DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and sspo

DIOPT Version :9

Sequence 1:	NP_001260800.2	Gene:	LRP1 / 35799	FlyBaseID:	FBgn0053087	Length:	4752	Species:	Drosophila melanogaster
Sequence 2:	XP_021325919.1	Gene:	sspo / 100036547	ZFINID:	ZDB-GENE-051114-1	Length:	5530	Species:	Danio rerio

Alignment Length:	4998	Identity:	918/4998 - (18%)
Similarity:	1363/4998 - (27%)	Gaps:	2325/4998 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   902 HLQRTGRAADLRIF---DIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCI 963
            :.||.|..|...||   ||.::.:.:|...|    |.|.                    ||.||.
Zfish    74 YYQRQGPKAACYIFKPPDIETEVVNRTVRQC----CEGW--------------------TGPHCT 114

  Fly   964 PQLAPSPIRPNCTSGYMCRS----TRQCLDTKDMCDG------FEDCEDGI----------DESS 1008
            ..::   :|..|.|.:.|..    ....|...:.|.|      :.:..|..          |..|
Zfish   115 QGVS---VRGQCFSTWTCEEFPGVQNSSLMALEQCCGHLWALSWRNASDHTCLSCTYTLLPDVGS 176

  Fly  1009 DP----------KGPCNVNTC-----------DKTHNFVCNGRCYQRSLLCSTIPYCSDGTDQAN 1052
            .|          :.|...:||           |:.| |...|.|  ..||.|:    :|||...
Zfish   177 SPVVRGGLLRGVRDPQASSTCMSWSGTHFRTFDRKH-FHFQGSC--TYLLASS----TDGTWAV- 233

  Fly  1053 CHQNTCNSNEFTCHKSGRC-------------------------------------IQLTWVND- 1079
             :.:|      .|..||||                                     :.:.|:.|
Zfish   234 -YIST------VCETSGRCRKDLRMMLGLGLVSIHKDNMTVNGLAVPQGEPLFQNGVSVHWLGDF 291

  Fly  1080 -----------------------------------GVVDCGPDDDSDETSETIFASKCPEFDCNN 1109
                                               ||.:..||||               |..:.
Zfish   292 VFVESGLGVRLKFDMENTIYLTVTAEHLTNTRGLCGVYNNNPDDD---------------FTTST 341

  Fly  1110 GRCRQFADVCDGIDNCGNN---ADEME---CEQECEHGEKYCRPIGCYGEMHMCDGIHD-CLDFS 1167
            |...|:|      .:.||:   .|:.:   |....|.|             |.||..:| .|...
Zfish   342 GSVSQYA------ASFGNSWRVQDQQQSQVCSDAAELG-------------HSCDLSNDVSLRRD 387

  Fly  1168 DEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTT 1232
            .|:.|:..|..                      ||            |||..:.|.  ..:|:|.
Zfish   388 AESACHLLKET----------------------PF------------SHCHHQVDP--GPYIDTC 416

  Fly  1233 RF-------DMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGH--- 1287
            .:       ...:|.:|   |.|..:.::|.....:...:.       .||  .:::|.||.
Zfish   417 LYLFCSLEVKDRDTAVC---DTLASYVRECAQQHIIISWRR-------RGF--CERVCPRGQVFS 469

  Fly  1288 ECSHRCHNT-------PEGYI-------CSCPDHLYL-----------------------QPNGK 1315
            :|...|..|       ..|..       |.||..:||                       |...:
Zfish   470 DCVSSCPATCASPRPPAAGQCRDECVGGCECPQGVYLHAGQCVRRDDCPCFHRRHSYSAGQTIRQ 534

  Fly  1316 RCSMQHAC----DHWDTCSQVCESSGKGYDCRCLDGFD---LGFDRFTCKSTAPDEPYVIFTNRQ 1373
            ||   :.|    ..|:..::.||:.........:..||   .|.....|:.||.::    |.:
Zfish   535 RC---NTCVCRAGQWECSTEKCEAQCSVLGAMHITTFDQKRYGLQTADCRFTAVED----FVD-- 590

  Fly  1374 DIKGINLKTLNV--------GNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDK---IYRGHLVG 1427
                   |.|::        |.....||.:          |...::.|..:.|.   :..||
Zfish   591 -------KKLSIIIGAGPCAGGEAGCLREM----------SITALHTTLTVTDAGSVLVNGH--- 635

