (64%)
		LDLa	3702..3736	CDD:238060	18/33 (55%)
		LDLa	3776..3808	CDD:197566	17/31 (55%)
		LDLa	3818..3849	CDD:197566	12/32 (38%)
		LDLa	3860..3894	CDD:238060	17/35 (49%)
		NHL	4029..>4158	CDD:302697	48/132 (36%)
		NHL repeat	4034..4074	CDD:271320	11/39 (28%)
		NHL repeat	4076..4115	CDD:271320	15/40 (38%)
		LY	4108..4150	CDD:214531	19/41 (46%)
		NHL repeat	4121..4158	CDD:271320	16/36 (44%)
		EGF_CA	<4386..4414	CDD:238011	17/27 (63%)
		EGF_CA	4415..4450	CDD:238011	12/35 (34%)
lrp1	XP_002939758.3	LDLa	34..67	CDD:197566	14/31 (45%)
		Ldl_recept_a	78..112	CDD:395011	13/35 (37%)
		FXa_inhibition	127..156	CDD:405372	9/30 (30%)
		FXa_inhibition	168..196	CDD:405372	14/27 (52%)
		LY	283..322	CDD:214531	11/45 (24%)
		LY	325..366	CDD:214531	12/40 (30%)
		LY	369..409	CDD:214531	19/39 (49%)
		FXa_inhibition	494..527	CDD:405372	8/34 (24%)
		LY	559..601	CDD:214531	13/52 (25%)
		LY	602..641	CDD:214531	13/38 (34%)
		LY	648..697	CDD:214531	14/48 (29%)
		LY	<708..741	CDD:214531	12/32 (38%)
		FXa_inhibition	811..846	CDD:405372	8/34 (24%)
		LDLa	857..889	CDD:197566	11/32 (34%)
		LDLa	899..932	CDD:238060	10/33 (30%)
		LDLa	939..971	CDD:197566	19/34 (56%)
		LDLa	982..1015	CDD:238060	14/32 (44%)
		LDLa	1019..1052	CDD:238060	13/32 (41%)
		LDLa	1066..1101	CDD:238060	15/34 (44%)
		LDLa	1108..1144	CDD:238060	2/35 (6%)
		LDLa	1149..1182	CDD:197566	11/32 (34%)
		FXa_inhibition	1189..1225	CDD:405372	13/35 (37%)
		LY	1340..1382	CDD:214531	28/41 (68%)
		LY	1384..1427	CDD:214531	31/42 (74%)
		LY	1428..1471	CDD:214531	23/43 (53%)
		FXa_inhibition	1544..1582	CDD:405372	17/38 (45%)
		LY	1617..1653	CDD:214531	11/41 (27%)
		LY	1654..1697	CDD:214531	13/42 (31%)
		LY	1701..1738	CDD:214531	12/42 (29%)
		LY	1738..1779	CDD:214531	10/44 (23%)
		FXa_inhibition	1851..1887	CDD:405372	14/38 (37%)
		LY	1960..2000	CDD:214531	23/46 (50%)
		LY	2001..2044	CDD:214531	21/42 (50%)
		LY	2046..2088	CDD:214531	15/43 (35%)
		FXa_inhibition	2160..2195	CDD:405372	18/34 (53%)
		YvrE	2253..>2443	CDD:225921	79/193 (41%)
		Ldl_recept_b	2343..2384	CDD:395012	19/40 (48%)
		LY	2369..2410	CDD:214531	22/40 (55%)
		LDLa	2527..2556	CDD:238060	12/28 (43%)
		LDLa	2565..2599	CDD:238060	13/35 (37%)
		LDLa	2604..2638	CDD:238060	15/49 (31%)
		LDLa	<2665..2687	CDD:238060	11/21 (52%)
		LDLa	2695..2729	CDD:238060	16/33 (48%)
		LDLa	2733..2764	CDD:197566	14/30 (47%)
		LDLa	2772..2805	CDD:197566	15/38 (39%)
		LDLa	2816..2848	CDD:197566	11/31 (35%)
		LDLa	2856..2889	CDD:197566	12/39 (31%)
		LDLa	2903..2937	CDD:238060	20/34 (59%)
		cEGF	2960..2983	CDD:403760	10/23 (43%)
		EGF_CA	2980..3014	CDD:214542	19/33 (58%)
		LY	3050..3094	CDD:214531	17/43 (40%)
		LY	3095..3137	CDD:214531	30/41 (73%)
		LY	3139..3181	CDD:214531	20/41 (49%)
		LY	3183..3224	CDD:214531	16/40 (40%)
		LY	3225..3265	CDD:214531	17/45 (38%)
		FXa_inhibition	3295..3331	CDD:405372	20/36 (56%)
		LDLa	3335..3366	CDD:238060	21/31 (68%)
		LDLa	3375..3409	CDD:238060	18/33 (55%)
		LDLa	3414..3449	CDD:238060	12/38 (32%)
		LDLa	3453..3486	CDD:197566	19/32 (59%)
		LDLa	3494..3527	CDD:197566	16/32 (50%)
		LDLa	3537..3571	CDD:238060	21/33 (64%)
		Ldl_recept_a	3574..3610	CDD:395011	19/35 (54%)
		LDLa	3614..3648	CDD:238060	17/36 (47%)
LDLa	3654..3686	CDD:197566	17/31 (55%)
LDLa	3696..3732	CDD:238060	14/37 (38%)
LDLa	3745..3775	CDD:238060	16/29 (55%)
LY	3954..3990	CDD:214531	10/35 (29%)
Ldl_recept_b	4011..4051	CDD:395012	14/39 (36%)
LY	4035..4076	CDD:214531	19/40 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1744
Inparanoid	1	1.050	2909	1.000	Inparanoid score	I20
OMA	1	1.010	-	-		QHG46025
OrthoDB	1	1.010	-	-		D1326at33208
OrthoFinder	1	1.000	-	-		FOG0002316
OrthoInspector	1	1.000	-	-		otm48372
Panther	1	1.100	-	-	O	PTHR22722
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080