DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and lrp1b

DIOPT Version :9

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:XP_031749368.1 Gene:lrp1b / 100485687 XenbaseID:XB-GENE-1019540 Length:2321 Species:Xenopus tropicalis


Alignment Length:2532 Identity:870/2532 - (34%)
Similarity:1233/2532 - (48%) Gaps:450/2532 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  2434 LREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLY 2498
            :.|||.|..:|::.|..:::||||||..|.|.||.|:|...:||:.|||..||.||:|...:|||
 Frog     1 MSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLSGQNAQVIVSTDIVTPNGLTIDHPAEKLY 65

  Fly  2499 WADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLR 2563
            ::|..|.||||..||||:|.|:..|.|...|::|::.|.:||:|||..|::|:|||||.:...||
 Frog    66 YSDGSLGKIERCEYDGSHRHVIVRSGPGTFFSLAIHNDYIFWSDWVRRAILRSNKYTGGETKVLR 130

  Fly  2564 EHVT-RPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVN 2627
            ..:. :||||:||.|.:..|..:.|..:||.|.|:|::...|:..|.|....:..:..||::. |
 Frog   131 SDIPHQPMGIIAVSNDTNTCKLSPCSYMNGGCHDLCLITPDGRINCSCRGDRVLVNDNRCVSK-N 194

  Fly  2628 TSCGL-SQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCD 2691
            :||.: |::.|.:||||....|||.:.||.|.|||.:|||..|.|.....:|.||||||....|:
 Frog   195 SSCNMFSEFECANGECIEYHQTCDGIVHCKDRSDEKQSYCENRSCWRGFRLCGNHRCIPNNKVCN 259

  Fly  2692 GEQQCGDGSDETPLLCK---CQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDF 2753
            .|..|||.|||  |.||   |.|.:                |||..|.||.:...|:.:.||.|.
 Frog   260 DEDDCGDNSDE--LDCKISTCASTE----------------FRCTDGTCITKSAQCNQIIDCADA 306

  Fly  2754 SDEKMCAPIPCEK------NDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDP 2812
            ||||.|....|..      ....|:.|.::::||:|.|.|||..||.|.:|||.|.......|:.
 Frog   307 SDEKNCNNTDCTHYYKLGVKTAGFIRCNSTSLCILPEWICDGANDCGDYSDELKCPAQNKQKCEE 371

  Fly  2813 GQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKT-CIPASWQCDGKSDCEDGS 2876
            ..|.|.:|.||:.:|.|||::||.||.||::|.|.|..:||||.|. ||...|.|||:.||.:|.
 Frog   372 NYFECQNGRCISNAWVCDGQRDCEDGRDELHCDTSCSWSQFACSKNKCISKQWVCDGEDDCGNGL 436

  Fly  2877 DEGPQ-CPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPP 2940
            ||..: |.:..|....|.|..|..|:|..|:||||:|||:|..:..:.|..|       :..|..
 Frog   437 DESEELCGSVTCAAGFFSCPGSHACVPSHWLCDGERDCPNGSDELSTADCAP-------VTTCDE 494

  Fly  2941 PAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQ-TCD 3004
            .|.:|.:.:||...::||.|:||..|.||...|    ..|.|  |.....|.||.|:..:. .||
 Frog   495 NAFMCNNKVCIPKQFMCDLDDDCGDGSDESLEC----GYHQC--GPEEFSCADGRCLLNSHWQCD 553

  Fly  3005 GKPDCGDGSDET--SSLCAHT-RGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNEC 3066
            |..||.|.|||.  :..|.:| :.|| :..|.||||.|:....|||.|:||.|.|||..|:||||
 Frog   554 GDFDCADHSDEAPLNKKCRNTEQSCN-SSSFMCKNGKCVPKGALCDTRDDCGDGSDERGCHVNEC 617

