DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and lrp6

DIOPT Version :10

Sequence 1:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster
Sequence 2:NP_001128156.2 Gene:lrp6 / 100003877 ZFINID:ZDB-GENE-090821-1 Length:1619 Species:Danio rerio


Alignment Length:1769 Identity:508/1769 - (28%)
Similarity:793/1769 - (44%) Gaps:312/1769 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1365 PYVIFTNRQDIKGINL------KTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRG 1423
            |.:::.||:|::.::.      .||.:|    .|.:..|:|::|   :...|||:||.::.|.|.
Zfish    21 PLLLYANRRDLRLVDAAHGRANATLVMG----GLEDAAAVDYIY---AQGLIYWSDVSEESIKRT 78

  Fly  1424 HLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPR 1488
            ...|.:...|:..:.|||::.:|||.||:|..|||.||..::||||:|:|:.|:.|...:::.||
Zfish    79 LFNGSAPSGVQTTVISGLASPDGLACDWMGNKLYWTDSETNRIEVAELDGTHRKVLFWQDLDQPR 143

  Fly  1489 AIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAK 1553
            ||||||..|.::||||.: .|:||||.|.|..|.:|.   :....|||||||||.|:::||.|||
Zfish   144 AIALDPGRGFMYWTDWGE-IPKIERAGMDGSLRSVIV---ETEIYWPNGLTLDYQQQQLYWADAK 204

  Fly  1554 SDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQ 1618
            .:.|..:..|||...||::..  |.||||::::|:.::||||.|.|:...:|..|.:.:.:....
Zfish   205 FNCIHRSNLDGSSREVVVKGS--LPHPFALTLYEDTLFWTDWNTHSIHSCHKHTGENSREVHSNI 267

  Fly  1619 SQPFGIQVLHSSRQPWD-RNPCGENNGGCSHLCLLS-GRGTFKCECPHVMRLDPANERNCVPN-E 1680
            ..|..|.|....|||.| .:||...||||||||||| .:..::|.||..::| ..:.::|... .
Zfish   268 FSPMDIHVYSQQRQPMDVASPCSVRNGGCSHLCLLSPAKPYYQCACPTGVQL-LEDHKSCRDGPS 331

  Fly  1681 QVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISN 1745
            |:||.....::|.|.|..|:...|  :.|:..:.....||:...|..|:|:|.:...|..:.:..
Zfish   332 QLLLLARRTDLRRISLDTPDFTDI--VLQAEDIRHAIAIDYDPVEGHIYWTDDEVRAIRRSLLDG 394

  Fly  1746 GLIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLD 1808
            ...:.::.:.:..|.|.||||||||:|:: :|..:..:  :.|.|....| |.|||:...:||||
Zfish   395 SDAQLVVTSQVNHPDGIAVDWIARNLYWTDTGTDRIEV--TRLNGTMRKILISEDLDEPRAIVLD 457

  Fly  1809 PANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA------ 1863
            |..|.|||    :| |.:.::|::.||||.|.::.  ..:|   ..|.:|:..:::|:.      
Zfish   458 PVAGYMYW----TDWGEVPKIERAALDGSQRMVMV--NTSLGWPNGLALDYSERKIYWGDAKTDV 516

  Fly  1864 -----YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMS 1923
                 .|.||           |:||:...:..:...|:....:|:.:..:..|.:..|.: :...
Zfish   517 IEVMEMDGSG-----------RRVLLEDNLPHVFGFTLLGDYIYWTDWQRRSIERVHKRS-TERE 569

  Fly  1924 YLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCL-ATSSIDHVCRCALGYDVEPNNPTG 1987
            .:......:..:|..:.....|.|.|| || .|||..||| ....:.  |.|.:|.::..:..|.
Zfish   570 VIIDQLPDLMGIKATFVHQTFGVNPCA-WA-NGGCSHLCLYRPQGVS--CACPIGLELMADLSTC 630

  Fly  1988 CVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSI 2052
            .||.|..:|.....::.:.:...:..      ..:|::.|..||.:|:....:.:||.|..|.:|
Zfish   631 IVPEAFLLFSRHTDIRRISLETNNNN------VAIPLTGVKEASALDFDITDNRIYWTDITLKTI 689

  Fly  2053 SRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVV- 2116
            ||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.||||:|||.||.|:| 
Zfish   690 SRAFMNGSSLEHVVE----FGL---DYPEGMAVDWLGKNLYWADTGTNRIEVAKLDGQHRQVLVW 747

  Fly  2117 SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLV-NQTRANWAVGSLVLDIEATKV 2177
            .:|:.|.|||:||.:|.:::..   :..|.|..:|||....|| |..|||    .|.:|....::
Zfish   748 KDLDSPRALALDPAEGFMYWTEWGGRPKIDRAAMDGSGRITLVPNVGRAN----GLTIDYAERRL 808

  Fly  2178 YWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSK 2242
            ||.: ....|::......|..:::.:.|.:|..|.:..||:||.:  :::..|..|...: .|::
Zfish   809 YWTD-LDTTLIESSNMLGLEREVIADDLPHPFGLTQYQDYIYWTD--WSQRSIERANKTS-GQNR 869

  Fly  2243 VVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCL-FNGTSAVCAC-AHSRLASDGYSCEP 2305
            .|:|...|.:.|:.::....|.|.|.||.:||.|..||| ....|..|.| ||..|.:|..:|..
Zfish   870 TVIQGHLDYVMDILVFHSSRQSGWNACAATNGHCSHLCLAVPVCSFTCGCPAHYSLNTDNKTCSA 934

  Fly  2306 YENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQV 2370
            ..:|||||.::.|..:.|    |:.....:|.....:|||.||.|:..::.:|:.|.:.:.|.:.
Zfish   935 PTSFLLFSQKTAINRMVM----DELQSPDIILPIHSLRNVRAIDYDPLDRHLYWIDAKQNVIRRA 995