  Fly  1428 ESLRNVEAVIHSGL----STTEGLAVDWVGKNLYW-IDSNLDQIEVAKLNGSFRRTLIAGNMESP 1487
               ||...|:...|    :::..|.:...|..|.| :|..|..|           ||..|.....
Zfish   636 ---RNPLPVVTGDLLVRRASSSVLLIQAFGAQLMWHLDGPLLFI-----------TLQPGFAHKV 686

  Fly  1488 RAIALDPREGLLFWTDWDD-NSPR--IERASMSGDGRRMISTSWQLSAGWPNGLTLD----YTQK 1545
            |.:.     |.|.|:..|| .:|.  :|.::.|...:.::.     |...|:.:|.|    .||:
Zfish   687 RGLC-----GTLSWSQHDDFTTPEGDVENSAASFAAKFIVG-----SCPAPSAMTSDPCGTLTQR 741

  Fly  1546 RVYWVDAKSDSISSTMYDGSEHHVVLRN-------KEILS-------HPFAISVFENYV----YW 1592
            | ...:.....|.|.::... |.||.|.       .|:.|       |...::.:..:.    ..
Zfish   742 R-QLAERVCSVIHSNVFQAC-HDVVDREPFMRLCVSEVCSCGPQASCHCSVLTAYATHCAQEGAL 804

  Fly  1593 TDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGT 1657
            ..||..:........|   ||.|..     |.....|....||...|..:.|  |.:| :||
Zfish   805 LSWRNHTFCPVQCSGG---QVYQEC-----GRLCGTSCADLWDGWSCEPDEG--SRVC-VSG--- 855

  Fly  1658 FKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFL 1722
              |:||..:..|...:  |||                      .|..|.  :|...:.|
Zfish   856 --CQCPDGLAQDAQGQ--CVP----------------------VHMCPC--KSGDTLHP------ 886

  Fly  1723 VDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNL 1787
                              ||.|       ||.|                        ||....
Zfish   887 ------------------AGSS-------INNN------------------------CNTCVC-- 900

  Fly  1788 KGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLT 1852
                                  |.|    :.:.:|.|..:|.|  ..||
Zfish   901 ----------------------ARG----VWNCTDLSCPELNQ--CPGS---------------- 921

  Fly  1853 MDFDSQRLYYAYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKE 1917
                                          |:.||.:.:.:.:..|..|               :
Zfish   922 ------------------------------LIFSPRSCLRTCSSPNSPL---------------D 941

  Fly  1918 ACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEP 1982
            ||         |:.|                                     |.|.|
Zfish   942 AC---------TEPI-------------------------------------HGCIC-------- 952

  Fly  1983 NNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDN 2047
              |.|            .||.|.:.:.|.|     .|.                .:...||:
Zfish   953 --PEG------------TVLLGDQCVKPDE-----CPC----------------HHNGRLYF--- 979

  Fly  2048 ELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHR 2112
                         ..:||.:..|....::|.|..|.|:  .:|....:.....|    ..||.|
Zfish   980 -------------TNDTISKDCNTCVCREQRWHCGQAL--CSGTCVATGDPHYI----TFDGRH- 1024

  Fly  2113 YVVVSNLEKPTALAVDPLQGLLFYVTQQHI--GRVGLDGSQPFVLVNQTRANWAVGSLVLDIEAT 2175
            |..:.:.|   .:.|....| ||.|:.:::  |..|:..::...|        .:|:..:.:...
Zfish  1025 YSFLGDCE---YVLVQESSG-LFSVSAENVPCGSTGVTCTKSVTL--------TIGNTAIHLLRG 1077

  Fly  2176 KVYWCERYPDALMKVDYDGNLREQLLNESLNNPVAL-AKMGDYLYWAENKYNEGIIRVAPLANLS 2239
            |.......|..|.| .|.|:   .|:.|.:...|:| :::|..|.|      :|
Zfish  1078 KAVTVNGIPVTLPK-SYSGS---GLILERVGLFVSLSSRLGVTLLW------DG----------- 1121