  Fly  3067 LIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCA 3129
            |...:  |..:|:|..|||:|.|.||:: |......|.|||||....||||.||||||:||||||
 Frog   618 LSKRVSGCSQDCQDLPVGYKCKCWPGFR-LKNDGKTCVDIDECLSGFPCSQQCINTYGTYKCLCA 681

  Fly  3130 KGYALVDHHT--CKATSNVSMELIFSNRYYIRQVDMTG-NGSILINELSNAVALDYDWDSQCLYW 3191
            .||.:...:.  ||:.|.....|:.::.:.||::...| |.::|...|:|.:|:|:|:..:.:||
 Frog   682 DGYQIHPEYPNGCKSLSEEDPFLLLADHHEIRKMSTDGLNYTMLKQGLNNVIAMDFDYREEVIYW 746

  Fly  3192 SDVTSTVGT-IKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRK 3255
            .|.:.:.|: :.|.....:..:.:|...:  |:.|||||:.|||||.|.....||||:|:|.|..
 Frog   747 IDSSRSNGSRVNRMFVNGSDVKVVHNTAI--PNALAVDWIGKNLYWFDTEKRVIEVSKLNGLYPT 809

  Fly  3256 VLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQ 3320
            :|:::.::.||.::|.|...:::|.|..:.||:|:.||||:|..::|...:..|.||||.:..::
 Frog   810 ILVSKKIKFPRDLSLDPQTGYLYWIDCCEYPHVGRVGMDGTNQSVVIETMISRPMALTIDYVNKR 874

  Fly  3321 LFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFN 3385
            ::|  |.|:.|..||::|::      |...|..::..:.|:.::|.:|||:|.:|||:......:
 Frog   875 IYW--ANENHIEFSDMNGSN------RHKVPYQDVQGVIALTLFEDYIYWTDGKTKSLNRAHKTS 931

  Fly  3386 GQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCPTNFILA 3448
            |:|..:||.:.|...|:.::|.|||.. :..:||...|  ||.||:|||::. :.|.|||||.||
 Frog   932 GENKASLINSWHAISDIEIYHAYRQPD-VPDHPCKMNNGDCSHLCLLSPQKS-HTCACPTNFYLA 994

  Fly  3449 DDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTH 3513
            :|.:||.:||||:.|.| ||.|||||:|:|||.||||||||||..||.|.|:||::||.:..|..
 Frog   995 EDKKTCLSNCTASQFRC-NTDKCIPFWWKCDTVDDCGDGSDEPAECPEFKCQPGRFQCGSGLCAL 1058

  Fly  3514 PSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACT 3578
            |:.:|||.|.|||.|||||||.:.|.....||    .....|:....||:|..||...|||..|.
 Frog  1059 PAFICDGENDCGDNSDELNCDTYVCLSGQFKC----TKKQKCIPINLRCNGQNDCGDEEDEIDCP 1119

  Fly  3579 PLVCKKDQFQCGNNR-CMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDD 3642
            ...|..|.|||...: |:..:||||.|.||.|.|||||||..:||.::|||.:..|||..||||.
 Frog  1120 ENSCSPDHFQCKTTKHCISKLWVCDEDSDCADGSDEANCDKKACGLHEFQCKNKNCIPDHWRCDG 1184

  Fly  3643 DHDCPNGEDEPA----------------SCFSSKATCDPTY-------------------FKCNN 3672
            .:||.:..||.:                .|.||:..||..|                   |:|:.
 Frog  1185 QNDCGDNSDEESCKPQTCALKEFLCSNGDCISSRFWCDGEYDCADGSDERNCETGCSKEQFQCST 1249

  Fly  3673 SKCIPGRWRCDYENDCGDGSDELNCQ--MRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEIN 3735
            .:||..:|:||...||..|.||.||:  ...||.||:.|.:|.|:....||:||..|.|.|||.:
 Frog  1250 GQCISAKWKCDGHEDCKSGEDEKNCEPVSPTCSSSEYVCDSGGCVSAYLRCNGEYDCADGSDEND 1314