  Fly  2371 HFNGT-----------GHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQN 2424
            ..:|.           |..:.|:...    |:.||.:..::|||.....|...       ..|.:
Zfish   996 QEDGNQSVTVVSGAVGGSNLGLQPYD----LSIDIYSRFIYWTSELTNVINVT-------RTDGS 1049

  Fly  2425 QVHVKKVLSLR-EDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNAL 2488
            :|.|    .|| |.||||.|||.|..|.:|::|..|.||.|:|..|.|...||:..:::..|.||
Zfish  1050 RVGV----VLRGEHDKPRAIAVNPERGYMYFSNLQERSPKIERCALDGTEREVLFFSNLGRPVAL 1110

  Fly  2489 TLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANK 2553
            .:|.|..||:|.|..|.:||.::..|:||:|:..|.......:.|:|:.|:|.|.....:.|.:|
Zfish  1111 AVDNELGKLFWVDMDLRRIESSDLSGANRIVIEDSNILQPVGLTVFGNFLYWIDRQQQMIERIHK 1175

  Fly  2554 YTGTDVLFLREHVTRPMGIVAVQNTSI-NCDANQCKILNGQCEDVCILNKSGQATCHC-TQGVLA 2616
            .|......::..:.....|.||....: ....:.|...||.|..:||:...|...|.| ...||.
Zfish  1176 VTREGRTKIQARIASLSDIHAVHQLDMQEYSKHPCTSDNGGCTHICIVKGDGTTRCSCPIHLVLL 1240

  Fly  2617 PDGRRCIAPVNTSCGLSQYNCHSGE--CIPLELTCDNVTHCADGSDEFRSYCIFRQCP---ETHF 2676
            .|...|..|  .:|...|::|.|||  |||....||....|.|.|||       |.||   ...|
Zfish  1241 QDELSCGEP--PTCSPEQFSCVSGEVDCIPQAWRCDGFAECDDSSDE-------RDCPVCSSREF 1296

  Fly  2677 MCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRK 2741
            .|.:.:|:....:|:||..|.|.|||.    ||:.    :.|:        |.|.|.:|:||.|.
Zfish  1297 QCDSRQCVDAALRCNGEINCQDRSDEN----KCEV----LCPA--------DQFTCSNGQCIGRH 1345

  Fly  2742 FLCDSLKDCRDFSDEKMC----APIPCEKND---------MTFVHCGNSTIC---IMPRWRCDGD 2790
            ..||:..||.|.|||..|    .|.....|.         :.||......:|   :.|:.:.|.|
Zfish  1346 KKCDNNMDCTDNSDEIGCYATEEPSFAPTNTIGSIVGVVMVLFVVGAVYFVCQRVLCPQMKDDAD 1410

  Fly  2791 -----------PDCPDGTDELDCANHTSLSCD-PGQFRCASGNCIAGSWHCDGEKDCPDGSDEIN 2843
                       |..|.|.    ..:..|||.. ||..|   |..:.||....|....|       
Zfish  1411 TMTNDFVVHGPPPVPLGY----VPHPASLSGSLPGMSR---GKSVMGSLSIMGGSSGP------- 1461

  Fly  2844 CRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCP------------------------N 2884
                      ..|:..:      .|.|.....|.:|...|                        |
Zfish  1462 ----------PYDRAHV------TGASSSSSSSTKGAYFPPILNPPPSPATVRSQYTMEFGYSSN 1510

  Fly  2885 RPC-------RPHLFQ--------CKSSGRCIPQKWVCDGE----KDCP--------SGLGDEGS 2922
            .|.       ||:.::        |.:.        |||.:    :..|        .|...:.:
Zfish  1511 SPSTHRSYSYRPYSYRHFAPPTTPCSTD--------VCDSDYTPGRRAPHASSATAAKGYASDLN 1567

  Fly  2923 EDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSL 2987
            .|..|       :|..|.|.          |.|: ..:|:|       |.|.|:  |::  ..|.
Zfish  1568 YDSEP-------LPPPPTPR----------SQYL-SAEENC-------ESCPPS--PYT--ERSY 1603

  Fly  2988 MHQ--------CQD 2993
            .||        |.|
Zfish  1604 SHQLYPPPPSPCTD 1617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531 20/41 (49%)
LY 1477..1521 CDD:214531 21/43 (49%)
LY 1533..1567 CDD:214531 19/33 (58%)
LY 1568..1611 CDD:214531 16/42 (38%)
FXa_inhibition 1639..1676 CDD:464251 16/37 (43%)
LY 1751..1789 CDD:214531 13/38 (34%)
LY 1794..1838 CDD:214531 21/45 (47%)
LY 2078..2112 CDD:214531 18/33 (55%)
NHL <2082..>2152 CDD:302697 34/73 (47%)
NHL repeat 2082..2120 CDD:271320 21/38 (55%)
FXa_inhibition 2269..2303 CDD:464251 15/35 (43%)
LY 2430..2471 CDD:214531 20/41 (49%)
LY 2475..2517 CDD:214531 15/41 (37%)
LDLa 2630..2661 CDD:238060 14/32 (44%)
LDLa 2671..2702 CDD:238060 11/33 (33%)
LDLa 2727..2759 CDD:238060 15/31 (48%)
LDLa 2773..2802 CDD:238060 7/42 (17%)
LDLa 2810..2844 CDD:238060 8/34 (24%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 7/55 (13%)
LDLa 2938..2969 CDD:197566 6/30 (20%)
LDLa 2989..3015 CDD:197566 4/13 (31%)
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
lrp6NP_001128156.2 None
Blue background indicates that the domain is not in the aligned region.

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