  Fly  2240 QSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLC-LFNGTSAVCACAHSRLASDGYSC 2303
                          .:::|.:.:       .|.:|....|| .|:|.:
Zfish  1122 --------------GMRVYVRLM-------PHLHGRVGGLCGNFDGDA----------------- 1148

  Fly  2304 EPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEE-------------- 2354
               ||.  |:.|..|                |.|...|..|...|:.:..:
Zfish  1149 ---END--FTTRQGI----------------MESTPELFGNSWKISPSCPDVADQDLRDPCFINP 1192

  Fly  2355 QLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYD-IVNEQLFWTSNNNATIRSVELRHLS 2418
            ..|.::..:.:.|||..|:.....|..:|.       || .|.:.....|..:.......:...:
Zfish  1193 HRVTWAKKKCAVINQEIFSSCHSEVPYQQY-------YDWCVFDACGCDSGGDCECLCTAVAAYA 1250

  Fly  2419 EHADQNQVHVK----KVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIK 2479
            |..::..|:|:    ::..|:.::   |:..|.|           |:.|......|.
Zfish  1251 EECNRRGVYVRWRSQELCPLQCEN---GLVYEAC-----------GAACSPACPSTP-------- 1293

  Fly  2480 TDIKMPNALTLDLE--------QQKLYWADARLDKIE-RTNYDGS----NRVVLAHSTPKHAFAM 2531
               .:.::|...|.        |..:|..||.:...: ...:|||    ..:|..|.
Zfish  1294 ---SLSDSLCSALSCVEGCFCPQGTVYHDDACISPSQCPCEWDGSVFPAGAMVTQHC-------- 1347

  Fly  2532 AVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCED 2596
                     .:|.:::            ||:..::|                  .|...:.:...
Zfish  1348 ---------QNWSVYS------------LFIILNIT------------------HCTRFSSEVFT 1373

  Fly  2597 VCI---LNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSG--ECIPLELTCDNVTHCA 2656
            ..:   ||.|.:::  |:.|:....|..|  |..:.|..|::.|..|  .|||....|||...|.
Zfish  1374 ALLHYGLNVSIRSS--CSAGLWQCVGSPC--PPPSPCKDSEFRCSGGSERCIPAVWVCDNEDDCG 1434

  Fly  2657 DGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNN 2721
            |||||   .|.. .||..||.|....|:|.|.:|||...|.|.|||            |..|.:.
Zfish  1435 DGSDE---VCPI-TCPPEHFRCSGGACLPVELRCDGHPDCADQSDE------------DFCPPST 1483

  Fly  2722 NTKEMPD-MFRCGSGECIPRKFLCDSLKDC--RDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMP 2783
            .....|. .|||.:|.|:|...:||...||  .|.|||..|. :.|.:.:.   .| :|..|::.
Zfish  1484 PESGCPSGEFRCANGRCVPGHKVCDGRMDCGFADDSDEYDCG-VVCRQEEF---RC-SSGRCVLF 1543

  Fly  2784 RWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTE- 2847
            ..||||..||.|.:||..|.      |..|:.:|....|::....|||.:|||.|.||:.|..:
Zfish  1544 LHRCDGHDDCGDYSDERGCV------CALGELQCPGDQCVSAERVCDGNRDCPSGIDELICPAKG 1602

  Fly  2848 CRHNQFACDK-TCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEK 2911
            |...:|.|.. .|:|.:|:|||::||.||||| .:| :|.|:...|.|:|..:|:..:.:|||..
Zfish  1603 CSQFEFGCTSGQCVPLAWRCDGETDCLDGSDE-KRC-SRTCQSDQFLCQSGDQCVQYQQLCDGTP 1665

  Fly  2912 DCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEY--EGCV 2974
            :|     .:.|::....||. ..||.| |.:..|.:..|:::..||:|..|||.|:||.  :...
Zfish  1666 NC-----RDASDESLDNCGS-TRIPPC-PGSFSCDNRTCVNASRVCNGIPDCPKGEDEILCDKVR 1723

  Fly  2975 PAFQPHS-------CPGGSLMHQCQDGLCIFKNQTCDGKPDC--GDGSDET-------------- 3016
            |:..|.|       ||    ...|.||.|:..|..|:|..||  .:.|||:
Zfish  1724 PSAAPPSEGNISRICP----EFTCADGSCVPFNTMCNGVSDCPGTEASDESGCGVWGPWGPWSAC 1784