  Fly  3736 CNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNC----TCHSDHFSCGNGKCIMSRWKC 3796
            |...||||||:|.....||..::.|||..||.|||||.||    .|.:|.|.|.|..|.:..|.|
 Frog  1315 CVAECKENQFRCRNRAYCIPLRWFCDGVQDCVDGSDEDNCERANICRADEFLCNNTLCKLQLWLC 1379

  Fly  3797 DGWDDCLDGSDESLETCAKTHC-HANAFKC-RNQLCVRNSALCDGINDCGENEDESDAVCAALPK 3859
            ||.|||.|.|||..|.|.|..| ....|:| .|::|:|...:|:|:::||:|.||  |.|||..|
 Frog  1380 DGEDDCGDNSDEVPEMCVKFLCPPTRPFRCHNNRVCLRTEQICNGLDECGDNSDE--ACCAARQK 1442

  Fly  3860 ---CRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQ-------------------------- 3895
               |:.|:|.|.|..|||...:||...:|.|.|||..|:                          
 Frog  1443 VKPCKKDEFTCNNKKCISVDLQCDKFDDCGDESDEQGCKMEMGEFSCEDDVNPCGDDAYCNQTNT 1507

  Fly  3896 PPVC----GF------------------GSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASG 3938
            |.||    ||                  ||||..|...| |.|.|.|...:   .|:|.:|:|..
 Frog  1508 PAVCHCKAGFQRNLKNRQCEDINECLLLGSCSHHCTNLK-GSYRCLCDRNF---LERNHSCIAQD 1568

  Fly  3939 -PDQILLLASEQE-FRFILP----AKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFW------ 3991
             .||:|.:|::.| ..|..|    ||.:..:.:.:    :.:|...|:.:  :..::.|      
 Frog  1569 TEDQVLYVANDTEVLSFTYPFRHNAKHQQISRIAY----NSRITGMDMYL--QGNMIIWSTQFNP 1627

  Fly  3992 ----IDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNI-PELDDPKSLAVDWISQRVYIIDS 4051
                .::.||                    |..||..:..| ||...|:.:|||||:..:|..| 
 Frog  1628 GGIFFNTFHG--------------------RGGKETKSGLICPEFKRPRDIAVDWIAGNIYWTD- 1671

  Fly  4052 RHNQI-----------------------------LATDIEGKKYISLVSTGMNPTDIVLEPESRI 4087
             |:::                             |.|.|.|:.|.           |.:.|:..:
 Frog  1672 -HSRMHWFSYYTSHWTSLRYSINVGQIHGPNCTRLLTHIAGEPYA-----------IAVNPKKGM 1724

  Fly  4088 MIWSTL--ENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDR 4150
            |.|:.:  .:.|..|::||:.::.:|::::..|..|.:|:.:.||||||:....|.|.:::|.|.
 Frog  1725 MYWTVIGDRSHIEEAAMDGTLRRIIVQKNLQRPTGLVVDHYSQRLYWADFEMSVIGTVKMDGSDL 1789

  Fly  4151 NVVRRFGNRE---KPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYL-LKGYRSSDIGILHPMK 4211
            .:.  ..:::   .|.:||:||||:|.........::.||||....|| |...::..:.|.|..|
 Frog  1790 MIA--VSSKQGLLYPHRIDIFEDYIYGAGLKNGAFRIQKFGNGVMEYLNLNVEKTKSVLISHHYK 1852

  Fly  4212 QNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQC-NLG 4275
            | .|:.|||....|.   .:|:|:..   |.||.|:||.::. :|.|..|....|.|.|.| |.|
 Frog  1853 Q-PNLPNPCLDIKCD---FICLLNPS---GASCACSEGKILV-NGTCMDHNSADDLCKLTCENRG 1909

