Protein Alignment Mlh1 and mutL

DIOPT Version :10

• Sequence 1: NP_477022.1
• Gene: Mlh1 / 35796
• FlyBaseID: FBgn0011659
• Length: 664
• Species: Drosophila melanogaster
• Sequence 2: NP_418591.1
• Gene: mutL / 948691
• ECOCYCID: EG11281
• Length: 615
• Species: Escherichia coli
• Alignment Length: 661
• Identity: 178/661 - (26%)
• Similarity: 291/661 - (44%)
• Gaps: 159/661 - (24%)

  Fly    10 IRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRRED 74
            |:.|...:.|:|||||:::|||:.:|||:||||||.:|.|.:.::.||.||::|:|||.||::::
E. coli     3 IQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDE 67

  Fly    75 LAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATYADGK-LQ 138
            ||:...|..|||:...:||..|.:.|||||||||||.|:.|::.::||:::..::| ||:|: :.
E. coli    68 LALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQA-YAEGRDMN 131

  Fly   139 GQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAVHNPRVGFTLRKQGDAQ 203
            ...||.|...||.:.:.|||||.|.||:.||:...||..:.|::.|.|:....|...|...|...
E. coli   132 VTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIV 196

  Fly   204 PALR-TPVASSRSENIRIIYGAAISKELL--EFSHRDEVYK------FEAECLITQVNYSAKKCQ 259
            ...| .|....:...:..|.|.|..::.|  |:.|.|...:      ......:.::.|    |
E. coli   197 RQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQY----C- 256

  Fly   260 MLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVH------- 317
               ::|.|::....:..::.......|.....|...:.|.:.|..:||||||.||||.
E. coli   257 ---YVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLV 318

  Fly   318 --FLYQEEIVDSIKQQVEA------------RLLGSN---ATRTFYKQ--LRLPGAPDLDETQLA 363
              |:|| .::..::||:|.            |.:..|   |.|..:.:  .|.|.||.......:
E. coli   319 HDFIYQ-GVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPAS 382

  Fly   364 ---------------DKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQEASRLPEES 413
                           .|.|....:::::|.:..|||.   ||  :......:::||...|:
E. coli   383 GSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKLK---AP--EPQEPALAANSQSFGRV---- 438

  Fly   414 FRVT-----AAKKSREVRLSSV-LDMRKRVERQ----------CSVQLRSTLKNLVYVGCVDERR 462
              :|     .|...|:..:|.: |.:.:|..||          |:..|...|:..|   ..:|:.
E. coli   439 --LTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVCAQPLLIPLRLKV---SAEEKS 498

  Fly   463 ALFQHETRLYMCNTRSFSEELFYQRMIYEFQ-NCSEITI-SPPLPLKE--LLIL----------- 512
            ||.:.::.|              ..:..:|| :...:|| :.||||::  |.||
E. coli   499 ALEKAQSAL--------------AELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQ 549

  Fly   513 --------------SLESEAAGWTPEDGDKAELADGAADI------LLKKAPIMREYFGLRISED 557
                          :|.||.|.|:     .|:.....||:      |:|..|            .
E. coli   550 SVFEPGNIAQWIARNLMSEHAQWS-----MAQAITLLADVERLCPQLVKTPP------------G 597

  Fly   558 GMLESLPSLLH 568
            |:|:|:.  ||
E. coli   598 GLLQSVD--LH 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mlh1	NP_477022.1	mutl	8..317	CDD:273155	109/316 (34%)
		Mlh1_C	426..664	CDD:465109	40/189 (21%)
mutL	NP_418591.1	mutL	1..613	CDD:234630	178/661 (27%)