  Fly  3017 -----SSLCAHTRGCN-GTDDFR--------CKNGACIHADLLCD-------RRNDCADFSDEEL 3060
                 |.:.:..|.|: |..|.|        |.:.||     ..|       ..::|:.......
Zfish  1785 SRSCGSGIMSRQRSCSPGLSDCRGHKKQRQQCYSTAC-----AVDGYWSPWSTWSNCSKSCGGVE 1844

  Fly  3061 CNVNECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYK 3125
            ....||..|......|.|               ||...::.|||      :||:|.|.:.
Zfish  1845 IRQRECFPPQNGGRSCAD---------------LPGETNMTTDI------RPCAQDCSDV----- 1883

  Fly  3126 CLCAKGYALVDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLY 3190
             .|..|  ||. |||     .|..|..::        ::|..:.             |.||:|.
Zfish  1884 -SCPAG--LVS-HTC-----ASCPLTCAH--------VSGTATC-------------DPDSKCF- 1917

  Fly  3191 WSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRK 3255
                   .|.   :||:.......||.:   |....|..|:...||             .|:..|
Zfish  1918 -------AGC---WCPEGKVMNADHQCV---PPEECVCEVSGVRYW-------------PGQQVK 1956

  Fly  3256 VLINEYLREPRGIALH--PYQQ---HIFWSD---WGDSPHIGKAGMDGSNPKMIIRDGLGW---- 3308
            |..:..:.| ||...|  |..:   |..||.   ||:.  :|..|:          ..:.|
Zfish  1957 VGCDICVCE-RGRTQHCQPNPECSVHCGWSSWSLWGEC--LGPCGV----------QSVQWSFRS 2008

  Fly  3309 PNALTISFETQQ---LFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAV-W----- 3364
            ||..|.....:|   ::....|..|...|:.:                .|.|.:|:.. |
Zfish  2009 PNNPTKHGNGRQCRGIYRKARRCQTEPCSECE----------------YLGHTYAVGERWKGGQC 2057

  Fly  3365 -------------------------EGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRV 3404
                                     :|||.   ...:..|.|.....:|.:|:.||  .||.|.:
Zfish  2058 QLCQCLPNLTVQCGPYCPYAATGCPQGHIL---TPAEGDECCHCEERRNGSTITTT--TPMILPI 2117

  Fly  3405 -FHPYR-------------------------QQQP---------MSGNPCLAANCST------LC 3428
             ..|.|                         |..|         .:|:|..|...:|      |.
Zfish  2118 TLEPSRPPEGPPTVPTYPLPPGDECWSALGVQSLPAVSFSSSSHQAGHPPSAGRLNTGDPHRDLQ 2182

  Fly  3429 VLSPEEPYYKCM---CPTNFILADDGRTCRANCTAAH------------FECV------------ 3466
            ..|||...||.:   .|.:......|...:.:....|            |:..
Zfish  2183 GWSPEPEQYKELPHGTPEDTRHPSHGPYLQIDLLTQHNITGVLTQGGGVFDTFVSSFYLQFSSDG 2247

  Fly  3467 ---NTYK-------------------------------------CIP------FYWRCDTQDDCG 3485
               :|||                                     .:|      .|.|.:.. .|.
Zfish  2248 LQWSTYKEMITDARPKAKVFQGNSDDRGVSLARLDRMVSARFIRILPHDFQNGIYLRVEIM-GCP 2311

  Fly  3486 DGSDEPETCPPFH--C---EPGQYQCANKKCTHPSNLCDGINQCGDGSDELNC------------ 3533
            ||:.....|||.|  |   .||       .|.....||||:..|.||:||.:|
Zfish  2312 DGTGPGAVCPPGHFLCPAPPPG-------LCIEEKLLCDGVPHCPDGADERDCKHTNISHITPTA 2369

  Fly  3534 ------------------------DKFTCF------DNHMKCGATANSS---------------- 3552
                                    .|..|.      |..:..|...:||
Zfish  2370 AALRTPSKIRTTPTLLTTTEGGPSQKGVCASALGLEDGRVHYGQLTSSSYRENNPADAGRLNVVP 2434