  Fly  4276 TCKIVDH-VPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGAR 4339
            .|.|.:. .|:|.|.|.|.||.||...|:.||.|.|.|: |.||   ..|   .|||..|::|..
 Frog  1910 RCIINEKGDPRCHCWPSFSGERCEINHCNNYCLNGGTCT-ASAL---GRP---TCTCAVGFTGPN 1967

  Fly  4340 CETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCEHCRNLTCENGGICRETLTGTPQCEC 4404
            |  ....|::.|.|||:|.:|             .|.|                      |.|.|
 Frog  1968 C--GRKVCENFCQNGGTCSVS-------------AGNQ----------------------PYCHC 1995

  Fly  4405 PDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTC--SER 4467
            .:.:||.||:...|..:|.|..||.|:..|..:|.||..|.|..||.:.|.. | :||.|  .:.
 Frog  1996 LNEYTGDRCQFHVCHHYCVNSESCTIADDGSVECVCPIRYEGTKCEVDKCLR-C-HGGLCIIDKN 2058

  Fly  4468 GGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHI--IKGVALCN 4530
            ...::|.|....|..||:           .||.            .|.|.|||.:  ...:..|.
 Frog  2059 SHDVNCNCSNGKIASSCQ-----------LCDG------------YCYNGGTCQLDPETNIPACI 2100

  Fly  4531 CTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVC 4595
            |:..:....|...|   |||..||.|.|:|.:..:..|.|.|...|.|..||.|           
 Frog  2101 CSLGFKSQRCDQKV---NPCDYYCQNEGLCTITAFNEPQCKCSANWSGKQCERP----------- 2151

  Fly  4596 RPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLK 4660
            .|.||                        :.:.|.|..:..:|.||| ::.|:..|..|.:...:
 Frog  2152 APKSS------------------------KSDNTSSRSIAIIVPLVL-LVTLITTLVIGLLLCKR 2191

  Fly  4661 KHR-----------------IAQP------FSHAR-----LTDNVEIMLTNAMYRGDADEA---- 4693
            :.|                 |..|      ..|..     |..|..|.|..:.:.|....|    
 Frog  2192 RRRAKTIRRQPIINGGMNVEIGNPSYNMYEVDHGHNDGSLLDPNFIIELDKSRFIGGGPTAYKIA 2256