  Fly  3553 ------------------AFCVDNVK--------------------------------------- 3560
                              .|.||.::
Zfish  2435 NVMVMEPGWSPLPADPHPYFQVDFLEPTWVSGVVTQGSERMWGYLTKYRLAFALVENQFINFTES 2499

  Fly  3561 --------------------------------------------------------RC------- 3562
                                                                    ||
Zfish  2500 GDTDAPPKMFEVRMVSRTPVTRWLPRLVRARFLRIIPVEFRHTFYLRVEVLGCRGGRCVVWLVTP 2564

  Fly  3563 ---------------------------------------------DGVKDCPGGEDESACTP--- 3579
                                                         .||....||.|....||
Zfish  2565 SSLVTTVPPGVPGVQNYTEPAGRPGYHNYTSGAPGLQTKSPQDGRPGVATPTGGPDLHIITPTAT 2629

  Fly  3580 --------------LVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVS---------- 3620
                          :.|.:.||.|....|:....||||..||||.|||.:|.:.|
Zfish  2630 AFWDASTPYDELPRVECVEGQFSCRTFGCVEDELVCDGHEDCPDGSDELHCGSASPPPGRVSPSQ 2694

  Fly  3621 -------CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE-----------------PASC----- 3656
                   |....:.|.||.|:.|..|||...||.:|.||                 ..||
Zfish  2695 RPLLPKLCSSKQWSCWSGECVSLDRRCDLHSDCADGSDENDCYDCILSSWASWSQCSVSCGLGSI 2759

  Fly  3657 FSSK---------ATCDPTYF---KCNNSKC-IPGRWR-------CDYE---------------- 3685
            |..|         .:|....|   .|....| :.|:|.       ||..
Zfish  2760 FRQKNILRDARPGGSCGGAQFDSRPCFLQACPVSGQWSEWTQWSGCDVPCAGGLMVRNRTCSNPP 2824

  Fly  3686 -----NDC-GDGSDELNCQMRNC---SESEFRCGTGKCIKHNYRC-DGE-----IHCDDNSDEIN 3735
                 .|| |.......|..::|   ::::..|..|..:.....| .|:     :.|.|...|.|
Zfish  2825 PKNGGRDCEGMSRQTHTCNTQSCGSDTDTQSGCTGGMILMDESDCLAGKFSPCPLTCSDLHSERN 2889

  Fly  3736 CNITCKE----------------NQFKCAAF-----------------NTCINKQYKCDGDDDCP 3767
            |.:.|..                |..:|..|                 ::|:           |.
Zfish  2890 CTLNCTAGCHCPPGLFLQSGRCVNVSECECFWNGSLIQPGQDVSNSSCSSCV-----------CK 2943

  Fly  3768 DG---SDEVNCTCHSD----------HFSCGNGKCIMSRWK-------------CDG-------- 3798
            ||   .||.:|....|          ..|||.|  :..|::             |:|
Zfish  2944 DGRVLCDESSCVARCDWSAWSSWTSCDSSCGTG--VQHRYRSPLSAVGALHVEPCEGDSTEARRC 3006

  Fly  3799 ------------------WDDC-------LD--GSDESLETCAKTH-CHANAFK---CRNQLCVR 3832
                              |.:|       :|  |..:...:|..|| |..:|.:   |....|..
Zfish  3007 SVPCTDGADGAQWSDWTHWSECSKTCFHHVDAVGMRKRFRSCNHTHTCAGDADEQEPCNTLHCPV 3071

  Fly  3833 N------SALCDGINDCGENEDESDAVCAALPK------CRHDQFQCENDDCISKAFRCDGQYNC 3885
            |      |:..|..:||......|:..|:..|.      |.....|..  ||  ....|.|.  |
Zfish  3072 NGGWSSWSSWSDCSSDCDSGVQTSERFCSFPPPLYGGLVCPGPHMQTR--DC--NVQPCTGV--C 3130

  Fly  3886 VDGSD---EMNCQPPVCGFGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPDQILLLAS 3947
            .||..   :..|:   ...|:|.::|::..|   :.:||...:.|      |..| |...|...|
Zfish  3131 PDGMTFLWKHQCE---AQGGACPRVCLDAMA---DVQCASECYDG------CYCS-PGFYLFNKS 3182

  Fly  3948 EQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGT 4012
            ....:| .|...:|.                  |:.|.|::
Zfish  3183 CVHLQF-CPCVHQGA------------------LLMPGDSV------------------------ 3204

  Fly  4013 GVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPT 4077
                                 |:              ||.:|   .|.:.|:     :..|..|.
Zfish  3205 ---------------------PR--------------DSCNN---CTCVNGE-----MQCGEEPC 3226

  Fly  4078 DIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGW-------PISLSMDYPTGRLYWADY 4135
            .:                                  ..||       ..|.:.|....|    .|
Zfish  3227 PV----------------------------------HCGWSEWTSWSACSRTCDVGIRR----RY 3253

  Fly  4136 RKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGT----YLL 4196
            |.||           |....||.|                     :.:..:.|.|..:    :.:
Zfish  3254 RSGT-----------NPAPAFGGR---------------------VCEGERIGLDTCSVTPCFGV 3286

  Fly  4197 K---------------GYRSSDIGIL--HPMKQNRNISN--PCAK----------DPCKSSRALC 4232
            |               ||||...|.:  |..:|..:..|  ||..          ..|...:.||
Zfish  3287 KGPWSRWSECSVSCGGGYRSRTRGPIRSHGTQQQFSACNLQPCGNRSGCSGGQQWSVCVREQLLC 3351

  Fly  4233 I-LSSESSVGY----SCKCAEGYVMTDD-----GVCKAHADIPDYCP-----LQCNLGTCKIVDH 4282
            . |.:|:....    .|:|.||..:.|.     .:|..|.:...:.|     ..||
Zfish  3352 SDLGTEAQKDAHCHPGCQCPEGSALQDGECVPVSLCHCHVNGEQHKPRATVNKDCN--------- 3407

  Fly  4283 VPKCICQPQFEGEL--CEHYRC---SGYCQ--NYGVCSVAPALPGSQ-------EPPP----LKC 4329
              .|.|:   .|:|  |....|   .|:..  .:|||||:..: |.|       :|.|    |.|
Zfish  3408 --NCTCE---SGKLVNCTSVDCDVDGGWSSWTPWGVCSVSCGV-GLQSRYRFCSDPEPAGAGLPC 3466

  Fly  4330 T-------------CT--AGWS-------------------------------GARCE------- 4341
            |             |:  .|||                               |.:||
Zfish  3467 TGAHRDDRVCASTPCSRDGGWSDWSSWTDCSKSCGGGVKSRRRDCDRPIRTADGDQCEGLDTEVT 3531

  Fly  4342 ------------------------TSMPA-------CQSRCHNGGSCL---ISETEGMKC----S 4368
                                    .|.|.       |:.||..|..|.   :..:.|.:|    |
Zfish  3532 LCNTQHCAVSSCSHVSGSVFSACGPSCPRSCDDLTFCEWRCEPGCYCTDGKVLTSNGTECVEQDS 3596

  Fly  4369 CP--KMFTGEQC---------EHCRNLTCENGGI---------------------CRET-----L 4396
            ||  .:.|||:.         :.|.|.|||.|.:                     |.:|     :
Zfish  3597 CPCLDLNTGERVQPGDTVPTPDACNNCTCEGGRLSCTDHPCPVDGDWCQWSAWTPCSKTCGLEWV 3661

  Fly  4397 TGTPQCECPDGFTGKRCEIDECAD---------------------FCKNGGS------------C 4428
            :....|.||:..:|..    .|||                     :|...||            |
Zfish  3662 SRYRSCSCPEPMSGGA----PCADQQEEHAGLGVQIQRQPCPSISYCPVDGSWGSWSSWSECDAC 3722

  Fly  4429 VISTKGQRQCKCPSGYF------GEHCESNSCRDFCRNGGTCSERGG------------------ 4469
            ...:..||||..|...|      ||..:|.:|.|   |...||:.||
Zfish  3723 AGVSVRQRQCHSPPARFGGLPCMGESLQSRACHD---NTTVCSDCGGGQQEWVCGKPCPRSCSDL 3784