  Fly  4694 ----PTFASEDDKG-------NFANPVYESMYADAIPEPVSTEITHS-----TAPDERKGLL 4739
                |.:.:.|.||       |::||||..::.|.          |:     .:.:|||.||
 Frog  2257 HKAPPIYLNSDLKGPLNPGPNNYSNPVYAKLFVDG----------HNCRNSLISIEERKELL 2308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:278487
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
FXa_inhibition 1289..1317 CDD:291342
LY 1434..1476 CDD:214531
LY 1477..1521 CDD:214531
LY 1533..1567 CDD:214531
LY 1568..1611 CDD:214531
FXa_inhibition 1639..1676 CDD:291342
LY 1794..1838 CDD:214531
LY 2078..2112 CDD:214531
NHL <2082..>2152 CDD:302697
NHL repeat 2082..2120 CDD:271320
FXa_inhibition 2269..2303 CDD:291342
LY 2430..2471 CDD:214531 17/36 (47%)
LY 2475..2517 CDD:214531 23/41 (56%)
LDLa 2630..2661 CDD:238060 14/31 (45%)
LDLa 2671..2702 CDD:238060 14/30 (47%)
LDLa 2727..2759 CDD:238060 14/31 (45%)
LDLa 2773..2802 CDD:238060 14/28 (50%)
LDLa 2810..2844 CDD:238060 16/33 (48%)
LDLa 2848..2878 CDD:238060 15/30 (50%)
LDLa 2887..2916 CDD:197566 14/28 (50%)
LDLa 2938..2969 CDD:197566 11/30 (37%)
LDLa 2989..3015 CDD:197566 11/26 (42%)
LDLa 3030..3061 CDD:238060 16/30 (53%)
EGF_CA 3062..>3091 CDD:214542 14/30 (47%)
EGF_CA 3103..3141 CDD:214542 23/39 (59%)
LY 3212..3254 CDD:214531 19/41 (46%)
LY 3255..3297 CDD:214531 14/41 (34%)
LY 3299..3340 CDD:214531 13/40 (33%)
LY 3354..3389 CDD:214531 10/34 (29%)
LDLa 3458..3490 CDD:238060 23/31 (74%)
LDLa 3499..3533 CDD:238060 18/33 (55%)
LDLa 3582..3616 CDD:238060 18/34 (53%)
LDLa 3621..3652 CDD:197566 14/30 (47%)
LDLa 3663..3697 CDD:238060 15/52 (29%)
LDLa 3702..3736 CDD:238060 16/33 (48%)
LDLa 3776..3808 CDD:197566 15/31 (48%)
LDLa 3818..3849 CDD:197566 11/32 (34%)
LDLa 3860..3894 CDD:238060 15/33 (45%)
NHL 4029..>4158 CDD:302697 38/159 (24%)
NHL repeat 4034..4074 CDD:271320 14/68 (21%)
NHL repeat 4076..4115 CDD:271320 9/40 (23%)
LY 4108..4150 CDD:214531 13/41 (32%)
NHL repeat 4121..4158 CDD:271320 12/36 (33%)
EGF_CA <4386..4414 CDD:238011 6/27 (22%)
EGF_CA 4415..4450 CDD:238011 12/34 (35%)
lrp1bXP_031749368.1 Ldl_recept_b 17..58 CDD:395012 21/40 (53%)
LY 42..84 CDD:214531 23/41 (56%)
LDLa 201..230 CDD:238060 14/28 (50%)
LDLa 246..273 CDD:238060 16/28 (57%)
LDLa 278..312 CDD:238060 16/49 (33%)
LDLa 327..361 CDD:238060 15/33 (45%)
LDLa 369..403 CDD:238060 16/33 (48%)
LDLa 407..438 CDD:197566 15/30 (50%)
LDLa 447..480 CDD:197566 15/32 (47%)
LDLa 531..564 CDD:197566 13/34 (38%)
LDLa 578..612 CDD:238060 18/34 (53%)
cEGF 635..658 CDD:403760 10/23 (43%)
EGF_CA 655..685 CDD:214542 22/29 (76%)
Ldl_recept_b 744..782 CDD:423042 9/39 (23%)
LY 767..805 CDD:214531 18/39 (46%)
LY 810..851 CDD:214531 14/40 (35%)
LY 854..893 CDD:214531 13/46 (28%)
FXa_inhibition 964..1000 CDD:405372 18/36 (50%)
LDLa 1004..1035 CDD:197566 23/31 (74%)
LDLa 1044..1078 CDD:238060 18/33 (55%)
LDLa 1083..1118 CDD:238060 12/38 (32%)
LDLa 1123..1158 CDD:238060 18/34 (53%)
LDLa 1163..1197 CDD:238060 16/33 (48%)
LDLa 1202..1236 CDD:238060 6/33 (18%)
LDLa 1240..1274 CDD:238060 12/33 (36%)
LDLa 1281..1315 CDD:238060 16/33 (48%)
LDLa 1319..1354 CDD:238060 19/34 (56%)
LDLa 1360..1391 CDD:238060 15/30 (50%)
LDLa 1446..1480 CDD:238060 15/33 (45%)
EGF_CA 1528..1562 CDD:214542 11/37 (30%)
NHL 1625..1822 CDD:302697 52/231 (23%)
LY <1655..>1674 CDD:214531 9/20 (45%)
Ldl_recept_b 1723..1763 CDD:423042 9/39 (23%)
LY 1747..1788 CDD:214531 13/40 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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