  Fly  4470 -------------RLSCTCPPRYI---GESCESDLCKTSSPPHFC--DNTKVPT----------- 4505
                         .|||.||...:   |...|.::|:       |  .||.:..
Zfish  3785 HGDTECVDDPESCSLSCGCPGHTLLQDGVCVEPEMCR-------CKYHNTSISAVSDSGNVSWSW 3842

  Fly  4506 --------RDP----------CT----LMICQNAGTCHIIKG----VALCNCTDQWNGDLCTLPV 4544
                    .:|          ||    ::.|.:...||:..|    .|..:|:.|..|.:.....
Zfish  3843 SDASDWQITEPGETISSHCHNCTCEAGVLQCDSVPGCHVDGGWSQWGAWSDCSAQCGGGVKLRDR 3907

  Fly  4545 TDDNPCARYCANGGVCHLDEYRLPHC---SCI--GEW-------------------QGNACEMPP 4585
            ..|||..:  :.|..|...|.:..||   :|.  |.|                   :..:|..||
Zfish  3908 QCDNPTPQ--SGGRQCAGSERQQKHCNTHNCTDSGPWLQWSRWSACTVSCGGGSQSRSRSCSTPP 3970

  Fly  4586 HCVGGE-----CNV-------CRPGSSINECLCENNRVVP-----------CLSDSAD 4620
             |:|..     ||.       |.||....|  ||:....|           |.|:..|
Zfish  3971 -CLGKRRQSKTCNTQVCLEVGCPPGRLYRE--CEHGEGCPFSCSQVSGLEGCYSEGCD 4025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	NP_001260800.2	LDLa	87..118	CDD:197566
		LDLa	126..163	CDD:238060
		EGF_CA	246..283	CDD:214542
		Ldl_recept_b	449..487	CDD:278487
		LY	472..513	CDD:214531
		LY	817..852	CDD:214531
		LDLa	1057..1092	CDD:197566	14/107 (13%)
		LDLa	1104..1134	CDD:238060	7/35 (20%)
		FXa_inhibition	1289..1317	CDD:291342	10/64 (16%)
		LY	1434..1476	CDD:214531	9/46 (20%)
		LY	1477..1521	CDD:214531	12/46 (26%)
		LY	1533..1567	CDD:214531	8/37 (22%)
		LY	1568..1611	CDD:214531	9/60 (15%)
		FXa_inhibition	1639..1676	CDD:291342	10/36 (28%)
		LY	1794..1838	CDD:214531	8/43 (19%)
		LY	2078..2112	CDD:214531	7/33 (21%)
		NHL	<2082..>2152	CDD:302697	16/71 (23%)
		NHL repeat	2082..2120	CDD:271320	8/37 (22%)
		FXa_inhibition	2269..2303	CDD:291342	6/34 (18%)
		LY	2430..2471	CDD:214531	6/40 (15%)
		LY	2475..2517	CDD:214531	9/54 (17%)
		LDLa	2630..2661	CDD:238060	14/32 (44%)
		LDLa	2671..2702	CDD:238060	14/30 (47%)
		LDLa	2727..2759	CDD:238060	15/34 (44%)
		LDLa	2773..2802	CDD:238060	12/28 (43%)
		LDLa	2810..2844	CDD:238060	13/33 (39%)
		LDLa	2848..2878	CDD:238060	14/30 (47%)
		LDLa	2887..2916	CDD:197566	9/28 (32%)
		LDLa	2938..2969	CDD:197566	11/30 (37%)
		LDLa	2989..3015	CDD:197566	10/27 (37%)
		LDLa	3030..3061	CDD:238060	7/45 (16%)
		EGF_CA	3062..>3091	CDD:214542	5/28 (18%)
		EGF_CA	3103..3141	CDD:214542	12/37 (32%)
		LY	3212..3254	CDD:214531	8/41 (20%)
		LY	3255..3297	CDD:214531	14/49 (29%)
		LY	3299..3340	CDD:214531	8/47 (17%)
		LY	3354..3389	CDD:214531	9/65 (14%)
		LDLa	3458..3490	CDD:238060	11/101 (11%)
		LDLa	3499..3533	CDD:238060	13/36 (36%)
		LDLa	3582..3616	CDD:238060	16/33 (48%)
		LDLa	3621..3652	CDD:197566	12/30 (40%)
		LDLa	3663..3697	CDD:238060	11/66 (17%)
		LDLa	3702..3736	CDD:238060	8/42 (19%)
		LDLa	3776..3808	CDD:197566	12/89 (13%)
		LDLa	3818..3849	CDD:197566	9/39 (23%)
		LDLa	3860..3894	CDD:238060	9/36 (25%)
		NHL	4029..>4158	CDD:302697	19/135 (14%)
		NHL repeat	4034..4074	CDD:271320	6/39 (15%)
		NHL repeat	4076..4115	CDD:271320	1/38 (3%)
		LY	4108..4150	CDD:214531	9/48 (19%)
		NHL repeat	4121..4158	CDD:271320	8/36 (22%)
		EGF_CA	<4386..4414	CDD:238011	9/53 (17%)
		EGF_CA	4415..4450	CDD:238011	15/73 (21%)
sspo	XP_021325919.1	VWD	190..342	CDD:214566	29/181 (16%)
		C8	392..458	CDD:312319	17/113 (15%)
		TIL	462..517	CDD:307783	12/54 (22%)
		VWD	557..706	CDD:321964	38/193 (20%)
		C8	745..814	CDD:214843	11/69 (16%)
		TIL	817..876	CDD:307783	22/98 (22%)
		VWD	1009..1157	CDD:306577	40/228 (18%)
		C8	1196..1269	CDD:214843	13/79 (16%)
		TIL	1272..1328	CDD:307783	12/80 (15%)
		LDLa	1409..1439	CDD:197566	13/29 (45%)
		LDLa	1445..1479	CDD:238060	17/45 (38%)
		LDLa	1488..1524	CDD:238060	15/35 (43%)
		LDLa	1528..1562	CDD:238060	13/37 (35%)
		LDLa	1564..1598	CDD:238060	13/33 (39%)
		LDLa	1603..1637	CDD:238060	16/34 (47%)
		LDLa	1640..1673	CDD:197566	10/37 (27%)
		LDLa	1687..1719	CDD:238060	12/31 (39%)
		TSP1	1775..1821	CDD:214559	7/45 (16%)
		TSP1	1827..1886	CDD:214559	15/85 (18%)
		TIL	1885..1940	CDD:307783	20/97 (21%)
		TSP1	1984..2037	CDD:214559	13/64 (20%)
		FA58C	2144..2309	CDD:238014	22/165 (13%)
		LDLa	2320..2357	CDD:238060	17/43 (40%)
		FA58C	2400..2551	CDD:330301	7/150 (5%)
		LDLa	2646..2680	CDD:238060	16/33 (48%)
		LDLa	2702..2736	CDD:238060	14/33 (42%)
		TSP1	2742..2791	CDD:214559	7/48 (15%)
		TSP1	2796..2847	CDD:214559	7/50 (14%)
		TIL	2875..2917	CDD:307783	7/41 (17%)
		TSP1	2960..3009	CDD:214559	7/50 (14%)
		TSP1	3019..3070	CDD:214559	10/50 (20%)
		TSP1	3232..3283	CDD:214559	14/86 (16%)
		TSP1	3288..3329	CDD:214559	8/40 (20%)
		TIL	3335..3387	CDD:307783	10/51 (20%)
		TSP1	3430..3482	CDD:214559	12/52 (23%)
		TSP1	3487..3538	CDD:214559	5/50 (10%)
		TIL	3548..3597	CDD:307783	9/48 (19%)
		TSP1	3643..>3685	CDD:214559	9/45 (20%)
		TSP1	3885..3936	CDD:214559	12/52 (23%)
		TSP1	3942..3986	CDD:214559	8/44 (18%)
		TSP1	4113..4165	CDD:214559
		TSP1	4184..4232	CDD:214559
		TSP1	4249..4301	CDD:214559
		TSP1	4307..4358	CDD:214559
		TIL	4363..4418	CDD:307783
		TSP1	4557..4608	CDD:214559
		TSP1	4614..4665	CDD:214559
		TIL	4719..4774	CDD:307783
		TSP1	4884..4933	CDD:214559
		TIL	4948..4993	CDD:307783
		TSP1	5037..5084	CDD:214559
		TSP1	5090..5139	CDD:214559
		TIL	5143..5197	CDD:307783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910